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Select item 102297431.

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN

Kaini Zhang, Chen Yang, Xin Zhou, Jin Liang, Jianjin Guo, Min Li, Yi Zhang, Shulin Shao, Peng Sun, Kai Li, Jingjing Huang, Fang Chen, Xiubin Liang, Dongming Su

Cell Mol Life Sci. 2023 Jun; 80(6): 168. Published online 2023 May 30. doi: 10.1007/s00018-023-04820-w

PMCID:: PMC10229743

Abstract Article PDF–2.9M

Select item 101122812.

TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

François Le Guerroué, Eric N Bunker, William M Rosencrans, Jack T Nguyen, Mohammed A Basar, Achim Werner, Tsui-Fen Chou, Chunxin Wang, Richard J Youle

Mol Cell. Author manuscript; available in PMC 2024 Mar 16.

Published in final edited form as: Mol Cell. 2023 Mar 16; 83(6): 927–941.e8. Published online 2023 Mar 9. doi: 10.1016/j.molcel.2023.02.023

PMCID:: PMC10112281

Abstract Article PDF–2.4M

Select item 91023583.

RNase 7 Inhibits Uropathogenic Escherichia coli-Induced Inflammation in Bladder Cells under a High-Glucose Environment by Regulating the JAK/STAT Signaling Pathway

Chen-Hsun Ho, Pin-Wen Liao, Chia-Kwung Fan, Shih-Ping Liu, Po-Ching Cheng

Int J Mol Sci. 2022 May; 23(9): 5156. Published online 2022 May 5. doi: 10.3390/ijms23095156

PMCID:: PMC9102358

Abstract Article PDF–5.7M

Select item 85925354.

Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial activity and associates with pediatric urinary tract infections

Keith R. Pierce, Tad Eichler, Claudia Mosquera Vasquez, Andrew L. Schwaderer, Aaron Simoni, Steven Creacy, David S. Hains, John D. Spencer

J Clin Invest. 2021 Nov 15; 131(22): e149807. Published online 2021 Nov 15. doi: 10.1172/JCI149807

PMCID:: PMC8592535

Abstract Article PDF–484K

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 66837116.

Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection

Tad Eichler, Kristin Bender, Matthew J. Murtha, Laura Schwartz, Jackie Metheny, Lindsey Solden, Robert M. Jaggers, Michael T. Bailey, Sudipti Gupta, Claudia Mosquera, Christina Ching, Krista La Perle, Birong Li, Brian Becknell, John David Spencer

J Am Soc Nephrol. 2019 Aug; 30(8): 1385–1397. Published online 2019 Jun 25. doi: 10.1681/ASN.2018090929

PMCID:: PMC6683711

Abstract Article

Select item 63935687.

RAE1 mediated ZEB1 expression promotes epithelial–mesenchymal transition in breast cancer

Ji Hoon Oh, Ji-Yeon Lee, Sungsook Yu, Yejin Cho, Sumin Hur, Ki Taek Nam, Myoung Hee Kim

Sci Rep. 2019; 9: 2977. Published online 2019 Feb 27. doi: 10.1038/s41598-019-39574-8

PMCID:: PMC6393568

Abstract Article PDF–3.5M

Select item 56553278.

RNase 7 participates in cutaneous innate control of Corynebacterium amycolatum

Stephanie Walter, Franziska Rademacher, Nicole Kobinger, Maren Simanski, Regine Gläser, Jürgen Harder

Sci Rep. 2017; 7: 13862. Published online 2017 Oct 24. doi: 10.1038/s41598-017-14383-z

PMCID:: PMC5655327

Abstract Article PDF–2.6M

Select item 55760609.

Insulin and the PI3K/AKT Signaling Pathway Regulate Ribonuclease 7 Expression in the Human Urinary Tract

Tad Eichler, Brian Becknell, Robert S. Easterling, Susan E. Ingraham, Daniel M. Cohen, Andrew Schwaderer, David S. Hains, Birong Li, Ariel Cohen, Jackie Metheny, Susheela Trindandapani, John David Spencer

Kidney Int. Author manuscript; available in PMC 2017 Aug 30.

