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Select item 107985631.

MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension

Ayelén M. Santamans, Beatriz Cicuéndez, Alfonso Mora, María Villalba-Orero, Sanela Rajlic, María Crespo, Paula Vo, Madison Jerome, Álvaro Macías, Juan Antonio López, Magdalena Leiva, Susana F. Rocha, Marta León, Elena Rodríguez, Luis Leiva, Aránzazu Pintor Chocano, Inés García Lunar, Ana García-Álvarez, Pablo Hernansanz-Agustín, Víctor I. Peinado, Joan Albert Barberá, Borja Ibañez, Jesús Vázquez, Jessica B. Spinelli, Andreas Daiber, Eduardo Oliver, Guadalupe Sabio

Sci Adv. 2024 Jan 19; 10(3): eadk6524. Published online 2024 Jan 19. doi: 10.1126/sciadv.adk6524

PMCID:: PMC10798563

Abstract Article PDF–1.8M

Select item 86641292.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

Marcel Morgenstern, Christian D. Peikert, Philipp Lübbert, Ida Suppanz, Cinzia Klemm, Oliver Alka, Conny Steiert, Nataliia Naumenko, Alexander Schendzielorz, Laura Melchionda, Wignand W.D. Mühlhäuser, Bettina Knapp, Jakob D. Busch, Sebastian B. Stiller, Stefan Dannenmaier, Caroline Lindau, Mariya Licheva, Christopher Eickhorst, Riccardo Galbusera, Ralf M. Zerbes, Michael T. Ryan, Claudine Kraft, Vera Kozjak-Pavlovic, Friedel Drepper, Sven Dennerlein, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann, Bettina Warscheid

Cell Metab. 2021 Dec 7; 33(12): 2464–2483.e18. doi: 10.1016/j.cmet.2021.11.001

PMCID:: PMC8664129

Abstract Article

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73342164.

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Lucía Barbier-Torres, Karen A. Fortner, Paula Iruzubieta, Teresa C. Delgado, Emily Giddings, Youdinghuan Chen, Devin Champagne, David Fernández-Ramos, Daniela Mestre, Beatriz Gomez-Santos, Marta Varela-Rey, Virginia Gutiérrez de Juan, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Carmelo García-Monzón, Águeda González-Rodríguez, Dhaval Oza, Felipe Valença-Pereira, Qian Fang, Javier Crespo, Patricia Aspichueta, Frederic Tremblay, Brock C. Christensen, Juan Anguita, María Luz Martínez-Chantar, Mercedes Rincón

Nat Commun. 2020; 11: 3360. Published online 2020 Jul 3. doi: 10.1038/s41467-020-16991-2

PMCID:: PMC7334216

Abstract Article PDF–3.1M

Select item 69691065.

The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis

Miguel Angel Pascual-Itoiz, Ainize Peña-Cearra, Itziar Martín-Ruiz, José Luis Lavín, Carolina Simó, Héctor Rodríguez, Estibaliz Atondo, Juana María Flores, Ana Carreras-González, Julen Tomás-Cortázar, Diego Barriales, Ainhoa Palacios, Virginia García-Cañas, Aize Pellón, Asier Fullaondo, Ana Mª Aransay, Rafael Prados-Rosales, Rebeca Martín, Juan Anguita, Leticia Abecia

Sci Rep. 2020; 10: 572. Published online 2020 Jan 17. doi: 10.1038/s41598-019-57348-0

PMCID:: PMC6969106

Abstract Article PDF–3.1M

Select item 63211856.

High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines

Shixiong Wang, Sachin Kumar Singh, Madhumohan R. Katika, Sandra Lopez-Aviles, Antoni Hurtado

Int J Mol Sci. 2018 Dec; 19(12): 4123. Published online 2018 Dec 19. doi: 10.3390/ijms19124123

PMCID:: PMC6321185

Abstract Article PDF–2.8M

Select item 60771177.

ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells

Federica Alessandrini, Laura Pezzè, Daniel Menendez, Michael A. Resnick, Yari Ciribilli

Neoplasia. 2018 Aug; 20(8): 857–870. Published online 2018 Jul 17. doi: 10.1016/j.neo.2018.06.008

PMCID:: PMC6077117

Abstract Article PDF–1.2M

Select item 57272178.

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

Lucía Barbier-Torres, Paula Iruzubieta, David Fernández-Ramos, Teresa C. Delgado, Daniel Taibo, Virginia Guitiérrez-de-Juan, Marta Varela-Rey, Mikel Azkargorta, Nicolas Navasa, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Jorge Simon, Fernando Lopitz-Otsoa, Sofia Lachiondo-Ortega, Javier Crespo, Steven Masson, Misti Vanette McCain, Erica Villa, Helen Reeves, Felix Elortza, Maria Isabel Lucena, Maria Isabel Hernández-Alvarez, Antonio Zorzano, Raúl J. Andrade, Shelly C. Lu, José M. Mato, Juan Anguita, Mercedes Rincón, María Luz Martínez-Chantar

Nat Commun. 2017; 8: 2068. Published online 2017 Dec 12. doi: 10.1038/s41467-017-01970-x

PMCID:: PMC5727217

Abstract Article PDF–3.1M

Select item 54610319.

