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Items: 1 to 20 of 30

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth
Aida Rashidi, Leah K. Billingham, Andrew Zolp, Tzu-yi Chia, Caylee Silvers, Joshua L. Katz, Cheol H. Park, Suzi Delay, Lauren Boland, Yuheng Geng, Steven M. Markwell, Crismita Dmello, Victor A. Arrieta, Kaylee Zilinger, Irene M. Jacob, Aurora Lopez-Rosas, David Hou, Brandyn Castro, Alicia M. Steffens, Kathleen McCortney, Jordain P Walshon, Mariah S. Flowers, Hanchen Lin, Hanxiang Wang, Junfei Zhao, Adam Sonabend, Peng Zhang, Atique U. Ahmed, Daniel J. Brat, Dieter H. Heiland, Catalina Lee-Chang, Maciej S. Lesniak, Navdeep S. Chandel, Jason Miska
Cell Metab. Author manuscript; available in PMC 2025 Jan 2.
Published in final edited form as: Cell Metab. 2024 Jan 2; 36(1): 62–77.e8. Published online 2023 Dec 21. doi: 10.1016/j.cmet.2023.11.013
PMCID:
PMC10842612
AbstractArticlePDF–2.4M
3.
Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development
Angelica S. Martinez-Ramirez, Thomas L. Borders, Leena Paul, Matthew Schipma, Xinkun Wang, Farida Korobova, Christopher V. Wright, Beatriz Sosa-Pineda
Gastro Hep Adv. 2022; 1(5): 807–823. Published online 2022 May 26. doi: 10.1016/j.gastha.2022.05.013
PMCID:
PMC10569262
AbstractArticlePDF–6.7M
4.
Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment
Li Yu, Lingwei Wang, Guang Hu, Laibin Ren, Chen Qiu, Shun Li, Xiaohui Zhou, Shanze Chen, Rongchang Chen
Front Immunol. 2022; 13: 937331. Published online 2022 Sep 13. doi: 10.3389/fimmu.2022.937331
PMCID:
PMC9513582
AbstractArticlePDF–6.4M
5.
Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice
Märit Jensen, Christian Müller, Norbert Hübner, Giannino Patone, Kathrin Saar, Chi-un Choe, Edzard Schwedhelm, Tanja Zeller
Sci Rep. 2022; 12: 5108. Published online 2022 Mar 24. doi: 10.1038/s41598-022-08846-1
PMCID:
PMC8948300
AbstractArticlePDF–1.5M
6.
Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia
Juliane Hannemann, Kathrin Cordts, Anika Seniuk, Chi-un Choe, Lena Schmidt-Hutten, Jorge Duque Escobar, Florian Weinberger, Rainer Böger, Edzard Schwedhelm
Front Physiol. 2021; 12: 703069. Published online 2021 Aug 18. doi: 10.3389/fphys.2021.703069
PMCID:
PMC8416470
AbstractArticlePDF–1.7M
7.
Creatine mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer
Olivia A. Maguire, Sarah E. Ackerman, Sarah K. Szwed, Aarthi V. Maganti, François Marchildon, Xiaojing Huang, Daniel J. Kramer, Adriana Rosas-Villegas, Rebecca G. Gelfer, Lauren E. Turner, Victor Ceballos, Asal Hejazi, Bozena Samborska, Janane F. Rahbani, Christien B. Dykstra, Matthew G. Annis, Ji-Dung Luo, Thomas S. Carroll, Caroline S. Jiang, Andrew J. Dannenberg, Peter M. Siegel, Sarah A. Tersey, Raghavendra G. Mirmira, Lawrence Kazak, Paul Cohen
Cell Metab. Author manuscript; available in PMC 2022 Mar 2.
Published in final edited form as: Cell Metab. 2021 Mar 2; 33(3): 499–512.e6. Published online 2021 Feb 16. doi: 10.1016/j.cmet.2021.01.018
PMCID:
PMC7954401
AbstractArticlePDF–1.5M
8.
Marker enzyme activities in hindleg from creatine-deficient AGAT and GAMT KO mice – differences between models, muscles, and sexes
Karina Barsunova, Marko Vendelin, Rikke Birkedal
Sci Rep. 2020; 10: 7956. Published online 2020 May 14. doi: 10.1038/s41598-020-64740-8
PMCID:
PMC7224371
AbstractArticlePDF–1.4M
9.
Analysis of L-arginine:glycine amidinotransferase-, creatine- and homoarginine-dependent gene regulation in the murine heart
Märit Jensen, Christian Müller, Chi-un Choe, Edzard Schwedhelm, Tanja Zeller
Sci Rep. 2020; 10: 4821. Published online 2020 Mar 16. doi: 10.1038/s41598-020-61638-3
PMCID:
PMC7076046
AbstractArticlePDF–2.3M
10.
Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure
Markus Reichold, Enriko D. Klootwijk, Joerg Reinders, Edgar A. Otto, Mario Milani, Carsten Broeker, Chris Laing, Julia Wiesner, Sulochana Devi, Weibin Zhou, Roland Schmitt, Ines Tegtmeier, Christina Sterner, Hannes Doellerer, Kathrin Renner, Peter J. Oefner, Katja Dettmer, Johann M. Simbuerger, Ralph Witzgall, Horia C. Stanescu, Simona Dumitriu, Daniela Iancu, Vaksha Patel, Monika Mozere, Mehmet Tekman, Graciana Jaureguiberry, Naomi Issler, Anne Kesselheim, Stephen B. Walsh, Daniel P. Gale, Alexander J. Howie, Joana R. Martins, Andrew M. Hall, Michael Kasgharian, Kevin O’Brien, Carlos R. Ferreira, Paldeep S. Atwal, Mahim Jain, Alexander Hammers, Geoffrey Charles-Edwards, Chi-Un Choe, Dirk Isbrandt, Alberto Cebrian-Serrano, Ben Davies, Richard N. Sandford, Christopher Pugh, David S. Konecki, Sue Povey, Detlef Bockenhauer, Uta Lichter-Konecki, William A. Gahl, Robert J. Unwin, Richard Warth, Robert Kleta
J Am Soc Nephrol. 2018 Jul; 29(7): 1849–1858. Published online 2018 Apr 13. doi: 10.1681/ASN.2017111179
PMCID:
PMC6050927
AbstractArticle
11.
Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine
Kiterie M E Faller, Dorothee Atzler, Debra J McAndrew, Sevasti Zervou, Hannah J Whittington, Jillian N Simon, Dunja Aksentijevic, Michiel ten Hove, Chi-un Choe, Dirk Isbrandt, Barbara Casadei, Jurgen E Schneider, Stefan Neubauer, Craig A Lygate
Cardiovasc Res. 2018 Mar 1; 114(3): 417–430. Published online 2017 Dec 11. doi: 10.1093/cvr/cvx242
PMCID:
PMC5982714
AbstractArticlePDF–1.0M
12.
Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity
Lawrence Kazak, Edward T. Chouchani, Gina Z. Lu, Mark P. Jedrychowski, Curtis J. Bare, Amir Mina, Manju Kumari, Song Zhang, Ivan Vuckovic, Dina Laznik-Bogoslavski, Petras Dzeja, Alexander S. Banks, Evan D. Rosen, Bruce M. Spiegelman
Cell Metab. Author manuscript; available in PMC 2018 Oct 3.
Published in final edited form as: Cell Metab. 2017 Oct 3; 26(4): 660–671.e3. Published online 2017 Aug 24. doi: 10.1016/j.cmet.2017.08.009
Correction in:
Cell Metab. 2017 Oct 3; 26(4): 693.
PMCID:
PMC5629120
AbstractArticlePDF–1.0M
13.
Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans
Hsiang-Chih Lu, Qiumin Tan, Maxime WC Rousseaux, Wei Wang, Ji-Yoen Kim, Ronald Richman, Ying-Wooi Wan, Szu-Ying Yeh, Jay M Patel, Xiuyun Liu, Tao Lin, Yoontae Lee, John D Fryer, Jing Han, Maria Chahrour, Richard H Finnell, Yunping Lei, Maria E Zurita-Jimenez, Priyanka Ahimaz, Kwame Anyane-Yeboa, Lionel Van Maldergem, Daphne Lehalle, Nolwenn Jean-Marcais, Anne-Laure Mosca-Boidron, Julien Thevenon, Margot A Cousin, Della E Bro, Brendan C Lanpher, Eric W Klee, Nora Alexander, Matthew N Bainbridge, Harry T Orr, Roy V Sillitoe, M. Cecilia Ljungberg, Zhandong Liu, Christian P Schaaf, Huda Y Zoghbi
Nat Genet. Author manuscript; available in PMC 2017 Oct 1.
Published in final edited form as: Nat Genet. 2017 Apr; 49(4): 527–536. Published online 2017 Mar 13. doi: 10.1038/ng.3808
PMCID:
PMC5374026
AbstractArticlePDF–2.6M
14.
Creatine maintains intestinal homeostasis and protects against colitis
Emre Turer, William McAlpine, Kuan-wen Wang, Tianshi Lu, Xiaohong Li, Miao Tang, Xiaoming Zhan, Tao Wang, Xiaowei Zhan, Chun-Hui Bu, Anne R. Murray, Bruce Beutler
Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7): E1273–E1281. Published online 2017 Jan 30. doi: 10.1073/pnas.1621400114
PMCID:
PMC5321020
AbstractArticlePDF–1.5M
15.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
16.
Hepatocyte Nuclear Factor 4α Is Essential for Embryonic Development of the Mouse Colon
Wendy D. Garrison, Michele A. Battle, Chuhu Yang, Klaus H. Kaestner, Frances M. Sladek, Stephen A. Duncan
Gastroenterology. Author manuscript; available in PMC 2013 Feb 25.
Published in final edited form as: Gastroenterology. 2006 Apr; 130(4): 1207–1220. doi: 10.1053/j.gastro.2006.01.003
PMCID:
PMC3581272
AbstractArticlePDF–7.8M
17.
Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake
C I Nabuurs, C U Choe, A Veltien, H E Kan, L J C van Loon, R J T Rodenburg, J Matschke, B Wieringa, G J Kemp, D Isbrandt, A Heerschap
J Physiol. 2013 Jan 15; 591(Pt 2): 571–592. Published online 2012 Nov 5. doi: 10.1113/jphysiol.2012.241760
PMCID:
PMC3577527
AbstractArticlePDF–1.5M
18.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
19.
Short-Chain 3-Hydroxyacyl-Coenzyme A Dehydrogenase Associates with a Protein Super-Complex Integrating Multiple Metabolic Pathways
Srinivas B. Narayan, Stephen R. Master, Anthony N. Sireci, Charlene Bierl, Paige E. Stanley, Changhong Li, Charles A. Stanley, Michael J. Bennett
PLoS One. 2012; 7(4): e35048. Published online 2012 Apr 9. doi: 10.1371/journal.pone.0035048
PMCID:
PMC3322157
AbstractArticlePDF–219K
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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