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Select item 108379061.

Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development

Xiangyan Wang, Yan Zhang, Jianjie Yu, Yabo Ma, Yaxiu Xu, Jiaqi Shi, Zhipeng Qi, Xinfeng Liu

BMC Genomics. 2024; 25: 139. Published online 2024 Feb 3. doi: 10.1186/s12864-024-10058-y

PMCID:: PMC10837906

Abstract Article PDF–7.1M

Select item 102403462.

Bone marrow mesenchymal stem cell‐derived exosomes reduce insulin resistance and obesity in mice via the PI3K/AKT signaling pathway

Hongwei Shi, Xiaojing Hao, Yaqin Sun, Huilin Zhang, Yating Zhao, Bin Wang, Jiayin Lu, Wei Hou, Yi Yan, Xiuju Yu, Linli Xue, Xiaomao Luo, Haidong Wang

FEBS Open Bio. 2023 Jun; 13(6): 1015–1026. Published online 2023 May 2. doi: 10.1002/2211-5463.13615

PMCID:: PMC10240346

Abstract Article PDF–1.5M

Select item 100860333.

LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway

Jung-Hsuan Chang, Chia-Hua Chou, Jui-Ching Wu, Keng-Mao Liao, Wei-Jia Luo, Wei-Lun Hsu, Xuan-Ren Chen, Sung-Liang Yu, Szu-Hua Pan, Pan-Chyr Yang, Kang-Yi Su

Commun Biol. 2023; 6: 389. Published online 2023 Apr 10. doi: 10.1038/s42003-023-04778-2

PMCID:: PMC10086033

Abstract Article PDF–5.9M

Select item 100373414.

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

Tina Nguyen, Anthony Lau, Julia Bier, Kristen C. Cooke, Helen Lenthall, Stephanie Ruiz-Diaz, Danielle T. Avery, Henry Brigden, David Zahra, William A Sewell, Luke Droney, Satoshi Okada, Takaki Asano, Hassan Abolhassani, Zahra Chavoshzadeh, Roshini S. Abraham, Nipunie Rajapakse, Eric W. Klee, Joseph A. Church, Andrew Williams, Melanie Wong, Christoph Burkhart, Gulbu Uzel, David R. Croucher, David E. James, Cindy S. Ma, Robert Brink, Stuart G. Tangye, Elissa K. Deenick

J Exp Med. 2023 Jun 5; 220(6): e20221020. Published online 2023 Mar 21. doi: 10.1084/jem.20221020

PMCID:: PMC10037341

Abstract Article PDF–6.2M

Select item 99052875.

Short-term PI3K inhibition prevents breast cancer in preclinical models

Amy T. Ku, Adelaide I.J. Young, Ahmed Atef Ibrahim, Wen Bu, Weiyu Jiang, Meng Lin, Laterrica C. Williams, Bryant Lee McCue, George Miles, Chandandeep Nagi, Fariba Behbod, Yi Li

Cancer Prev Res (Phila) Author manuscript; available in PMC 2023 Aug 6.

Published in final edited form as: Cancer Prev Res (Phila). 2023 Feb 6; 16(2): 65–73. doi: 10.1158/1940-6207.CAPR-22-0275

PMCID:: PMC9905287

Abstract Article PDF–2.1M

Select item 98413336.

The MASTL/PP2A cell cycle kinase‐phosphatase module restrains PI3K‐Akt activity in an mTORC1‐dependent manner

Belén Sanz‐Castillo, Begoña Hurtado, Diana Vara‐Ciruelos, Aicha El Bakkali, Dario Hermida, Beatriz Salvador‐Barbero, Diego Martínez‐Alonso, José González‐Martínez, Clara Santiveri, Ramón Campos‐Olivas, Pilar Ximénez‐Embún, Javier Muñoz, Mónica Álvarez‐Fernández, Marcos Malumbres

EMBO J. 2023 Jan; 42(2): e110833. Published online 2022 Nov 10. doi: 10.15252/embj.2022110833

PMCID:: PMC9841333

Abstract Article PDF–2.7M

Select item 95293707.

PI3Kγ INHIBITION ALLEVIATES SYMPTOMS AND INCREASES AXON NUMBER IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MICE

H. LI, D. PARK, P. M. ABDUL-MUNEER, B. XU, H. WANG, B. XING, D. WU, S. LI

Neuroscience. Author manuscript; available in PMC 2022 Oct 3.

Published in final edited form as: Neuroscience. 2013 Dec 3; 253: 89–99. Published online 2013 Sep 3. doi: 10.1016/j.neuroscience.2013.08.051

PMCID:: PMC9529370

Abstract Article PDF–1.5M

Select item 94265868.

Phosphatidylinositol 3-Kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling

Axel Dietschmann, Sebastian Schruefer, Stefanie Westermann, Fiona Henkel, Kirstin Castiglione, Ralf Willebrand, Jasmin Adam, Jürgen Ruland, Roland Lang, Donald C. Sheppard, Julia Esser-von-Bieren, Daniel Radtke, Sven Krappmann, David Voehringer

mBio. 2022 Jul-Aug; 13(4): e01239-22. Published online 2022 Jun 13. doi: 10.1128/mbio.01239-22

PMCID:: PMC9426586

Abstract Article PDF–4.6M

Select item 83132399.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 824504110.

Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling

Qian Wang, Chenqi Tao, Abdul Hannan, Sungtae Yoon, Xuanyu Min, John Peregrin, Xiuxia Qu, Hongge Li, Honglian Yu, Jean Zhao, Xin Zhang

Sci Adv. 2021 Jul; 7(27): eabf1068. Published online 2021 Jun 30. doi: 10.1126/sciadv.abf1068

PMCID:: PMC8245041

Abstract Article PDF–1.8M

Select item 801061811.

The role of striated muscle Pik3r1 in glucose and protein metabolism following chronic glucocorticoid exposure

Tzu-Chieh Chen, Taiyi Kuo, Mohamad Dandan, Rebecca A. Lee, Maggie Chang, Sneha D. Villivalam, Szu-Chi Liao, Damian Costello, Mahalakshmi Shankaran, Hussein Mohammed, Sona Kang, Marc K. Hellerstein, Jen-Chywan Wang

J Biol Chem. 2021 Jan-Jun; 296: 100395. Published online 2021 Feb 7. doi: 10.1016/j.jbc.2021.100395

PMCID:: PMC8010618

Abstract Article PDF–2.5M

Select item 796814412.

Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes

Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó

Cell Rep. Author manuscript; available in PMC 2021 Mar 17.

Published in final edited form as: Cell Rep. 2021 Feb 9; 34(6): 108729. doi: 10.1016/j.celrep.2021.108729

PMCID:: PMC7968144

Abstract Article PDF–1.7M

Select item 793877013.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 780145314.

The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus

Christian Huisman, Young A. Kim, Shin Jeon, Bongjin Shin, Jeonghoon Choi, Su Jeong Lim, Sung Min Youn, Younjung Park, Medha K. C., Sangsoo Kim, Soo-Kyung Lee, Seunghee Lee, Jae W. Lee

Nat Commun. 2021; 12: 256. Published online 2021 Jan 11. doi: 10.1038/s41467-020-20511-7

PMCID:: PMC7801453

Abstract Article PDF–5.6M

Select item 740849215.

Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells

Rebecca Cornelis, Stefanie Hahne, Adriano Taddeo, Georg Petkau, Darya Malko, Pawel Durek, Manja Thiem, Lukas Heiberger, Lena Peter, Elodie Mohr, Cora Klaeden, Koji Tokoyoda, Francesco Siracusa, Bimba Franziska Hoyer, Falk Hiepe, Mir-Farzin Mashreghi, Fritz Melchers, Hyun-Dong Chang, Andreas Radbruch

Cell Rep. 2020 Aug 4; 32(5): 107982. Published online 2020 Aug 4. doi: 10.1016/j.celrep.2020.107982

PMCID:: PMC7408492

Abstract Article

Select item 738551516.

Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure

Albert Kwok, Ilona Zvetkova, Sam Virtue, Ineke Luijten, Isabel Huang-Doran, Patsy Tomlinson, David A. Bulger, James West, Steven Murfitt, Julian Griffin, Rafeah Alam, Daniel Hart, Rachel Knox, Peter Voshol, Antonio Vidal-Puig, Jørgen Jensen, Stephen O'Rahilly, Robert K. Semple

Mol Metab. 2020 Oct; 40: 101020. Published online 2020 May 19. doi: 10.1016/j.molmet.2020.101020

PMCID:: PMC7385515

Abstract Article PDF–3.3M

Select item 723210017.

Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion

Michael Riedelberger, Philipp Penninger, Michael Tscherner, Bernhard Hadriga, Carina Brunnhofer, Sabrina Jenull, Anton Stoiber, Christelle Bourgeois, Andriy Petryshyn, Walter Glaser, Andreas Limbeck, Michael A. Lynes, Gernot Schabbauer, Guenter Weiss, Karl Kuchler

iScience. 2020 May 22; 23(5): 101121. Published online 2020 May 4. doi: 10.1016/j.isci.2020.101121

PMCID:: PMC7232100

Abstract Article PDF–34M

Select item 722702818.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 708834619.

Inhibition of the PI3K/AKT Signaling Pathway or Overexpression of Beclin1 Blocks Reinfection of Streptococcus pneumoniae After Infection of Influenza A Virus in Severe Community-Acquired Pneumonia

Zhaohui Yang, Xiaoguang Zou, Peiqing Feng, Huaibing Zhan, Dani Xiong, Jianmin Lang

Inflammation. 2019; 42(5): 1741–1753. Published online 2019 Jul 2. doi: 10.1007/s10753-019-01035-9

PMCID:: PMC7088346

Abstract Article PDF–934K

Select item 694907920.

CircRNA AFF4 promotes osteoblast cells proliferation and inhibits apoptosis via the Mir-7223-5p/PIK3R1 axis

Bobin Mi, Yuan Xiong, Lang Chen, Chenchen Yan, Yori Endo, Yi Liu, Jing Liu, Liangcong Hu, Yiqiang Hu, Yun Sun, Faqi Cao, Wu Zhou, Guohui Liu

Aging (Albany NY) 2019 Dec 31; 11(24): 11988–12001. Published online 2019 Dec 17. doi: 10.18632/aging.102524

PMCID:: PMC6949079

Abstract Article PDF–3.2M

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