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Select item 107063001.

Loss of Uncoupling Protein 1 Expression in the Subcutaneous Adipose Tissue Predicts Childhood Obesity

Katalin Gyurina, Mariia Yarmak, László Sasi-Szabó, Sarolta Molnár, Gábor Méhes, Tamás Röszer

Int J Mol Sci. 2023 Dec; 24(23): 16706. Published online 2023 Nov 24. doi: 10.3390/ijms242316706

PMCID:: PMC10706300

Abstract Article PDF–22M

Select item 106890382.

Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease

Claudia Huesca-Gómez, Yazmín Estela Torres-Paz, Giovanny Fuentevilla-Álvarez, Nadia Janet González-Moyotl, Edgar Samuel Ramírez-Marroquín, Xicótencatl Vásquez-Jiménez, Víctor Sainz-Escarrega, María Elena Soto, Reyna Samano, Ricardo Gamboa

Arch Endocrinol Metab. 2023 Mar-Apr; 67(2): 214–223. Published online 2023 Jan 17. doi: 10.20945/2359-3997000000582

PMCID:: PMC10689038

Abstract Article PDF–311K

Select item 104136603.

Structural basis of purine nucleotide inhibition of human uncoupling protein 1

Scott A. Jones, Prerana Gogoi, Jonathan J. Ruprecht, Martin S. King, Yang Lee, Thomas Zögg, Els Pardon, Deepak Chand, Stefan Steimle, Danielle M. Copeman, Camila A. Cotrim, Jan Steyaert, Paul G. Crichton, Vera Moiseenkova-Bell, Edmund R. S. Kunji

Sci Adv. 2023 Jun 2; 9(22): eadh4251. Published online 2023 May 31. doi: 10.1126/sciadv.adh4251

PMCID:: PMC10413660

Abstract Article PDF–1.1M

Select item 94984184.

Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia

Alena A. Nikanorova, Nikolay A. Barashkov, Vera G. Pshennikova, Nyurgun N. Gotovtsev, Georgii P. Romanov, Aisen V. Solovyev, Sargylana S. Kuzmina, Nikolay N. Sazonov, Sardana A. Fedorova

Genes (Basel) 2022 Sep; 13(9): 1612. Published online 2022 Sep 8. doi: 10.3390/genes13091612

PMCID:: PMC9498418

Abstract Article PDF–1.8M

Select item 92655315.

Chronic Fatty Acid Depletion Induces Uncoupling Protein 1 (UCP1) Expression to Coordinate Mitochondrial Inducible Proton Leak in a Human-Brown-Adipocyte Model

Yukimasa Takeda, Ping Dai

Cells. 2022 Jul; 11(13): 2038. Published online 2022 Jun 27. doi: 10.3390/cells11132038

PMCID:: PMC9265531

Abstract Article PDF–6.6M

Select item 92431626.

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

Riccardo Cavalieri, Marlou Klein Hazebroek, Camila A. Cotrim, Yang Lee, Edmund R.S. Kunji, Martin Jastroch, Susanne Keipert, Paul G. Crichton

Mol Metab. 2022 Aug; 62: 101526. Published online 2022 Jun 9. doi: 10.1016/j.molmet.2022.101526

PMCID:: PMC9243162

Abstract Article PDF–1.4M

Select item 90661087.

Mitochondrial Protein UCP1 Inhibits the Malignant Behaviors of Triple-negative Breast Cancer through Activation of Mitophagy and Pyroptosis

Jing Xia, Changbin Chu, Wanqing Li, Hong Chen, Wenhua Xie, Rui Cheng, Kai Hu, Xi Li

Int J Biol Sci. 2022; 18(7): 2949–2961. Published online 2022 Apr 18. doi: 10.7150/ijbs.68438

PMCID:: PMC9066108

Abstract Article PDF–3.2M

Select item 88003488.

UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients

Jinfa Huang, Guilian Wang, Kedan Liao, Ning Xie, Kaixian Deng

J Ovarian Res. 2022; 15: 16. Published online 2022 Jan 28. doi: 10.1186/s13048-022-00951-z

PMCID:: PMC8800348

Abstract Article PDF–2.2M

Select item 86550499.

Macrophages expressing uncoupling protein 1 increase in adipose tissue in response to cold in humans

Brian S. Finlin, Hasiyet Memetimin, Amy L. Confides, Beibei Zhu, Philip M. Westgate, Esther E. Dupont-Versteegden, Philip A. Kern

Sci Rep. 2021; 11: 23598. Published online 2021 Dec 8. doi: 10.1038/s41598-021-03014-3

PMCID:: PMC8655049

Abstract Article PDF–2.2M

Select item 854810510.