Published in final edited form as: Kidney Int. 2016 Sep; 90(3): 568–579. Published online 2016 Jul 9. doi: 10.1016/j.kint.2016.04.025

PMCID:: PMC5576060

Abstract Article PDF–3.2M

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 484901611.

RNase 7 in Cutaneous Defense

Franziska Rademacher, Maren Simanski, Jürgen Harder

Int J Mol Sci. 2016 Apr; 17(4): 560. Published online 2016 Apr 14. doi: 10.3390/ijms17040560

PMCID:: PMC4849016

Abstract Article PDF–793K

Select item 461721112.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 428129213.

Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract

Brian Becknell, Tad Eichler, Susana Beceiro, Birong Li, Robert Easterling, Ashley R. Carpenter, Cindy James, Kirk M. McHugh, David S. Hains, Santiago Partida-Sanchez, John David Spencer

Kidney Int. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Kidney Int. 2015 Jan; 87(1): 151–161. Published online 2014 Jul 30. doi: 10.1038/ki.2014.268

PMCID:: PMC4281292

Abstract Article PDF–1.9M

Select item 399158014.

Infection of Keratinocytes with Trichophytum rubrum Induces Epidermal Growth Factor-Dependent RNase 7 and Human Beta-Defensin-3 Expression

Yasemin Helene Firat, Maren Simanski, Franziska Rademacher, Lena Schröder, Jochen Brasch, Jürgen Harder

PLoS One. 2014; 9(4): e93941. Published online 2014 Apr 18. doi: 10.1371/journal.pone.0093941

PMCID:: PMC3991580

Abstract Article PDF–846K

Select item 398196115.

An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract

John David Spencer, Andrew L. Schwaderer, Tad Eichler, Huanyu Wang, Jennifer Kline, Sheryl S. Justice, Daniel M. Cohen, David S. Hains

Kidney Int. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Kidney Int. 2014 May; 85(5): 1179–1191. Published online 2013 Oct 9. doi: 10.1038/ki.2013.395

PMCID:: PMC3981961

Abstract Article PDF–1.3M

Select item 371716616.

Prenatal human skin expresses the antimicrobial peptide RNase 7

Christopher Schuster, Regine Gläser, Christian Fiala, Wolfgang Eppel, Jürgen Harder, Jens-M. Schröder, Adelheid Elbe-Bürger

Arch Dermatol Res. 2013; 305(6): 545–549. Published online 2013 Apr 2. doi: 10.1007/s00403-013-1340-y

PMCID:: PMC3717166

Abstract Article PDF–341K

Select item 361236817.

Ribonuclease 7, an antimicrobial peptide up-regulated during infection, contributes to microbial defense of the human urinary tract

John David Spencer, Andrew L. Schwaderer, Huanyu Wang, Julianne Bartz, Jennifer Kline, Tad Eichler, Kristin R. DeSouza, Sunder Sims-Lucas, Peter Baker, David S. Hains

Kidney Int. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: Kidney Int. 2013 Apr; 83(4): 615–625. Published online 2013 Jan 9. doi: 10.1038/ki.2012.410

PMCID:: PMC3612368

Abstract Article PDF–1.3M

Select item 360540118.

IL-17A and IFN-γ Synergistically Induce RNase 7 Expression via STAT3 in Primary Keratinocytes

Maren Simanski, Franziska Rademacher, Lena Schröder, Hanna Maria Schumacher, Regine Gläser, Jürgen Harder

PLoS One. 2013; 8(3): e59531. Published online 2013 Mar 21. doi: 10.1371/journal.pone.0059531

PMCID:: PMC3605401

Abstract Article PDF–432K

Select item 358520819.

MicroRNA-762 Is Upregulated in Human Corneal Epithelial Cells in Response to Tear Fluid and Pseudomonas aeruginosa Antigens and Negatively Regulates the Expression of Host Defense Genes Encoding RNase7 and ST2

James Mun, Connie Tam, Gary Chan, Jong Hun Kim, David Evans, Suzanne Fleiszig

PLoS One. 2013; 8(2): e57850. Published online 2013 Feb 28. doi: 10.1371/journal.pone.0057850

PMCID:: PMC3585208

Abstract Article PDF–471K

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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