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Select item 113584721.

EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors

Gaylor Boulay, Liliane C. Broye, Rui Dong, Sowmya Iyer, Rajendran Sanalkumar, Yu-Hang Xing, Rémi Buisson, Shruthi Rengarajan, Beverly Naigles, Benoît Duc, Angela Volorio, Mary E. Awad, Raffaele Renella, Ivan Chebib, G. Petur Nielsen, Edwin Choy, Gregory M. Cote, Lee Zou, Igor Letovanec, Ivan Stamenkovic, Miguel N. Rivera, Nicolò Riggi

Nat Commun. 2024; 15: 7460. Published online 2024 Aug 28. doi: 10.1038/s41467-024-51851-3

PMCID:: PMC11358472

Abstract Article PDF–4.0M

Select item 113043192.

Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development

Gang Wang, Hangdi Wu, Xiuwen Zhai, Li Zhang, Changming Zhang, Chen Cheng, Xiaodong Xu, Erzhi Gao, Xushen Xiong, Jin Zhang, Zhihong Liu

Adv Sci (Weinh) 2024 Aug; 11(29): 2308556. Published online 2024 May 29. doi: 10.1002/advs.202308556

PMCID:: PMC11304319

Abstract Article PDF–8.6M

Select item 111603043.

Overexpression of the Wilms' tumor gene WT1 in human bone and soft‐tissue sarcomas

Takafumi Ueda, Yusuke Oji, Norifumi Naka, Yoko Nakano, Eigo Takahashi, Satoko Koga, Momotaro Asada, Ai Ikeba, Shin‐ichi Nakatsuka, Sakie Abeno, Naoki Hosen, Yasuhiko Tomita, Katsuyuki Aozasa, Noriyuki Tamai, Akira Myoui, Hideki Yoshikawa, Haruo Sugiyama

Cancer Sci. 2003 Mar; 94(3): 271–276. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01432.x

PMCID:: PMC11160304

Abstract Article PDF–314K

Select item 111602684.

Overexpression of the Wilms' tumor gene WT1 in colorectal adenocarcinoma

Yusuke Oji, Hirofumi Yamamoto, Masaya Nomura, Yoko Nakano, Ai Ikeba, Shin‐ichi Nakatsuka, Sakie Abeno, Eiji Kiyotoh, Tanyarat Jomgeow, Mitsugu Sekimoto, Riichiro Nezu, Yukinobu Yoshikawa, Yoshifumi Inoue, Naoki Hosen, Manabu Kawakami, Akihiro Tsuboi, Yoshihiro Oka, Hiroyasu Ogawa, Shigeo Souda, Katsuyuki Aozasa, Morito Monden, Haruo Sugiyama

Cancer Sci. 2003 Aug; 94(8): 712–717. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01507.x

PMCID:: PMC11160268

Abstract Article PDF–438K

Select item 111601925.

Overexpression of the Wilms' tumor gene WT1 in head and neck squamous cell carcinoma

Yusuke Oji, Hidenori Inohara, Mitsuhiro Nakazawa, Yoko Nakano, Shiro Akahani, Shin‐ichi Nakatsuka, Satoko Koga, Ai Ikeba, Sakie Abeno, Yuichiro Honjo, Yoshifumi Yamamoto, Soichi Iwai, Kaori Yoshida, Yoshihiro Oka, Hiroyasu Ogawa, Jun‐ichi Yoshida, Katsuyuki Aozasa, Takeshi Kubo, Haruo Sugiyama

Cancer Sci. 2003 Jun; 94(6): 523–529. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01477.x

PMCID:: PMC11160192

Abstract Article PDF–299K

Select item 111601826.

Overexpression of the Wilms' tumor gene WT1 in primary thyroid cancer

Yusuke Oji, Yasuo Miyoshi, Satoko Koga, Yoko Nakano, Akiko Ando, Shin‐ichi Nakatsuka, Ai Ikeba, Eigo Takahashi, Nao Sakaguchi, Asumi Yokota, Naoki Hosen, Kazuhiro Ikegame, Manabu Kawakami, Akihiro Tsuboi, Yoshihiro Oka, Hiroyasu Ogawa, Katsuyuki Aozasa, Shinzaburo Noguchi, Haruo Sugiyama

Cancer Sci. 2003 Jul; 94(7): 606–611. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01490.x

PMCID:: PMC11160182

Abstract Article PDF–334K

Select item 111585177.

Overexpression of the Wilms' tumor gene WT1 in primary astrocytic tumors

Yusuke Oji, Tsuyoshi Suzuki, Yoko Nakano, Motohiko Maruno, Shin‐ichi Nakatsuka, Tanyarat Jomgeow, Sakie Abeno, Naoya Tatsumi, Asumi Yokota, Sayaka Aoyagi, Tsutomu Nakazawa, Ken Ito, Keisuke Kanato, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Manabu Kawakami, Akihiro Tsuboi, Yoshihiro Oka, Katsuyuki Aozasa, Toshiki Yoshimine, Haruo Sugiyama

Cancer Sci. 2004 Oct; 95(10): 822–827. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2004.tb02188.x

PMCID:: PMC11158517

Abstract Article PDF–1.1M

Select item 110913218.

Homeobox regulator Wilms Tumour 1 is displaced by androgen receptor at cis-regulatory elements in the endometrium of PCOS patients

David W. James, Marcos Quintela, Lisa Lucini, Nour Al Abdullah Al Kafri, Gareth D. Healey, Nicholas Jones, Kinza Younas, Adnan Bunkheila, Lavinia Margarit, Lewis W. Francis, Deyarina Gonzalez, R. Steven Conlan

Front Endocrinol (Lausanne) 2024; 15: 1368494. Published online 2024 Apr 30. doi: 10.3389/fendo.2024.1368494

Correction in:: Front Endocrinol (Lausanne). 2024; 15: 1450375.

