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Items: 1 to 20 of 151

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
A novel αB-crystallin R123W variant drives hypertrophic cardiomyopathy by promoting maladaptive calcium-dependent signal transduction
Chun Chou, Gregory L. Martin, Gayani Perera, Junya Awata, Amy Larson, Robert Blanton, Michael T. Chin
Front Cardiovasc Med. 2023; 10: 1223244. Published online 2023 Jun 26. doi: 10.3389/fcvm.2023.1223244
Correction in:
Front Cardiovasc Med. 2024; 11: 1455263.
PMCID:
PMC10331725
AbstractArticlePDF–46M
3.
MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis
Xiaodong Zou, Hongsheng Ouyang, Feng Lin, Huanyu Zhang, Yang Yang, Daxin Pang, Renzhi Han, Xiaochun Tang
Cell Death Dis. 2022 Nov; 13(11): 948. Published online 2022 Nov 10. doi: 10.1038/s41419-022-05403-6
PMCID:
PMC9649783
AbstractArticlePDF–4.3M
4.
Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling
Eric J Hall, Soumojit Pal, Michael S Glennon, Puneeth Shridhar, Sidney L Satterfield, Beth Weber, Qinkun Zhang, Guy Salama, Hind Lal, Jason R Becker
Cardiovasc Res. 2022 Jun; 118(9): 2124–2138. Published online 2021 Jul 30. doi: 10.1093/cvr/cvab257
PMCID:
PMC9302887
AbstractArticlePDF–1.3M
5.
Modulation of myosin by cardiac myosin binding protein-C peptides improves cardiac contractility in ex-vivo experimental heart failure models
Luqia Hou, Mohit Kumar, Priti Anand, Yinhong Chen, Nesrine El-Bizri, Chad J. Pickens, W. Michael Seganish, Sakthivel Sadayappan, Gayathri Swaminath
Sci Rep. 2022; 12: 4337. Published online 2022 Mar 14. doi: 10.1038/s41598-022-08169-1
PMCID:
PMC8921245
AbstractArticlePDF–5.7M
6.
Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling
Soumojit Pal, Benjamin R. Nixon, Michael S. Glennon, Puneeth Shridhar, Sidney L. Satterfield, Yan Ru Su, Jason R. Becker
J Am Heart Assoc. 2021 Aug 3; 10(15): e021768. Published online 2021 Jul 29. doi: 10.1161/JAHA.121.021768
PMCID:
PMC8475701
AbstractArticlePDF–2.4M
7.
Translational investigation of electrophysiology in hypertrophic cardiomyopathy
Frederik Flenner, Christiane Jungen, Nadine Küpker, Antonia Ibel, Martin Kruse, Jussi T. Koivumäki, Anna Rinas, Antonia T.L. Zech, Alexandra Rhoden, Paul J.M. Wijnker, Marc D. Lemoine, Anna Steenpass, Evaldas Girdauskas, Thomas Eschenhagen, Christian Meyer, Jolanda van der Velden, Monica Patten-Hamel, Torsten Christ, Lucie Carrier
J Mol Cell Cardiol. 2021 Aug; 157: 77–89. doi: 10.1016/j.yjmcc.2021.04.009
PMCID:
PMC8320769
AbstractArticle
8.
Mutations in myosin S2 alter cardiac myosin-binding protein-C interaction in hypertrophic cardiomyopathy in a phosphorylation-dependent manner
Rohit R. Singh, James W. McNamara, Sakthivel Sadayappan
J Biol Chem. 2021 Jul; 297(1): 100836. Published online 2021 May 27. doi: 10.1016/j.jbc.2021.100836
PMCID:
PMC8239744
AbstractArticlePDF–3.0M
9.
Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility
Thomas L. Lynch, IV, Mohit Kumar, James W. McNamara, Diederik W.D. Kuster, Mayandi Sivaguru, Rohit R. Singh, Michael J. Previs, Kyoung Hwan Lee, Gina Kuffel, Michael J. Zilliox, Brian Leei Lin, Weikang Ma, Aaron M. Gibson, Burns C. Blaxall, Michelle L Nieman, John N. Lorenz, Dana M. Leichter, Owen P. Leary, Paul M.L. Janssen, Pieter P. de Tombe, Richard J. Gilbert, Roger Craig, Thomas Irving, David M. Warshaw, Sakthivel Sadayappan
J Mol Cell Cardiol. Author manuscript; available in PMC 2022 Jul 1.
Published in final edited form as: J Mol Cell Cardiol. 2021 Jul; 156: 33–44. Published online 2021 Mar 26. doi: 10.1016/j.yjmcc.2021.03.009
PMCID:
PMC8217138
AbstractArticlePDF–2.0M
10.
Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation
Chaohui Zhang, Yuxin Li, Jiaheng Cao, Beibei Yu, Kaiyue Zhang, Ke Li, Xinhui Xu, Zhikun Guo, Yinming Liang, Xiao Yang, Zhongzhou Yang, Yunfu Sun, Vesa Kaartinen, Keyue Ding, Jikui Wang
Open Biol. 2021 Jun; 11(6): 210020. Published online June 2, 2021. doi: 10.1098/rsob.210020
PMCID:
PMC8169207
AbstractArticlePDF–2.4M
11.
Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy
Min-Chi Ku, Frank Kober, Yi-Ching Lai, Andreas Pohlmann, Fatimunnisa Qadri, Michael Bader, Lucie Carrier, Thoralf Niendorf
J Cardiovasc Magn Reson. 2021; 23: 63. Published online 2021 May 31. doi: 10.1186/s12968-021-00754-z
PMCID:
PMC8166121
AbstractArticlePDF–3.2M
12.
