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Select item 109366841.

MAP4K2 connects the Hippo pathway to autophagy in response to energy stress

Gayoung Seo, Joshua Mckinley, Wenqi Wang

Autophagy. 2024; 20(3): 704–706. Published online 2023 Nov 8. doi: 10.1080/15548627.2023.2280876

PMCID:: PMC10936684

Abstract Article PDF–684K

Select item 90229442.

The Hippo pathway kinases LATS1 and 2 attenuate cellular responses to heavy metals through phosphorylating MTF1

Han Han, Hiroki J Nakaoka, Line Hofmann, Jeff Jiajing Zhou, Clinton Yu, Lisha Zeng, Junyu Nan, Gayoung Seo, Rebecca Elizabeth Vargas, Bing Yang, Ruxi Qi, Lee Bardwell, Dmitry A. Fishman, Ken W.Y. Cho, Lan Huang, Ray Luo, Rahul Warrior, Wenqi Wang

Nat Cell Biol. Author manuscript; available in PMC 2022 Jul 13.

Published in final edited form as: Nat Cell Biol. 2022 Jan; 24(1): 74–87. Published online 2022 Jan 13. doi: 10.1038/s41556-021-00813-8

PMCID:: PMC9022944

Abstract Article PDF–8.9M

Select item 89515563.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 76458635.

N‐Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS‐CoV‐2 Main Protease

Tomas Koudelka, Juliane Boger, Alessandra Henkel, Robert Schönherr, Stefanie Krantz, Sabine Fuchs, Estefanía Rodríguez, Lars Redecke, Andreas Tholey

Proteomics. 2021 Jan; 21(2): 2000246. Published online 2020 Nov 17. doi: 10.1002/pmic.202000246

PMCID:: PMC7645863

Abstract Article PDF–497K

Select item 74273276.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 73823137.

MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation

Gayoung Seo, Han Han, Rebecca Elizabeth Vargas, Bing Yang, Xu Li, Wenqi Wang

Cell Rep. Author manuscript; available in PMC 2020 Jul 25.

Published in final edited form as: Cell Rep. 2020 Jul 7; 32(1): 107860. doi: 10.1016/j.celrep.2020.107860

PMCID:: PMC7382313

Abstract Article PDF–2.6M

Select item 49462028.

Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma

Julie Marie Matthews, Shruti Bhatt, Matthew P. Patricelli, Tyzoon K. Nomanbhoy, Xiaoyu Jiang, Yasodha Natkunam, Andrew J. Gentles, Ezequiel Martinez, Daxing Zhu, Jennifer Rose Chapman, Elena Cortizas, Ragini Shyam, Shideh Chinichian, Ranjana Advani, Li Tan, Jianming Zhang, Hwan Geun Choi, Robert Tibshirani, Sara J. Buhrlage, Dita Gratzinger, Ramiro Verdun, Nathanael S. Gray, Izidore S. Lossos

Blood. 2016 Jul 14; 128(2): 239–248. Prepublished online 2016 May 5. doi: 10.1182/blood-2016-02-696856

PMCID:: PMC4946202

Abstract Article

Select item 42928089.

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

Li Tan, Tyzoon Nomanbhoy, Deepak Gurbani, Matthew Patricelli, John Hunter, Jiefei Geng, Lina Herhaus, Jianming Zhang, Eduardo Pauls, Youngjin Ham, Hwan Geun Choi, Ting Xie, Xianming Deng, Sara J. Buhrlage, Taebo Sim, Philip Cohen, Gopal Sapkota, Kenneth D. Westover, Nathanael S. Gray

J Med Chem. 2015 Jan 8; 58(1): 183–196. Published online 2014 Jul 17. doi: 10.1021/jm500480k

PMCID:: PMC4292808

Abstract Article PDF–5.8M

Select item 389478610.

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Mikko Taipale, Irina Krykbaeva, Martina Koeva, Can Kayatekin, Kenneth D. Westover, Georgios I. Karras, Susan Lindquist

Cell. Author manuscript; available in PMC 2014 Jan 17.

Published in final edited form as: Cell. 2012 Aug 31; 150(5): 987–1001. doi: 10.1016/j.cell.2012.06.047

PMCID:: PMC3894786

Abstract Article PDF–5.0M

Select item 382088111.

Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB

Zhong Guo, Xiaomin Hou, Roger S. Goody, Aymelt Itzen

J Biol Chem. 2013 Nov 8; 288(45): 32466–32474. Published online 2013 Sep 26. doi: 10.1074/jbc.M113.498329

PMCID:: PMC3820881

Abstract Article PDF–2.0M

Select item 334609312.

A Rab8 Guanine Nucleotide Exchange Factor-Effector Interaction Network Regulates Primary Ciliogenesis

Shanshan Feng, Andreas Knödler, Jinqi Ren, Jian Zhang, Xiaoyu Zhang, Yujuan Hong, Shaohui Huang, Johan Peränen, Wei Guo

J Biol Chem. 2012 May 4; 287(19): 15602–15609. Published online 2012 Mar 19. doi: 10.1074/jbc.M111.333245

PMCID:: PMC3346093

Abstract Article PDF–2.2M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 317764714.

Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele

Adrienne Tin, Owen M. Woodward, Wen Hong Linda Kao, Ching-Ti Liu, Xiaoning Lu, Michael A. Nalls, Daniel Shriner, Mariam Semmo, Ermeg L. Akylbekova, Sharon B. Wyatt, Shih-Jen Hwang, Qiong Yang, Alan B. Zonderman, Adebowale A. Adeyemo, Cameron Palmer, Yan Meng, Muredach Reilly, Michael G. Shlipak, David Siscovick, Michele K. Evans, Charles N. Rotimi, Michael F. Flessner, Michael Köttgen, L. Adrienne Cupples, Caroline S. Fox, Anna Köttgen

Hum Mol Genet. 2011 Oct 15; 20(20): 4056–4068. Published online 2011 Jul 18. doi: 10.1093/hmg/ddr307

PMCID:: PMC3177647

Abstract Article PDF–256K

Select item 303367215.

Genome-wide YFP Fluorescence Complementation Screen Identifies New Regulators for Telomere Signaling in Human Cells

Ok-Hee Lee, Hyeung Kim, Quanyuan He, Hwa Jin Baek, Dong Yang, Liuh-Yow Chen, Jiancong Liang, Heekyung Kate Chae, Amin Safari, Dan Liu, Zhou Songyang

Mol Cell Proteomics. 2011 Feb; 10(2): M110.001628. Published online 2010 Nov 11. doi: 10.1074/mcp.M110.001628

PMCID:: PMC3033672

Abstract Article PDF–1.5M

Select item 294516816.

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators

Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452

PMCID:: PMC2945168

Abstract Article PDF–153K

Select item 277583217.

Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip

Philippa J. Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R. Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J. Newhouse, Anna Dominiczak, Nilesh J. Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C. Shields, on behalf of the ASCOT investigators, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, on behalf of the NORDIL investigators, Shah Ebrahim, Michael G. Marmot, George Davey Smith, Debbie A. Lawlor, Patricia B. Munroe, for the BRIGHT Consortium, Ian N. Day, Mika Kivimaki, John Whittaker, Steve E. Humphries, Aroon D. Hingorani

Am J Hum Genet. 2009 Nov 13; 85(5): 628–642. doi: 10.1016/j.ajhg.2009.10.014

PMCID:: PMC2775832

Abstract Article PDF–2.8M

Select item 31068118.

A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus

Siradanahalli C. Guru, Sunita K. Agarwal, Pachiappan Manickam, Shodimu-Emmanuel Olufemi, Judy S. Crabtree, Jane M. Weisemann, Mary Beth Kester, Young S. Kim, Yingping Wang, Michael R. Emmert-Buck, Lance A. Liotta, Allen M. Spiegel, Mark S. Boguski, Bruce A. Roe, Francis S. Collins, Stephen J. Marx, Lee Burns, Settara C. Chandrasekharappa

Genome Res. 1997 Jul; 7(7): 725–735. doi: 10.1101/gr.7.7.725

PMCID:: PMC310681

Abstract Article PDF–1.0M

Select item 13924119.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

Select item 13354520.

Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2

Deborah N. Chadee, Takashi Yuasa, John M. Kyriakis

Mol Cell Biol. 2002 Feb; 22(3): 737–749. doi: 10.1128/MCB.22.3.737-749.2002

PMCID:: PMC133545

Abstract Article PDF–557K

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