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Select item 114768221.

MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac Injury through Maintaining SLC25A10-Mediated Mitochondrial Glutathione Import

Tao Xu, Guilan Chen

Int J Mol Sci. 2024 Oct; 25(19): 10832. Published online 2024 Oct 9. doi: 10.3390/ijms251910832

PMCID:: PMC11476822

Abstract Article PDF–7.9M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 104151653.

Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis

Qiaoli Tang, Wanting Shi, Ming Liu, Liqin Tang, Wei Ren, Shaolin Shi

Clin Sci (Lond) 2023 Aug; 137(15): 1195–1208. Published online 2023 Aug 10. doi: 10.1042/CS20230164

PMCID:: PMC10415165

Abstract Article PDF–8.8M

Select item 68174474.

Esophageal 3D organoids of MPV17^-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition

Manti Guha, Satish Srinivasan, Maura M. Sheehan, Takashi Kijima, Gordon Ruthel, Kelly Whelan, Koji Tanaka, Andres Klein-Szanto, Prasanna M. Chandramouleeswaran, Hiroshi Nakagawa, Narayan G. Avadhani

Oncotarget. 2019 Oct 22; 10(58): 6245–6259. Published online 2019 Oct 22. doi: 10.18632/oncotarget.27264

PMCID:: PMC6817447

Abstract Article PDF–3.8M

Select item 66629755.

Cytochrome c oxidase dysfunction enhances phagocytic function and osteoclast formation in macrophages

Rajesh Angireddy, Hasan Raza Kazmi, Satish Srinivasan, Li Sun, Jameel Iqbal, Serge Y. Fuchs, Manti Guha, Takashi Kijima, Tony Yuen, Mone Zaidi, Narayan G. Avadhani

FASEB J. 2019 Aug; 33(8): 9167–9181. Published online 2019 May 7. doi: 10.1096/fj.201900010RR

PMCID:: PMC6662975

Abstract Article

Select item 62411216.

hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction

Manti Guha, Satish Srinivasan, F. Bradley Johnson, Gordon Ruthel, Kip Guja, Miguel Garcia-Diaz, Brett A. Kaufman, M. Rebecca Glineburg, JiKang Fang, Hiroshi Nakagawa, Jeelan Basha, Tapas Kundu, Narayan G. Avadhani

PLoS One. 2018; 13(11): e0206897. Published online 2018 Nov 14. doi: 10.1371/journal.pone.0206897

PMCID:: PMC6241121

Abstract Article PDF–2.6M

Select item 57283947.

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model

Chloe F. Moss, Ilaria Dalla Rosa, Lilian E. Hunt, Takehiro Yasukawa, Robert Young, Aleck W. E. Jones, Kaalak Reddy, Radha Desai, Sam Virtue, Greg Elgar, Peter Voshol, Martin S. Taylor, Ian J. Holt, Martin A. M. Reijns, Antonella Spinazzola

Nucleic Acids Res. 2017 Dec 15; 45(22): 12808–12815. Published online 2017 Nov 2. doi: 10.1093/nar/gkx1009

PMCID:: PMC5728394

Abstract Article PDF–2.1M

Select item 50452008.

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa

PLoS Genet. 2016 Sep; 12(9): e1006355. Published online 2016 Sep 30. doi: 10.1371/journal.pgen.1006355

PMCID:: PMC5045200

Abstract Article PDF–2.9M

Select item 47118919.

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria

Ilaria Dalla Rosa, Yolanda Cámara, Romina Durigon, Chloe F. Moss, Sara Vidoni, Gokhan Akman, Lilian Hunt, Mark A. Johnson, Sarah Grocott, Liya Wang, David R. Thorburn, Michio Hirano, Joanna Poulton, Robert W. Taylor, Greg Elgar, Ramon Martí, Peter Voshol, Ian J. Holt, Antonella Spinazzola

PLoS Genet. 2016 Jan; 12(1): e1005779. Published online 2016 Jan 13. doi: 10.1371/journal.pgen.1005779

PMCID:: PMC4711891

Abstract Article PDF–4.0M

Select item 404210210.

Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro

Gabriela Casalena, Stefanie Krick, Ilse Daehn, Liping Yu, Wenjun Ju, Shaolin Shi, Su-yi Tsai, Vivette D'Agati, Maja Lindenmeyer, Clemens D. Cohen, Detlef Schlondorff, Erwin P. Bottinger

Am J Physiol Renal Physiol. 2014 Jun 1; 306(11): F1372–F1380. Published online 2014 Mar 5. doi: 10.1152/ajprenal.00608.2013

PMCID:: PMC4042102

Abstract Article

Select item 317805911.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 296499212.

Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice

Natalia Papeta, Zongyu Zheng, Eric A. Schon, Sonja Brosel, Mehmet M. Altintas, Samih H. Nasr, Jochen Reiser, Vivette D. D’Agati, Ali G. Gharavi

J Clin Invest. 2010 Nov 1; 120(11): 4055–4064. Published online 2010 Oct 18. doi: 10.1172/JCI43721

PMCID:: PMC2964992

Abstract Article PDF–2.5M

Select item 286370013.

A Novel Transcriptional Repressor, Rhit, Is Involved in Heat-Inducible and Age-Dependent Expression of Mpv17-Like Protein, a Participant in Reactive Oxygen Species Metabolism

Reiko Iida, Misuzu Ueki, Toshihiro Yasuda

Mol Cell Biol. 2010 May; 30(10): 2306–2315. Published online 2010 Mar 15. doi: 10.1128/MCB.01025-09

PMCID:: PMC2863700

Abstract Article PDF–984K

Select item 277884414.

A mitochondrial protein compendium elucidates complex I disease biology

David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha

Cell. Author manuscript; available in PMC 2009 Nov 18.

Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016

PMCID:: PMC2778844

Abstract Article PDF–1.2M

Select item 264464215.

Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice

Carlo Viscomi, Antonella Spinazzola, Marco Maggioni, Erika Fernandez-Vizarra, Valeria Massa, Claudio Pagano, Roberto Vettor, Marina Mora, Massimo Zeviani

Hum Mol Genet. 2009 Jan 1; 18(1): 12–26. Published online 2008 Sep 24. doi: 10.1093/hmg/ddn309

PMCID:: PMC2644642

Abstract Article PDF–6.0M

Select item 255627016.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108