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Select item 112828591.

MARCH1 negatively regulates TBK1-mTOR signaling pathway by ubiquitinating TBK1

Xiao Li, Kai Cheng, Meng-Di Shang, Yong Yang, Bin Hu, Xi Wang, Xiao-Dan Wei, Yan-Chun Han, Xiao-Gang Zhang, Meng-Hua Dong, Zhen-Lin Yang, Jiu-Qiang Wang

BMC Cancer. 2024; 24: 902. Published online 2024 Jul 26. doi: 10.1186/s12885-024-12667-y

PMCID:: PMC11282859

Abstract Article PDF–3.9M

Select item 112456862.

Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation

Joël E. J. Beaumont, Lydie M. O. Barbeau, Jinzhe Ju, Kim G. Savelkouls, Freek G. Bouwman, Marijke I. Zonneveld, Annelies Bronckaers, Kim R. Kampen, Tom G. H. Keulers, Kasper M. A. Rouschop

J Extracell Vesicles. 2024 Jul; 13(7): e12449. Published online 2024 Jul 13. doi: 10.1002/jev2.12449

PMCID:: PMC11245686

Abstract Article PDF–5.5M

Select item 111388113.

DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders

Kyra L. Feuer, Xi Peng, Christian K. Yovo, Dimitrios Avramopoulos

Mol Psychiatry. Author manuscript; available in PMC 2024 May 30.

Published in final edited form as: Mol Psychiatry. 2023 Oct; 28(10): 4353–4362. Published online 2023 Jul 21. doi: 10.1038/s41380-023-02186-w

PMCID:: PMC11138811

Abstract Article PDF–849K

Select item 111146914.

Regulatory T cells, mTOR kinase, and metabolic activity

Claudio Procaccini, Giuseppe Matarese

Cell Mol Life Sci. 2012 Dec; 69(23): 3975–3987. Published online 2012 Jul 4. doi: 10.1007/s00018-012-1058-6

PMCID:: PMC11114691

Abstract Article PDF–328K

Select item 111131445.

The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation

Inna M. Yasinska, Bernhard F. Gibbs, Gurprit S. Lall, Vadim V. Sumbayev

Cell Mol Life Sci. 2014 Feb; 71(4): 699–710. Published online 2013 Jul 20. doi: 10.1007/s00018-013-1421-2

PMCID:: PMC11113144

Abstract Article PDF–886K

Select item 110470056.

SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis

Tong Xu, Xichuan Li, Wennan Zhao, Xue Wang, Leixin Jin, Zhiqiang Feng, Huixiang Li, Mingzhe Zhang, Yiqing Tian, Ge Hu, Yuan Yue, Xintong Dai, Changliang Shan, Weihua Zhang, Chunze Zhang, Youcai Zhang

J Exp Clin Cancer Res. 2024; 43: 126. Published online 2024 Apr 26. doi: 10.1186/s13046-024-03053-4

PMCID:: PMC11047005

Abstract Article PDF–5.8M

Select item 109850797.

Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop

Sheng Yang, JiaJun Xie, ZhiJie Pan, HongMei Guan, YueSheng Tu, YuanJian Ye, ShouBin Huang, ShiQiang Fu, KangXian Li, ZhiWei Huang, XiaoQi Li, ZhanJun Shi, Le Li, Yang Zhang

Exp Mol Med. 2024 Mar; 56(3): 630–645. Published online 2024 Mar 1. doi: 10.1038/s12276-024-01190-6

PMCID:: PMC10985079

Abstract Article PDF–8.4M

Select item 109640778.

mirna-383-5p Functions as an Anti-oncogene in Glioma through the Akt/mTOR Signaling Pathway by Targeting VEGFA

Yan Liu, Zhen Wang, Zhi Tang, Yao Fu, Lei Wang

Curr Cancer Drug Targets. 2024 Feb 13; 24(4): 463–475. Published online 2024 Feb 13. doi: 10.2174/1568009623666230817102104

PMCID:: PMC10964077

Abstract Article PDF–27M

Select item 109316429.

mTOR Signaling: Recent Progress

Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou

Int J Mol Sci. 2024 Mar; 25(5): 2587. Published online 2024 Feb 23. doi: 10.3390/ijms25052587

PMCID:: PMC10931642

Article PDF–177K

Select item 1093085110.

PI3K/Akt/mTOR通路介导巨噬细胞自噬影响矽尘致肺成纤维细胞表型转化

杜悦, 黄芳财, 关岚, 曾明

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Aug 28; 48(8): 1152–1162. Chinese. doi: 10.11817/j.issn.1672-7347.2023.220581

PMCID:: PMC10930851

Abstract Article PDF–2.2M

Select item 1090808711.

Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway

Yan Luo, Feng Zhou, Xiaojing Wang, Runwei Yang, Yi Li, Xiaochun Wu, Bin Ye

J Orthop Surg Res. 2024; 19: 158. Published online 2024 Mar 1. doi: 10.1186/s13018-024-04642-x

PMCID:: PMC10908087

Abstract Article PDF–2.0M

Select item 1090533312.

CCL2 promotes metastasis and epithelial–mesenchymal transition of non‐small cell lung cancer via PI3K/Akt/mTOR and autophagy pathways

Hui Xu, Jin Wang, Murad Al‐Nusaif, Huipeng Ma, Weidong Le

Cell Prolif. 2024 Mar; 57(3): e13560. Published online 2023 Oct 18. doi: 10.1111/cpr.13560

PMCID:: PMC10905333

Abstract Article PDF–9.3M

Select item 1089618113.

Malignant Brain Aging: The Formidable Link Between Dysregulated Signaling Through Mechanistic Target of Rapamycin Pathways and Alzheimer’s Disease (Type 3 Diabetes)

Suzanne M. de la Monte

J Alzheimers Dis. Author manuscript; available in PMC 2024 Feb 26.

Published in final edited form as: J Alzheimers Dis. 2023; 95(4): 1301–1337. doi: 10.3233/JAD-230555

PMCID:: PMC10896181

Abstract Article PDF–522K

Select item 1087803514.

Human cytomegalovirus modulates mTORC1 to redirect mRNA translation within quiescently infected monocytes

Michael J. Miller, Dilruba Akter, Jamil Mahmud, Gary C. Chan

J Virol. 2024 Feb; 98(2): e01888-23. Published online 2024 Jan 30. doi: 10.1128/jvi.01888-23

PMCID:: PMC10878035

Abstract Article PDF–3.6M

Select item 1084978215.

AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR‐ULK1‐autophagy axis

Li Zhu, Jiahe Wang, Zuping Wu, Sirui Chen, Yuying He, Yukun Jiang, Guowen Luo, Zhuoxuan Wu, Yuyu Li, Jing Xie, Shujuan Zou, Chenchen Zhou

Cell Prolif. 2024 Feb; 57(2): e13546. Published online 2023 Sep 20. doi: 10.1111/cpr.13546

PMCID:: PMC10849782

Abstract Article PDF–12M

Select item 1084521016.

A Dual PI3 Kinase/mTOR Inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines

David E Durrant, Anindita Das, Samya Dyer, Rakesh C Kukreja

Biochim Biophys Acta Gen Subj. Author manuscript; available in PMC 2024 Feb 6.

Published in final edited form as: Biochim Biophys Acta Gen Subj. 2020 Jun; 1864(6): 129556. Published online 2020 Feb 14. doi: 10.1016/j.bbagen.2020.129556