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Select item 109115991.

Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets

Anastasiia Stratiievska, Olga Filippova, Tahsin Özpolat, Daire Byrne, S. Lawrence Bailey, Aastha Chauhan, Molly Y. Mollica, Jeff Harris, Kali Esancy, Junmei Chen, Ajay K. Dhaka, Nathan J. Sniadecki, José A. López, Moritz Stolla

PLoS One. 2024; 19(3): e0289395. Published online 2024 Mar 4. doi: 10.1371/journal.pone.0289395

PMCID:: PMC10911599

Abstract Article PDF–2.2M

Select item 109076042.

Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer

Alessandro Alaimo, Sacha Genovesi, Nicole Annesi, Dario De Felice, Saurav Subedi, Alice Macchia, Federico La Manna, Yari Ciani, Federico Vannuccini, Vera Mugoni, Michela Notarangelo, Michela Libergoli, Francesca Broso, Riccardo Taulli, Ugo Ala, Aurora Savino, Martina Cortese, Somayeh Mirzaaghaei, Valeria Poli, Ian Marc Bonapace, Mauro Giulio Papotti, Luca Molinaro, Claudio Doglioni, Orazio Caffo, Adriano Anesi, Michael Nagler, Giovanni Bertalot, Francesco Giuseppe Carbone, Mattia Barbareschi, Umberto Basso, Erik Dassi, Massimo Pizzato, Alessandro Romanel, Francesca Demichelis, Marianna Kruithof-de Julio, Andrea Lunardi

EMBO J. 2024 Mar; 43(5): 780–805. Published online 2024 Feb 5. doi: 10.1038/s44318-024-00040-5

PMCID:: PMC10907604

Abstract Article PDF–5.4M

Select item 108551323.

Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells

Szymon Ludwiczak, Jacqueline Reinhard, Peter S. Reinach, Aruna Li, Jakub Oronowicz, Aisha Yousf, Vinodh Kakkassery, Stefan Mergler

Int J Mol Sci. 2024 Feb; 25(3): 1733. Published online 2024 Jan 31. doi: 10.3390/ijms25031733

PMCID:: PMC10855132

Abstract Article PDF–3.0M

Select item 106025804.

TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold‐Sensing TRPM8 Channel

Xiaobo Li, Qi Qi, Yong Li, Qun Miao, Wenqian Yin, Jinghua Pan, Zhan Zhao, Xiaoying Chen, Fan Yang, Xiaofeng Zhou, Maohua Huang, Chenran Wang, Lijuan Deng, Dandan Huang, Ming Qi, Shuran Fan, Yiran Zhang, Shenghui Qiu, Weiqing Deng, Tongzheng Liu, Minfeng Chen, Wencai Ye, Dongmei Zhang

Adv Sci (Weinh) 2023 Oct; 10(30): 2302717. Published online 2023 Aug 27. doi: 10.1002/advs.202302717

PMCID:: PMC10602580

Abstract Article PDF–5.6M

Select item 105872375.

Structure of human TRPM8 channel

Sergii Palchevskyi, Mariusz Czarnocki-Cieciura, Giulio Vistoli, Silvia Gervasoni, Elżbieta Nowak, Andrea R. Beccari, Marcin Nowotny, Carmine Talarico

Commun Biol. 2023; 6: 1065. Published online 2023 Oct 19. doi: 10.1038/s42003-023-05425-6

PMCID:: PMC10587237

Abstract Article PDF–4.1M

Select item 100926586.

TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling

Ester Pagano, Barbara Romano, Donatella Cicia, Fabio A. Iannotti, Tommaso Venneri, Giuseppe Lucariello, Maria Francesca Nanì, Fabio Cattaneo, Paola De Cicco, Maria D'Armiento, Marcello De Luca, Ruggiero Lionetti, Stefania Lama, Paola Stiuso, Pietro Zoppoli, Geppino Falco, Silvia Marchianò, Stefano Fiorucci, Raffaele Capasso, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo

Br J Pharmacol. 2023 Jan; 180(2): 235–251. Published online 2022 Oct 17. doi: 10.1111/bph.15960

PMCID:: PMC10092658

Abstract Article PDF–2.8M

Select item 98650487.

Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells

Nathalie Baumlin, Neerupma Silswal, John S. Dennis, Asef J. Niloy, Michael D. Kim, Matthias Salathe

Int J Mol Sci. 2023 Jan; 24(2): 1694. Published online 2023 Jan 15. doi: 10.3390/ijms24021694

PMCID:: PMC9865048

Abstract Article PDF–2.4M

Select item 95439078.

The cation channel TRPM8 influences the differentiation and function of human monocytes

Eve Hornsby, Hamish W. King, Madusha Peiris, Roberto Buccafusca, Wing‐Yiu Jason Lee, Elinor S. Wing, L. Ashley Blackshaw, James O. Lindsay, Andrew J. Stagg

J Leukoc Biol. 2022 Sep; 112(3): 365–381. Published online 2022 Mar 1. doi: 10.1002/JLB.1HI0421-181R

PMCID:: PMC9543907

Abstract Article PDF–5.3M

Select item 95406149.

Cold sensor, hot topic: TRPM8 plays a role in monocyte function and differentiation

Brie Trusiano, Juselyn D. Tupik, Irving C. Allen

J Leukoc Biol. 2022 Sep; 112(3): 361–363. Published online 2022 May 15. doi: 10.1002/JLB.3CE0222-099R

PMCID:: PMC9540614

Abstract Article PDF–391K

Select item 928494710.

