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Select item 108914441.

Low nuclear expression of HIF‐hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence‐free survival in clear cell renal cell carcinoma

Lassi Luomala, Kalle Mattila, Paula Vainio, Harry Nisén, Teijo Pellinen, Jouni Lohi, Teemu D. Laajala, Petrus Järvinen, Anna‐Riina Koskenniemi, Panu Jaakkola, Tuomas Mirtti

Cancer Med. 2024 Feb; 13(3): e6998. Published online 2024 Feb 24. doi: 10.1002/cam4.6998

PMCID:: PMC10891444

Abstract Article PDF–1.9M

Select item 108262602.

Association of the C allele of rs479200 in the EGLN1 gene with COVID-19 severity in Indian population: a novel finding

Renuka Harit, Sajal De, Piyoosh Kumar Singh, Deepika Kashyap, Manish Kumar, Dibakar Sahu, Chander Prakash Yadav, Mradul Mohan, Vineeta Singh, Ram Singh Tomar, Kailash C. Pandey, Kapil Vashisht

Hum Genomics. 2024; 18: 7. Published online 2024 Jan 30. doi: 10.1186/s40246-024-00572-1

Correction in:: Hum Genomics. 2024; 18: 17.

PMCID:: PMC10826260

Abstract Article PDF–985K

Select item 107050433.

Prolyl hydroxylase 2 inhibits glycolytic activity in colorectal cancer via the NF-κB signaling pathway

Lisha Xiang, Hao Wei, Wentao Ye, Shuang Wu, Ganfeng Xie

Int J Oncol. 2024 Jan; 64(1): 2. Published online 2023 Nov 15. doi: 10.3892/ijo.2023.5590

PMCID:: PMC10705043

Abstract Article PDF–5.4M

Select item 106205894.

Characterization of genetic variants in the EGLN1/PHD2 gene identified in a European collection of patients with erythrocytosis

Marine Delamare, Amandine Le Roy, Mathilde Pacault, Loïc Schmitt, Céline Garrec, Nada Maaziz, Matti Myllykoski, Antoine Rimbert, Valéna Karaghiannis, Bernard Aral, Mark Catherwood, Fabrice Airaud, Lamisse Mansour-Hendili, David Hoogewijs, Edoardo Peroni, Salam Idriss, Valentine Lesieur, Amandine Caillaud, Karim Si-Tayeb, Caroline Chariau, Anne Gaignerie, Minke Rab, Torsten Haferlach, Manja Meggendorfer, Stéphane Bézieau, Andrea Benetti, Nicole Casadevall, Pierre Hirsch, Christian Rose, Mathieu Wemeau, Frédéric Galacteros, Bruno Cassinat, Beatriz Bellosillo, Celeste Bento, Richard van Wijk, Petro E. Petrides, Maria Luigia Randi, Mary Frances McMullin, Peppi Koivunen, ECYT-3 consortium, François Girodon, Betty Gardie

Haematologica. 2023 Nov 1; 108(11): 3068–3085. Published online 2023 Jun 15. doi: 10.3324/haematol.2023.282913

PMCID:: PMC10620589

Abstract Article PDF–2.1M

Select item 105776355.

A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress

Weiwei Jiang, Mengyao Zhang, Chuan Gao, Chaojun Yan, Ronghui Gao, Ziwei He, Xin Wei, Jingjing Xiong, Zilun Ruan, Qian Yang, Jinpeng Li, Qifang Li, Ziyi Zhong, Mengna Zhang, Qianqian Yuan, Hankun Hu, Shuang Wang, Ming‐Ming Hu, Cheguo Cai, Gao‐Song Wu, Chao Jiang, Ya‐Lin Zhang, Chen‐Song Zhang, Jing Zhang

EMBO J. 2023 Oct; 42(20): e113743. Published online 2023 Sep 4. doi: 10.15252/embj.2023113743

PMCID:: PMC10577635

Abstract Article PDF–3.8M

Select item 96701996.

The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α

Daisheng Song, Kai Peng, Bradleigh E Palmer, Frank S Lee

EMBO J. 2022 Nov; 41(22): e112059. Published online 2022 Oct 11. doi: 10.15252/embj.2022112059

PMCID:: PMC9670199

Abstract Article PDF–1.4M

Select item 95699557.

