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Select item 112099351.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111595122.

The human endonuclease III enzyme is a relevant target to potentiate cisplatin cytotoxicity in Y‐box‐binding protein‐1 overexpressing tumor cells

David Guay, Chantal Garand, Shanti Reddy, Chris Schmutte, Michel Lebel

Cancer Sci. 2008 Apr; 99(4): 762–769. Published online 2008 Feb 27. doi: 10.1111/j.1349-7006.2008.00739.x

PMCID:: PMC11159512

Abstract Article PDF–347K

Select item 110592363.

Enhanced Sampling for Conformational Changes and Molecular Mechanisms of Human NTHL1

Ryan E. Odstrcil, Prashanta Dutta, Jin Liu

J Phys Chem Lett. Author manuscript; available in PMC 2024 Apr 30.

Published in final edited form as: J Phys Chem Lett. 2024 Mar 21; 15(11): 3206–3213. Published online 2024 Mar 14. doi: 10.1021/acs.jpclett.4c00161

PMCID:: PMC11059236

Abstract Article PDF–1.5M

Select item 106894554.

NTHL1 is a recessive cancer susceptibility gene

Anna K. Nurmi, Liisa M. Pelttari, Johanna I. Kiiski, Sofia Khan, Mika Nurmikolu, Maija Suvanto, Niina Aho, Tiina Tasmuth, Eija Kalso, Johanna Schleutker, Anne Kallioniemi, Päivi Heikkilä, FinnGen, Kristiina Aittomäki, Carl Blomqvist, Heli Nevanlinna

Sci Rep. 2023; 13: 21127. Published online 2023 Nov 30. doi: 10.1038/s41598-023-47441-w

PMCID:: PMC10689455

Abstract Article PDF–1.1M

Select item 104998215.

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets

Filip Mihalič, Caroline Benz, Eszter Kassa, Richard Lindqvist, Leandro Simonetti, Raviteja Inturi, Hanna Aronsson, Eva Andersson, Celestine N. Chi, Norman E. Davey, Anna K. Överby, Per Jemth, Ylva Ivarsson

Nat Commun. 2023; 14: 5636. Published online 2023 Sep 13. doi: 10.1038/s41467-023-41312-8

PMCID:: PMC10499821

Abstract Article PDF–2.6M

Select item 98066746.

Concurrent Reduced Expression of Contiguous PKD1, TSC2 and NTHL1 Leading to Kidney Diseases and Multiple Diverse Renal Cancers

SATORU MEGURO, TOMOYUKI KOGUCHI, YUSUKE HAKOZAKI, AKIFUMI ONAGI, KANAKO MATSUOKA, SEIJI HOSHI, JUNYA HATA, YUICHI SATO, HIDENORI AKAIHATA, MASAO KATAOKA, SOICHIRO OGAWA, YOSHIYUKI KOJIMA

Cancer Genomics Proteomics. 2023 Jan-Feb; 20(1): 40–50. Published online 2023 Jan 3. doi: 10.21873/cgp.20363

PMCID:: PMC9806674

Abstract Article PDF–5.1M

Select item 97979887.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 97725588.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 95403459.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 911973610.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 868279211.

Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis

Brittany L Carroll, Karl E Zahn, John P Hanley, Susan S Wallace, Julie A Dragon, Sylvie Doublié

Nucleic Acids Res. 2021 Dec 16; 49(22): 13165–13178. Published online 2021 Dec 6. doi: 10.1093/nar/gkab1162

PMCID:: PMC8682792

Abstract Article PDF–3.5M

Select item 866412912.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

Marcel Morgenstern, Christian D. Peikert, Philipp Lübbert, Ida Suppanz, Cinzia Klemm, Oliver Alka, Conny Steiert, Nataliia Naumenko, Alexander Schendzielorz, Laura Melchionda, Wignand W.D. Mühlhäuser, Bettina Knapp, Jakob D. Busch, Sebastian B. Stiller, Stefan Dannenmaier, Caroline Lindau, Mariya Licheva, Christopher Eickhorst, Riccardo Galbusera, Ralf M. Zerbes, Michael T. Ryan, Claudine Kraft, Vera Kozjak-Pavlovic, Friedel Drepper, Sven Dennerlein, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann, Bettina Warscheid

Cell Metab. 2021 Dec 7; 33(12): 2464–2483.e18. doi: 10.1016/j.cmet.2021.11.001

PMCID:: PMC8664129

Abstract Article

Select item 823207213.

