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Select item 114834871.

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury

Xiaolin Sun, Ning Huang, Peng Li, Xinyi Dong, Jiahong Yang, Xuemei Zhang, Wei-Xing Zong, Shenglan Gao, Hong Xin

Life Sci. Author manuscript; available in PMC 2024 Oct 17.

Published in final edited form as: Life Sci. 2023 May 15; 321: 121608. Published online 2023 Mar 21. doi: 10.1016/j.lfs.2023.121608

PMCID:: PMC11483487

Abstract Article PDF–3.0M

Select item 112101952.

TRIM21 and Fc-engineered antibodies: decoding its complex antibody binding mode with implications for viral neutralization

Johannes Reusch, Linda Elise Franken, Jakob Then, Philippe Ringler, Joachim Butzer, Thomas Juroschek, Christian Klein, Tilman Schlothauer, Laurent Larivière

Front Immunol. 2024; 15: 1401471. Published online 2024 Jun 12. doi: 10.3389/fimmu.2024.1401471

PMCID:: PMC11210195

Abstract Article PDF–7.5M

Select item 111833183.

TRIM21通过与ZSWIM1相互作用调节肺腺癌细胞的增殖和迁移

CHEN Luxuan, LIAN Qionghua, ZHANG Gui, WU Jiayao, ZENG Guandi, GAO Xuejuan

Zhongguo Fei Ai Za Zhi. 2024 May 20; 27(5): 337–344. Chinese. doi: 10.3779/j.issn.1009-3419.2024.101.13

PMCID:: PMC11183318

Abstract Article PDF–13M

Select item 111589844.

Presence of serum tripartite motif‐containing 21 antibodies in patients with esophageal squamous cell carcinoma

Mari Kuboshima, Hideaki Shimada, Tian‐Ling Liu, Fumio Nomura, Masaki Takiguchi, Takaki Hiwasa, Takenori Ochiai

Cancer Sci. 2006 May; 97(5): 380–386. Published online 2006 Apr 10. doi: 10.1111/j.1349-7006.2006.00192.x

PMCID:: PMC11158984

Abstract Article PDF–454K

Select item 110932115.

TRIM21 is critical in regulating hepatocellular carcinoma growth and response to therapy by altering the MST1/YAP pathway

Bo Shu, Yingxia Zhou, Guoqiong Lei, Yu Peng, Cong Ding, Zhuan Li, Chao He

Cancer Sci. 2024 May; 115(5): 1476–1491. Published online 2024 Mar 12. doi: 10.1111/cas.16134

PMCID:: PMC11093211

Abstract Article PDF–5.7M

Select item 110691466.

The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis

Ruyue Zhang, Daidi Zhang, Fugen Han, Xiaorui Song, Yaodong Zhang, Jie Zhang, Qingwen Zhu, Yanru Qin

J Exp Clin Cancer Res. 2024; 43: 135. Published online 2024 May 4. doi: 10.1186/s13046-024-03056-1

PMCID:: PMC11069146

Abstract Article PDF–11M

Select item 109704747.

TRIM21 Promotes Oxidative Stress and Ferroptosis through the SQSTM1-NRF2-KEAP1 Axis to Increase the Titers of H5N1 Highly Pathogenic Avian Influenza Virus

Yifan Wei, Yongxia Gu, Ziwei Zhou, Changrong Wu, Yanwei Liu, Hailiang Sun

Int J Mol Sci. 2024 Mar; 25(6): 3315. Published online 2024 Mar 14. doi: 10.3390/ijms25063315

PMCID:: PMC10970474

Abstract Article PDF–4.2M

Select item 108994268.

FGF19 promotes nasopharyngeal carcinoma progression by inducing angiogenesis via inhibiting TRIM21-mediated ANXA2 ubiquitination

Si Shi, Qicheng Zhang, Kaiwen Zhang, Wenhui Chen, Haijing Xie, Si Pan, Ziyi Xue, Bo You, Jianmei Zhao, Yiwen You

Cell Oncol (Dordr) 2024; 47(1): 283–301. Published online 2023 Oct 2. doi: 10.1007/s13402-023-00868-9

PMCID:: PMC10899426

Abstract Article PDF–14M

Select item 108821619.

Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response

Zhuoyuan Alex Li, Akhilesh Kumar Bajpai, Ruixue Wang, Yaxin Liu, Richard J. Webby, Esther Wilk, Weikuan Gu, Klaus Schughart, Kui Li, Lu Lu

Virus Res. 2024 Apr; 342: 199335. Published online 2024 Feb 17. doi: 10.1016/j.virusres.2024.199335

PMCID:: PMC10882161

Abstract Article PDF–4.7M

Select item 1076495810.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 1076143211.

