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Select item 114370901.

NADPH oxidase 4 deficiency promotes hepatocellular carcinoma arising from hepatic fibrosis by inducing M2-macrophages in the tumor microenvironment

Ji Young Kim, Wonseok Kang, Sera Yang, Su Hyun Park, Sang Yun Ha, Yong-Han Paik

Sci Rep. 2024; 14: 22358. Published online 2024 Sep 27. doi: 10.1038/s41598-024-72721-4

PMCID:: PMC11437090

Abstract Article PDF–8.0M

Select item 112914352.

NOX4 and its association with myeloperoxidase and osteopontin in regulating endochondral ossification

Kayoung Ko, Seohee Choi, Miri Jo, Chaeyoung Kim, Napissara Boonpraman, Jihyun Youm, Sun Shin Yi

J Vet Sci. 2024 Jul; 25(4): e49. Published online 2024 May 24. doi: 10.4142/jvs.24076

PMCID:: PMC11291435

Abstract Article PDF–13M

Select item 110957043.

Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy

Jinli Wang, Daniel A. Lai, Joshua J. Wang, Sarah X. Zhang

PLoS One. 2024; 19(5): e0303010. Published online 2024 May 15. doi: 10.1371/journal.pone.0303010

PMCID:: PMC11095704

Abstract Article PDF–1.5M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108497675.

Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity

Spencer Greatorex, Supreet Kaur, Chrysovalantou E. Xirouchaki, Pei K. Goh, Florian Wiede, Amanda J. Genders, Melanie Tran, YaoYao Jia, Arthe Raajendiran, Wendy A. Brown, Catriona A. McLean, Junichi Sadoshima, Matthew J. Watt, Tony Tiganis

J Clin Invest. 2024 Feb 1; 134(3): e162533. Published online 2024 Feb 1. doi: 10.1172/JCI162533

PMCID:: PMC10849767

Abstract Article PDF–38M

Select item 108396456.

Nox4-SH3YL1 complex is involved in diabetic nephropathy

Sae Rom Lee, Hye Eun Lee, Jung-Yeon Yoo, Eun Jung An, Soo-Jin Song, Ki-Hwan Han, Dae Ryong Cha, Yun Soo Bae

iScience. 2024 Feb 16; 27(2): 108868. Published online 2024 Jan 11. doi: 10.1016/j.isci.2024.108868

PMCID:: PMC10839645

Abstract Article PDF–7.3M

Select item 105984087.

Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy

Aleksandr E. Vendrov, Han Xiao, Andrey Lozhkin, Takayuki Hayami, Guomin Hu, Matthew J. Brody, Junichi Sadoshima, You-Yi Zhang, Marschall S. Runge, Nageswara R. Madamanchi

Redox Biol. 2023 Nov; 67: 102937. Published online 2023 Oct 19. doi: 10.1016/j.redox.2023.102937

PMCID:: PMC10598408

Abstract Article PDF–14M

Select item 105949138.

miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson’s disease model via regulation of Nox4/ROS/Nrf2 signaling

Songzhe He, Qiongqiong Wang, Liankuai Chen, Yusheng Jason He, Xiaofang Wang, Shaogang Qu

J Transl Med. 2023; 21: 747. Published online 2023 Oct 24. doi: 10.1186/s12967-023-04638-x

PMCID:: PMC10594913

Abstract Article PDF–18M

Select item 104416619.

Adipocyte-Derived Exosomal NOX4-Mediated Oxidative Damage Induces Premature Placental Senescence in Obese Pregnancy

Yuelan Tao, Wei Chen, Hongbing Xu, Jiacheng Xu, Huan Yang, Xin Luo, Miaomiao Chen, Jie He, Yuxiang Bai, Hongbo Qi

Int J Nanomedicine. 2023; 18: 4705–4726. Published online 2023 Aug 17. doi: 10.2147/IJN.S419081

PMCID:: PMC10441661

Abstract Article PDF–18M

Select item 1039993810.

Vasoprotective effects of NOX4 are mediated via polymerase and transient receptor potential melastatin 2 cation channels in endothelial cells

Rheure Alves-Lopes, Silvia Lacchini, Karla B. Neves, Adam Harvey, Augusto C. Montezano, Rhian M. Touyz

J Hypertens. 2023 Sep; 41(9): 1389–1400. Published online 2023 Jun 1. doi: 10.1097/HJH.0000000000003478

PMCID:: PMC10399938

Abstract Article PDF–3.5M

Select item 1037290511.

Role of Nox4 in Mitigating Inflammation and Fibrosis in Dextran Sulfate Sodium–Induced Colitis

Yura Lee, Sung-Hee Kim, Haengdueng Jeong, Kwang H. Kim, Donghun Jeon, Yejin Cho, Daekee Lee, Ki Taek Nam

Cell Mol Gastroenterol Hepatol. 2023; 16(3): 411–429. Published online 2023 May 18. doi: 10.1016/j.jcmgh.2023.05.002

PMCID:: PMC10372905

Abstract Article PDF–7.4M

Select item 1034443812.

