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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111396662.

Temozolomide resistance mechanisms: unveiling the role of translesion DNA polymerase kappa in glioblastoma spheroids in vitro

Diego Luis Ribeiro, Marcela Teatin Latancia, Izadora de Souza, Abu-Bakr Adetayo Ariwoola, Davi Mendes, Clarissa Ribeiro Reily Rocha, André Van Helvoort Lengert, Carlos Frederico Martins Menck

Biosci Rep. 2024 May 29; 44(5): BSR20230667. Published online 2024 May 29. doi: 10.1042/BSR20230667

PMCID:: PMC11139666

Abstract Article PDF–4.2M

Select item 106647563.

Biochemical Activity of 17 Cancer-Associated Variants of DNA Polymerase Kappa Predicted by Electrostatic Properties

Lakindu S. Pathira Kankanamge, Alexandra Mora, Mary Jo Ondrechen, Penny J. Beuning

Chem Res Toxicol. 2023 Nov 20; 36(11): 1789–1803. Published online 2023 Oct 26. doi: 10.1021/acs.chemrestox.3c00233

PMCID:: PMC10664756

Abstract Article PDF–4.1M

Select item 105658764.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102431165.

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification

Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt

J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706

PMCID:: PMC10243116

Abstract Article PDF–13M

Select item 96428146.

DNA Polymerases Eta and Kappa Exchange with the Polymerase Delta Holoenzyme to Complete Common Fragile Site Synthesis

Ryan P. Barnes, Suzanne E. Hile, Marietta Y. Lee, Kristin A. Eckert

DNA Repair (Amst) Author manuscript; available in PMC 2022 Nov 8.

Published in final edited form as: DNA Repair (Amst). 2017 Sep; 57: 1–11. Published online 2017 Jun 3. doi: 10.1016/j.dnarep.2017.05.006

PMCID:: PMC9642814

Abstract Article PDF–1.6M

Select item 91197367.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 91052358.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 86024519.

Identification of proximal SUMO-dependent interactors using SUMO-ID

Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland

Nat Commun. 2021; 12: 6671. Published online 2021 Nov 18. doi: 10.1038/s41467-021-26807-6

PMCID:: PMC8602451

Abstract Article PDF–11M

Select item 852662210.

Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA

Claudia Lancey, Muhammad Tehseen, Souvika Bakshi, Matthew Percival, Masateru Takahashi, Mohamed A. Sobhy, Vlad S. Raducanu, Kerry Blair, Frederick W. Muskett, Timothy J. Ragan, Ramon Crehuet, Samir M. Hamdan, Alfredo De Biasio

Nat Commun. 2021; 12: 6095. Published online 2021 Oct 19. doi: 10.1038/s41467-021-26251-6

PMCID:: PMC8526622

Abstract Article PDF–9.4M

Select item 846385311.

DNA polymerases η and κ bypass N²-guanine-O⁶-alkylguanine DNA alkyltransferase cross-linked DNA-peptides

Pratibha P. Ghodke, F. Peter Guengerich

J Biol Chem. 2021 Oct; 297(4): 101124. Published online 2021 Aug 28. doi: 10.1016/j.jbc.2021.101124

PMCID:: PMC8463853

Abstract Article PDF–1.9M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 766962813.

Translesion synthesis of 6-nitrochrysene-derived 2ʹ-deoxyadenosine adduct in human cells

Brent V. Powell, Jan Henric T. Bacurio, Ashis K. Basu

DNA Repair (Amst) Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: DNA Repair (Amst). 2020 Nov; 95: 102935. Published online 2020 Jul 18. doi: 10.1016/j.dnarep.2020.102935

PMCID:: PMC7669628

Abstract Article PDF–925K

Select item 742805114.

Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance

Kelsey Temprine, Nathaniel R. Campbell, Richard Huang, Erin M Langdon, Theresa Simon-Vermot, Krisha Mehta, Averill Clapp, Mollie Chipman, Richard M White

Sci Signal. Author manuscript; available in PMC 2020 Oct 28.

Published in final edited form as: Sci Signal. 2020 Apr 28; 13(629): eaau1453. Published online 2020 Apr 28. doi: 10.1126/scisignal.aau1453

PMCID:: PMC7428051

Abstract Article PDF–2.4M

Select item 719883315.

Kinetic Investigation of Translesion Synthesis across a 3-Nitrobenzanthrone-Derived DNA Lesion Catalyzed by Human DNA Polymerase Kappa

Kenneth K. Phi, Madison C. Smith, E. John Tokarsky, Zucai Suo

Chem Res Toxicol. Author manuscript; available in PMC 2020 May 5.

Published in final edited form as: Chem Res Toxicol. 2019 Aug 19; 32(8): 1699–1706. Published online 2019 Jul 18. doi: 10.1021/acs.chemrestox.9b00219

PMCID:: PMC7198833

Abstract Article PDF–616K

Select item 700203616.

Biochemical Characterization of Eight Genetic Variants of Human DNA Polymerase κ Involved in Error-free Bypass Across Bulky N²-Guanyl DNA Adducts

Insil Song, Eun-Jin Kim, In-Hyeok Kim, Eun-Mi Park, Kyung Eun Lee, Joo-Ho Shin, F. Peter Guengerich, Jeong-Yun Choi

Chem Res Toxicol. Author manuscript; available in PMC 2020 Feb 5.

Published in final edited form as: Chem Res Toxicol. 2014 May 19; 27(5): 919–930. Published online 2014 Apr 21. doi: 10.1021/tx500072m

PMCID:: PMC7002036

Abstract Article PDF–1.4M

Select item 689239317.

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

Kristen Mengwasser, Richard Adeyemi, Yumei Leng, Mei Yuk Choi, Connor Clairmont, Alan D’Andrea, Stephen J. Elledge

Mol Cell. Author manuscript; available in PMC 2019 Dec 4.

Published in final edited form as: Mol Cell. 2019 Mar 7; 73(5): 885–899.e6. Published online 2019 Jan 24. doi: 10.1016/j.molcel.2018.12.008

PMCID:: PMC6892393

Abstract Article PDF–1.7M

Select item 688587518.

The polymorphisms (rs3213801 and rs5744533) of DNA polymerase kappa gene are not related with glioma risk and prognosis: A case‐control study

Ying Wu, Linghui Zhou, Yujiao Deng, Na Li, Pengtao Yang, Shanshan Dong, Si Yang, Yi Zheng, Li Yao, Ming Zhang, Zhen Zhai, Zhijun Dai, Yuan Wu

Cancer Med. 2019 Dec; 8(17): 7446–7453. Published online 2019 Oct 8. doi: 10.1002/cam4.2566

PMCID:: PMC6885875

Abstract Article PDF–320K

Select item 669578119.

Mammalian DNA Polymerase Kappa Activity and Specificity

Hannah R. Stern, Jana Sefcikova, Victoria E. Chaparro, Penny J. Beuning

Molecules. 2019 Aug; 24(15): 2805. Published online 2019 Aug 1. doi: 10.3390/molecules24152805

PMCID:: PMC6695781

Abstract Article PDF–1.1M

Select item 638992920.

USP7 Regulates Cytokinesis through FBXO38 and KIF20B

Anna Georges, Etienne Coyaud, Edyta Marcon, Jack Greenblatt, Brian Raught, Lori Frappier

Sci Rep. 2019; 9: 2724. Published online 2019 Feb 25. doi: 10.1038/s41598-019-39368-y

PMCID:: PMC6389929

Abstract Article PDF–4.0M

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