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Select item 113579301.

High expression of SIGLEC7 may promote M2-type macrophage polarization leading to adverse prognosis in glioma patients

Wenhao An, Changyuan Ren, Lei Yuan, Zhiqiang Qiu, Peishen Wang, Yanwen Cheng, Zi He, Xinye Han, Shouwei Li, Yihua An

Front Immunol. 2024; 15: 1411072. Published online 2024 Aug 15. doi: 10.3389/fimmu.2024.1411072

PMCID:: PMC11357930

Abstract Article PDF–10M

Select item 112969142.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 108311613.

The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation

Natalie Stewart, John Daly, Olivia Drummond-Guy, Vignesh Krishnamoorthy, Jessica C. Stark, Nicholas M. Riley, Karla C. Williams, Carolyn R. Bertozzi, Simon Wisnovsky

J Biol Chem. 2024 Feb; 300(2): 105579. Published online 2023 Dec 21. doi: 10.1016/j.jbc.2023.105579

PMCID:: PMC10831161

Abstract Article PDF–2.1M

Select item 95405144.

Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities

Quentin Haas, Nikita Markov, Lukas Muerner, Viviana Rubino, Andrej Benjak, Monika Haubitz, Gabriela M. Baerlocher, Charlotte K. Y. Ng, Christian Münz, Carsten Riether, Adrian F. Ochsenbein, Hans-Uwe Simon, Stephan von Gunten

Front Immunol. 2022; 13: 996746. Published online 2022 Sep 23. doi: 10.3389/fimmu.2022.996746

PMCID:: PMC9540514

Abstract Article PDF–7.7M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80402686.

Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells

Atsushi Yoshimura, Yuki Asahina, Lan-Yi Chang, Takashi Angata, Hiroshi Tanaka, Ken Kitajima, Chihiro Sato

J Biol Chem. 2021 Jan-Jun; 296: 100477. Published online 2021 Feb 26. doi: 10.1016/j.jbc.2021.100477

PMCID:: PMC8040268

Abstract Article PDF–3.2M

Select item 78651657.

Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7

Simon Wisnovsky, Leonhard Möckl, Stacy A. Malaker, Kayvon Pedram, Gaelen T. Hess, Nicholas M. Riley, Melissa A. Gray, Benjamin A. H. Smith, Michael C. Bassik, W. E. Moerner, Carolyn R. Bertozzi

Proc Natl Acad Sci U S A. 2021 Feb 2; 118(5): e2015024118. Published online 2021 Jan 25. doi: 10.1073/pnas.2015024118

PMCID:: PMC7865165

Abstract Article PDF–1.6M

Select item 73667478.

Reduced Siglec‐7 expression on NK cells predicts NK cell dysfunction in primary hepatocellular carcinoma

L. Tao, S. Wang, L. Yang, L. Jiang, J. Li, X. Wang

Clin Exp Immunol. 2020 Aug; 201(2): 161–170. Published online 2020 May 17. doi: 10.1111/cei.13444

PMCID:: PMC7366747

Abstract Article PDF–1.5M

Select item 72508519.

Discovery of a new sialic acid binding region that regulates Siglec-7

Nao Yamakawa, Yu Yasuda, Atsushi Yoshimura, Ami Goshima, Paul R. Crocker, Gérard Vergoten, Yuji Nishiura, Takashi Takahashi, Shinya Hanashima, Kana Matsumoto, Yoshiki Yamaguchi, Hiroshi Tanaka, Ken Kitajima, Chihiro Sato

Sci Rep. 2020; 10: 8647. Published online 2020 May 26. doi: 10.1038/s41598-020-64887-4

PMCID:: PMC7250851

Abstract Article PDF–3.1M

Select item 716998310.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 716533711.

The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression

Yayun Zheng, Xue Ma, Dongmei Su, Yue Zhang, Lin Yu, Fangfei Jiang, Xue Zhou, Ying Feng, Fang Ma

J Immunol Res. 2020; 2020: 6243819. Published online 2020 Apr 6. doi: 10.1155/2020/6243819

PMCID:: PMC7165337

Abstract Article PDF–1.0M

Select item 716066312.

