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Select item 114943091.

Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming

Yatian Yang, Xiong Zhang, Demin Cai, Xingling Zheng, Xuan Zhao, June X. Zou, Jin Zhang, Alexander D. Borowsky, Marc A. Dall’Era, Eva Corey, Nicholas Mitsiades, Hsing-Jien Kung, Xinbin Chen, Jian Jian Li, Michael Downes, Ronald M. Evans, Hong-Wu Chen

Proc Natl Acad Sci U S A. 2024 Oct 15; 121(42): e2411321121. Published online 2024 Oct 9. doi: 10.1073/pnas.2411321121

PMCID:: PMC11494309

Abstract Article PDF–4.7M

Select item 114320792.

RNA Sequencing Reveals a Strong Predominance of THRA Splicing Isoform 2 in the Developing and Adult Human Brain

Eugenio Graceffo, Robert Opitz, Matthias Megges, Heiko Krude, Markus Schuelke

Int J Mol Sci. 2024 Sep; 25(18): 9883. Published online 2024 Sep 13. doi: 10.3390/ijms25189883

PMCID:: PMC11432079

Abstract Article PDF–6.8M

Select item 112962393.

Nuclear receptor Rev-erbα role in fine-tuning erythropoietin gene expression

Sumit Kumar, Rashmi Arora, Shalini Gupta, Nancy Ahuja, Ella Bhagyaraj, Ravikanth Nanduri, Rashi Kalra, Asheesh Kumar Khare, Saumyata Kumawat, Vipashu Kaushal, Mahathi Sharma, Pawan Gupta

Blood Adv. 2024 Jul 23; 8(14): 3705–3717. Published online 2024 May 17. doi: 10.1182/bloodadvances.2023012228

PMCID:: PMC11296239

Abstract Article PDF–2.4M

Select item 110396424.

Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development

Adina Sophie Graffunder, Audrey Amber Julie Bresser, Valeria Fernandez Vallone, Matthias Megges, Harald Stachelscheid, Peter Kühnen, Robert Opitz

Sci Rep. 2024; 14: 9355. Published online 2024 Apr 23. doi: 10.1038/s41598-024-59533-2

PMCID:: PMC11039642

Abstract Article PDF–4.5M

Select item 108157055.

Functional Characterization of Circadian Nuclear Receptors REV-ERBα and REV-ERBβ in Human Osteosarcoma Cell Cultures

Hana Cho, Ahee Yun, Joohee Kim, Eunjeong Park, Jong-Wha Jung, Sooyoung Chung, Gi Hoon Son

Int J Mol Sci. 2024 Jan; 25(2): 770. Published online 2024 Jan 7. doi: 10.3390/ijms25020770

PMCID:: PMC10815705

Abstract Article PDF–2.4M

Select item 107193386.

Sex-dependent relationship of polymorphisms in CLOCK and REV-ERBα genes with body mass index and lipid levels in children

Claudia Vales-Villamarín, Olaya de Dios, Ignacio Mahíllo-Fernández, Macarena Perales, Iris Pérez-Nadador, Teresa Gavela-Pérez, Leandro Soriano-Guillén, Carmen Garcés

Sci Rep. 2023; 13: 22127. Published online 2023 Dec 13. doi: 10.1038/s41598-023-49506-2

PMCID:: PMC10719338

Abstract Article PDF–1.7M

Select item 105316867.

Uncovering the Novel Role of NR1D1 in Regulating BNIP3-Mediated Mitophagy in Ulcerative Colitis

Yidong Chen, Junrong Li, Shuang Li, Yiyu Cheng, Xiaoyu Fu, Jiamin Li, Liangru Zhu

Int J Mol Sci. 2023 Sep; 24(18): 14222. Published online 2023 Sep 18. doi: 10.3390/ijms241814222

PMCID:: PMC10531686

Abstract Article PDF–12M

Select item 97181188.

Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions

Maria Virginia Giolito, Théo La Rosa, Diana Farhat, Serguei Bodoirat, Gabriela D. A. Guardia, Claire Domon‐Dell, Pedro A. F. Galante, Jean‐Noel Freund, Michelina Plateroti

Mol Oncol. 2022 Dec; 16(22): 3975–3993. Published online 2022 Oct 10. doi: 10.1002/1878-0261.13298

PMCID:: PMC9718118

Abstract Article PDF–2.2M

Select item 96744489.

Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2

Ling-Yue Sun, Yu-Yan Lyu, Heng-Yuan Zhang, Zhi Shen, Guan-Qiao Lin, Na Geng, Yu-Li Wang, Lin Huang, Ze-Hao Feng, Xiao Guo, Nan Lin, Song Ding, An-Cai Yuan, Lan Zhang, Kun Qian, Jun Pu

Circulation. 2022 Nov 22; 146(21): 1591–1609. Published online 2022 Jul 26. doi: 10.1161/CIRCULATIONAHA.121.057623

PMCID:: PMC9674448

Abstract Article PDF–7.1M

Select item 947546210.

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold

Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo

Theranostics. 2022; 12(14): 6189–6206. Published online 2022 Aug 21. doi: 10.7150/thno.72134

PMCID:: PMC9475462

Abstract Article PDF–4.6M

Select item 934857611.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 869101812.

Low thyroid hormone receptor alpha-2 (THRα-2) tumor expression is associated with unfavorable tumor characteristics and high breast cancer mortality

Malte Sandsveden, Signe Borgquist, Ann H. Rosendahl, Jonas Manjer

Breast Cancer Res. 2021; 23: 117. Published online 2021 Dec 20. doi: 10.1186/s13058-021-01496-7

PMCID:: PMC8691018

Abstract Article PDF–1.4M

Select item 832327413.

NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway

Huailin Wang, Yan Fu

BMC Cancer. 2021; 21: 871. Published online 2021 Jul 30. doi: 10.1186/s12885-021-08597-8

PMCID:: PMC8323274

Abstract Article PDF–4.7M

Select item 829031314.

Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi

Emery Di Cicco, Carla Moran, W. Edward Visser, Annarita Nappi, Erik Schoenmakers, Pamela Todd, Greta Lyons, Mehul Dattani, Raffaele Ambrosio, Silvia Parisi, Domenico Salvatore, Krishna Chatterjee, Monica Dentice

Thyroid. July 2021; 31(7): 1114–1126. Published online 2021 Jul 8. doi: 10.1089/thy.2020.0391

PMCID:: PMC8290313

Abstract Article PDF–2.1M

Select item 827269515.

Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study

Stefano Rizza, Alessio Luzi, Maria Mavilio, Marta Ballanti, Arianna Massimi, Ottavia Porzio, Andrea Magrini, Juliane Hannemann, Rossella Menghini, Michael Lehrke, Bart Staels, Peter J. Grant, Rainer H. Boger, Nikolaus Marx, Massimo Federici

Acta Diabetol. 2021; 58(8): 1111–1117. Published online 2021 Mar 31. doi: 10.1007/s00592-021-01676-z

PMCID:: PMC8272695

Abstract Article PDF–647K

Select item 825581616.

Helicobacter pylori–Induced Rev-erbα Fosters Gastric Bacteria Colonization by Impairing Host Innate and Adaptive Defense

Fang-Yuan Mao, Yi-Pin Lv, Chuan-Jie Hao, Yong-Sheng Teng, Yu-Gang Liu, Ping Cheng, Shi-Ming Yang, Weisan Chen, Tao Liu, Quan-Ming Zou, Rui Xie, Jing-Yu Xu, Yuan Zhuang

Cell Mol Gastroenterol Hepatol. 2021; 12(2): 395–425. Published online 2021 Mar 3. doi: 10.1016/j.jcmgh.2021.02.013

PMCID:: PMC8255816

Abstract Article PDF–12M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 815912518.

A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2

Sarah Paisdzior, Ellen Knierim, Gunnar Kleinau, Heike Biebermann, Heiko Krude, Rachel Straussberg, Markus Schuelke

Int J Mol Sci. 2021 May; 22(10): 5338. Published online 2021 May 19. doi: 10.3390/ijms22105338

PMCID:: PMC8159125

Abstract Article PDF–1.1M

Select item 804200419.

Thyroid hormone receptor α1 acts as a new squamous cell lung cancer diagnostic marker and poor prognosis predictor

Fatma El Zahraa A. Mohamed, Ali Omar Abdelaziz, Ahmed Hussein Kasem, Tarek Ellethy, Mariana F. Gayyed

Sci Rep. 2021; 11: 7944. Published online 2021 Apr 12. doi: 10.1038/s41598-021-86754-6

PMCID:: PMC8042004

Abstract Article PDF–1.6M

Select item 801772020.

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118

PMCID:: PMC8017720

Abstract Article PDF–1.9M

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