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Select item 103265921.

Dysregulation and oncogenic activities of ubiquitin specific peptidase 2a in the pathogenesis of hepatocellular carcinoma

Xinmu Zhang, Christina Nadolny, Qiwen Chen, Winifer Ali, Syed F Hashmi, Ruitang Deng

Am J Cancer Res. 2023; 13(6): 2392–2409. Published online 2023 Jun 15.

PMCID:: PMC10326592

Abstract Article PDF–1.6M

Select item 100827712.

The role of RNF149 in the pre-emptive quality control substrate ubiquitination

Aster Legesse, Nathali Kaushansky, Ilana Braunstein, Haddas Saad, Gerardo Lederkremer, Ami Navon, Ariel Stanhill

Commun Biol. 2023; 6: 385. Published online 2023 Apr 8. doi: 10.1038/s42003-023-04763-9

PMCID:: PMC10082771

Abstract Article PDF–2.2M

Select item 100796823.

Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

Jingjie Yi, Omid Tavana, Huan Li, Donglai Wang, Richard J. Baer, Wei Gu

Nat Commun. 2023; 14: 1941. Published online 2023 Apr 6. doi: 10.1038/s41467-023-37617-3

PMCID:: PMC10079682

Abstract Article PDF–3.3M

Select item 100058984.

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay

J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027

PMCID:: PMC10005898

Abstract Article PDF–6.7M

Select item 99865205.

Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin

Susan J. Qualls-Histed, Casey P. Nielsen, Jason A. MacGurn

iScience. 2023 Mar 17; 26(3): 106150. Published online 2023 Feb 6. doi: 10.1016/j.isci.2023.106150

PMCID:: PMC9986520

Abstract Article PDF–9.6M

Select item 97799976.

USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination

Lihuan Zhu, Zhizhong Chen, Tianxing Guo, Wenshu Chen, Lilan Zhao, Lingwen Guo, Xiaojie Pan

Biomed Res Int. 2022; 2022: 1525216. Published online 2022 Dec 15. doi: 10.1155/2022/1525216

PMCID:: PMC9779997

Abstract Article PDF–2.3M

Select item 97584357.

Deubiquitinase USP2 stabilizes the MRE11–RAD50–NBS1 complex at DNA double-strand break sites by counteracting the ubiquitination of NBS1

Hyunsup Kim, Dongmin Kim, Hyemin Choi, Gwangsu Shin, Joon-Kyu Lee

J Biol Chem. 2023 Jan; 299(1): 102752. Published online 2022 Nov 25. doi: 10.1016/j.jbc.2022.102752

PMCID:: PMC9758435

Abstract Article PDF–2.6M

Select item 97531508.

Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability

Dacai Xu, Jiawen Wu, Jinghong Chen, Liling Jiang, Juan Chen, Wenhao Bao, Xin Chen, Qianqian Yang, Xiaolan Zhang, Leyi Yao, Huabo Su, Jinbao Liu

FASEB J. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: FASEB J. 2021 Aug; 35(8): e21800. doi: 10.1096/fj.202001146RR

PMCID:: PMC9753150

Abstract Article PDF–1.9M

Select item 96975929.

ENKUR recruits FBXW7 to ubiquitinate and degrade MYH9 and further suppress MYH9‐induced deubiquitination of β‐catenin to block gastric cancer metastasis

Jiahao Liu, Zhan Liu, Weiwei Yan, Huiling Yang, Shiyi Fang, Shuting Deng, Yinghao Wen, Peng Shen, Yonghao Li, Rentao Hou, Xiong Liu, Tao Huang, Rong Li, Dayong Zheng, Zhen Liu, Weiyi Fang

MedComm (2020) 2022 Dec; 3(4): e185. Published online 2022 Nov 25. doi: 10.1002/mco2.185

PMCID:: PMC9697592

Abstract Article PDF–6.1M

Select item 962912110.

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong, Liduan Zheng

Autophagy. 2022; 18(11): 2615–2635. Published online 2022 Mar 6. doi: 10.1080/15548627.2022.2044651

PMCID:: PMC9629121

Abstract Article PDF–8.1M

Select item 934857611.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 928285712.

Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase

Lu Zhu, Qing Zhang, Ciro D Cordeiro, Sudeep Banjade, Richa Sardana, Yuxin Mao, Scott D Emr

eLife. 2022; 11: e77424. Published online 2022 Jun 30. doi: 10.7554/eLife.77424

PMCID:: PMC9282857

Abstract Article PDF–4.6M

Select item 918679313.

Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation

Mayuko Hashimoto, Masaki Fujimoto, Kohtarou Konno, Ming-Liang Lee, Yui Yamada, Koya Yamashita, Chitoku Toda, Michio Tomura, Masahiko Watanabe, Osamu Inanami, Hiroshi Kitamura

J Neurosci. 2022 Jun 8; 42(23): 4607–4618. doi: 10.1523/JNEUROSCI.2504-21.2022

PMCID:: PMC9186793

Abstract Article PDF–2.3M

Select item 897369014.

Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway

Jiachen Duan, Mengyuan Jin, Dongjing Yang, Jihua Shi, Jie Gao, Danfeng Guo, Hongwei Tang, Shuijun Zhang, Baoping Qiao

Bioengineered. 2022; 13(2): 4455–4467. Published online 2022 Feb 12. doi: 10.1080/21655979.2022.2033403

PMCID:: PMC8973690

Abstract Article PDF–2.9M

Select item 881694415.

Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes

Seongmin Yoon, Konstantin Bogdanov, David Wallach

Cell Death Differ. 2022 Feb; 29(2): 306–322. Published online 2022 Jan 9. doi: 10.1038/s41418-021-00924-7

PMCID:: PMC8816944

Abstract Article PDF–5.4M

Select item 846297416.

Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes

Weijun Gui, Siqi Shen, Zhihao Zhuang

J Am Chem Soc. Author manuscript; available in PMC 2021 Nov 18.

Published in final edited form as: J Am Chem Soc. 2020 Nov 18; 142(46): 19493–19501. Published online 2020 Nov 3. doi: 10.1021/jacs.9b12426

PMCID:: PMC8462974

Abstract Article PDF–975K

Select item 844680217.

USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates

Fengwu Zhang, Yongchao Zhao, Yi Sun

J Biol Chem. 2021 Oct; 297(4): 101109. Published online 2021 Aug 21. doi: 10.1016/j.jbc.2021.101109

PMCID:: PMC8446802

Abstract Article PDF–4.0M

Select item 841697818.

Decreased USP2a Expression Inhibits Trophoblast Invasion and Associates With Recurrent Miscarriage

Jiayu Wang, Jinli Ding, Sainan Zhang, Xin Chen, Sisi Yan, Yan Zhang, Tailang Yin

Front Immunol. 2021; 12: 717370. Published online 2021 Aug 19. doi: 10.3389/fimmu.2021.717370

PMCID:: PMC8416978

Abstract Article PDF–11M

Select item 816503019.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 802427820.

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

Omar M. Khan, Jorge Almagro, Jessica K. Nelson, Stuart Horswell, Vesela Encheva, Kripa S. Keyan, Bruce E. Clurman, Ambrosius P. Snijders, Axel Behrens

Nat Commun. 2021; 12: 2043. Published online 2021 Apr 6. doi: 10.1038/s41467-021-22319-5

PMCID:: PMC8024278

Abstract Article PDF–5.0M

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