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat

Hepatology. 2023 Aug; 78(2): 416–433. Published online 2022 Sep 17. doi: 10.1002/hep.32702

PMCID:: PMC10344438

Abstract Article PDF–2.2M

Select item 1022639813.

NADPH Oxidase 4 Contributes to Oxidative Stress in a Mouse Model of Myocardial Infarction

Qiang HUANG, Yanping CHEN

Physiol Res. 2023 Apr; 72(2): 177–186. Published online 2023 Apr 30. doi: 10.33549/physiolres.934992

PMCID:: PMC10226398

Abstract Article PDF–1.7M

Select item 1019301714.

NOX4–TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming

Jyotsana Pandey, Jennifer L. Larson-Casey, Mallikarjun H. Patil, Rutwij Joshi, Chun-sun Jiang, Yong Zhou, Chao He, A. Brent Carter

J Biol Chem. 2023 May; 299(5): 104695. Published online 2023 Apr 10. doi: 10.1016/j.jbc.2023.104695

PMCID:: PMC10193017

Abstract Article PDF–3.9M

Select item 1019172015.

Skeletal muscle Nox4 knockout prevents and Nox2 knockout blunts loss of maximal diaphragm force in mice with heart failure with reduced ejection fraction

Ravi A. Kumar, Dongwoo Hahn, Rachel C. Kelley, Derek R. Muscato, Alex Shamoun, Nuria Curbelo-Bermudez, W. Greyson Butler, Svetlana Yegorova, Terence E. Ryan, Leonardo F. Ferreira

Free Radic Biol Med. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Free Radic Biol Med. 2023 Jan; 194: 23–32. Published online 2022 Nov 24. doi: 10.1016/j.freeradbiomed.2022.11.025

PMCID:: PMC10191720

Abstract Article PDF–1.0M

Select item 1019028916.

Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non‐Amplification of Activin A‐ACVR2B‐NOX4 Axis Pathway

Jimin Jeon, Hyemi Lee, Min‐Seung Jeon, Seok‐Jung Kim, Cham Choi, Ki Woo Kim, Dong Joo Yang, Sangho Lee, Yong‐Soo Bae, Won Il Choi, Juyeon Jung, Seong‐il Eyun, Siyoung Yang

Adv Sci (Weinh) 2023 May; 10(14): 2205161. Published online 2023 Mar 22. doi: 10.1002/advs.202205161

PMCID:: PMC10190289

Abstract Article PDF–5.5M

Select item 1016797217.

Nox4 knockout does not prevent diaphragm atrophy, contractile dysfunction, or mitochondrial maladaptation in the early phase post-myocardial infarction in mice

Dongwoo Hahn, Ravi A. Kumar, Derek R. Muscato, Terence E. Ryan, Katrin Schröder, Leonardo F. Ferreira

Cell Physiol Biochem. Author manuscript; available in PMC 2023 May 9.

Published in final edited form as: Cell Physiol Biochem. 2021 Aug 20; 55(4): 489–504. doi: 10.33594/000000400

PMCID:: PMC10167972

Abstract Article PDF–1.4M

Select item 1012337618.

NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease

Napissara Boonpraman, Sunmi Yoon, Chae Young Kim, Jong-Seok Moon, Sun Shin Yi

Redox Biol. 2023 Jun; 62: 102698. Published online 2023 Apr 10. doi: 10.1016/j.redox.2023.102698

PMCID:: PMC10123376

Abstract Article PDF–11M

Select item 995065919.

NADPH oxidase 4 is dispensable for skin myofibroblast differentiation and wound healing

Aleksandra Malgorzata Siedlar, Tamara Seredenina, Anna Faivre, Yves Cambet, Marie-José Stasia, Dominik André-Lévigne, Marie-Luce Bochaton-Piallat, Brigitte Pittet-Cuénod, Sophie de Seigneux, Karl-Heinz Krause, Ali Modarressi, Vincent Jaquet

Redox Biol. 2023 Apr; 60: 102609. Published online 2023 Jan 13. doi: 10.1016/j.redox.2023.102609

PMCID:: PMC9950659

Abstract Article PDF–5.5M

Select item 994501720.

NADPH oxidase 4 deficiency attenuates experimental osteoarthritis in mice

Félix Renaudin, Karim Oudina, Maude Gerbaix, Manon McGilligan Subilia, Joris Paccaud, Vincent Jaquet, Karl-Heinz Krause, Serge Ferrari, Thomas Laumonier, Didier Hannouche

RMD Open. 2023; 9(1): e002856. Published online 2023 Feb 21. doi: 10.1136/rmdopen-2022-002856

PMCID:: PMC9945017

Abstract Article PDF–3.8M

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