PMCID:: PMC11091321

Abstract Article PDF–2.4M

Select item 110769929.

MAP4K4 and WT1 mediate SOX6‐induced cellular senescence by synergistically activating the ATF2–TGFβ2–Smad2/3 signaling pathway in cervical cancer

Han Zheng, Mingchen Liu, Shu Shi, Hongxin Huang, Xingwen Yang, Ziheng Luo, Yarong Song, Qiang Xu, Tingting Li, Lixiang Xue, Fengmin Lu, Jie Wang

Mol Oncol. 2024 May; 18(5): 1327–1346. Published online 2024 Feb 21. doi: 10.1002/1878-0261.13613

PMCID:: PMC11076992

Abstract Article PDF–3.9M

Select item 1106376110.

Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors

Justin W. Magrath, Shruthi Sanjitha Sampath, Dane A. Flinchum, Alifiani B. Hartono, Ilon N. Goldberg, Julia R. Boehling, Suzana D. Savkovic, Sean B. Lee

Cancer Res. 2024 May 2; 84(9): 1426–1442. Published online 2024 Apr 8. doi: 10.1158/0008-5472.CAN-23-3334

PMCID:: PMC11063761

Abstract Article PDF–24M

Select item 1103426211.

Immunogenicity of WT-1 peptides

Ashley Knights, Ludmila Müller, Graham Pawelec

Cancer Immunol Immunother. 2002 Aug; 51(6): 349. Published online 2002 Jun 14. doi: 10.1007/s00262-002-0303-5

PMCID:: PMC11034262

Article PDF–40K

Select item 1102970612.

P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma

Takeshi Terashima, Eishiro Mizukoshi, Kuniaki Arai, Tatsuya Yamashita, Mariko Yoshida, Hajime Ota, Ichiro Onishi, Masato Kayahara, Koushiro Ohtsubo, Takashi Kagaya, Masao Honda, Shuichi Kaneko

Cancer Immunol Immunother. 2014 May; 63(5): 479–489. Published online 2014 Mar 16. doi: 10.1007/s00262-014-1529-8

PMCID:: PMC11029706

Abstract Article PDF–892K

Select item 1102913913.

Gemcitabine enhances Wilms’ tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response

Akitaka Takahara, Shigeo Koido, Masaki Ito, Eijiro Nagasaki, Yukiko Sagawa, Takeo Iwamoto, Hideo Komita, Toshiki Ochi, Hiroshi Fujiwara, Masaki Yasukawa, Junichi Mineno, Hiroshi Shiku, Sumiyuki Nishida, Haruo Sugiyama, Hisao Tajiri, Sadamu Homma

Cancer Immunol Immunother. 2011 Sep; 60(9): 1289–1297. Published online 2011 May 24. doi: 10.1007/s00262-011-1033-3

PMCID:: PMC11029139

Abstract Article PDF–528K

Select item 1102912314.

Wilms' tumor protein 1 (WT1) peptide vaccination in AML patients: predominant TCR CDR3β sequence associated with remission in one patient is detectable in other vaccinated patients

Sebastian Ochsenreither, Alberto Fusi, Anne Geikowski, David Stather, Antonia Busse, Andrea Stroux, Anne Letsch, Ulrich Keilholz

Cancer Immunol Immunother. 2012 Mar; 61(3): 313–322. Published online 2011 Sep 7. doi: 10.1007/s00262-011-1099-y

PMCID:: PMC11029123

Abstract Article PDF–490K

Select item 1099131415.

Maintenance of WT1 expression in tumor cells is associated with a good prognosis in malignant glioma patients treated with WT1 peptide vaccine immunotherapy

Chisato Yokota, Naoki Kagawa, Koji Takano, Yasuyoshi Chiba, Manabu Kinoshita, Noriyuki Kijima, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama, Akihiro Tsuboi, Shuichi Izumoto, Haruhiko Kishima, Naoya Hashimoto

Cancer Immunol Immunother. 2022 Jan; 71(1): 189–201. Published online 2021 Jun 5. doi: 10.1007/s00262-021-02954-z

PMCID:: PMC10991314

Abstract Article PDF–1.4M

Select item 1099112616.

Identification of two distinct populations of WT1-specific cytotoxic T lymphocytes in co-vaccination of WT1 killer and helper peptides

Fumihiro Fujiki, Akihiro Tsuboi, Soyoko Morimoto, Naoya Hashimoto, Miki Inatome, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Kana Hasegawa, Naoki Hosen, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama

Cancer Immunol Immunother. 2021 Jan; 70(1): 253–263. Published online 2020 Jul 22. doi: 10.1007/s00262-020-02675-9

PMCID:: PMC10991126

Abstract Article PDF–650K

Select item 1051116717.

The miR-143/145 cluster induced by TGF-β1 suppresses Wilms’ tumor 1 expression in cultured human podocytes

Akifumi Tabei, Toru Sakairi, Hiroko Hamatani, Yuko Ohishi, Mitsuharu Watanabe, Masao Nakasatomi, Hidekazu Ikeuchi, Yoriaki Kaneko, Jeffrey B. Kopp, Keiju Hiromura

Am J Physiol Renal Physiol. 2023 Jul 1; 325(1): F121–F133. Published online 2023 May 11. doi: 10.1152/ajprenal.00313.2022