DNA methylation‐mediated Siglec‐7 regulation in natural killer cells via two 5′ promoter CpG sites

Hsin‐Ting Huang, Shih‐Chi Su, Tzeon‐Jye Chiou, Yen‐Hsi Lin, Yi‐Chen Shih, Yu‐Xuan Wu, Ting‐Hsi Fan, Yuh‐Ching Twu

Immunology. 2020 May; 160(1): 38–51. Published online 2020 Mar 5. doi: 10.1111/imm.13179

PMCID:: PMC7160663

Abstract Article PDF–1.1M

Select item 666120813.

Siglec-7 on peripheral blood eosinophils: surface expression and function

Fanny Legrand, Nadine Landolina, Ilan Zaffran, Robert O. Emeh, Elizabeth Chen, Amy D. Klion, Francesca Levi-Schaffer

Allergy. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Allergy. 2019 Jul; 74(7): 1257–1265. Published online 2019 Feb 26. doi: 10.1111/all.13730

PMCID:: PMC6661208

Abstract Article PDF–1.0M

Select item 597928814.

A Developed NK-92MI Cell Line with Siglec-7^neg Phenotype Exhibits High and Sustainable Cytotoxicity against Leukemia Cells

Chin-Han Huang, Yi-Jen Liao, Ting-Hsi Fan, Tzeon-Jye Chiou, Yen-Hsi Lin, Yuh-Ching Twu

Int J Mol Sci. 2018 Apr; 19(4): 1073. Published online 2018 Apr 4. doi: 10.3390/ijms19041073

PMCID:: PMC5979288

Abstract Article PDF–2.8M

Select item 561305715.

Siglec-7 expression is reduced on a natural killer (NK) cell subset of obese humans

Philip Rosenstock, Rüdiger Horstkorte, Vinayaga Srinivasan Gnanapragassam, Jörg Harth, Heike Kielstein

Immunol Res. 2017; 65(5): 1017–1024. Published online 2017 Aug 7. doi: 10.1007/s12026-017-8942-y

PMCID:: PMC5613057

Abstract Article PDF–1.4M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 538128517.

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes

Gitanjali Dharmadhikari, Katharina Stolz, Michael Hauke, Noel G. Morgan, Ajit Varki, Eelco de Koning, Sørge Kelm, Kathrin Maedler

Sci Rep. 2017; 7: 45319. Published online 2017 Apr 5. doi: 10.1038/srep45319

PMCID:: PMC5381285

Abstract Article PDF–2.4M

Select item 424610218.

Lectin Galactoside-binding Soluble 3 Binding Protein (LGALS3BP) Is a Tumor-associated Immunomodulatory Ligand for CD33-related Siglecs

Heinz Läubli, Frederico Alisson-Silva, Michal A. Stanczak, Shoib S. Siddiqui, Liwen Deng, Andrea Verhagen, Nissi Varki, Ajit Varki

J Biol Chem. 2014 Nov 28; 289(48): 33481–33491. Published online 2014 Oct 15. doi: 10.1074/jbc.M114.593129

PMCID:: PMC4246102

Abstract Article PDF–3.0M

Select item 397307319.

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

Camilla Jandus, Kayluz Frias Boligan, Obinna Chijioke, He Liu, Meike Dahlhaus, Thomas Démoulins, Christoph Schneider, Marc Wehrli, Robert E. Hunger, Gabriela M. Baerlocher, Hans-Uwe Simon, Pedro Romero, Christian Münz, Stephan von Gunten

J Clin Invest. 2014 Apr 1; 124(4): 1810–1820. Published online 2014 Feb 24. doi: 10.1172/JCI65899

PMCID:: PMC3973073

Abstract Article PDF–2.8M

Select item 387875220.

Sialic acid-binding Ig-like lectin-7 interacts with HIV-1 gp120 and facilitates infection of CD4^pos T cells and macrophages

Stefania Varchetta, Paolo Lusso, Kelly Hudspeth, Joanna Mikulak, Dalila Mele, Stefania Paolucci, Raffaello Cimbro, Mauro Malnati, Agostino Riva, Renato Maserati, Mario U Mondelli, Domenico Mavilio

Retrovirology. 2013; 10: 154. Published online 2013 Dec 13. doi: 10.1186/1742-4690-10-154

PMCID:: PMC3878752

Abstract Article PDF–1.4M

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