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Select item 111769571.

PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation

Daniela Chmiest, Silvia Podavini, Kalliopi Ioannidou, David Vallois, Chantal Décaillet, Montserrat Gonzalez, Manfredo Quadroni, Kevin Blackney, Rebekka Schairer, Laurence de Leval, Margot Thome

Blood Adv. 2024 Jun 11; 8(11): 2908–2923. Published online 2024 Mar 26. doi: 10.1182/bloodadvances.2023011901

PMCID:: PMC11176957

Abstract Article PDF–6.3M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100311363.

The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C θ via a critical Phospho-Thr-Pro motif in the V3 regulatory domain

Nikhil Ponnoor Anto, Amitha Muraleedharan, Pulak Ranjan Nath, Zuoming Sun, Chen Keasar, Etta Livneh, Alex Braiman, Amnon Altman, Kok-Fai Kong, Noah Isakov

Front Immunol. 2023; 14: 1126464. Published online 2023 Mar 8. doi: 10.3389/fimmu.2023.1126464

PMCID:: PMC10031136

Abstract Article PDF–5.6M

Select item 91197364.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 91052355.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 85019016.

Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs

Divya Ram Jayaram, Sigal Frost, Chanan Argov, Vijayasteltar Belsamma Liju, Nikhil Ponnoor Anto, Amitha Muraleedharan, Assaf Ben-Ari, Rose Sinay, Ilan Smoly, Ofra Novoplansky, Noah Isakov, Debra Toiber, Chen Keasar, Moshe Elkabets, Esti Yeger-Lotem, Etta Livneh

Proc Natl Acad Sci U S A. 2021 Oct 5; 118(40): e2018899118. Published online 2021 Sep 30. doi: 10.1073/pnas.2018899118

PMCID:: PMC8501901

Abstract Article PDF–1.8M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79155408.

The Emerging Function of PKCtheta in Cancer

Amandine Nicolle, Ye Zhang, Karine Belguise

Biomolecules. 2021 Feb; 11(2): 221. Published online 2021 Feb 5. doi: 10.3390/biom11020221

PMCID:: PMC7915540

Abstract Article PDF–881K

Select item 78834729.

Two novel pleiotropic loci associated with osteoporosis and abdominal obesity

Lu Liu, Xiao-Lin Yang, Hong Zhang, Zi-Jia Zhang, Xin-Tong Wei, Gui-Juan Feng, Ju Liu, Hui-Ping Peng, Rong Hai, Hui Shen, Qing Tian, Hong-Wen Deng, Yu-Fang Pei, Lei Zhang

Hum Genet. Author manuscript; available in PMC 2021 Feb 15.

Published in final edited form as: Hum Genet. 2020 Aug; 139(8): 1023–1035. Published online 2020 Apr 1. doi: 10.1007/s00439-020-02155-1

PMCID:: PMC7883472

Abstract Article PDF–884K

Select item 754902510.

Annexin A5 is essential for PKCθ translocation during T-cell activation

Zhaoqing Hu, Lin Li, Banghui Zhu, Yi Huang, Xinran Wang, Xiaolei Lin, Maoxia Li, Peipei Xu, Xuerui Zhang, Jing Zhang, Zichun Hua

J Biol Chem. 2020 Oct 9; 295(41): 14214–14221. Published online 2020 Aug 12. doi: 10.1074/jbc.RA120.015143

PMCID:: PMC7549025

Abstract Article PDF–3.4M

Select item 742732711.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 732286612.

PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim

Jessica H. Byerly, Elisa R. Port, Hanna Y. Irie

Breast Cancer Res. 2020; 22: 72. Published online 2020 Jun 29. doi: 10.1186/s13058-020-01302-w

PMCID:: PMC7322866

Abstract Article PDF–1.3M

Select item 720601913.

PKCθ-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization

Raj Kumar, Arul M. Mani, Nikhlesh K. Singh, Gadiparthi N. Rao

Cell Death Dis. 2020 May; 11(5): 325. Published online 2020 May 7. doi: 10.1038/s41419-020-2522-0

PMCID:: PMC7206019

Abstract Article PDF–16M

Select item 719584914.

Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling

Jiji Xie, Xuemei Han, Chensi Zhao, Ann J. Canonigo-Balancio, John R. Yates, III, Yingqiu Li, Björn F. Lillemeier, Amnon Altman

Sci Signal. Author manuscript; available in PMC 2020 May 2.

Published in final edited form as: Sci Signal. 2019 Apr 16; 12(577): eaar3349. Published online 2019 Apr 16. doi: 10.1126/scisignal.aar3349

PMCID:: PMC7195849

Abstract Article PDF–2.0M

Select item 709818615.

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy

Jan Balzarini

Nat Rev Microbiol. 2007; 5(8): 583–597. doi: 10.1038/nrmicro1707

PMCID:: PMC7098186

Abstract Article PDF–1.1M

Select item 695726116.

Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta

Agnes Czikora, Satyabrata Pany, Youngki You, Amandeep S. Saini, Nancy E. Lewin, Gary A. Mitchell, Adelle Abramovitz, Noemi Kedei, Peter M. Blumberg, Joydip Das

Biochim Biophys Acta Biomembr. Author manuscript; available in PMC 2020 Jan 13.

Published in final edited form as: Biochim Biophys Acta Biomembr. 2018 May; 1860(5): 1046–1056. Published online 2018 Jan 6. doi: 10.1016/j.bbamem.2018.01.007

PMCID:: PMC6957261

Abstract Article PDF–1.3M

Select item 692566317.

PRKCQ rs4750316 is associated with Vogt-Koyanagi-Harada syndrome in a Han Chinese population

Lei Xu, Tingting Zhao, Gangxiang Yuan, Shengping Hou, Wenxin Zeng, Feilan Chen

Mol Vis. 2019; 25: 834–842. Published online 2019 Dec 2.

PMCID:: PMC6925663

Abstract Article PDF–594K

Select item 659455118.

PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling

Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka, Jeremy M. Baskin

Cell Rep. Author manuscript; available in PMC 2019 Jun 26.

Published in final edited form as: Cell Rep. 2019 May 14; 27(7): 2157–2170.e8. doi: 10.1016/j.celrep.2019.04.060

PMCID:: PMC6594551

Abstract Article PDF–1.4M

Select item 629516519.

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression

Lei Yu, Natee Jearawiriyapaisarn, Mary P. Lee, Tomonori Hosoya, Qingqing Wu, Greggory Myers, Kim-Chew Lim, Ryo Kurita, Yukio Nakamura, Anne B. Vojtek, Jean-François Rual, James Douglas Engel

Genes Dev. 2018 Dec 1; 32(23-24): 1537–1549. doi: 10.1101/gad.318436.118

PMCID:: PMC6295165

Abstract Article PDF–3.5M

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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