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones

Anna Malinová, Zuzana Cvačková, Daniel Matějů, Zuzana Hořejší, Claire Abéza, Franck Vandermoere, Edouard Bertrand, David Staněk, Céline Verheggen

J Cell Biol. 2017 Jun 5; 216(6): 1579–1596. doi: 10.1083/jcb.201701165

PMCID:: PMC5461031

Abstract Article PDF–2.9M

Select item 504200410.

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles

Anja E. Eisenhardt, Adrian Sprenger, Michael Röring, Ricarda Herr, Florian Weinberg, Martin Köhler, Sandra Braun, Joachim Orth, Britta Diedrich, Ulrike Lanner, Natalja Tscherwinski, Simon Schuster, Nicolas Dumaz, Enrico Schmidt, Ralf Baumeister, Andreas Schlosser, Jörn Dengjel, Tilman Brummer

Oncotarget. 2016 May 3; 7(18): 26628–26652. Published online 2016 Mar 28. doi: 10.18632/oncotarget.8427

PMCID:: PMC5042004

Abstract Article PDF–7.5M

Select item 501613211.

Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase

Devanjan Sinha, Shubhi Srivastava, Patrick D'Silva

J Biol Chem. 2016 Aug 12; 291(33): 17345–17359. Published online 2016 Jun 21. doi: 10.1074/jbc.M116.738146

PMCID:: PMC5016132

Abstract Article PDF–4.5M

Select item 491745112.

Fine-tuning of CD8 T cell mitochondrial respiration by MCJ/DnaJC15 dictates protection to influenza virus

Devin P. Champagne, Ketki M. Hatle, Karen A. Fortner, Angelo D’Alessandro, Tina M. Thornton, Rui Yang, Daniel Torralba, Julen Tomás-Cortázar, Yong Woong Jun, Kyo Han Ahn, Kirk C. Hansen, Laura Haynes, Juan Anguita, Mercedes Rincon

Immunity. Author manuscript; available in PMC 2017 Jun 21.

Published in final edited form as: Immunity. 2016 Jun 21; 44(6): 1299–1311. Published online 2016 May 24. doi: 10.1016/j.immuni.2016.02.018

PMCID:: PMC4917451

Abstract Article PDF–1.6M

Select item 458850913.

Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages

Nicolás Navasa, Itziar Martin-Ruiz, Estíbaliz Atondo, James D. Sutherland, Miguel Angel Pascual-Itoiz, Ana Carreras-González, Hooman Izadi, Julen Tomás-Cortázar, Furkan Ayaz, Natalia Martin-Martin, Iviana M Torres, Rosa Barrio, Arkaitz Carracedo, Elias R. Olivera, Mercedes Rincón, Juan Anguita

Sci Rep. 2015; 5: 14692. Published online 2015 Sep 30. doi: 10.1038/srep14692

PMCID:: PMC4588509

Abstract Article PDF–814K

Select item 426658814.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 397319515.

Chaperoning mitochondrial permeability transition: regulation of transition pore complex by a J-protein, DnaJC15

D Sinha, P D'Silva

Cell Death Dis. 2014 Mar; 5(3): e1101. Published online 2014 Mar 6. doi: 10.1038/cddis.2014.72

PMCID:: PMC3973195

Abstract Article PDF–2.9M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 294347617.

Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Sher L. Hendrickson, James A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A. Kingsley, James J. Goedert, Gregory D. Kirk, Edward D. Gomperts, Susan P. Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien

PLoS One. 2010; 5(9): e12862. Published online 2010 Sep 21. doi: 10.1371/journal.pone.0012862

PMCID:: PMC2943476

Abstract Article PDF–461K

Select item 277326718.

A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB

Anna C. Need, Deborah K. Attix, Jill M. McEvoy, Elizabeth T. Cirulli, Kristen L. Linney, Priscilla Hunt, Dongliang Ge, Erin L. Heinzen, Jessica M. Maia, Kevin V. Shianna, Michael E. Weale, Lynn F. Cherkas, Gail Clement, Tim D. Spector, Greg Gibson, David B. Goldstein

Hum Mol Genet. 2009 Dec 1; 18(23): 4650–4661. Published online 2009 Sep 4. doi: 10.1093/hmg/ddp413

PMCID:: PMC2773267

Abstract Article PDF–151K

Select item 268304719.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67

PMCID:: PMC2683047

Abstract Article PDF–1.4M

Select item 267390220.

Guidelines for the nomenclature of the human heat shock proteins

Harm H. Kampinga, Jurre Hageman, Michel J. Vos, Hiroshi Kubota, Robert M. Tanguay, Elspeth A. Bruford, Michael E. Cheetham, Bin Chen, Lawrence E. Hightower

Cell Stress Chaperones. 2009 Jan; 14(1): 105–111. Published online 2008 Jul 29. doi: 10.1007/s12192-008-0068-7

PMCID:: PMC2673902

Abstract Article PDF–124K

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