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Items: 1 to 20 of 69

1.
PAXX binding to the NHEJ machinery explains functional redundancy with XLF
Murielle Seif-El-Dahan, Antonia Kefala-Stavridi, Philippe Frit, Steven W. Hardwick, Dima Y. Chirgadze, Taiana Maia De Oliviera, Jessica Andreani, Sébastien Britton, Nadia Barboule, Madeleine Bossaert, Arun Prasad Pandurangan, Katheryn Meek, Tom L. Blundell, Virginie Ropars, Patrick Calsou, Jean-Baptiste Charbonnier, Amanda K. Chaplin
Sci Adv. 2023 Jun 2; 9(22): eadg2834. Published online 2023 May 31. doi: 10.1126/sciadv.adg2834
Correction in:
Sci Adv. 2023 Sep 29; 9(39): eadj8489.
PMCID:
PMC10413649
AbstractArticlePDF–2.0M
2.
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair
Amanda K. Chaplin, Steven W. Hardwick, Antonia Kefala Stavridi, Christopher J. Buehl, Noah J. Goff, Virginie Ropars, Shikang Liang, Taiana Maia De Oliveira, Dimitri Y. Chirgadze, Katheryn Meek, Jean-Baptiste Charbonnier, Tom L. Blundell
Mol Cell. Author manuscript; available in PMC 2022 Aug 19.
Published in final edited form as: Mol Cell. 2021 Aug 19; 81(16): 3400–3409.e3. Published online 2021 Aug 4. doi: 10.1016/j.molcel.2021.07.005
PMCID:
PMC9006396
AbstractArticlePDF–3.0M
3.
X‐ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double‐strand break repair impacting cell and cancer biology
Michal Hammel, John A. Tainer
Protein Sci. 2021 Sep; 30(9): 1735–1756. Published online 2021 Jun 5. doi: 10.1002/pro.4133
PMCID:
PMC8376411
AbstractArticlePDF–4.8M
4.
The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF
Matthew Jessulat, Shahreen Amin, Mohsen Hooshyar, Ramy Malty, Mohamed Taha Moutaoufik, Mara Zilocchi, Zoe Istace, Sadhna Phanse, Hiroyuki Aoki, Katayoun Omidi, Daniel Burnside, Bahram Samanfar, Khaled A Aly, Ashkan Golshani, Mohan Babu
Nucleic Acids Res. 2021 Aug 20; 49(14): 8145–8160. Published online 2021 Jul 9. doi: 10.1093/nar/gkab585
PMCID:
PMC8373142
AbstractArticlePDF–2.0M
5.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
6.
ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents
Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stephane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José L. Neira, Juan Iovanna
JCI Insight. 2020 Sep 17; 5(18): e138117. Published online 2020 Sep 17. doi: 10.1172/jci.insight.138117
PMCID:
PMC7526551
AbstractArticlePDF–9.1M
7.
Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer
Shaokun Shu, Hua-Jun Wu, Jennifer Y. Ge, Rhamy Zeid, Isaac S. Harris, Bojana Jovanović, Katherine Murphy, Binbin Wang, Xintao Qiu, Jennifer E. Endress, Jaime Reyes, Klothilda Lim, Alba Font-Tello, Sudeepa Syamala, Tengfei Xiao, Chandra Sekhar Reddy Chilamakuri, Evangelia K. Papachristou, Clive D’Santos, Jayati Anand, Kunihiko Hinohara, Wei Li, Thomas O. McDonald, Adrienne Luoma, Rebecca J. Modiste, Quang-De Nguyen, Brittany Michel, Paloma Cejas, Cigall Kadoch, Jacob D. Jaffe, Kai W. Wucherpfennig, Jun Qi, X. Shirley Liu, Henry Long, Myles Brown, Jason S. Carroll, Joan S. Brugge, James Bradner, Franziska Michor, Kornelia Polyak
Mol Cell. Author manuscript; available in PMC 2021 Jun 18.
Published in final edited form as: Mol Cell. 2020 Jun 18; 78(6): 1096–1113.e8. Published online 2020 May 15. doi: 10.1016/j.molcel.2020.04.027
PMCID:
PMC7306005
AbstractArticlePDF–3.2M
8.
The canonical non-homologous end joining factor XLF promotes chromosomal deletion rearrangements in human cells
Ragini Bhargava, Felicia Wednesday Lopezcolorado, L. Jillianne Tsai, Jeremy M. Stark
J Biol Chem. 2020 Jan 3; 295(1): 125–137. Published online 2019 Nov 21. doi: 10.1074/jbc.RA119.010421
PMCID:
PMC6952595
AbstractArticlePDF–2.5M
9.
Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination
Brian Ruis, Amy Molan, Taylor Takasugi, Eric A. Hendrickson
DNA Repair (Amst) Author manuscript; available in PMC 2021 Jan 1.
Published in final edited form as: DNA Repair (Amst). 2020 Jan; 85: 102738. Published online 2019 Nov 12. doi: 10.1016/j.dnarep.2019.102738
PMCID:
PMC6952554
AbstractArticlePDF–2.0M
10.
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets
Kristen Mengwasser, Richard Adeyemi, Yumei Leng, Mei Yuk Choi, Connor Clairmont, Alan D’Andrea, Stephen J. Elledge
Mol Cell. Author manuscript; available in PMC 2019 Dec 4.
Published in final edited form as: Mol Cell. 2019 Mar 7; 73(5): 885–899.e6. Published online 2019 Jan 24. doi: 10.1016/j.molcel.2018.12.008
PMCID:
PMC6892393
AbstractArticlePDF–1.7M
11.