Ethnicity Differences in the Association of UCP1-3826A/G, UCP2-866G/A and Ala55Val, and UCP3-55C/T Polymorphisms with Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis

Rong Huang, Tingting Cai, Yunting Zhou, Yuming Wang, Huiying Wang, Ziyang Shen, Wenqing Xia, Xiaomei Liu, Bo Ding, Yong Luo, Rengna Yan, Huiqin Li, Jindan Wu, Jianhua Ma

Biomed Res Int. 2021; 2021: 3482879. Published online 2021 Oct 19. doi: 10.1155/2021/3482879

PMCID:: PMC8548105

Abstract Article PDF–748K

Select item 845604711.

Latent TGFβ-binding proteins regulate UCP1 expression and function via TGFβ2

D. Halbgebauer, J. Roos, J.B. Funcke, H. Neubauer, B.S. Hamilton, E. Simon, E.Z. Amri, K.M. Debatin, M. Wabitsch, P. Fischer-Posovszky, D. Tews

Mol Metab. 2021 Nov; 53: 101336. Published online 2021 Sep 1. doi: 10.1016/j.molmet.2021.101336

PMCID:: PMC8456047

Abstract Article PDF–2.0M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 812486913.

The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia

Alena A. Nikanorova, Nikolay A. Barashkov, Vera G. Pshennikova, Sergey S. Nakhodkin, Nyurgun N. Gotovtsev, Georgii P. Romanov, Aisen V. Solovyev, Sargylana S. Kuzmina, Nikolay N. Sazonov, Sardana A. Fedorova

Int J Mol Sci. 2021 May; 22(9): 4657. Published online 2021 Apr 28. doi: 10.3390/ijms22094657

PMCID:: PMC8124869

Abstract Article PDF–1.8M

Select item 801594114.

NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue

María Bové, Fermi Monto, Paloma Guillem-Llobat, M Dolores Ivorra, M Antonia Noguera, Andrea Zambrano, M Salome Sirerol-Piquer, Ana Cristina Requena, Mauricio García-Alonso, Teresa Tejerina, José T. Real, Isabel Fariñas, Pilar D’Ocon

Front Endocrinol (Lausanne) 2021; 12: 630097. Published online 2021 Mar 18. doi: 10.3389/fendo.2021.630097

PMCID:: PMC8015941

Abstract Article PDF–6.5M

Select item 798823315.

IRX3 Overexpression Enhances Ucp1 Expression In Vivo

Zhiyin Zhang, Qihan Wu, Yang He, Peng Lu, Danjie Li, Minglan Yang, Weiqiong Gu, Ruixin Liu, Jie Hong, Jiqiu Wang

Front Endocrinol (Lausanne) 2021; 12: 634191. Published online 2021 Mar 10. doi: 10.3389/fendo.2021.634191

PMCID:: PMC7988233

Abstract Article PDF–3.0M

Select item 788162816.

Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis

Xujia Liu, Zehua Jiang, Guihua Zhang, Tsz Kin Ng, Zhenggen Wu

BMC Ophthalmol. 2021; 21: 81. Published online 2021 Feb 12. doi: 10.1186/s12886-021-01838-1

PMCID:: PMC7881628

Abstract Article PDF–1.9M

Select item 760667617.

Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation

Laurent Vergnes, Jason Y. Lin, Graeme R. Davies, Christopher D. Church, Karen Reue

J Biol Chem. 2020 Oct 30; 295(44): 15054–15069. Published online 2020 Aug 27. doi: 10.1074/jbc.RA120.013322

PMCID:: PMC7606676

Abstract Article PDF–4.4M

Select item 756688118.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 755183219.

Increased Risk of High Body Fat and Altered Lipid Metabolism Associated to Suboptimal Consumption of Vitamin A Is Modulated by Genetic Variants rs5888 (SCARB1), rs1800629 (UCP1) and rs659366 (UCP2)

Sebastià Galmés, Andreu Palou, Francisca Serra

Nutrients. 2020 Sep; 12(9): 2588. Published online 2020 Aug 26. doi: 10.3390/nu12092588

PMCID:: PMC7551832

Abstract Article PDF–2.0M

Select item 724939520.

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases

Anna E. Pravednikova, Sergey Y. Shevchenko, Victor V. Kerchev, Manana R. Skhirtladze, Svetlana N. Larina, Zaur M. Kachaev, Alexander D. Egorov, Yulii V. Shidlovskii

Mol Med. 2020; 26: 51. Published online 2020 May 25. doi: 10.1186/s10020-020-00180-4

PMCID:: PMC7249395

Abstract Article PDF–1.3M

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