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Select item 113544361.

Genetic Polymorphisms in the HMGCR Gene and Associations with Cognitive Decline in Parkinson’s Disease Patients

Anna Pierzchlińska, Jarosław Sławek, Magdalena Kwaśniak-Butowska, Damian Malinowski, Nina Komaniecka, Monika Mak, Anna Czerkawska, Arnold Kukowka, Monika Białecka

Int J Mol Sci. 2024 Aug; 25(16): 8964. Published online 2024 Aug 17. doi: 10.3390/ijms25168964

PMCID:: PMC11354436

Abstract Article PDF–255K

Select item 108866332.

Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions

Jianqiu Wang, Markus Kunze, Andrea Villoria-González, Isabelle Weinhofer, Johannes Berger

Biomolecules. 2024 Feb; 14(2): 244. Published online 2024 Feb 19. doi: 10.3390/biom14020244

PMCID:: PMC10886633

Abstract Article PDF–17M

Select item 107953403.

Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease

Yulong Li, Jiawen Li, Xiaofang Tang, Jingjing Xu, Ru Liu, Lin Jiang, Jian Tian, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song, Jinqing Yuan, Xueyan Zhao

BMC Med Genomics. 2024; 17: 22. Published online 2024 Jan 17. doi: 10.1186/s12920-024-01802-0

PMCID:: PMC10795340

Abstract Article PDF–1.5M

Select item 105763204.

Association between HMGCR, CRP, and CETP gene polymorphisms and metabolic/inflammatory serum profile in healthy adolescents

Benedetta Perrone, Paola Ruffo, Giuseppina Augimeri, Diego Sisci, Maria Stefania Sinicropi, Giovanni Tripepi, Corrado Mammì, Daniela Bonofiglio, Francesca Luisa Conforti

J Transl Med. 2023; 21: 718. Published online 2023 Oct 13. doi: 10.1186/s12967-023-04571-z

PMCID:: PMC10576320

Abstract Article PDF–1022K

Select item 103986605.

C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains

Julia Jülg, Dieter Edbauer, Christian Behrends

EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895

PMCID:: PMC10398660

Abstract Article PDF–2.4M

Select item 102907976.

HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins

Jiawen Li, Xiaofang Tang, Jingjing Xu, Ru Liu, Lin Jiang, Lianjun Xu, Jian Tian, Xinxing Feng, Yajie Wu, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song, Jinqing Yuan, Xueyan Zhao

BMC Cardiovasc Disord. 2023; 23: 317. Published online 2023 Jun 24. doi: 10.1186/s12872-023-03285-w

PMCID:: PMC10290797

Abstract Article PDF–1.7M

Select item 102794727.

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

Julie K. Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, Michelle W. Ma, Cyrus Y. Jin, Marilyn Leonard, Eric S. Fischer, Eric J. Bennett

Cell Rep. Author manuscript; available in PMC 2023 Jun 19.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112496. Published online 2023 May 9. doi: 10.1016/j.celrep.2023.112496

PMCID:: PMC10279472

Abstract Article PDF–2.9M

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516159.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 1010594910.

SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis

Hongmei Yuan, Hongge Wu, Jing Cheng, Jie Xiong

Cancer Cell Int. 2023; 23: 71. Published online 2023 Apr 16. doi: 10.1186/s12935-023-02914-w

PMCID:: PMC10105949

Abstract Article PDF–12M

Select item 996371611.

Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone

Yuval Yogev, Zamir Shorer, Arie Koifman, Ohad Wormser, Max Drabkin, Daniel Halperin, Vadim Dolgin, Regina Proskorovski-Ohayon, Noam Hadar, Geula Davidov, Hila Nudelman, Raz Zarivach, Ilan Shelef, Yonatan Perez, Ohad S. Birk

Proc Natl Acad Sci U S A. 2023 Feb 14; 120(7): e2217831120. Published online 2023 Feb 6. doi: 10.1073/pnas.2217831120

PMCID:: PMC9963716

Abstract Article PDF–2.9M

Select item 923162312.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 919222813.

High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis

Keshob Chandra Das, Mohammad Uzzal Hossain, Md Moniruzzaman, Md Salimullah, Sharif Akhteruzzaman

Biomed Res Int. 2022; 2022: 4558867. Published online 2022 Jun 6. doi: 10.1155/2022/4558867

PMCID:: PMC9192228

Abstract Article PDF–1.9M

Select item 911973614.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 862037515.

A Possible Role for HMG-CoA Reductase Inhibitors and Its Association with HMGCR Genetic Variation in Parkinson’s Disease

Anna Pierzchlińska, Marek Droździk, Monika Białecka

Int J Mol Sci. 2021 Nov; 22(22): 12198. Published online 2021 Nov 11. doi: 10.3390/ijms222212198

PMCID:: PMC8620375

Abstract Article PDF–709K

Select item 855290716.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 852757817.

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity

Yuehui Zhang, Limin Shang, Jing Zhang, Yuchen Liu, Chaozhi Jin, Yanan Zhao, Xiaobo Lei, Wenjing Wang, Xia Xiao, Xiuyuan Zhang, Yujiao Liu, Linlin Liu, Meng-Wei Zhuang, Qingkun Mi, Chunyan Tian, Jianwei Wang, Fuchu He, Pei-Hui Wang, Jian Wang

Cell Chem Biol. 2022 Jan 20; 29(1): 5–18.e6. Published online 2021 Oct 20. doi: 10.1016/j.chembiol.2021.10.008

PMCID:: PMC8527578

Abstract Article PDF–4.5M

Select item 827460318.

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome

Jérémy A. Ferreira Barbosa, Samantha Sparapani, Jonathan Boulais, Robert Lodge, Éric A. Cohen

J Virol. 2021 Aug; 95(15): e00971-20. Prepublished online 2021 May 19. Published online 2021 Jul 12. doi: 10.1128/JVI.00971-20

PMCID:: PMC8274603

Abstract Article PDF–4.2M

Select item 821166319.

Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells

Katsuhiko Warita, Takuro Ishikawa, Akihiro Sugiura, Jiro Tashiro, Hiroaki Shimakura, Yoshinao Z. Hosaka, Ken-ichi Ohta, Tomoko Warita, Zoltán N. Oltvai

Sci Rep. 2021; 11: 12763. Published online 2021 Jun 17. doi: 10.1038/s41598-021-91928-3

PMCID:: PMC8211663

Abstract Article PDF–2.5M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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