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Select item 110277931.

Ring domains are essential for GATOR2-dependent mTORC1 activation

Cong Jiang, Xiaoming Dai, Shaohui He, Hongfei Zhou, Lan Fang, Jianping Guo, Songlei Liu, Tao Zhang, Weijuan Pan, Haihong Yu, Tianmin Fu, Dali Li, Hiroyuki Inuzuka, Ping Wang, Jianru Xiao, Wenyi Wei

Mol Cell. Author manuscript; available in PMC 2024 Apr 19.

Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 74–89.e9. Published online 2022 Dec 16. doi: 10.1016/j.molcel.2022.11.021

PMCID:: PMC11027793

Abstract Article PDF–3.0M

Select item 105896732.

Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction

Inna Radzishevsky, Maali Odeh, Oded Bodner, Salman Zubedat, Lihi Shaulov, Maxim Litvak, Kayoko Esaki, Takeo Yoshikawa, Bella Agranovich, Wen-Hong Li, Alex Radzishevsky, Eyal Gottlieb, Avi Avital, Herman Wolosker

Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2302780120. Published online 2023 Oct 9. doi: 10.1073/pnas.2302780120

PMCID:: PMC10589673

Abstract Article PDF–6.8M

Select item 101625433.

Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice

Rui Sun, Siying Guo, Yoko Shuda, Anish B. Chakka, Lora H. Rigatti, Guangyi Zhao, Mohammed A. E. Ali, Christopher Y. Park, Uma Chandran, Jian Yu, Christopher J. Bakkenist, Masahiro Shuda, Patrick S. Moore, Yuan Chang

PLoS One. 2023; 18(5): e0282722. Published online 2023 May 5. doi: 10.1371/journal.pone.0282722

PMCID:: PMC10162543

Abstract Article PDF–1.3M

Select item 100046044.

Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice

Simon Cao, Michael J. Jurczak, Yoko Shuda, Rui Sun, Masahiro Shuda, Yuan Chang, Patrick S. Moore

PLoS One. 2023; 18(3): e0282914. Published online 2023 Mar 10. doi: 10.1371/journal.pone.0282914

PMCID:: PMC10004604

Abstract Article PDF–1.2M

Select item 98919565.

Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai

J Cachexia Sarcopenia Muscle. 2023 Feb; 14(1): 198–213. Published online 2022 Nov 17. doi: 10.1002/jcsm.13121

PMCID:: PMC9891956

Abstract Article PDF–4.2M

Select item 98887256.

Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent

Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer

PLoS Genet. 2023 Jan; 19(1): e1010595. Published online 2023 Jan 19. doi: 10.1371/journal.pgen.1010595

PMCID:: PMC9888725

Abstract Article PDF–6.9M

Select item 97991527.

Loss of 4E-BPs prevents the hindlimb immobilization-induced decrease in protein synthesis in skeletal muscle

Gregory N. Kincheloe, Paul A. Roberson, Allyson L. Toro, Bruce A. Stanley, Anne E. Stanley, Leonard S. Jefferson, Michael D. Dennis, Scot R. Kimball

J Appl Physiol (1985) 2023 Jan 1; 134(1): 72–83. Published online 2022 Dec 1. doi: 10.1152/japplphysiol.00563.2022

PMCID:: PMC9799152

Abstract Article

Select item 97581778.

Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice

Seok-Ting J. Ang, Elisa M. Crombie, Han Dong, Kuan-Ting Tan, Adriel Hernando, Dejie Yu, Stuart Adamson, Seonyoung Kim, Dominic J. Withers, Hua Huang, Shih-Yin Tsai

Nat Commun. 2022; 13: 7792. Published online 2022 Dec 17. doi: 10.1038/s41467-022-35547-0

PMCID:: PMC9758177

Abstract Article PDF–11M

Select item 97580579.

A critical period of translational control during brain development at codon resolution

Dermot Harnett, Mateusz C. Ambrozkiewicz, Ulrike Zinnall, Alexandra Rusanova, Ekaterina Borisova, Amelie N. Drescher, Marta Couce-Iglesias, Gabriel Villamil, Rike Dannenberg, Koshi Imami, Agnieszka Münster-Wandowski, Beatrix Fauler, Thorsten Mielke, Matthias Selbach, Markus Landthaler, Christian M. T. Spahn, Victor Tarabykin, Uwe Ohler, Matthew L. Kraushar

Nat Struct Mol Biol. 2022; 29(12): 1277–1290. Published online 2022 Dec 8. doi: 10.1038/s41594-022-00882-9

PMCID:: PMC9758057

Abstract Article PDF–15M

Select item 956187010.

ER, Mitochondria, and ISR Regulation by mt‐HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts

Laura Gorrell, Elena Makareeva, Shakib Omari, Satoru Otsuru, Sergey Leikin

Adv Sci (Weinh) 2022 Oct; 9(29): 2201273. Published online 2022 Aug 21. doi: 10.1002/advs.202201273

PMCID:: PMC9561870

Abstract Article PDF–4.8M

Select item 923297511.

Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency

Nan Guan, Hanako Kobayashi, Ken Ishii, Olena Davidoff, Feng Sha, Talat A. Ikizler, Chuan-Ming Hao, Navdeep S. Chandel, Volker H. Haase

Kidney Int. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Kidney Int. 2022 Jul; 102(1): 108–120. Published online 2022 Mar 24. doi: 10.1016/j.kint.2022.02.030

PMCID:: PMC9232975

Abstract Article PDF–1.7M

Select item 912882112.

Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy

Lena H Nguyen, Youfen Xu, Travorn Mahadeo, Longbo Zhang, Tiffany V Lin, Heather A Born, Anne E Anderson, Angélique Bordey

Brain. 2022 Apr; 145(4): 1310–1325. Published online 2021 Nov 25. doi: 10.1093/brain/awab390

PMCID:: PMC9128821

Abstract Article PDF–1.7M

Select item 871808813.

H19X‐encoded miR‐322(424)/miR‐503 regulates muscle mass by targeting translation initiation factors

Rui Liang, Xiaopeng Shen, Fan Wang, Xin Wang, Alex DesJarlais, Anam Syed, Raymond Saba, Zhi Tan, Fang Yu, Xuan Ji, Shreesti Shrestha, Yinghong Ren, Jin Yang, Yoonjung Park, Robert J. Schwartz, Benjamin Soibam, Bradley K. McConnell, M. David Stewart, Ashok Kumar, Yu Liu

J Cachexia Sarcopenia Muscle. 2021 Dec; 12(6): 2174–2186. Published online 2021 Oct 26. doi: 10.1002/jcsm.12827

PMCID:: PMC8718088

Abstract Article PDF–9.5M

Select item 835779014.

The zinc finger/RING domain protein Unkempt regulates cognitive flexibility

Elin Vinsland, Pranetha Baskaran, Simeon R. Mihaylov, Carl Hobbs, Hannah Wood, Ihssane Bouybayoune, Kriti Shah, Corinne Houart, Andrew R. Tee, Jernej Murn, Cathy Fernandes, Joseph M. Bateman

Sci Rep. 2021; 11: 16299. Published online 2021 Aug 11. doi: 10.1038/s41598-021-95286-y

PMCID:: PMC8357790

Abstract Article PDF–2.4M

Select item 835604115.

TLR5 Supports Development of Placental Labyrinthine Zone in Mice

Jensen H. C. Yiu, Samson W. M. Cheung, Jieling Cai, Kam-Suen Chan, Jing Chen, Lai Yee Cheong, Hau-Tak Chau, Aimin Xu, Raymond H. W. Li, Connie W. Woo

Front Cell Dev Biol. 2021; 9: 711253. Published online 2021 Jul 28. doi: 10.3389/fcell.2021.711253

PMCID:: PMC8356041

Abstract Article PDF–4.6M

Select item 831912316.

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

Gerald C. Tiu, Craig H. Kerr, Craig M. Forester, Pallavi S. Krishnarao, Hannah D. Rosenblatt, Nitin Raj, Travis C. Lantz, Olena Zhulyn, Margot E. Bowen, Leila Shokat, Laura D. Attardi, Davide Ruggero, Maria Barna

Dev Cell. Author manuscript; available in PMC 2022 Jul 26.

Published in final edited form as: Dev Cell. 2021 Jul 26; 56(14): 2089–2102.e11. Published online 2021 Jul 8. doi: 10.1016/j.devcel.2021.06.013

PMCID:: PMC8319123

Abstract Article PDF–2.5M

Select item 831323917.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 824504118.

Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling

Qian Wang, Chenqi Tao, Abdul Hannan, Sungtae Yoon, Xuanyu Min, John Peregrin, Xiuxia Qu, Hongge Li, Honglian Yu, Jean Zhao, Xin Zhang

Sci Adv. 2021 Jul; 7(27): eabf1068. Published online 2021 Jun 30. doi: 10.1126/sciadv.abf1068

PMCID:: PMC8245041

Abstract Article PDF–1.8M

Select item 813450419.

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill, Ing Swie Goping

Nat Commun. 2021; 12: 2939. Published online 2021 May 19. doi: 10.1038/s41467-021-23269-8

PMCID:: PMC8134504

Abstract Article PDF–14M

Select item 805392120.

4E-BP2–dependent translation in parvalbumin neurons controls epileptic seizure threshold

Vijendra Sharma, Rapita Sood, Danning Lou, Tzu-Yu Hung, Maxime Lévesque, Yelin Han, Jeremy Y. Levett, Peng Wang, Shravan Murthy, Shannon Tansley, Siyan Wang, Nadeem Siddiqui, Soroush Tahmasebi, Kobi Rosenblum, Massimo Avoli, Jean-Claude Lacaille, Nahum Sonenberg, Arkady Khoutorsky

Proc Natl Acad Sci U S A. 2021 Apr 13; 118(15): e2025522118. Published online 2021 Apr 5. doi: 10.1073/pnas.2025522118