Cardiac myosin binding protein-C phosphorylation accelerates β-cardiac myosin detachment rate in mouse myocardium
Bertrand C. W. Tanner, Michael J. Previs, Yuan Wang, Jeffrey Robbins, Bradley M. Palmer
Am J Physiol Heart Circ Physiol. 2021 May 1; 320(5): H1822–H1835. Published online 2021 Mar 5. doi: 10.1152/ajpheart.00673.2020
PMCID:
PMC8163640
AbstractArticle
13.
The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle
Sheema Rahmanseresht, Kyoung H. Lee, Thomas S. O’Leary, James W. McNamara, Sakthivel Sadayappan, Jeffrey Robbins, David M. Warshaw, Roger Craig, Michael J. Previs
J Gen Physiol. 2021 Mar 1; 153(3): e202012726. Published online 2021 Feb 1. doi: 10.1085/jgp.202012726
PMCID:
PMC7852460
AbstractArticlePDF–5.8M
14.
Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy
Maike Schuldt, Jiayi Pei, Magdalena Harakalova, Larissa M. Dorsch, Saskia Schlossarek, Michal Mokry, Jaco C. Knol, Thang V. Pham, Tim Schelfhorst, Sander R. Piersma, Cris dos Remedios, Michiel Dalinghaus, Michelle Michels, Folkert W. Asselbergs, Marie-Jo Moutin, Lucie Carrier, Connie R. Jimenez, Jolanda van der Velden, Diederik W.D. Kuster
Circ Heart Fail. 2021 Jan; 14(1): e007022. Published online 2021 Jan 12. doi: 10.1161/CIRCHEARTFAILURE.120.007022
PMCID:
PMC7819533
AbstractArticlePDF–2.7M
15.
A Novel “Cut And Paste” Method for In Situ Replacement of cMyBP-C Reveals a New Role for cMyBP-C in the Regulation of Contractile Oscillations
Nathaniel C. Napierski, Kevin Granger, Paul R. Langlais, Hannah R Moran, Joshua Strom, Katia Touma, Samantha P. Harris
Circ Res. Author manuscript; available in PMC 2021 Mar 13.
Published in final edited form as: Circ Res. 2020 Mar 13; 126(6): 737–749. Published online 2020 Feb 13. doi: 10.1161/CIRCRESAHA.119.315760
PMCID:
PMC7577522
AbstractArticlePDF–1.9M
16.
AAV9 gene transfer of cMyBPC N-terminal domains ameliorates cardiomyopathy in cMyBPC-deficient mice
Jiayang Li, Ranganath Mamidi, Chang Yoon Doh, Joshua B. Holmes, Nikhil Bharambe, Rajesh Ramachandran, Julian E. Stelzer
JCI Insight. 2020 Sep 3; 5(17): e130182. Published online 2020 Sep 3. doi: 10.1172/jci.insight.130182
PMCID:
PMC7526450
AbstractArticlePDF–9.7M
17.
Phosphorylation of cardiac myosin–binding protein-C contributes to calcium homeostasis
Mohit Kumar, Kobra Haghighi, Evangelia G. Kranias, Sakthivel Sadayappan
J Biol Chem. 2020 Aug 7; 295(32): 11275–11291. Published online 2020 Jun 18. doi: 10.1074/jbc.RA120.013296
PMCID:
PMC7415972
AbstractArticlePDF–3.9M
18.
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation
Tomoya Sakamoto, Timothy R. Matsuura, Shibiao Wan, David M. Ryba, Junil Kim, Kyoung Jae Won, Ling Lai, Christopher Petucci, Nataliya Petrenko, Kiran Musunuru, Rick B. Vega, Daniel P. Kelly
Circ Res. Author manuscript; available in PMC 2021 Jun 5.
Published in final edited form as: Circ Res. 2020 Jun 5; 126(12): 1685–1702. Published online 2020 Mar 26. doi: 10.1161/CIRCRESAHA.119.316100
PMCID:
PMC7274895
AbstractArticlePDF–2.7M
19.
Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury
David Y. Barefield, James W. McNamara, Thomas L. Lynch, IV, Diederik W. D. Kuster, Suresh Govindan, Lauren Haar, Yang Wang, Erik N. Taylor, John N. Lorenz, Michelle L. Nieman, Guangshuo Zhu, Pradeep K. Luther, Andras Varró, Dobromir Dobrev, Xun Ai, Paul M.L. Janssen, David A. Kass, Walter Keith Jones, Richard J. Gilbert, Sakthivel Sadayappan
J Mol Cell Cardiol. Author manuscript; available in PMC 2020 May 14.
Published in final edited form as: J Mol Cell Cardiol. 2019 Apr; 129: 236–246. Published online 2019 Mar 9. doi: 10.1016/j.yjmcc.2019.03.006
PMCID:
PMC7222036
AbstractArticlePDF–1.8M
20.
Cardiomyocyte HIPK2 Maintains Basal Cardiac Function via ERK Signaling
Yuanjun Guo, Jennifer Y. Sui, Kyungsoo Kim, Zhentao Zhang, Xiaoyan A. Qu, Young-Jae Nam, Robert N. Willette, Joey V. Barnett, Bjorn C. Knollmann, Thomas Force, Hind Lal
Circulation. Author manuscript; available in PMC 2020 Nov 26.
Published in final edited form as: Circulation. 2019 Nov 26; 140(22): 1820–1833. Published online 2019 Oct 4. doi: 10.1161/CIRCULATIONAHA.119.040740
PMCID:
PMC7219521
AbstractArticlePDF–4.5M

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