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Select item 115193781.

Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration

Dayoung Kim, Jonathan A. Cooper, David M. Helfman

Sci Rep. 2024; 14: 25786. Published online 2024 Oct 28. doi: 10.1038/s41598-024-76868-y

PMCID:: PMC11519378

Abstract Article PDF–8.3M

Select item 112969142.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112099353.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 100729064.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 99775745.

The tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease

Li Zuo, Wei-Ting Kuo, Feng Cao, Sandra D. Chanez-Paredes, Daniel Zeve, Prabhath Mannam, Léa Jean-François, Anne Day, W Vallen Graham, Yan Y. Sweat, Nitesh Shashikanth, David T. Breault, Jerrold R. Turner

Gut. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Gut. 2023 May; 72(5): 870–881. Published online 2022 May 10. doi: 10.1136/gutjnl-2021-326534

PMCID:: PMC9977574

Abstract Article PDF–5.2M

Select item 96291216.

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong, Liduan Zheng

Autophagy. 2022; 18(11): 2615–2635. Published online 2022 Mar 6. doi: 10.1080/15548627.2022.2044651

PMCID:: PMC9629121

Abstract Article PDF–8.1M

Select item 92792857.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 92518378.

SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK

Xiu Shi, Xuejiao Yu, Juan Wang, Shimin Bian, Qiutong Li, Fengqing Fu, Xinwei Zou, Lin Zhang, Robert C. Bast, Jr., Zhen Lu, Lingchuan Guo, Youguo Chen, Jinhua Zhou

Mol Oncol. 2022 Jul; 16(13): 2558–2574. Published online 2022 Mar 25. doi: 10.1002/1878-0261.13208

PMCID:: PMC9251837

Abstract Article PDF–12M

Select item 90626599.

Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0

Fujun Hou, Zeyu Sun, Yue Deng, Siyu Chen, Xiyuan Yang, Feiyang Ji, Menghao Zhou, Keyi Ren, Dongli Pan

Front Microbiol. 2022; 13: 856471. Published online 2022 Apr 18. doi: 10.3389/fmicb.2022.856471

PMCID:: PMC9062659

Abstract Article PDF–3.5M

Select item 889702210.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 868476411.

Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis

Nilay Taneja, Sophie M. Baillargeon, Dylan T. Burnette

Mol Biol Cell. 2021 Oct 1; 32(20): br3. doi: 10.1091/mbc.E20-09-0608

PMCID:: PMC8684764

Abstract Article PDF–2.4M

Select item 848126912.

CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis

Guangliang Wang, Xiaofeng Zhang, Wei Cheng, Yanxuan Mo, Juan Chen, Zhiming Cao, Xiaogang Chen, Huiqin Cui, Shanshan Liu, Li Huang, Ming Liu, Lei Ma, Ning-Fang Ma

Cell Death Dis. 2021 Oct; 12(10): 891. Published online 2021 Sep 29. doi: 10.1038/s41419-021-04167-9

Correction in:: Cell Death Dis. 2022 Mar; 13(3): 196.

PMCID:: PMC8481269

Abstract Article PDF–3.7M

Select item 828372913.

A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis

Yen-Ju Huang, Tsung-Chun Lee, Yu-Chen Pai, Been-Ren Lin, Jerrold R Turner, Linda Chia-Hui Yu

Carcinogenesis. 2021 Jul; 42(7): 961–974. Published online 2021 May 17. doi: 10.1093/carcin/bgab038

PMCID:: PMC8283729

Abstract Article PDF–35M

Select item 799833614.

MYLK and PTGS1 Genetic Variations Associated with Osteoporosis and Benign Breast Tumors in Korean Women

Hye-Won Cho, Hyun-Seok Jin, Yong-Bin Eom

Genes (Basel) 2021 Mar; 12(3): 378. Published online 2021 Mar 6. doi: 10.3390/genes12030378

PMCID:: PMC7998336

Abstract Article PDF–1.0M

Select item 742732715.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 732206716.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 716998317.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 713599718.

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I

Ivanka R. Sevrieva, Birgit Brandmeier, Saraswathi Ponnam, Mathias Gautel, Malcolm Irving, Kenneth S. Campbell, Yin-Biao Sun, Thomas Kampourakis

J Biol Chem. 2020 Apr 3; 295(14): 4398–4410. Published online 2020 Feb 21. doi: 10.1074/jbc.RA119.011945

PMCID:: PMC7135997

Abstract Article PDF–3.3M

Select item 698120619.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 666259520.

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence

Izumi Horikawa, Kaori Fujita, Lisa M. Miller Jenkins, Yukiharu Hiyoshi, Abdul M. Mondal, Borivoj Vojtesek, David P. Lane, Ettore Appella, Curtis C. Harris

Nat Commun. Author manuscript; available in PMC 2019 Jul 29.

Published in final edited form as: Nat Commun. 2014 Aug 21; 5: 4706. Published online 2014 Aug 21. doi: 10.1038/ncomms5706

PMCID:: PMC6662595

Abstract Article PDF–1.6M

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