PMC Links for GEO Profiles (Select 82509656) - PMC

Select item 103959141.

Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy

Dong Han, Wei Wang, Julie Heejin Jeon, Tao Shen, Xiangsheng Huang, Ping Yi, Bingning Dong, Feng Yang

PLoS Biol. 2023 Aug; 21(8): e3002227. Published online 2023 Aug 2. doi: 10.1371/journal.pbio.3002227

PMCID:: PMC10395914

Select item 95751302.

Promotor methylation status of MAPK4 is a novel epigenetic biomarker for prognosis of recurrence in patients with thymic epithelial tumors

Wei Guan, Songlin Li, Zhimin Zhang, He Xiao, Juan He, Jian Li, Xuan He, Jia Luo, Yun Liu, Lin Lei, Jungang Ma, Lizhao Chen, Chuan Chen

Thorac Cancer. 2022 Oct; 13(20): 2844–2853. Published online 2022 Sep 8. doi: 10.1111/1759-7714.14628

PMCID:: PMC9575130

Abstract Article PDF–2.1M

Select item 87526623.

MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade

Wei Wang, Dong Han, Qinbo Cai, Tao Shen, Bingning Dong, Michael T. Lewis, Runsheng Wang, Yanling Meng, Wolong Zhou, Ping Yi, Chad J. Creighton, David D. Moore, Feng Yang

Nat Commun. 2022; 13: 245. Published online 2022 Jan 11. doi: 10.1038/s41467-021-27921-1

PMCID:: PMC8752662

Abstract Article PDF–4.3M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78804155.

MAPK4 promotes prostate cancer by concerted activation of androgen receptor and AKT

Tao Shen, Wei Wang, Wolong Zhou, Ilsa Coleman, Qinbo Cai, Bingning Dong, Michael M. Ittmann, Chad J. Creighton, Yingnan Bian, Yanling Meng, David R. Rowley, Peter S. Nelson, David D. Moore, Feng Yang

J Clin Invest. 2021 Feb 15; 131(4): e135465. Published online 2021 Feb 15. doi: 10.1172/JCI135465

PMCID:: PMC7880415

Abstract Article PDF–9.0M

Select item 77580506.

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele

PLoS Biol. 2020 Dec; 18(12): e3000975. Published online 2020 Dec 11. doi: 10.1371/journal.pbio.3000975

PMCID:: PMC7758050

Abstract Article PDF–4.2M

Select item 74273277.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 73828588.

MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer

Shuzhen Tian, Lili Lou, Mengyuan Tian, Guangping Lu, Jianghua Tian, Xi Chen

J Exp Clin Cancer Res. 2020; 39: 143. Published online 2020 Jul 25. doi: 10.1186/s13046-020-01644-5

PMCID:: PMC7382858

Abstract Article PDF–4.2M

Select item 63911079.

MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling

Wei Wang, Tao Shen, Bingning Dong, Chad J. Creighton, Yanling Meng, Wolong Zhou, Qing Shi, Hao Zhou, Yinjie Zhang, David D. Moore, Feng Yang

J Clin Invest. 2019 Mar 1; 129(3): 1015–1029. Published online 2019 Jan 28. doi: 10.1172/JCI97712

PMCID:: PMC6391107

Abstract Article PDF–7.5M

Select item 501331510.

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family

Xu Li, Kim My Tran, Kathryn E. Aziz, Alexey V. Sorokin, Junjie Chen, Wenqi Wang

Mol Cell Proteomics. 2016 Sep; 15(9): 3030–3044. Published online 2016 Jul 18. doi: 10.1074/mcp.M116.060277

PMCID:: PMC5013315

Abstract Article PDF–3.2M

Select item 397542911.

Comparative Molecular Dynamics Simulations of Mitogen-Activated Protein Kinase-Activated Protein Kinase 5

Inger Lindin, Yimingjiang Wuxiuer, Aina Westrheim Ravna, Ugo Moens, Ingebrigt Sylte

Int J Mol Sci. 2014 Mar; 15(3): 4878–4902. Published online 2014 Mar 19. doi: 10.3390/ijms15034878

PMCID:: PMC3975429

Abstract Article PDF–3.6M

Select item 389478612.

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Mikko Taipale, Irina Krykbaeva, Martina Koeva, Can Kayatekin, Kenneth D. Westover, Georgios I. Karras, Susan Lindquist

Cell. Author manuscript; available in PMC 2014 Jan 17.

Published in final edited form as: Cell. 2012 Aug 31; 150(5): 987–1001. doi: 10.1016/j.cell.2012.06.047

PMCID:: PMC3894786

Abstract Article PDF–5.0M

Select item 341909513.

Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Sergiy Kostenko, Gianina Dumitriu, Ugo Moens

J Mol Signal. 2012; 7: 9. Published online 2012 Jul 16. doi: 10.1186/1750-2187-7-9

PMCID:: PMC3419095

Abstract Article PDF–1.7M

Select item 326170814.

Toward an understanding of the protein interaction network of the human liver

Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang

Mol Syst Biol. 2011; 7: 536. Published online 2011 Oct 11. doi: 10.1038/msb.2011.67