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Select item 113894101.

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota

Mingyang Cheng, Bin Xu, Yu Sun, Junhong Wang, Yiyuan Lu, Chunwei Shi, Tianxu Pan, Wenhui Zhao, Xiaoxu Li, Xiaomei Song, Jianzhong Wang, Nan Wang, Wentao Yang, Yanlong Jiang, Haibin Huang, Guilian Yang, Yan Zeng, Dongqin Yang, Chunfeng Wang, Xin Cao

mBio. 2024 Sep; 15(9): e02043-24. Published online 2024 Aug 20. doi: 10.1128/mbio.02043-24

PMCID:: PMC11389410

Abstract Article PDF–2.8M

Select item 112665902.

PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration

Ji Wang, Shiquan Shen, Jian You, Zhaotao Wang, Yan Li, Yanming Chen, Yonghua Tuo, Danmin Chen, Haoming Yu, Jingbo Zhang, Fangran Wang, Xiao Pang, Zongyu Xiao, Qing Lan, Yezhong Wang

Cell Death Dis. 2024 Jul; 15(7): 524. Published online 2024 Jul 23. doi: 10.1038/s41419-024-06920-2

PMCID:: PMC11266590

Abstract Article PDF–6.5M

Select item 111156123.

WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway

Dong Gao, Ruipeng Wang, Bingfeng Li, Yongkang Yang, Zhonghe Zhai, Dan-Ying Chen

Cell Mol Life Sci. 2009 Aug; 66(15): 2573–2584. Published online 2009 Jun 12. doi: 10.1007/s00018-009-0059-6

PMCID:: PMC11115612

Abstract Article PDF–618K

Select item 111147094.

PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1

Hyun Jung Lee, Sung Hee Jang, Hyeyoung Kim, Joo Heon Yoon, Kwang Chul Chung

Cell Mol Life Sci. 2012 Oct; 69(19): 3301–3315. Published online 2012 May 29. doi: 10.1007/s00018-012-1004-7

PMCID:: PMC11114709

Abstract Article PDF–896K

Select item 110739745.

Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression

Shinichiro Matsui, Chihiro Ri, Lyndsey C. Bolanos, Kwangmin Choi, Asuka Shibamiya, Arata Ishii, Koji Takaishi, Nagisa Oshima-Hasegawa, Shokichi Tsukamoto, Yusuke Takeda, Naoya Mimura, Akihide Yoshimi, Koutaro Yokote, Daniel T. Starczynowski, Emiko Sakaida, Tomoya Muto

Leukemia. 2024; 38(5): 1032–1045. Published online 2024 Apr 12. doi: 10.1038/s41375-024-02245-3

PMCID:: PMC11073974

Abstract Article PDF–1.6M

Select item 109401546.

SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination

Da Chen, Jiangni Wu, Xinze Qiu, Shibo Luo, Shanpei Huang, Erdan Wei, Mengbin Qin, Jiean Huang, Shiquan Liu

Cancer Gene Ther. 2024; 31(3): 410–419. Published online 2023 Dec 22. doi: 10.1038/s41417-023-00711-1

PMCID:: PMC10940154

Abstract Article PDF–14M

Select item 108681737.

Potential involvement of circulating exosomal miRNA-146a in disease activity and TRAF6 gene expression in juvenile proliferative lupus nephritis

Poorichaya Somparn, Aunaymon Srichaimongkol, Suwaphit Jungjing, Bunsita Wanthong, Saharat Nanthawong, Leelahavanichkul Asada, Marut Tangwattanachuleepron, Pornpimol Rianthavorn

Lupus Sci Med. 2024; 11(1): e001078. Published online 2024 Feb 14. doi: 10.1136/lupus-2023-001078

PMCID:: PMC10868173

Abstract Article PDF–1.2M

Select item 108444578.

Mechanism of miR-7 mediating TLR4/TRAF6/NF-κB inflammatory pathway in colorectal cancer

Jianfeng Ren, Bing Han, Ping Feng, Gang Shao, Yunli Chang

Funct Integr Genomics. 2024; 24(1): 24. Published online 2024 Feb 5. doi: 10.1007/s10142-024-01307-0

PMCID:: PMC10844457

Abstract Article PDF–6.3M

Select item 107112239.

c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6

Yanli Jiang, Longfei Li, Ruozhen Wu, Liulin Wu, Bin Zhang, Jian-Zhi Wang, Rong Liu, Fei Liu, Jing Wang, Xiaochuan Wang

J Biol Chem. 2023 Dec; 299(12): 105462. Published online 2023 Nov 15. doi: 10.1016/j.jbc.2023.105462

PMCID:: PMC10711223

Abstract Article PDF–2.9M

Select item 1070380910.

POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6

Wenshuo Yang, Xiaohan Cui, Danping Sun, Guorui Sun, Zhibo Yan, Meng Wei, Zuoyang Wang, Wenbin Yu

Cell Death Dis. 2023 Dec; 14(12): 802. Published online 2023 Dec 7. doi: 10.1038/s41419-023-06332-8

PMCID:: PMC10703809

Abstract Article PDF–9.3M

Select item 1068708511.

The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8⁺ T-cell immunity

Jizhang Yu, Jikai Cui, Xi Zhang, Heng Xu, Zhang Chen, Yuan Li, Yuqing Niu, Song Wang, Shuan Ran, Yanqiang Zou, Weicong Ye, Dan Zhang, Cheng Zhou, Jiahong Xia, Jie Wu

Cell Mol Immunol. 2023 Dec; 20(12): 1445–1456. Published online 2023 Nov 7. doi: 10.1038/s41423-023-01093-y

PMCID:: PMC10687085

Abstract Article PDF–4.8M

Select item 1068425812.

YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis

Meng Zhou, Yuzhen Liu, Haoxiang Xu, Xu Chen, Nana Zheng, Zhimin Duan, Yiping Ge, Dongqing Li, Tong Lin, Rong Zeng, Qing Chen, Min Li

J Innate Immun. 2023 Jan-Dec; 15(1): 822–835. Published online 2023 Oct 30. doi: 10.1159/000534704

PMCID:: PMC10684258

Abstract Article PDF–1.7M

Select item 1064388913.

Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA

Grant R. Campbell, Pratima Rawat, Stephen A. Spector

J Innate Immun. 2023 Jan-Dec; 15(1): 96–106. Published online 2022 Jul 4. doi: 10.1159/000525292

PMCID:: PMC10643889

Abstract Article PDF–1.2M

Select item 1058798614.

TRAF6 promotes chemoresistance to paclitaxel of triple negative breast cancer via regulating PKM2‐mediated glycolysis

Han Xu, Longzhi Li, Bing Dong, Ji Lu, Kun Zhou, Xiaoxing Yin, Huizhen Sun

Cancer Med. 2023 Oct; 12(19): 19807–19820. Published online 2023 Sep 25. doi: 10.1002/cam4.6552

PMCID:: PMC10587986

Abstract Article PDF–51M

Select item 1034487815.

β‐arrestin 2 negatively regulates lung cancer progression by inhibiting the TRAF6 signaling axis for NF-κB activation and autophagy induced by TLR3 and TLR4

Ji Young Kim, Ji Hye Shin, Mi-Jeong Kim, Yeeun Kang, Ji Su Lee, Juhee Son, Soo-Kyung Jeong, Daesik Kim, Duk-Hwan Kim, Eunyoung Chun, Ki-Young Lee

Cell Death Dis. 2023 Jul; 14(7): 422. Published online 2023 Jul 13. doi: 10.1038/s41419-023-05945-3

PMCID:: PMC10344878

Abstract Article PDF–9.3M

Select item 1033483816.

Sufu limits sepsis-induced lung inflammation via regulating phase separation of TRAF6

Yehua Li, Jiayin Peng, Yuanxin Xia, Chenyu Pan, Yu Li, Weijie Gu, Jia Wang, Chaoxiong Wang, Yuang Wang, Jiawen Song, Xuan Zhou, Liya Ma, Yiao Jiang, Biao Liu, Qiongni Feng, Wenjia Wang, Shi Jiao, Liwei An, Dianfan Li, Zhaocai Zhou, Yun Zhao

Theranostics. 2023; 13(11): 3761–3780. Published online 2023 Jun 26. doi: 10.7150/thno.83676

PMCID:: PMC10334838

Abstract Article PDF–8.8M

Select item 1033332617.

Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma

Yatian Li, Zhenyue Gao, Yuhong Wang, Bo Pang, Binbin Zhang, Ruxin Hu, Yuqing Wang, Chao Liu, Xuebin Zhang, Jingxuan Yang, Mei Mei, Yongzhi Wang, Xuan Zhou, Min Li, Yu Ren

Nat Commun. 2023; 14: 4062. Published online 2023 Jul 10. doi: 10.1038/s41467-023-39845-z