XLF/Cernunnos: An important but puzzling participant in the nonhomologous end joining DNA repair pathway
Vijay Menon, Lawrence F. Povirk
DNA Repair (Amst) Author manuscript; available in PMC 2019 Aug 7.
Published in final edited form as: DNA Repair (Amst). 2017 Oct; 58: 29–37. Published online 2017 Aug 18. doi: 10.1016/j.dnarep.2017.08.003
PMCID:
PMC6685063
AbstractArticlePDF–1.2M
12.
Extreme Phenotypes With Identical Mutations: Two Patients With Same Non-sense NHEJ1 Homozygous Mutation
Maria J. Recio, Nerea Dominguez-Pinilla, Melina Soledad Perrig, Carmen Rodriguez Vigil-Iturrate, Nerea Salmón-Rodriguez, Cristina Martinez Faci, María J. Castro-Panete, Javier Blas-Espada, Marta López-Nevado, Raquel Ruiz-Garcia, Rebeca Chaparro-García, Luis M. Allende, Luis Ignacio Gonzalez-Granado
Front Immunol. 2018; 9: 2959. Published online 2019 Jan 7. doi: 10.3389/fimmu.2018.02959
PMCID:
PMC6330288
AbstractArticlePDF–985K
13.
XLF and APLF bind to Ku80 on two remote sites to ensure DNA repair by non-homologous end-joining
Clement Nemoz, Virginie Ropars, Philippe Frit, Amandine Gontier, Pascal Drevet, Jinchao Yu, Raphaël Guerois, Aurelien Pitois, Audrey Comte, Christine Delteil, Nadia Barboule, Pierre Legrand, Sonia Baconnais, Yandong Yin, Satish Tadi, Emeline Barbet-Massin, Imre Berger, Eric Le Cam, Mauro Modesti, Eli Rothenberg, Patrick Calsou, Jean-Baptiste Charbonnier
Nat Struct Mol Biol. Author manuscript; available in PMC 2018 Nov 13.
Published in final edited form as: Nat Struct Mol Biol. 2018 Oct; 25(10): 971–980. Published online 2018 Oct 5. doi: 10.1038/s41594-018-0133-6
PMCID:
PMC6234012
AbstractArticlePDF–2.3M
14.
PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair
Andrew Craxton, Deeksha Munnur, Rebekah Jukes-Jones, George Skalka, Claudia Langlais, Kelvin Cain, Michal Malewicz
Nat Commun. 2018; 9: 3877. Published online 2018 Sep 24. doi: 10.1038/s41467-018-06127-y
PMCID:
PMC6155126
AbstractArticlePDF–3.4M
15.
MRI is a DNA Damage Response Adaptor during Classical Non-Homologous End Joining
Putzer J. Hung, Britney Johnson, Bo-Ruei Chen, Andrea K. Byrum, Andrea L. Bredemeyer, William T. Yewdell, Tanya E. Johnson, Brian J. Lee, Shruthi Deivasigamani, Issa Hindi, Parmeshwar Amatya, Michael L. Gross, Tanya T. Paull, David J. Pisapia, Jayanta Chaudhuri, John J. H. Petrini, Nima Mosammaparast, Gaya K. Amarasinghe, Shan Zha, Jessica K. Tyler, Barry P. Sleckman
Mol Cell. Author manuscript; available in PMC 2019 Jul 19.
Published in final edited form as: Mol Cell. 2018 Jul 19; 71(2): 332–342.e8. Published online 2018 Jul 12. doi: 10.1016/j.molcel.2018.06.018
PMCID:
PMC6083883
AbstractArticlePDF–1.2M
16.
LuTHy: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells
Philipp Trepte, Sabrina Kruse, Simona Kostova, Sheila Hoffmann, Alexander Buntru, Anne Tempelmeier, Christopher Secker, Lisa Diez, Aline Schulz, Konrad Klockmeier, Martina Zenkner, Sabrina Golusik, Kirstin Rau, Sigrid Schnoegl, Craig C Garner, Erich E Wanker
Mol Syst Biol. 2018 Jul; 14(7): e8071. Published online 2018 Jul 11. doi: 10.15252/msb.20178071
PMCID:
PMC6039870
AbstractArticlePDF–2.1M
17.
Inhibition of PC4 radiosensitizes non‐small cell lung cancer by transcriptionally suppressing XLF
Tian Zhang, Xiaojie Liu, Xiuli Chen, Jing Wang, Yuwen Wang, Dong Qian, Qingsong Pang, Ping Wang
Cancer Med. 2018 Apr; 7(4): 1326–1337. Published online 2018 Mar 9. doi: 10.1002/cam4.1332
PMCID:
PMC5911594
AbstractArticlePDF–1.1M
18.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
19.
Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining
Davide Normanno, Aurélie Négrel, Abinadabe J de Melo, Stéphane Betzi, Katheryn Meek, Mauro Modesti
eLife. 2017; 6: e22900. Published online 2017 May 13. doi: 10.7554/eLife.22900
PMCID:
PMC5468090
AbstractArticlePDF–5.8M
20.
XLF-mediated NHEJ activity in hepatocellular carcinoma therapy resistance
Sitian Yang, Xiao Qi Wang
BMC Cancer. 2017; 17: 344. Published online 2017 May 19. doi: 10.1186/s12885-017-3345-y
PMCID:
PMC5437682
AbstractArticlePDF–2.4M

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