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Items: 1 to 20 of 246

1.
Syk protein inhibitors treatment for the allergic symptoms associated with hyper immunoglobulin E syndromes: A focused on a computational approach
Mariam Mansouri, Ghyzlane ElHaddoumi, Ilham Kandoussi, Lahcen Belyamani, Azeddine Ibrahimi, Naima El Hafidi
Int J Immunopathol Pharmacol. 2024 Jan-Dec; 38: 03946320241282030. Published online 2024 Sep 6. doi: 10.1177/03946320241282030
PMCID:
PMC11380138
AbstractArticlePDF–2.4M
2.
Syk is indispensable for CpG-induced activation and differentiation of human B cells
Mariann Kremlitzka, Bernadett Mácsik-Valent, Anna Erdei
Cell Mol Life Sci. 2015 Jun; 72(11): 2223–2236. Published online 2014 Dec 28. doi: 10.1007/s00018-014-1806-x
PMCID:
PMC11113211
AbstractArticlePDF–1.2M
3.
A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane
Cláudia Almeida Loureiro, Francisco R. Pinto, Patrícia Barros, Paulo Matos, Peter Jordan
Cell Mol Life Sci. 2020 Dec; 77(23): 4997–5015. Published online 2020 Jan 23. doi: 10.1007/s00018-020-03448-4
Correction in:
Cell Mol Life Sci. 2024 Dec; 81(1): 328.
PMCID:
PMC11105000
AbstractArticlePDF–4.7M
4.
SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights
Ren Geng, Yao Zhao, Wanzhen Xu, Xiaoshan Ma, Yining Jiang, Xuefei Han, Liyan Zhao, Yunqian Li
J Transl Med. 2024; 22: 338. Published online 2024 Apr 9. doi: 10.1186/s12967-024-05149-z
PMCID:
PMC11003053
AbstractArticlePDF–5.8M
5.
Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets
Pengyu Zhang, Fiorella A. Solari, Johan W. M. Heemskerk, Marijke J. E. Kuijpers, Albert Sickmann, Ulrich Walter, Kerstin Jurk
Int J Mol Sci. 2023 May; 24(9): 7776. Published online 2023 Apr 24. doi: 10.3390/ijms24097776
PMCID:
PMC10178361
AbstractArticlePDF–3.2M
6.
Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Maria Prendecki, Kavita Gulati, Noelle Pisacano, Damilola Pinheiro, Tejal Bhatt, Marie‐Anne Mawhin, Frederic Toulza, Esteban S. Masuda, Andrew Cowburn, Katharine M. Lodge, Frederick W. K. Tam, Candice Roufosse, Charles D. Pusey, Stephen P. McAdoo
Arthritis Rheumatol. 2023 Jan; 75(1): 84–97. Published online 2022 Nov 25. doi: 10.1002/art.42321
PMCID:
PMC10099805
AbstractArticlePDF–2.7M
7.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
8.
Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19
Gustaf Wigerblad, Seth A. Warner, Marcos J. Ramos-Benitez, Lela Kardava, Xin Tian, Rui Miao, Robert Reger, Mala Chakraborty, Susan Wong, Yogendra Kanthi, Anthony F. Suffredini, Stefania Dell’Orso, Stephen Brooks, Christopher King, Oksana Shlobin, Steven D. Nathan, Jonathan Cohen, Susan Moir, Richard W. Childs, Mariana J. Kaplan, Daniel S. Chertow, Jeffrey R. Strich
Sci Adv. 2023 Jan; 9(1): eade8272. Published online 2023 Jan 4. doi: 10.1126/sciadv.ade8272
PMCID:
PMC9812373
AbstractArticlePDF–1.8M
9.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
10.
A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas
Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Maria Luisa Guerrera, Zachary R. Hunter, M. Lia Palomba, Kimon V. Argyropoulos, Christopher J. Patterson, Alexa G. Canning, Kirsten Meid, Joshua Gustine, Andrew R. Branagan, Catherine A. Flynn, Shayna Sarosiek, Jorge J. Castillo, Jinhua Wang, Sara J. Buhrlage, Nathanael S. Gray, Nikhil C. Munshi, Kenneth C. Anderson, Steven P. Treon, Guang Yang
Blood Adv. 2022 Jun 14; 6(11): 3332–3338. Published online 2022 Jun 3. doi: 10.1182/bloodadvances.2021006147
PMCID:
PMC9198919
AbstractArticlePDF–1.4M
11.
Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear
Gina Perrella, Samantha J. Montague, Helena C. Brown, Lourdes Garcia Quintanilla, Alexandre Slater, David Stegner, Mark Thomas, Johan W. M. Heemskerk, Steve P. Watson
Int J Mol Sci. 2022 Jan; 23(1): 493. Published online 2022 Jan 1. doi: 10.3390/ijms23010493
PMCID:
PMC8745592
AbstractArticlePDF–3.7M
12.
STING-Mediated Interferon Induction by Herpes Simplex Virus 1 Requires the Protein Tyrosine Kinase Syk
Chenyao Wang, Nikhil Sharma, Manoj Veleeparambil, Patricia M. Kessler, Belinda Willard, Ganes C. Sen
mBio. 2021 Nov-Dec; 12(6): e03228-21. Published online 2021 Dec 21. doi: 10.1128/mbio.03228-21
PMCID:
PMC8689565
AbstractArticlePDF–4.8M
13.
