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Select item 106530491.

Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration

Mohamed Elnagdy, Yali Wang, Walter Rodriguez, JingWen Zhang, Philip Bauer, Daniel W. Wilkey, Michael Merchant, Jianmin Pan, Zainab Farooqui, Robert Cannon, Shesh Rai, Claudio Maldonado, Shirish Barve, Craig J. McClain, Leila Gobejishvili

J Pathol. Author manuscript; available in PMC 2024 Nov 1.

Published in final edited form as: J Pathol. 2023 Nov; 261(3): 361–371. Published online 2023 Sep 21. doi: 10.1002/path.6194

PMCID:: PMC10653049

Abstract Article PDF–1.5M

Select item 89861522.

Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins

Amy J. Tibbo, Delphine Mika, Sara Dobi, Jiayue Ling, Aisling McFall, Gonzalo S. Tejeda, Connor Blair, Ruth MacLeod, Niall MacQuaide, Caglar Gök, William Fuller, Brian O. Smith, Godfrey L. Smith, Grégoire Vandecasteele, Thomas Brand, George S. Baillie

J Mol Cell Cardiol. 2022 Apr; 165: 86–102. doi: 10.1016/j.yjmcc.2022.01.001

PMCID:: PMC8986152

Abstract Article PDF–8.9M

Select item 86982903.

Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice

Abigail Boyd, Ileana V. Aragon, Justin Rich, Will McDonough, Marianna Oditt, Daniel Irelan, Edward Fiedler, Lina Abou Saleh, Wito Richter

Biology (Basel) 2021 Dec; 10(12): 1355. Published online 2021 Dec 20. doi: 10.3390/biology10121355

PMCID:: PMC8698290

Abstract Article PDF–2.5M

Select item 82188894.

The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.

Abigail Boyd, Ileana V. Aragon, Lina Abou Saleh, Dylan Southers, Wito Richter

Biochem J. Author manuscript; available in PMC 2022 May 28.

Published in final edited form as: Biochem J. 2021 May 28; 478(10): 1891–1906. doi: 10.1042/BCJ20210212

PMCID:: PMC8218889

Abstract Article PDF–2.0M

Select item 80522865.

Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice

Ileana V. Aragon, Abigail Boyd, Lina Abou Saleh, Justin Rich, Will McDonough, Anna Koloteva, Wito Richter

Biochem Pharmacol. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Biochem Pharmacol. 2021 Apr; 186: 114477. Published online 2021 Feb 18. doi: 10.1016/j.bcp.2021.114477

PMCID:: PMC8052286

Abstract Article PDF–1.7M

Select item 79545136.

PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice

Will McDonough, Ileana V. Aragon, Justin Rich, James M. Murphy, Lina Abou Saleh, Abigail Boyd, Anna Koloteva, Wito Richter

FASEB J. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: FASEB J. 2020 Sep; 34(9): 12533–12548. Published online 2020 Aug 1. doi: 10.1096/fj.202001016RR

PMCID:: PMC7954513

Abstract Article PDF–852K

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 66649158.

Homeostatic Control of Sensory Output in Basal Vomeronasal Neurons: Activity-Dependent Expression of Ether-à-Go-Go-Related Gene Potassium Channels

Silke Hagendorf, Daniela Fluegge, Corinna Engelhardt, Marc Spehr

J Neurosci. 2009 Jan 7; 29(1): 206–221. doi: 10.1523/JNEUROSCI.3656-08.2009

PMCID:: PMC6664915

Abstract Article PDF–889K

Select item 61315909.

P/Q Type Calcium Channel Cav2.1 Defines a Unique Subset of Glomeruli in the Mouse Olfactory Bulb

Martina Pyrski, Mahbuba Tusty, Eugenia Eckstein, Livio Oboti, Diego J. Rodriguez-Gil, Charles A. Greer, Frank Zufall

Front Cell Neurosci. 2018; 12: 295. Published online 2018 Sep 4. doi: 10.3389/fncel.2018.00295

PMCID:: PMC6131590

Abstract Article PDF–4.2M

Select item 564508210.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 539168611.

Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness

Gregg W. Crabtree, Ziyi Sun, Mirna Kvajo, Jantine A.C. Broek, Karine Fénelon, Heather McKellar, Lan Xiao, Bin Xu, Sabine Bahn, James M. O'Donnell, Joseph A. Gogos

J Neurosci. 2017 Apr 12; 37(15): 4158–4180. doi: 10.1523/JNEUROSCI.4345-15.2017

PMCID:: PMC5391686

Abstract Article PDF–5.2M

Select item 538276812.

Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages

Jing-Xing Yang, Kou-Chou Hsieh, Yi-Ling Chen, Chien-Kuo Lee, Marco Conti, Tsung-Hsien Chuang, Chin-Pyng Wu, S.-L. Catherine Jin

Sci Rep. 2017; 7: 46165. Published online 2017 Apr 6. doi: 10.1038/srep46165

PMCID:: PMC5382768

Abstract Article PDF–1.3M

Select item 477876513.

Genetic Ablation of Type III Adenylyl Cyclase Exerts Region-Specific Effects on Cilia Architecture in the Mouse Nose

Rosemary C. Challis, Huikai Tian, Wenbin Yin, Minghong Ma

PLoS One. 2016; 11(3): e0150638. Published online 2016 Mar 4. doi: 10.1371/journal.pone.0150638

PMCID:: PMC4778765

Abstract Article PDF–2.8M

Select item 464749014.

Mapping of genetic loci that modulate differential colonization by Escherichia coli O157:H7 TUV86-2 in advanced recombinant inbred BXD mice

Lisa M. Russo, Nourtan F. Abdeltawab, Alison D. O’Brien, Malak Kotb, Angela R. Melton-Celsa

BMC Genomics. 2015; 16: 947. Published online 2015 Nov 16. doi: 10.1186/s12864-015-2127-7

PMCID:: PMC4647490

Abstract Article PDF–3.7M

Select item 431517315.

The Upstream Conserved Regions (UCRs) Mediate Homo- and Hetero-oligomerization of Type 4 Cyclic Nucleotide Phosphodiesterases (PDE4s)

Moses Xie, Brigitte Blackman, Colleen Scheitrum, Delphine Mika, Elise Blanchard, Tao Lei, Marco Conti, Wito Richter

Biochem J. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Biochem J. 2014 May 1; 459(3): 539–550. doi: 10.1042/BJ20131681

PMCID:: PMC4315173

Abstract Article PDF–1.4M

Select item 397728416.

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

Becky C. Carlyle, Angus C. Nairn, Min Wang, Yang Yang, Lu E. Jin, Arthur A. Simen, Brian P. Ramos, Kelly A. Bordner, George E. Craft, Peter Davies, Mihovil Pletikos, Nenad Šestan, Amy F. T. Arnsten, Constantinos D. Paspalas

Proc Natl Acad Sci U S A. 2014 Apr 1; 111(13): 5036–5041. Published online 2014 Mar 18. doi: 10.1073/pnas.1322360111

PMCID:: PMC3977284

Abstract Article PDF–1.4M

Select item 391316517.

Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases

Alessandra Ghigo, Alessia Perino, Hind Mehel, Alexandra Zahradníková, Jr, Fulvio Morello, Jérôme Leroy, Viacheslav O. Nikolaev, Federico Damilano, James Cimino, Elisa De Luca, Wito Richter, Ruth Westenbroek, William A. Catterall, Jin Zhang, Chen Yan, Marco Conti, Ana Maria Gomez, Grégoire Vandecasteele, Emilio Hirsch, Rodolphe Fischmeister

Circulation. Author manuscript; available in PMC 2014 Feb 4.

Published in final edited form as: Circulation. 2012 Oct 23; 126(17): 2073–2083. Published online 2012 Sep 24. doi: 10.1161/CIRCULATIONAHA.112.114074

PMCID:: PMC3913165

Abstract Article PDF–617K

Select item 322382718.

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

Jérôme Leroy, Wito Richter, Delphine Mika, Liliana R.V. Castro, Aniella Abi-Gerges, Moses Xie, Colleen Scheitrum, Florence Lefebvre, Julia Schittl, Philippe Mateo, Ruth Westenbroek, William A. Catterall, Flavien Charpentier, Marco Conti, Rodolphe Fischmeister, Grégoire Vandecasteele

J Clin Invest. 2011 Jul 1; 121(7): 2651–2661. Published online 2011 Jun 13. doi: 10.1172/JCI44747

PMCID:: PMC3223827

Abstract Article PDF–1.6M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 300275220.

Phosphodiesterase 4B is essential for T_H2-cell function and development of airway hyperresponsiveness in allergic asthma

S.-L. Catherine Jin, Sho Goya, Susumu Nakae, Dan Wang, Matthew Bruss, Chiaoyin Hou, Dale Umetsu, Marco Conti

J Allergy Clin Immunol. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: J Allergy Clin Immunol. 2010 Dec 1; 126(6): 1252–1259.e12. doi: 10.1016/j.jaci.2010.08.014

PMCID:: PMC3002752

Abstract Article PDF–1.2M

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