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation

Yulemi Gonzalez Quesada, Luc DesGroseillers

Int J Mol Sci. 2022 Oct; 23(19): 11588. Published online 2022 Sep 30. doi: 10.3390/ijms231911588

PMCID:: PMC9569955

Abstract Article PDF–2.1M

Select item 95262828.

Differential methylation in EGLN1 associates with blood oxygen saturation and plasma protein levels in high-altitude pulmonary edema

Kavita Sharma, Aastha Mishra, Himanshu Singh, Tashi Thinlas, M. A. Qadar Pasha

Clin Epigenetics. 2022; 14: 123. Published online 2022 Sep 30. doi: 10.1186/s13148-022-01338-z

PMCID:: PMC9526282

Abstract Article PDF–1.5M

Select item 94450019.

Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2

Tianshi Feng, Xuemei Zhao, Ping Gu, Wah Yang, Cunchuan Wang, Qingyu Guo, Qiaoyun Long, Qing Liu, Ying Cheng, Jin Li, Cynthia Kwan Yui Cheung, Donghai Wu, Xinyu Kong, Yong Xu, Dewei Ye, Shuang Hua, Kerry Loomes, Aimin Xu, Xiaoyan Hui

Nat Commun. 2022; 13: 5208. Published online 2022 Sep 5. doi: 10.1038/s41467-022-32871-3

PMCID:: PMC9445001

Abstract Article PDF–5.7M

Select item 943393810.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 935143511.

A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

Namrata Bora-Singhal, Biswarup Saha, Durairaj Mohankumar, Jaya Padmanabhan, Domenico Coppola, Srikumar Chellappan

Cancer Res Commun. 2022 Jul; 2(7): 624–638. Published online 2022 Jul 12. doi: 10.1158/2767-9764.CRC-21-0084

PMCID:: PMC9351435

Abstract Article PDF–13M

Select item 927928512.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 917141113.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 911973614.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910523515.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 909198816.

AMP‐activated protein kinase α1 phosphorylates PHD2 to maintain systemic iron homeostasis

Cheng Wang, Wencheng Zhang, Wenjing Xu, Zhaoyu Liu, Kai Huang

Clin Transl Med. 2022 May; 12(5): e854. Published online 2022 May 11. doi: 10.1002/ctm2.854

Correction in:: Clin Transl Med. 2023 Jun; 13(6): e1306.

PMCID:: PMC9091988

Abstract Article PDF–3.0M

Select item 874425717.

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins

Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo

BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y

PMCID:: PMC8744257

Abstract Article PDF–6.0M

Select item 856705618.

Baicalein resensitizes tamoxifen‐resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia‐inducible factor‐1α

Yan Chen, Jingyu Zhang, Minqin Zhang, Yuxuan Song, Yue Zhang, Shuangqin Fan, Shuang Ren, Lingyun Fu, Nenling Zhang, Hui Hui, Xiangchun Shen

Clin Transl Med. 2021 Nov; 11(11): e577. Published online 2021 Nov 4. doi: 10.1002/ctm2.577

PMCID:: PMC8567056

Abstract Article PDF–9.0M

Select item 856393419.

β-arrestin 2 stimulates degradation of HIF-1α and modulates tumor progression of glioblastoma

Woom-Yee Bae, Jae-Sun Choi, Seungyoon Nam, Joo-Won Jeong

Cell Death Differ. 2021 Nov; 28(11): 3092–3104. Published online 2021 May 18. doi: 10.1038/s41418-021-00802-2

PMCID:: PMC8563934

Abstract Article PDF–2.2M

Select item 852757820.

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity

Yuehui Zhang, Limin Shang, Jing Zhang, Yuchen Liu, Chaozhi Jin, Yanan Zhao, Xiaobo Lei, Wenjing Wang, Xia Xiao, Xiuyuan Zhang, Yujiao Liu, Linlin Liu, Meng-Wei Zhuang, Qingkun Mi, Chunyan Tian, Jianwei Wang, Fuchu He, Pei-Hui Wang, Jian Wang

Cell Chem Biol. 2022 Jan 20; 29(1): 5–18.e6. Published online 2021 Oct 20. doi: 10.1016/j.chembiol.2021.10.008

PMCID:: PMC8527578

Abstract Article PDF–4.5M

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