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Select item 110146571.

A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis

Jingwen Yang, Lingxin Zhu, Haichun Pan, Hiroki Ueharu, Masako Toda, Qian Yang, Shawn A. Hallett, Lorin E. Olson, Yuji Mishina

J Clin Invest. 2024 Apr 15; 134(8): e165787. Published online 2024 Mar 11. doi: 10.1172/JCI165787

PMCID:: PMC11014657

Abstract Article PDF–16M

Select item 109453492.

NPC1 is required for postnatal islet β cell differentiation by maintaining mitochondria turnover

Bei Liu, Duanyi Hua, Linyan Shen, Tingting Li, Zheying Tao, Chenyang Fu, Zhongzheng Tang, Jie Yang, Li Zhang, Aifang Nie, Yiran Jiang, Jiqiu Wang, Yang Li, Yanyun Gu, Guang Ning

Theranostics. 2024; 14(5): 2058–2074. Published online 2024 Feb 24. doi: 10.7150/thno.90946

PMCID:: PMC10945349

Abstract Article PDF–9.7M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 95421624.

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier

J Comp Neurol. 2022 Aug; 530(11): 1773–1949. Published online 2022 Mar 18. doi: 10.1002/cne.25312

PMCID:: PMC9542162

Abstract Article PDF–28M

Select item 93738225.

MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation

Jyun-Ni Chi, Jhih-Yu Yang, Chia-Hsin Hsueh, Ching-Yi Tsai, Huai-Chia Chuang, Tse-Hua Tan

Theranostics. 2022; 12(13): 5744–5760. Published online 2022 Jul 18. doi: 10.7150/thno.72148

PMCID:: PMC9373822

Abstract Article PDF–3.2M

Select item 91569446.

Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity

Dominic Santoleri, Hee-Woong Lim, Matthew J. Emmett, Julian Stoute, Matthew J. Gavin, Jaimarie Sostre-Colón, Kahealani Uehara, Jaclyn E. Welles, Kathy Fange Liu, Mitchell A. Lazar, Paul M. Titchenell

iScience. 2022 Jun 17; 25(6): 104410. Published online 2022 May 16. doi: 10.1016/j.isci.2022.104410

PMCID:: PMC9156944

Abstract Article PDF–3.6M

Select item 87704587.

Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes

Bodour S. Rajab, Sarah Kassab, Connor D. Stonall, Hussam Daghistani, Stephen Gibbons, Mamas Mamas, David Smith, Aleksandr Mironov, Zainab AlBalawi, Yin Hua Zhang, Florence Baudoin, Min Zi, Sukhpal Prehar, Elizabeth J. Cartwright, Ashraf Kitmitto

Sci Rep. 2022; 12: 978. Published online 2022 Jan 19. doi: 10.1038/s41598-022-04929-1

PMCID:: PMC8770458

Abstract Article PDF–4.0M

Select item 84819778.

Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption

Sébastien Kessler, Gwenaël Labouèbe, Sophie Croizier, Sevasti Gaspari, David Tarussio, Bernard Thorens

iScience. 2021 Oct 22; 24(10): 103122. Published online 2021 Sep 11. doi: 10.1016/j.isci.2021.103122

PMCID:: PMC8481977

Abstract Article PDF–5.5M

Select item 84098099.

Glucokinase is required for high‐starch diet‐induced β‐cell mass expansion in mice

Kazuhisa Tsuchida, Akinobu Nakamura, Hideaki Miyoshi, Kelaier Yang, Yuki Yamauchi, Shinichiro Kawata, Kazuno Omori, Kiyohiko Takahashi, Naoyuki Kitao, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Yusuke Seino, Yasuo Terauchi, Tatsuya Atsumi

J Diabetes Investig. 2021 Sep; 12(9): 1545–1554. Published online 2021 Mar 30. doi: 10.1111/jdi.13532

PMCID:: PMC8409809

Abstract Article PDF–1.1M

Select item 837951010.

Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice

Antoine Rohrbach, Emilie Caron, Rafik Dali, Maxime Brunner, Roxane Pasquettaz, Irina Kolotuev, Federico Santoni, Bernard Thorens, Fanny Langlet

Mol Metab. 2021 Nov; 53: 101311. Published online 2021 Jul 26. doi: 10.1016/j.molmet.2021.101311

PMCID:: PMC8379510

Abstract Article PDF–5.3M

Select item 825156211.

Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease

Evans Quilichini, Mélanie Fabre, Christoffer Nord, Thassadite Dirami, Axelle Le Marec, Silvia Cereghini, Raymond C Pasek, Maureen Gannon, Ulf Ahlgren, Cécile Haumaitre

J Pathol. 2021 May; 254(1): 31–45. Published online 2021 Mar 18. doi: 10.1002/path.5629

PMCID:: PMC8251562

Abstract Article PDF–46M

Select item 811718512.

Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes

Sharona Tornovsky-Babeay, Noa Weinberg-Corem, Rachel Schyr Ben Haroush, Dana Avrahami, Judith Lavi, Eseye Feleke, Klaus H. Kaestner, Yuval Dor, Benjamin Glaser

Diabetologia. Author manuscript; available in PMC 2022 May 1.

Published in final edited form as: Diabetologia. 2021 May; 64(5): 1133–1143. Published online 2021 Feb 9. doi: 10.1007/s00125-021-05390-x

PMCID:: PMC8117185

Abstract Article PDF–790K

Select item 805218613.

Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene

Ildem Akerman, Miguel Angel Maestro, Elisa De Franco, Vanessa Grau, Sarah Flanagan, Javier García-Hurtado, Gerhard Mittler, Philippe Ravassard, Lorenzo Piemonti, Sian Ellard, Andrew T. Hattersley, Jorge Ferrer

Cell Rep. 2021 Apr 13; 35(2): 108981. Published online 2021 Apr 13. doi: 10.1016/j.celrep.2021.108981

PMCID:: PMC8052186

Abstract Article

Select item 797324914.

Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states

Varun Bahl, Catherine Lee May, Alanis Perez, Benjamin Glaser, Klaus H. Kaestner

Mol Metab. 2021 Jul; 49: 101193. Published online 2021 Feb 19. doi: 10.1016/j.molmet.2021.101193

PMCID:: PMC7973249

Abstract Article PDF–1.6M

Select item 725495715.

MANF is indispensable for the proliferation and survival of pancreatic β-cells

Maria Lindahl, Tatiana Danilova, Erik Palm, Päivi Lindholm, Vootele Võikar, Elina Hakonen, Jarkko Ustinov, Jaan-Olle Andressoo, Brandon K. Harvey, Timo Otonkoski, Jari Rossi, Mart Saarma

Cell Rep. Author manuscript; available in PMC 2020 May 28.

Published in final edited form as: Cell Rep. 2014 Apr 24; 7(2): 366–375. Published online 2014 Apr 13. doi: 10.1016/j.celrep.2014.03.023

PMCID:: PMC7254957

Abstract Article PDF–930K

Select item 695131416.

FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression

Noriko Kodani, Jun Nakae, Masaki Kobayashi, Osamu Kikuchi, Tadahiro Kitamura, Hiroshi Itoh

iScience. 2020 Jan 24; 23(1): 100798. Published online 2019 Dec 23. doi: 10.1016/j.isci.2019.100798

PMCID:: PMC6951314

Abstract Article PDF–20M

Select item 674425917.

HCF-1 regulates de novo lipogenesis through a nutrient sensitive complex with ChREBP

Elizabeth A. Lane, Dong Wook Choi, Luisa Garcia-Haro, Zebulon G. Levine, Meghan Tedoldi, Suzanne Walker, Nika N. Danial

Mol Cell. Author manuscript; available in PMC 2020 Jul 25.

Published in final edited form as: Mol Cell. 2019 Jul 25; 75(2): 357–371.e7. Published online 2019 Jun 18. doi: 10.1016/j.molcel.2019.05.019

PMCID:: PMC6744259

Abstract Article PDF–2.9M

Select item 665797718.

Circular RNA profile in liver tissue of EpCAM knockout mice

Yanhong Yang, Shaomin Liu, Zili Lei, Guibin Chen, Li Huang, Fei Yang, Yuting Lei, Yanyan Liu, Lanxiang Yang, Wanwan Liu, Liangxue Lai, Jiao Guo

Int J Mol Med. 2019 Sep; 44(3): 1063–1077. Published online 2019 Jul 8. doi: 10.3892/ijmm.2019.4270

PMCID:: PMC6657977

Abstract Article PDF–2.4M

Select item 654162319.

Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice

Meng Li, Yanqi Dang, Qiong Li, Wenjun Zhou, Jianping Zuo, Zemin Yao, Li Zhang, Guang Ji

Sci Rep. 2019; 9: 8003. Published online 2019 May 29. doi: 10.1038/s41598-019-44576-7

PMCID:: PMC6541623

Abstract Article PDF–4.1M

Select item 642533820.

The APOE^∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson, Arianne van Koppen, Aswin L. Menke, Elsbet J. Pieterman, Anita M. van den Hoek, J. Wouter Jukema, Brendan Leighton, Ann-Cathrine Jönsson-Rylander, Hans M. G. Princen

J Diabetes Res. 2019; 2019: 9727952. Published online 2019 Feb 21. doi: 10.1155/2019/9727952

PMCID:: PMC6425338

Abstract Article PDF–5.4M

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