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Select item 110502391.

Association between Platelet-Derived Growth Factor Receptor Alpha Gene Polymorphisms and Platelet-Rich Plasma’s Efficiency in Treating Lateral Elbow Tendinopathy—A Prospective Cohort Study

Alicja Jarosz, Anna Balcerzyk-Matić, Joanna Iwanicka, Tomasz Iwanicki, Tomasz Nowak, Karol Szyluk, Marcin Kalita, Sylwia Górczyńska-Kosiorz, Wojciech Kania, Paweł Niemiec

Int J Mol Sci. 2024 Apr; 25(8): 4266. Published online 2024 Apr 12. doi: 10.3390/ijms25084266

PMCID:: PMC11050239

Abstract Article PDF–1.9M

Select item 110103572.

Pediatric-type high-grade gliomas with PDGFRA amplification in adult patients with Li-Fraumeni syndrome: clinical and molecular characterization of three cases

Yuji Kibe, Fumiharu Ohka, Kosuke Aoki, Junya Yamaguchi, Kazuya Motomura, Eiji Ito, Kazuhito Takeuchi, Yuichi Nagata, Satoshi Ito, Nobuhiko Mizutani, Yoshiki Shiba, Sachi Maeda, Tomohide Nishikawa, Hiroki Shimizu, Ryuta Saito

Acta Neuropathol Commun. 2024; 12: 57. Published online 2024 Apr 11. doi: 10.1186/s40478-024-01762-7

PMCID:: PMC11010357

Abstract Article PDF–1.8M

Select item 109209993.

Molecular and clinicopathological features of KIT/PDGFRAwild‐type gastrointestinal stromal tumors

Toshirou Nishida, Yoichi Naito, Tsuyoshi Takahashi, Takuro Saito, Shigeo Hisamori, Dai Manaka, Katsuhiro Ogawa, Seiichi Hirota, Hitoshi Ichikawa

Cancer Sci. 2024 Mar; 115(3): 894–904. Published online 2024 Jan 5. doi: 10.1111/cas.16058

PMCID:: PMC10920999

Abstract Article PDF–710K

Select item 105226724.

Association of PDGFRA polymorphisms with the risk of corneal astigmatism in a Japanese population

Hideharu Fukasaku, Akira Meguro, Masaki Takeuchi, Nobuhisa Mizuki, Masao Ota, Kengo Funakoshi

Sci Rep. 2023; 13: 16075. Published online 2023 Sep 26. doi: 10.1038/s41598-023-43333-1

PMCID:: PMC10522672

Abstract Article PDF–1.3M

Select item 105141695.

PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance

Bianca Soares Carlotto, Patricia Trevisan, Valentina Oliveira Provenzi, Fabiano Pasqualotto Soares, Rafael Fabiano Machado Rosa, Marileila Varella-Garcia, Paulo Ricardo Gazzola Zen

Neuromolecular Med. 2023; 25(3): 441–450. Published online 2023 Aug 23. doi: 10.1007/s12017-023-08749-y

PMCID:: PMC10514169

Abstract Article PDF–867K

Select item 105112566.

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour

Valli Priya, Niraj Kumari, Narendra Krishnani

Turk Patoloji Derg. 2020; 36(2): 116–125. Published online 2020 May 15. doi: 10.5146/tjpath.2019.01470

PMCID:: PMC10511256

Abstract Article PDF–2.3M

Select item 102931327.

Identification of an Activating PDGFRA Deletion in a Novel Sinonasal Soft Tissue Neoplasm

James A. Watkins, Helen Hatcher, Shalini Malhotra, Furrat Amen, Jonathan Bruty, Jamie Trotman, Patrick Tarpey, John A. Tadross

Head Neck Pathol. 2023 Jun; 17(2): 576–580. Published online 2023 Feb 1. doi: 10.1007/s12105-023-01526-0

PMCID:: PMC10293132

Abstract Article PDF–1.0M

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 98831629.

Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML)

Sophie Steinhäuser, Patricia Silva, Lennart Lenk, Thomas Beder, Alina Hartmann, Sonja Hänzelmann, Lars Fransecky, Martin Neumann, Lorenz Bastian, Simone Lipinski, Kathrin Richter, Miriam Bultmann, Emely Hübner, Shuli Xia, Christoph Röllig, Fotini Vogiatzi, Denis Martin Schewe, Veronica Yumiceba, Kristin Schultz, Malte Spielmann, Claudia Dorothea Baldus

Leukemia. 2023; 37(1): 134–142. Published online 2022 Nov 21. doi: 10.1038/s41375-022-01751-6

PMCID:: PMC9883162

Abstract Article PDF–2.5M

Select item 917141110.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 915928911.

