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Select item 112412021.

Exploring the Roles of Key Mediators IKBKE and HSPA1A in Alzheimer’s Disease and Hepatocellular Carcinoma through Bioinformatics Analysis

Yiying Wang, Yakun Yang, Ce Liang, Hailin Zhang

Int J Mol Sci. 2024 Jul; 25(13): 6934. Published online 2024 Jun 25. doi: 10.3390/ijms25136934

PMCID:: PMC11241202

Abstract Article PDF–9.7M

Select item 102361642.

Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response

Ying Nie, Dongqing Deng, Lumin Mou, Qizhou Long, Jinzhi Chen, Jiahong Wu

J Microbiol Biotechnol. 2023 May 28; 33(5): 600–606. Published online 2023 Feb 15. doi: 10.4014/jmb.2210.10006

PMCID:: PMC10236164

Abstract Article PDF–1.4M

Select item 100729063.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100205014.

Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency

Julia Wegner, Charlotte Hunkler, Katrin Ciupka, Gunther Hartmann, Martin Schlee

Front Immunol. 2023; 14: 1073608. Published online 2023 Mar 3. doi: 10.3389/fimmu.2023.1073608

PMCID:: PMC10020501

Abstract Article PDF–3.8M

Select item 99224685.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 95080956.

Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin α7 is counteracted by TBK1-p62 axis-mediated autophagy

Xuyuan Wang, Li Jiang, Guangwen Wang, Wenjun Shi, Yuzhen Hu, Bo Wang, Xianying Zeng, Guobin Tian, Guohua Deng, Jianzhong Shi, Liling Liu, Chengjun Li, Hualan Chen

Cell Mol Immunol. 2022 Oct; 19(10): 1168–1184. Published online 2022 Sep 2. doi: 10.1038/s41423-022-00906-w

PMCID:: PMC9508095

Abstract Article PDF–4.4M

Select item 93600007.

OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

Daisuke Oikawa, Min Gi, Hidetaka Kosako, Kouhei Shimizu, Hirotaka Takahashi, Masayuki Shiota, Shuhei Hosomi, Keidai Komakura, Hideki Wanibuchi, Daisuke Tsuruta, Tatsuya Sawasaki, Fuminori Tokunaga

Cell Death Dis. 2022 Aug; 13(8): 694. Published online 2022 Aug 8. doi: 10.1038/s41419-022-05145-5

PMCID:: PMC9360000

Abstract Article PDF–6.1M

Select item 93459378.

IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis

Wei Xie, Qiwei Jiang, Xueji Wu, Lei Wang, Bing Gao, Zicheng Sun, Xiaomei Zhang, Lang Bu, Ying Lin, Qiang Huang, Jie Li, Jianping Guo

Cell Death Differ. 2022 Aug; 29(8): 1528–1540. Published online 2022 Jan 22. doi: 10.1038/s41418-022-00940-1

PMCID:: PMC9345937

Abstract Article PDF–5.6M

Select item 92741879.

MST4 negatively regulates type I interferons production via targeting MAVS-mediated pathway

Wei Liu, Zhenling Ma, Yaru Wu, Cui Yuan, Yanyan Zhang, Zeyang Liang, Yu Yang, Wenwen Zhang, Pengtao Jiao

Cell Commun Signal. 2022; 20: 103. Published online 2022 Jul 12. doi: 10.1186/s12964-022-00922-3

PMCID:: PMC9274187

Abstract Article PDF–5.7M

Select item 892033410.

Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype

Younglang Lee, Alex W. Wessel, Jiazhi Xu, Julia G. Reinke, Eries Lee, Somin M. Kim, Amy P. Hsu, Jevgenia Zilberman-Rudenko, Sha Cao, Clinton Enos, Stephen R. Brooks, Zuoming Deng, Bin Lin, Adriana A. de Jesus, Daniel N. Hupalo, Daniela G.P. Piotto, Maria T. Terreri, Victoria R. Dimitriades, Clifton L. Dalgard, Steven M. Holland, Raphaela Goldbach-Mansky, Richard M. Siegel, Eric P. Hanson

J Clin Invest. 2022 Mar 15; 132(6): e128808. Published online 2022 Mar 15. doi: 10.1172/JCI128808

PMCID:: PMC8920334

Abstract Article PDF–8.8M

Select item 880381611.

