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Items: 1 to 20 of 48

1.
Acid ceramidase expression reduces IFNγ secretion by mouse CD4+ T cells and is crucial for maintaining B-cell numbers in mice
Putri Mandasari, Claudia Hollmann, Rehan-Haider Zaidi, Samira Löw, Jann Schrama, Dominik Wigger, Fabian Schumacher, Burkhard Kleuser, Niklas Beyersdorf
Front Immunol. 2024; 15: 1309846. Published online 2024 Jun 11. doi: 10.3389/fimmu.2024.1309846
PMCID:
PMC11196608
ArticlePDF–4.4M
2.
Spinal muscular atrophy-like phenotype in a mouse model of acid ceramidase deficiency
Murtaza S. Nagree, Jitka Rybova, Annie Kleynerman, Carissa J. Ahrenhoerster, Jennifer T. Saville, TianMeng Xu, Maxwell Bachochin, William M. McKillop, Michael W. Lawlor, Alexey V. Pshezhetsky, Olena Isaeva, Matthew D. Budde, Maria Fuller, Jeffrey A. Medin
Commun Biol. 2023; 6: 560. Published online 2023 May 25. doi: 10.1038/s42003-023-04932-w
PMCID:
PMC10212955
ArticlePDF–13M
3.
Contribution of Hepatic Steatosis–Intensified Extracellular Vesicle Release to Aggravated Inflammatory Endothelial Injury in Liver-Specific Asah1 Gene Knockout Mice
Xinxu Yuan, Owais M. Bhat, Yao Zou, Yang Zhang, Pin-Lan Li
Am J Pathol. 2023 Apr; 193(4): 493–508. doi: 10.1016/j.ajpath.2022.12.007
PMCID:
PMC10123522
ArticlePDF–5.1M
4.
Impaired autophagic flux and dedifferentiation in podocytes lacking Asah1 gene: Role of lysosomal TRPML1 channel
Guangbi Li, Dandan Huang, Yao Zou, Jason Kidd, Todd W.B. Gehr, Ningjun Li, Joseph K. Ritter, Pin-Lan Li
Biochim Biophys Acta Mol Cell Res. Author manuscript; available in PMC 2023 Jan 23.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2023 Jan; 1870(1): 119386. Published online 2022 Oct 24. doi: 10.1016/j.bbamcr.2022.119386
PMCID:
PMC9869931
ArticlePDF–1.7M
5.
Cell-intrinsic ceramides determine T cell function during melanoma progression
Matthias Hose, Anne Günther, Eyad Naser, Fabian Schumacher, Tina Schönberger, Julia Falkenstein, Athanasios Papadamakis, Burkhard Kleuser, Katrin Anne Becker, Erich Gulbins, Adriana Haimovitz-Friedman, Jan Buer, Astrid M Westendorf, Wiebke Hansen
eLife. 2022; 11: e83073. Published online 2022 Nov 25. doi: 10.7554/eLife.83073
PMCID:
PMC9699697
ArticlePDF–6.0M
6.
The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis
Anne Günther, Matthias Hose, Hanna Abberger, Fabian Schumacher, Ylva Veith, Burkhard Kleuser, Kai Matuschewski, Karl Sebastian Lang, Erich Gulbins, Jan Buer, Astrid M Westendorf, Wiebke Hansen
eLife. 2022; 11: e77975. Published online 2022 Sep 12. doi: 10.7554/eLife.77975
PMCID:
PMC9499531
ArticlePDF–3.5M
7.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
ArticlePDF–1.6M
8.
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Sarah Alsamman, Stephanie A. Christenson, Amy Yu, Nadia M.E. Ayad, Meghan S. Mooring, Joe M. Segal, Jimmy Kuang-Hsien Hu, Johanna R. Schaub, Steve S. Ho, Vikram Rao, Megan M. Marlow, Scott M. Turner, Mai Sedki, Lorena Pantano, Sarani Ghoshal, Diego Dos Santos Ferreira, Hsiao-Yen Ma, Caroline C. Duwaerts, Regina Espanol-Suner, Lan Wei, Benjamin Newcomb, Izolda Mileva, Daniel Canals, Yusuf A. Hannun, Raymond T. Chung, Aras N. Mattis, Bryan C. Fuchs, Andrew M. Tager, Dean Yimlamai, Valerie M. Weaver, Alan C. Mullen, Dean Sheppard, Jennifer Y. Chen
Sci Transl Med. Author manuscript; available in PMC 2021 Mar 19.
Published in final edited form as: Sci Transl Med. 2020 Aug 19; 12(557): eaay8798. doi: 10.1126/scitranslmed.aay8798
PMCID:
PMC7976849
ArticlePDF–3.5M
9.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
ArticlePDF–2.0M
10.
Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections
Katrin Anne Becker, Rabea Verhaegh, Hedda-Luise Verhasselt, Simone Keitsch, Matthias Soddemann, Barbara Wilker, Gregory C. Wilson, Jan Buer, Syed A. Ahmad, Michael J. Edwards, Erich Gulbins
Infect Immun. 2021 Feb; 89(2): e00677-20. Prepublished online 2020 Nov 2. Published online 2021 Jan 19. doi: 10.1128/IAI.00677-20
PMCID:
PMC7822142
ArticlePDF–3.8M
11.