Differences in the dynamics of the tandem‐SH2 modules of the Syk and ZAP‐70 tyrosine kinases
Helen T. Hobbs, Neel H. Shah, Jean M. Badroos, Christine L. Gee, Susan Marqusee, John Kuriyan
Protein Sci. 2021 Dec; 30(12): 2373–2384. Published online 2021 Oct 23. doi: 10.1002/pro.4199
PMCID:
PMC8605373
AbstractArticlePDF–5.8M
14.
SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis
Carmelo Luci, Elodie Vieira, Manon Bourinet, Déborah Rousseau, Stéphanie Bonnafous, Stéphanie Patouraux, Lauren Lefevre, Frederic Larbret, Virginie Prod’homme, Antonio Iannelli, Albert Tran, Rodolphe Anty, Béatrice Bailly-Maitre, Marcel Deckert, Philippe Gual
Cell Mol Gastroenterol Hepatol. 2022; 13(1): 173–191. Published online 2021 Aug 16. doi: 10.1016/j.jcmgh.2021.08.004
PMCID:
PMC8593618
AbstractArticlePDF–2.0M
15.
Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling
Laurence M. Gagné, Nadine Morin, Noémie Lavoie, Nicolas Bisson, Jean-Philippe Lambert, Frédérick A. Mallette, Marc-Étienne Huot
J Biol Chem. 2021 Nov; 297(5): 101291. Published online 2021 Oct 9. doi: 10.1016/j.jbc.2021.101291
PMCID:
PMC8551655
AbstractArticlePDF–3.5M
16.
TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity
Xueer Wang, Honghai Zhang, Zhugui Shao, Wanxin Zhuang, Chao Sui, Feng Liu, Xiaorong Chen, Jinxiu Hou, Lingli Kong, Hansen Liu, Yi Zheng, Bingyu Liu, Tian Chen, Lei Zhang, Xinming Jia, Chengjiang Gao
Signal Transduct Target Ther. 2021; 6: 298. Published online 2021 Aug 6. doi: 10.1038/s41392-021-00711-3
PMCID:
PMC8342987
AbstractArticlePDF–6.2M
17.
Comprehensive analysis of Syk gene methylation in colorectal cancer
Fanqin Bu, Xiaojian Zhu, Sicheng Liu, Kang Lin, Jinfeng Zhu, Jun Huang
Immun Inflamm Dis. 2021 Sep; 9(3): 923–931. Published online 2021 May 12. doi: 10.1002/iid3.449
PMCID:
PMC8342196
AbstractArticlePDF–4.8M
18.
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice
Lin Wang, Dominik Aschenbrenner, Zhiyang Zeng, Xiya Cao, Daniel Mayr, Meera Mehta, Melania Capitani, Neil Warner, Jie Pan, Liren Wang, Qi Li, Tao Zuo, Sarit Cohen-Kedar, Jiawei Lu, Rico Chandra Ardy, Daniel J. Mulder, Dilan Dissanayake, Kaiyue Peng, Zhiheng Huang, Xiaoqin Li, Yuesheng Wang, Xiaobing Wang, Shuchao Li, Samuel Bullers, Anís N. Gammage, Klaus Warnatz, Ana-Iris Schiefer, Gergely Krivan, Vera Goda, Walter H.A. Kahr, Mathieu Lemaire, Genomics England Research Consortium, Chien-Yi Lu, Iram Siddiqui, Michael G. Surette, Daniel Kotlarz, Karin R. Engelhardt, Helen R. Griffin, Robert Rottapel, Hélène Decaluwe, Ronald M. Laxer, Michele Proietti, Sophie Hambleton, Suzanne Elcombe, Cong-Hui Guo, Bodo Grimbacher, Iris Dotan, Siew C. Ng, Spencer A. Freeman, Scott B. Snapper, Christoph Klein, Kaan Boztug, Ying Huang, Dali Li, Holm H. Uhlig, Aleixo M. Muise
Nat Genet. Author manuscript; available in PMC 2021 Sep 29.
Published in final edited form as: Nat Genet. 2021 Apr; 53(4): 500–510. Published online 2021 Mar 29. doi: 10.1038/s41588-021-00803-4
PMCID:
PMC8245161
AbstractArticlePDF–5.6M
19.
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer
Teresa Sadras, Mickaël Martin, Kohei Kume, Mark E. Robinson, Supraja Saravanakumar, Gal Lenz, Zhengshan Chen, Joo Y. Song, Tanya Siddiqi, Laura Oksa, Anne Marie Knapp, Jevon Cutler, Kadriye Nehir Cosgun, Lars Klemm, Veronika Ecker, Janet Winchester, Dana Ghergus, Pauline Soulas-Sprauel, Friedemann Kiefer, Nora Heisterkamp, Akhilesh Pandey, Vu Ngo, Lili Wang, Hassan Jumaa, Maike Buchner, Jürgen Ruland, Wing-Chung Chan, Eric Meffre, Thierry Martin, Markus Müschen
Mol Cell. Author manuscript; available in PMC 2022 May 20.
Published in final edited form as: Mol Cell. 2021 May 20; 81(10): 2094–2111.e9. Published online 2021 Apr 19. doi: 10.1016/j.molcel.2021.03.043
PMCID:
PMC8239336
AbstractArticlePDF–3.6M
20.
PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα
Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz
iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686
PMCID:
PMC8220391
AbstractArticlePDF–4.4M

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