A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells

Hongli Yin, Ozge Karayel, Ying-Yin Chao, Thomas Seeholzer, Isabel Hamp, Oliver Plettenburg, Torben Gehring, Christina Zielinski, Matthias Mann, Daniel Krappmann

Cell Mol Life Sci. 2022 Feb; 79(2): 112. Published online 2022 Jan 31. doi: 10.1007/s00018-022-04154-z

PMCID:: PMC8803816

Abstract Article PDF–9.2M

Select item 873872712.

Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense

Weihong Xie, Shouheng Jin, Chenqiu Zhang, Shuai Yang, Yaoxing Wu, Yong Zhao, Zhou Songyang, Jun Cui

Cell Death Differ. 2022 Jan; 29(1): 40–53. Published online 2021 Jul 13. doi: 10.1038/s41418-021-00833-9

PMCID:: PMC8738727

Abstract Article PDF–5.2M

Select item 867291513.

The Kinase MAP4K1 Inhibits Cytosolic RNA-Induced Antiviral Signaling by Promoting Proteasomal Degradation of TBK1/IKKε

Tian-Sheng He, Jingping Huang, Tian Chen, Zhi Zhang, Kuntai Cai, Jingge Yu, Liang-Guo Xu

Microbiol Spectr. 2021 Nov-Dec; 9(3): e01458-21. Published online 2021 Dec 15. doi: 10.1128/Spectrum.01458-21

PMCID:: PMC8672915

Abstract Article PDF–4.7M

Select item 846389514.

TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation

Fabian A. Fischer, Linda F. M. Mies, Sohaib Nizami, Eirini Pantazi, Sara Danielli, Benjamin Demarco, Michael Ohlmeyer, Michelle Sue Jann Lee, Cevayir Coban, Jonathan C. Kagan, Elena Di Daniel, Jelena S. Bezbradica

Proc Natl Acad Sci U S A. 2021 Sep 21; 118(38): e2009309118. Published online 2021 Sep 13. doi: 10.1073/pnas.2009309118

PMCID:: PMC8463895

Abstract Article PDF–1.5M

Select item 842838515.

Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity

Lin Lv, Juan Bai, Yanni Gao, Ling Jin, Xianwei Wang, Mingzhu Cao, Xing Liu, Ping Jiang

J Virol. 2021 Oct; 95(19): e00923-21. Prepublished online 2021 Jul 14. Published online 2021 Sep 9. doi: 10.1128/JVI.00923-21

PMCID:: PMC8428385

Abstract Article PDF–3.1M

Select item 820506916.

Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression

Yaoxing Wu, Shouheng Jin, Qingxiang Liu, Yu Zhang, Ling Ma, Zhiyao Zhao, Shuai Yang, Yi-Ping Li, Jun Cui

Autophagy. 2021; 17(6): 1379–1392. Published online 2020 May 31. doi: 10.1080/15548627.2020.1761653

PMCID:: PMC8205069

Abstract Article PDF–3.6M

Select item 817256617.

IKKε isoform switching governs the immune response against EV71 infection

Ya-Ling Chang, Yu-Wen Liao, Min-Hsuan Chen, Sui-Yuan Chang, Yao-Ting Huang, Bing-Ching Ho, Sung-Liang Yu

Commun Biol. 2021; 4: 663. Published online 2021 Jun 2. doi: 10.1038/s42003-021-02187-x

PMCID:: PMC8172566

Abstract Article PDF–3.5M

Select item 816846318.

SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1

Liyan Sui, Yinghua Zhao, Wenfang Wang, Ping Wu, Zedong Wang, Yang Yu, Zhijun Hou, Guangyun Tan, Quan Liu

Front Immunol. 2021; 12: 662989. Published online 2021 May 18. doi: 10.3389/fimmu.2021.662989

PMCID:: PMC8168463

Abstract Article PDF–2.9M

Select item 816503019.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 757627820.

IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling

Matthew Carr, Sami Mamand, Kathryn L. Chapman, Trevor Perrior, Simon D. Wagner

J Cell Mol Med. 2020 Oct; 24(19): 11573–11582. Published online 2020 Aug 28. doi: 10.1111/jcmm.15774

PMCID:: PMC7576278

Abstract Article PDF–850K

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