Current view of ligand and lipid recognition by the menthol receptor TRPM8

Ying Yin, Seok-Yong Lee

Trends Biochem Sci. Author manuscript; available in PMC 2022 Jul 15.

Published in final edited form as: Trends Biochem Sci. 2020 Sep; 45(9): 806–819. Published online 2020 Jun 9. doi: 10.1016/j.tibs.2020.05.008

PMCID:: PMC9284947

Abstract Article PDF–3.4M

Select item 922446311.

TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination

Guillaume P. Grolez, Giorgia Chinigò, Alexandre Barras, Mehdi Hammadi, Lucile Noyer, Kateryna Kondratska, Etmar Bulk, Thibauld Oullier, Séverine Marionneau-Lambot, Marilyne Le Mée, Stéphanie Rétif, Stéphanie Lerondel, Antonino Bongiovanni, Tullio Genova, Sébastien Roger, Rabah Boukherroub, Albrecht Schwab, Alessandra Fiorio Pla, Dimitra Gkika

Int J Mol Sci. 2022 Jun; 23(12): 6672. Published online 2022 Jun 15. doi: 10.3390/ijms23126672

PMCID:: PMC9224463

Abstract Article PDF–3.7M

Select item 903197112.

Deciphering the Role of the rs2651899, rs10166942, and rs11172113 Polymorphisms in Migraine: A Meta-Analysis

Vasileios Siokas, Ioannis Liampas, Athina-Maria Aloizou, Maria Papasavva, Christos Bakirtzis, Eleftherios Lavdas, Panagiotis Liakos, Nikolaos Drakoulis, Dimitrios P. Bogdanos, Efthimios Dardiotis

Medicina (Kaunas) 2022 Apr; 58(4): 491. Published online 2022 Mar 29. doi: 10.3390/medicina58040491

PMCID:: PMC9031971

Abstract Article PDF–5.7M

Select item 896166813.

Trpm8 Expression in Human and Mouse Castration Resistant Prostate Adenocarcinoma Paves the Way for the Preclinical Development of TRPM8-Based Targeted Therapies

Sacha Genovesi, Riccardo Moro, Beatrice Vignoli, Dario De Felice, Marco Canossa, Rodolfo Montironi, Francesco Giuseppe Carbone, Mattia Barbareschi, Andrea Lunardi, Alessandro Alaimo

Biomolecules. 2022 Feb; 12(2): 193. Published online 2022 Jan 23. doi: 10.3390/biom12020193

PMCID:: PMC8961668

Abstract Article PDF–63M

Select item 896129014.

The TRPM8 channel as a potential therapeutic target for bladder hypersensitive disorders

Naoki Aizawa, Tomoe Fujita

J Smooth Muscle Res. 2022; 58: 11–21. Published online 2022 Mar 30. doi: 10.1540/jsmr.58.11

PMCID:: PMC8961290

Abstract Article PDF–530K

Select item 882244815.

Cold pain sensitivity is associated with single-nucleotide polymorphisms of PAR2/F2RL1 and TRPM8

Moe Soeda, Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kyoko Nakayama, Yuko Ebata, Tatsuya Ichinohe, Ken-ichi Fukuda, Kazutaka Ikeda

Mol Pain. 2021; 17: 17448069211002009. Published online 2021 Mar 25. doi: 10.1177/17448069211002009

PMCID:: PMC8822448

Abstract Article PDF–479K

Select item 864338516.

Molecular Sensors of Temperature, Pressure, and Pain with Special Focus on TRPV1, TRPM8, and PIEZO2 Ion Channels

Ru-Rong Ji, Seok-Yong Lee

Neurosci Bull. 2021 Dec; 37(12): 1745–1749. Published online 2021 Nov 25. doi: 10.1007/s12264-021-00798-2

PMCID:: PMC8643385

Article PDF–783K

Select item 839516617.

TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation

Carolina Izquierdo, Mercedes Martín-Martínez, Isabel Gómez-Monterrey, Rosario González-Muñiz

Int J Mol Sci. 2021 Aug; 22(16): 8502. Published online 2021 Aug 7. doi: 10.3390/ijms22168502

PMCID:: PMC8395166

Abstract Article PDF–7.9M

Select item 829227918.

Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8

Vivien Becker, Xin Hui, Lisa Nalbach, Emmanuel Ampofo, Peter Lipp, Michael D. Menger, Matthias W. Laschke, Yuan Gu

Angiogenesis. 2021; 24(3): 613–630. Published online 2021 Mar 2. doi: 10.1007/s10456-021-09772-y

PMCID:: PMC8292279

Abstract Article PDF–2.9M

Select item 816739819.

TRPM8 protein expression in hormone naïve local and lymph node metastatic prostate cancer

Andrea Lunardi, Mattia Barbareschi, Francesco Giuseppe Carbone, Luca Morelli, Matteo Brunelli, Nicolò Fortuna, Sacha Genovesi, Alessandro Alaimo

Pathologica. 2021 Apr; 113(2): 95–101. Published online 2021 Mar 18. doi: 10.32074/1591-951X-262

PMCID:: PMC8167398

Abstract Article PDF–1.5M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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