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Items: 1 to 20 of 31

1.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
2.
Neuroprotective Role of a Proline-Rich Akt Substrate in Apoptotic Neuronal Cell Death after Stroke: Relationships with Nerve Growth Factor
Atsushi Saito, Purnima Narasimhan, Takeshi Hayashi, Shuzo Okuno, Michel Ferrand-Drake, Pak H. Chan
J Neurosci. 2004 Feb 18; 24(7): 1584–1593. doi: 10.1523/JNEUROSCI.5209-03.2004
PMCID:
PMC6730448
AbstractArticlePDF–606K
3.
PRAS40 alleviates neurotoxic prion peptide‐induced apoptosis via mTOR‐AKT signaling
Wei Yang, Li‐Feng Yang, Zhi‐Qi Song, Syed Zahid Ali Shah, Yong‐Yong Cui, Chao‐Si Li, Hua‐Fen Zhao, Hong‐Li Gao, Xiang‐Mei Zhou, De‐Ming Zhao
CNS Neurosci Ther. 2017 May; 23(5): 416–427. Published online 2017 Mar 14. doi: 10.1111/cns.12685
PMCID:
PMC6492730
AbstractArticlePDF–985K
4.
Overexpression of PRAS40T246A in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration and Skin Tumor Development
Okkyung Rho, Jaya Srivastava, Jiyoon Cho, John DiGiovanni
J Invest Dermatol. Author manuscript; available in PMC 2018 Nov 8.
Published in final edited form as: J Invest Dermatol. 2016 Oct; 136(10): 2070–2079. Published online 2016 Jun 24. doi: 10.1016/j.jid.2016.06.013
PMCID:
PMC6223616
AbstractArticlePDF–863K
5.
TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer
Jonathan M. Cooper, Yi-Hung Ou, Elizabeth A. McMillan, Rachel M. Vaden, Aubhishek Zaman, Brian O. Bodemann, Gurbani Makkar, Bruce A. Posner, Michael A. White
Cancer Res. Author manuscript; available in PMC 2018 Sep 15.
Published in final edited form as: Cancer Res. 2017 Sep 15; 77(18): 5077–5094. Published online 2017 Jul 17. doi: 10.1158/0008-5472.CAN-17-0829
PMCID:
PMC5833933
AbstractArticlePDF–2.9M
6.
Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
Gianluca Figlia, Camilla Norrmén, Jorge A Pereira, Daniel Gerber, Ueli Suter
eLife. 2017; 6: e29241. Published online 2017 Sep 7. doi: 10.7554/eLife.29241
PMCID:
PMC5589416
AbstractArticlePDF–6.6M
7.
Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors
Lluís Cordón-Barris, Sònia Pascual-Guiral, Shaobin Yang, Lydia Giménez-Llort, Silvia Lope-Piedrafita, Carlota Niemeyer, Enrique Claro, Jose M. Lizcano, Jose R. Bayascas
Mol Cell Biol. 2016 Dec 1; 36(23): 2967–2982. Prepublished online 2016 Sep 19. Published online 2016 Nov 14. doi: 10.1128/MCB.00230-16
PMCID:
PMC5108884
AbstractArticlePDF–8.5M
8.
Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival
Laura J. Smithson, David H. Gutmann
Genes Dev. 2016 Jun 15; 30(12): 1383–1388. doi: 10.1101/gad.279661.116
PMCID:
PMC4926861
AbstractArticlePDF–500K
9.
Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy
Achira Roy, Jonathan Skibo, Franck Kalume, Jing Ni, Sherri Rankin, Yiling Lu, William B Dobyns, Gordon B Mills, Jean J Zhao, Suzanne J Baker, Kathleen J Millen
eLife. 2015; 4: e12703. Published online 2015 Dec 3. doi: 10.7554/eLife.12703
PMCID:
PMC4744197
AbstractArticlePDF–7.5M
10.
PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways
Xiaoxing Xiong, Rong Xie, Hongfei Zhang, Lijuan Gu, Weiying Xie, Michelle Cheng, Zhihong Jian, Kristina Kovacina, Heng Zhao
Neurobiol Dis. Author manuscript; available in PMC 2015 May 29.
Published in final edited form as: Neurobiol Dis. 2014 Jun; 66: 43–52. Published online 2014 Feb 27. doi: 10.1016/j.nbd.2014.02.006
PMCID:
PMC4448971
AbstractArticlePDF–1.4M
11.
A high resolution spatiotemporal atlas of gene expression of the developing mouse brain
Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones
Neuron. Author manuscript; available in PMC 2015 Jul 16.
Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033
PMCID:
PMC4319559
AbstractArticlePDF–3.0M
12.
Phosphoproteomics screen reveals Akt isoform-specific signals linking RNA processing to lung cancer
Ioannis Sanidas, Christos Polytarchou, Maria Hatziapostolou, Scott A. Ezell, Filippos Kottakis, Lan Hu, Ailan Guo, Jianxin Xie, Michael J. Comb, Dimitrios Iliopoulos, Philip N. Tsichlis
Mol Cell. Author manuscript; available in PMC 2015 Feb 20.
Published in final edited form as: Mol Cell. 2014 Feb 20; 53(4): 577–590. Published online 2014 Jan 23. doi: 10.1016/j.molcel.2013.12.018
PMCID:
PMC3947584
AbstractArticlePDF–5.0M
13.
PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity
Mirko Völkers, Shirin Doroudgar, Nathalie Nguyen, Mathias H Konstandin, Pearl Quijada, Shabana Din, Luis Ornelas, Donna J Thuerauf, Natalie Gude, Kilian Friedrich, Stephan Herzig, Christopher C Glembotski, Mark A Sussman
EMBO Mol Med. 2014 Jan; 6(1): 57–65. Published online 2013 Oct 31. doi: 10.1002/emmm.201303183
PMCID:
PMC3936489
AbstractArticlePDF–1.3M
14.
Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1
Mirko Völkers, Haruhiro Toko, Shirin Doroudgar, Shabana Din, Pearl Quijada, Anya Y. Joyo, Luis Ornelas, Eri Joyo, Donna J. Thuerauf, Mathias H. Konstandin, Natalie Gude, Christopher C. Glembotski, Mark A. Sussman
Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31): 12661–12666. Published online 2013 Jul 10. doi: 10.1073/pnas.1301455110
PMCID:
PMC3732982
AbstractArticlePDF–1.2M
15.
Interaction of PDK1 with Phosphoinositides Is Essential for Neuronal Differentiation but Dispensable for Neuronal Survival
Tinatin Zurashvili, Lluís Cordón-Barris, Gerard Ruiz-Babot, Xiangyu Zhou, Jose M. Lizcano, Nestor Gómez, Lydia Giménez-Llort, Jose R. Bayascas
Mol Cell Biol. 2013 Mar; 33(5): 1027–1040. doi: 10.1128/MCB.01052-12
Correction in:
Mol Cell Biol. 2016 Jun 15; 36(12): 1818.
PMCID:
PMC3623085
AbstractArticlePDF–3.4M
16.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
17.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
18.
Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism
Antonella Caccamo, Monica A. Maldonado, Smita Majumder, David X. Medina, Walter Holbein, Andrea Magrí, Salvatore Oddo
J Biol Chem. 2011 Mar 18; 286(11): 8924–8932. Published online 2011 Jan 25. doi: 10.1074/jbc.M110.180638
PMCID:
PMC3058958
AbstractArticlePDF–1.3M
19.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
20.
PRAS40 Regulates Protein Synthesis and Cell Cycle in C2C12 Myoblasts
Abid A Kazi, Charles H Lang
Mol Med. 2010 Sep-Oct; 16(9-10): 359–371. Published online 2010 May 5. doi: 10.2119/molmed.2009.00168
PMCID:
PMC2935957
AbstractArticlePDF–3.4M

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