N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation

Rongjun Xie, Longfei Liu, Xianzhou Lu, Chengjian He, Hongyi Yao, Guoxin Li

Gastric Cancer. 2024; 27(1): 49–71. Published online 2023 Oct 28. doi: 10.1007/s10120-023-01437-7

PMCID:: PMC10761432

Abstract Article PDF–22M

Select item 1072126512.

Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators

Kostas C. Nikolaou, Svenja Godbersen, Muthiah Manoharan, Stefan Wieland, Markus H. Heim, Markus Stoffel

JCI Insight. 2023 Nov 8; 8(21): e164694. Published online 2023 Nov 8. doi: 10.1172/jci.insight.164694

PMCID:: PMC10721265

Abstract Article PDF–2.5M

Select item 1061767313.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 1060304714.

Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling

Ri-Xu Liu, Rong-He Gu, Zhi-Peng Li, Zhi-Quan Hao, Qin-Xiao Hu, Zhen-Yan Li, Xiao-Gang Wang, Wang Tang, Xiao-He Wang, Yu-Kai Zeng, Zhen-Wei Li, Qiu Dong, Xiao-Feng Zhu, Di Chen, Ke-Wei Zhao, Rong-Hua Zhang, Zhen-Gang Zha, Huan-Tian Zhang

Bone Res. 2023; 11: 56. Published online 2023 Oct 26. doi: 10.1038/s41413-023-00296-3

PMCID:: PMC10603047

Abstract Article PDF–11M

Select item 1058246515.

TRIM21‐Promoted FSP1 Plasma Membrane Translocation Confers Ferroptosis Resistance in Human Cancers

Jun Gong, Yuhui Liu, Wenjia Wang, Ruizhi He, Qilong Xia, Lin Chen, Chunle Zhao, Yang Gao, Yongkang Shi, Yu Bai, Yangwei Liao, Qi Zhang, Feng Zhu, Min Wang, Xu Li, Renyi Qin

Adv Sci (Weinh) 2023 Oct; 10(29): 2302318. Published online 2023 Aug 16. doi: 10.1002/advs.202302318

PMCID:: PMC10582465

Abstract Article PDF–8.3M

Select item 1058143116.

Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC progression

Furong Liu, Zhibin Liao, Lu Qin, Ze Zhang, Qiaofeng Zhang, Shenqi Han, Weifeng Zeng, Hongwei Zhang, Yachong Liu, Jia Song, Wei Chen, He Zhu, Huifang Liang, Xiaoping Chen, Bixiang Zhang, Zhanguo Zhang

Hepatology. 2023 Nov; 78(5): 1384–1401. Published online 2023 Jan 13. doi: 10.1097/HEP.0000000000000268

PMCID:: PMC10581431

Abstract Article PDF–2.2M

Select item 1056100717.

TRIM21 enhances bortezomib sensitivity in multiple myeloma by halting prosurvival autophagy

Jing Chen, Wen Cao, Xi Huang, Qingxiao Chen, Shuting Ye, Jianwei Qu, Yang Liu, Xing Guo, Shunnan Yao, Enfan Zhang, Jingsong He, Anqi Li, Li Yang, Zhen Cai

Blood Adv. 2023 Oct 10; 7(19): 5752–5770. Published online 2023 Apr 24. doi: 10.1182/bloodadvances.2022008241

PMCID:: PMC10561007

Abstract Article PDF–9.0M

Select item 1050838318.

USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway

Yinghui Liu, Jingjing Ma, Shimin Lu, Pengzhan He, Weiguo Dong

Chin Med J (Engl) 2023 Sep 20; 136(18): 2229–2242. Published online 2023 Jul 13. doi: 10.1097/CM9.0000000000002714

PMCID:: PMC10508383

Abstract Article PDF–37M

Select item 1046271119.

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication

Augusto C. Montezano, Livia L. Camargo, Sheon Mary, Karla B Neves, Francisco J Rios, Ross Stein, Rheure A. Lopes, Wendy Beattie, Jacqueline Thomson, Vanessa Herder, Agnieszka M. Szemiel, Steven McFarlane, Massimo Palmarini, Rhian M. Touyz

Sci Rep. 2023; 13: 14086. Published online 2023 Aug 28. doi: 10.1038/s41598-023-41115-3