Prevalence and Characterization of Biallelic and Monoallelic NTHL1 and MSH3 Variant Carriers From a Pan-Cancer Patient Population

Erin E. Salo-Mullen, Anna Maio, Semanti Mukherjee, Chaitanya Bandlamudi, Jinru Shia, Yelena Kemel, Karen A. Cadoo, Ying Liu, Maria Carlo, Megha Ranganathan, Sarah Kane, Preethi Srinivasan, Shweta S. Chavan, Mark T. A. Donoghue, Caitlin Bourque, Margaret Sheehan, Prince Rainier Tejada, Zalak Patel, Angela G. Arnold, Jennifer A. Kennedy, Kimberly Amoroso, Kelsey Breen, Amanda Catchings, Rosalba Sacca, Vanessa Marcell, Arnold J. Markowitz, Alicia Latham, Michael Walsh, Maksym Misyura, Ozge Ceyhan-Birsoy, David B. Solit, Michael F. Berger, Mark E. Robson, Barry S. Taylor, Kenneth Offit, Diana Mandelker, Zsofia K. Stadler

JCO Precis Oncol. 2021; 5: PO.20.00443. Published online 2021 Feb 26. doi: 10.1200/PO.20.00443

PMCID:: PMC8232072

Abstract Article PDF–541K

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 789969615.

Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer

Fadwa A. Elsayed, Judith E. Grolleman, Abiramy Ragunathan, NTHL1 study group, Daniel D. Buchanan, Tom van Wezel, Richarda M. de Voer

Gastroenterology. Author manuscript; available in PMC 2021 Feb 22.

Published in final edited form as: Gastroenterology. 2020 Dec; 159(6): 2241–2243.e6. Published online 2020 Aug 26. doi: 10.1053/j.gastro.2020.08.042

PMCID:: PMC7899696

Article PDF–466K

Select item 774806716.

NTHL1 in Genomic Integrity, Aging and Cancer

Lipsa Das, Victoria G. Quintana, Joann B. Sweasy

DNA Repair (Amst) Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: DNA Repair (Amst). 2020 Sep; 93: 102920. doi: 10.1016/j.dnarep.2020.102920

PMCID:: PMC7748067

Abstract Article PDF–1.3M

Select item 766737517.

Evaluating the role of NTHL1 p.Q90* allele in inherited breast cancer predisposition

Timo Kumpula, Anna Tervasmäki, Tuomo Mantere, Susanna Koivuluoma, Laura Huilaja, Kaisa Tasanen, Robert Winqvist, Richarda M. de Voer, Katri Pylkäs

Mol Genet Genomic Med. 2020 Nov; 8(11): e1493. Published online 2020 Sep 19. doi: 10.1002/mgg3.1493

PMCID:: PMC7667375

Abstract Article PDF–274K

Select item 718013418.

An Excimer Clamp for Measuring Damaged Base Excision by the DNA Repair Enzyme NTH1

Yong Woong Jun, David L. Wilson, Anna M. Kietrys, Elizabeth R. Lotsof, Savannah G. Conlon, Sheila S. David, Eric T. Kool

Angew Chem Int Ed Engl. Author manuscript; available in PMC 2021 May 4.

Published in final edited form as: Angew Chem Int Ed Engl. 2020 May 4; 59(19): 7450–7455. Published online 2020 Mar 17. doi: 10.1002/anie.202001516

PMCID:: PMC7180134

Abstract Article PDF–980K

Select item 676993019.

Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners

Eunate Gallardo-Vara, Lidia Ruiz-Llorente, Juan Casado-Vela, María J. Ruiz-Rodríguez, Natalia López-Andrés, Asit K. Pattnaik, Miguel Quintanilla, Carmelo Bernabeu

Cells. 2019 Sep; 8(9): 1082. Published online 2019 Sep 13. doi: 10.3390/cells8091082

PMCID:: PMC6769930

Abstract Article PDF–4.3M

Select item 674682220.

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei

Giovanni Nassa, Giorgio Giurato, Annamaria Salvati, Valerio Gigantino, Giovanni Pecoraro, Jessica Lamberti, Francesca Rizzo, Tuula A. Nyman, Roberta Tarallo, Alessandro Weisz

Sci Data. 2019; 6: 173. Published online 2019 Sep 16. doi: 10.1038/s41597-019-0179-2

PMCID:: PMC6746822

Abstract Article PDF–2.0M

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