EGFRvIII Tumorigenicity Requires PDGFRA Co-Signaling and Reveals Therapeutic Vulnerabilities in Glioblastoma

Alan T. Yeo, Hyun Jung Jun, Vicky A. Appleman, Piyan Zhang, Hemant Varma, Jann N. Sarkaria, Al Charest

Oncogene. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Oncogene. 2021 Apr; 40(15): 2682–2696. Published online 2021 Mar 11. doi: 10.1038/s41388-021-01721-9

PMCID:: PMC9159289

Abstract Article PDF–3.1M

Select item 907546712.

Platelet‐Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension

Julien Solinc, Jessica Raimbault‐Machado, France Dierick, Lamiaa El Bernoussi, Ly Tu, Raphaël Thuillet, Nathalie Mougenot, Bénédicte Hoareau‐Coudert, Virginie Monceau, Catherine Pavoine, Fabrice Atassi, David Sassoon, Giovanna Marazzi, Richard P. Harvey, Peter Schofield, Daniel Christ, Marc Humbert, Christophe Guignabert, Florent Soubrier, Sophie Nadaud

J Am Heart Assoc. 2022 Apr 5; 11(7): e023021. Published online 2022 Mar 29. doi: 10.1161/JAHA.121.023021

PMCID:: PMC9075467

Abstract Article PDF–3.7M

Select item 899963013.

PDGF/PDGFR: A Possible Molecular Target in Scleroderma Fibrosis

Chiara Paolini, Silvia Agarbati, Devis Benfaremo, Matteo Mozzicafreddo, Silvia Svegliati, Gianluca Moroncini

Int J Mol Sci. 2022 Apr; 23(7): 3904. Published online 2022 Mar 31. doi: 10.3390/ijms23073904

PMCID:: PMC8999630

Abstract Article PDF–1.1M

Select item 889702214.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 880772515.

EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

Qu-Jing Gai, Zhen Fu, Jiang He, Min Mao, Xiao-Xue Yao, Yan Qin, Xi Lan, Lin Zhang, Jing-Ya Miao, Yan-Xia Wang, Jiang Zhu, Fei-Cheng Yang, Hui-Min Lu, Ze-Xuan Yan, Fang-Lin Chen, Yu Shi, Yi-Fang Ping, You-Hong Cui, Xia Zhang, Xindong Liu, Xiao-Hong Yao, Sheng-Qing Lv, Xiu-Wu Bian, Yan Wang

Signal Transduct Target Ther. 2022; 7: 33. Published online 2022 Feb 2. doi: 10.1038/s41392-021-00855-2

PMCID:: PMC8807725

Abstract Article PDF–7.7M

Select item 878684416.

An oncogenic splice variant of PDGFRα in adult glioblastoma as a therapeutic target for selective CDK4/6 inhibitors

Taiji Hamada, Toshiaki Akahane, Seiya Yokoyama, Nayuta Higa, Mari Kirishima, Kei Matsuo, Michiko Shimokawa, Koji Yoshimoto, Akihide Tanimoto

Sci Rep. 2022; 12: 1275. Published online 2022 Jan 24. doi: 10.1038/s41598-022-05391-9

PMCID:: PMC8786844

Abstract Article PDF–2.1M

Select item 847129017.

PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling

Zelei Yang, Xiaoyun Tang, Todd P. W. McMullen, David N. Brindley, Denise G. Hemmings

Int J Mol Sci. 2021 Sep; 22(18): 9817. Published online 2021 Sep 10. doi: 10.3390/ijms22189817

PMCID:: PMC8471290

Abstract Article PDF–1.7M

Select item 845268018.

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

Maximilian Y. Deng, Dominik Sturm, Elke Pfaff, Martin Sill, Damian Stichel, Gnana Prakash Balasubramanian, Stephan Tippelt, Christof Kramm, Andrew M. Donson, Adam L. Green, Chris Jones, Jens Schittenhelm, Martin Ebinger, Martin U. Schuhmann, Barbara C. Jones, Cornelis M. van Tilburg, Andrea Wittmann, Andrey Golanov, Marina Ryzhova, Jonas Ecker, Till Milde, Olaf Witt, Felix Sahm, David Reuss, David Sumerauer, Josef Zamecnik, Andrey Korshunov, Andreas von Deimling, Stefan M. Pfister, David T. W. Jones

Nat Commun. 2021; 12: 5530. Published online 2021 Sep 20. doi: 10.1038/s41467-021-25708-y

PMCID:: PMC8452680

Abstract Article PDF–1.2M

Select item 816503019.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 804030520.

Identification of low-dose radiation-induced exosomal circ-METRN and miR-4709-3p/GRB14/PDGFRα pathway as a key regulatory mechanism in Glioblastoma progression and radioresistance: Functional validation and clinical theranostic significance

Xinxin Wang, Qinchen Cao, Yonggang Shi, Xiaolong Wu, Yin Mi, Ke Liu, Quancheng Kan, Ruitai Fan, Zhangsuo Liu, Mingzhi Zhang

Int J Biol Sci. 2021; 17(4): 1061–1078. Published online 2021 Mar 2. doi: 10.7150/ijbs.57168

PMCID:: PMC8040305

Abstract Article PDF–5.3M

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