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Select item 105093111.

KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation

Karina C. Lockwood, Travis B. Lear, Shristi Rajbhandari, Alison C. McKelvey, Sarah R. Dunn, Áine N. Boudreau, Yuan Liu, Bill B. Chen

FEBS J. Author manuscript; available in PMC 2023 Sep 28.

Published in final edited form as: FEBS J. 2023 Aug; 290(15): 3802–3811. Published online 2023 Apr 7. doi: 10.1111/febs.16780

PMCID:: PMC10509311

Abstract Article PDF–1.6M

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 70637953.

Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients

Rasmus Rydbirk, Jonas Folke, Florence Busato, Elodie Roché, Alisha Shahzad Chauhan, Annemette Løkkegaard, Anne-Mette Hejl, Matthias Bode, Morten Blaabjerg, Mette Møller, Erik Hvid Danielsen, Tomasz Brudek, Bente Pakkenberg, Jorg Tost, Susana Aznar

Acta Neuropathol Commun. 2020; 8: 29. Published online 2020 Mar 9. doi: 10.1186/s40478-020-00908-7

PMCID:: PMC7063795

Abstract Article PDF–1.4M

Select item 70531694.

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment

Sathish Kumar, Rina Barouch-Bentov, Fei Xiao, Stanford Schor, Szuyuan Pu, Elise Biquand, Albert Lu, Brett D. Lindenbach, Yves Jacob, Caroline Demeret, Shirit Einav

Cell Rep. Author manuscript; available in PMC 2020 Mar 3.

Published in final edited form as: Cell Rep. 2019 Feb 12; 26(7): 1800–1814.e5. doi: 10.1016/j.celrep.2019.01.075

PMCID:: PMC7053169

Abstract Article PDF–2.3M

Select item 69375695.

Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro

Sunil Singh, Joel Ng, Digant Nayak, J. Sivaraman

J Biol Chem. 2019 Dec 27; 294(52): 19934–19949. Published online 2019 Nov 15. doi: 10.1074/jbc.RA119.010327

PMCID:: PMC6937569

Abstract Article PDF–3.8M

Select item 68910976.

Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

Divya Achuthankutty, Roshan Singh Thakur, Peter Haahr, Saskia Hoffmann, Alexandros P. Drainas, Anna H. Bizard, Joachim Weischenfeldt, Ian D. Hickson, Niels Mailand

J Cell Biol. 2019 Dec 2; 218(12): 3943–3953. Published online 2019 Oct 15. doi: 10.1083/jcb.201905064

PMCID:: PMC6891097

Abstract Article PDF–2.7M

Select item 67953997.

KIAA0317 regulates pulmonary inflammation through SOCS2 degradation

Travis B. Lear, Alison C. McKelvey, John W. Evankovich, Shristi Rajbhandari, Tiffany A. Coon, Sarah R. Dunn, James D. Londino, Bryan J. McVerry, Yingze Zhang, Eleanor Valenzi, Christine L. Burton, Rachael Gordon, Sebastien Gingras, Karina C. Lockwood, Michael J. Jurczak, Robert Lafyatis, Mark J. Shlomchik, Yuan Liu, Bill B. Chen

JCI Insight. 2019 Oct 3; 4(19): e129110. Published online 2019 Oct 3. doi: 10.1172/jci.insight.129110

PMCID:: PMC6795399

Abstract Article PDF–50M

Select item 65512668.

FAM105A/OTULINL is a pseudodebuiquitinase of the OTU-class that localizes to the ER membrane

Derek F. Ceccarelli, Sofiia Ivantsiv, Amber Anne Mullin, Etienne Coyaud, Noah Manczyk, Pierre Maisonneuve, Igor Kurinov, Liang Zhao, Chris Go, Anne-Claude Gingras, Brian Raught, Sabine Cordes, Frank Sicheri

Structure. Author manuscript; available in PMC 2020 Jun 4.

Published in final edited form as: Structure. 2019 Jun 4; 27(6): 1000–1012.e6. Published online 2019 May 2. doi: 10.1016/j.str.2019.03.022

PMCID:: PMC6551266

Abstract Article PDF–3.4M

Select item 56405069.

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

Martin A. Michel, Kirby N. Swatek, Manuela K. Hospenthal, David Komander

Mol Cell. 2017 Oct 5; 68(1): 233–246.e5. doi: 10.1016/j.molcel.2017.08.020

PMCID:: PMC5640506

Abstract Article

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 498812511.

System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes

Wei Zhang, Kuen-Phon Wu, Maria A. Sartori, Hari B. Kamadurai, Alban Ordureau, Chong Jiang, Peter Y. Mercredi, Ryan Murchie, Jicheng Hu, Avinash Persaud, Manjeet Mukherjee, Nan Li, Anne Doye, John R. Walker, Yi Sheng, Zhenyue Hao, Yanjun Li, Kevin R. Brown, Emmanuel Lemichez, Junjie Chen, Yufeng Tong, J. Wade Harper, Jason Moffat, Daniela Rotin, Brenda A. Schulman, Sachdev S. Sidhu

Mol Cell. Author manuscript; available in PMC 2017 Apr 7.

Published in final edited form as: Mol Cell. 2016 Apr 7; 62(1): 121–136. Published online 2016 Mar 3. doi: 10.1016/j.molcel.2016.02.005

PMCID:: PMC4988125

Abstract Article PDF–1.2M

Select item 488635912.

Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4

Travis Lear, Alison C. McKelvey, Shristi Rajbhandari, Sarah R. Dunn, Tiffany A. Coon, William Connelly, Joe Y. Zhao, Daniel J. Kass, Yingze Zhang, Yuan Liu, Bill B. Chen

J Exp Med. 2016 May 30; 213(6): 1029–1046. doi: 10.1084/jem.20151229

PMCID:: PMC4886359

Abstract Article PDF–4.3M

Select item 439008513.

Assembly and structure of Lys³³-linked polyubiquitin reveals distinct conformations

Yosua Adi Kristariyanto, Soo-Youn Choi, Syed Arif Abdul Rehman, Maria Stella Ritorto, David G Campbell, Nicholas A Morrice, Rachel Toth, Yogesh Kulathu

Biochem J. 2015 Apr 15; 467(Pt 2): 345–352. Published online 2015 Apr 2. doi: 10.1042/BJ20141502