Abnormal podocyte TRPML1 channel activity and exosome release in mice with podocyte-specific Asah1 gene deletion
Guangbi Li, Dandan Huang, Owais M. Bhat, Justin L. Poklis, Aolin Zhang, Yao Zou, Jason Kidd, Todd W.B. Gehr, Pin-Lan Li
Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2022 Feb 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Feb; 1866(2): 158856. Published online 2020 Nov 19. doi: 10.1016/j.bbalip.2020.158856
PMCID:
PMC7770122
ArticlePDF–2.1M
12.
Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene: Role of Ceramide Accumulation in Glomeruli
Guangbi Li, Jason Kidd, Cristin Kaspar, Sara Dempsey, Owais M. Bhat, Sarah Camus, Joseph K. Ritter, Todd W.B. Gehr, Erich Gulbins, Pin-Lan Li
Am J Pathol. 2020 Jun; 190(6): 1211–1223. doi: 10.1016/j.ajpath.2020.02.008
PMCID:
PMC7280759
ArticlePDF–3.2M
13.
Acid Ceramidase Deficiency is Characterized by a Unique Plasma Cytokine and Ceramide Profile that is Altered by Therapy
Shaalee Dworski, Ping Lu, Aneal Khan, Bruno Maranda, John J. Mitchell, Rossella Parini, Maja Di Rocco, Boris Hugle, Makoto Yoshimitsu, Bo Magnusson, Balahan Makay, Nur Arslan, Norberto Guelbert, Karoline Ehlert, Andrea Jarisch, Janet Gardner-Medwin, Rawane Dagher, Maria Teresa Terreri, Charles Marques Lorenco, Lilianna Barillas-Arias, Pranoot Tanpaiboon, Alexander Solyom, James S. Norris, Xingxuan He, Edward H. Schuchman, Thierry Levade, Jeffrey A. Medin
Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2020 Apr 30.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2017 Feb; 1863(2): 386–394. Published online 2016 Dec 1. doi: 10.1016/j.bbadis.2016.11.031
PMCID:
PMC7192210
ArticlePDF–2.4M
14.
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer, Burkhard Kleuser, Eduard B. Babiychuk, Beate Sodeik, Jürgen Seibel, Urs F. Greber, Philipp A. Lang, Erich Gulbins, Karl S. Lang
Nat Commun. 2020; 11: 1338. Published online 2020 Mar 12. doi: 10.1038/s41467-020-15072-8
PMCID:
PMC7067866
ArticlePDF–3.8M
15.
Arterial Medial Calcification through Enhanced small Extracellular Vesicle Release in Smooth Muscle-Specific Asah1 Gene Knockout Mice
Owais M. Bhat, Guangbi Li, Xinxu Yuan, Dandan Huang, Erich Gulbins, Rakesh C. Kukreja, Pin-Lan Li
Sci Rep. 2020; 10: 1645. Published online 2020 Feb 3. doi: 10.1038/s41598-020-58568-5
PMCID:
PMC6997457
ArticlePDF–3.2M
16.
Acid Sphingomyelinase Deficiency Ameliorates Farber Disease
Nadine Beckmann, Katrin Anne Becker, Stephanie Kadow, Fabian Schumacher, Melanie Kramer, Claudine Kühn, Walter J. Schulz-Schaeffer, Michael J. Edwards, Burkhard Kleuser, Erich Gulbins, Alexander Carpinteiro
Int J Mol Sci. 2019 Dec; 20(24): 6253. Published online 2019 Dec 11. doi: 10.3390/ijms20246253
PMCID:
PMC6941101
ArticlePDF–4.5M
17.
Endothelial Acid Ceramidase in Exosome-Mediated Release of NLRP3 Inflammasome Products during Hyperglycemia: Evidence from Endothelium-Specific Deletion of Asah1 Gene
Xinxu Yuan, Owais M. Bhat, Hannah Lohner, Yang Zhang, Pin-Lan Li
Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec; 1864(12): 158532. Published online 2019 Oct 21. doi: 10.1016/j.bbalip.2019.158532
PMCID:
PMC6909250
ArticlePDF–1.2M
18.
Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment
Fabian P.S. Yu, Benjamin S. Sajdak, Jakub Sikora, Alexander E. Salmon, Murtaza S. Nagree, Jiří Gurka, Iris S. Kassem, Daniel M. Lipinski, Joseph Carroll, Jeffrey A. Medin
Am J Pathol. 2019 Feb; 189(2): 320–338. doi: 10.1016/j.ajpath.2018.10.018
PMCID:
PMC6412726
Article
19.
Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment
Mel Pilar Espaillat, Ashley J. Snider, Zhijuan Qiu, Breana Channer, Nicolas Coant, Edward H. Schuchman, Richard R. Kew, Brian S. Sheridan, Yusuf A. Hannun, Lina M. Obeid
FASEB J. 2018 May; 32(5): 2339–2353. Published online 2018 Jan 8. doi: 10.1096/fj.201700585R
PMCID:
PMC6207279
Article
20.
Inhibition of Pannexin-1 Channel Activity by Adiponectin in Podocytes: Role of Acid Ceramidase Activation
Guangbi Li, Qinghua Zhang, Jinni Hong, Joseph K. Ritter, Pin-Lan Li
Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2019 Oct 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct; 1863(10): 1246–1256. Published online 2018 Aug 1. doi: 10.1016/j.bbalip.2018.07.016
PMCID:
PMC6180945
ArticlePDF–1.9M

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