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Select item 108158711.

LIGHT/TNFSF14 Affects Adipose Tissue Phenotype

Angela Oranger, Graziana Colaianni, Giuseppe Ingravallo, Vincenza Sara Scarcella, Maria Felicia Faienza, Maria Grano, Silvia Colucci, Giacomina Brunetti

Int J Mol Sci. 2024 Jan; 25(2): 716. Published online 2024 Jan 5. doi: 10.3390/ijms25020716

PMCID:: PMC10815871

Abstract Article PDF–7.7M

Select item 104919842.

LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment

Na Zhang, Xiaohong Liu, Juliang Qin, Yue Sun, Hao Xiong, Boxu Lin, Kexin Liu, Binghe Tan, Chenglin Zhang, Chenshen Huang, Shancheng Ren, Mingyao Liu, Bing Du

Mol Ther. 2023 Sep 6; 31(9): 2575–2590. Published online 2023 Jul 5. doi: 10.1016/j.ymthe.2023.06.015

PMCID:: PMC10491984

Abstract Article PDF–7.2M

Select item 101389193.

Tumor Necrosis Factor Superfamily 14 (LIGHT) Restricts Neovascularization by Decreasing Circulating Endothelial Progenitor Cells and Function

Chien-Yi Hsu, Chun-Yao Huang, Chun-Ming Shih, Yi-Wen Lin, Po-Hsun Huang, Shing-Jong Lin, Chen-Wei Liu, Cheng-Yen Lin, Feng-Yen Lin

Int J Mol Sci. 2023 Apr; 24(8): 6997. Published online 2023 Apr 10. doi: 10.3390/ijms24086997

PMCID:: PMC10138919

Abstract Article PDF–9.5M

Select item 98424174.

LIGHT Amplification by NF-κB Contributes to TLR3 Signaling Pathway-Induced Acute Hepatitis

Dongming Lai, Zejian Lv, Xiaohua Lu, Peng Shang, Yunyun Geng, Pu Wang

Mediators Inflamm. 2023; 2023: 3732315. Published online 2023 Jan 9. doi: 10.1155/2023/3732315

PMCID:: PMC9842417

Abstract Article PDF–1.3M

Select item 94229955.

Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection

Goo-Young Seo, Daisuke Takahashi, Qingyang Wang, Zbigniew Mikulski, Angeline Chen, Ting-Fang Chou, Paola Marcovecchio, Sara McArdle, Ashu Sethi, Jr-Wen Shui, Masumi Takahashi, Charles D. Surh, Hilde Cheroutre, Mitchell Kronenberg

Sci Immunol. Author manuscript; available in PMC 2023 Jul 29.

Published in final edited form as: Sci Immunol. 2022 Jul 29; 7(73): eabm6931. Published online 2022 Jul 29. doi: 10.1126/sciimmunol.abm6931

PMCID:: PMC9422995

Abstract Article PDF–3.1M

Select item 78872126.

LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells

S. S. Höpner, Ana Raykova, R. Radpour, M. A. Amrein, D. Koller, G. M. Baerlocher, C. Riether, A. F. Ochsenbein

Nat Commun. 2021; 12: 1065. Published online 2021 Feb 16. doi: 10.1038/s41467-021-21317-x

PMCID:: PMC7887212

Abstract Article PDF–5.2M

Select item 75796837.

LIGHT aggravates sepsis‐associated acute kidney injury via TLR4‐MyD88‐NF‐κB pathway

Yu Zhong, Shun Wu, Yan Yang, Gui‐qing Li, Li Meng, Quan‐you Zheng, You Li, Gui‐lian Xu, Ke‐qin Zhang, Kan‐fu Peng

J Cell Mol Med. 2020 Oct; 24(20): 11936–11948. Published online 2020 Sep 3. doi: 10.1111/jcmm.15815

PMCID:: PMC7579683

Abstract Article PDF–2.7M

Select item 72182848.

Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection

Seo J. Park, Rachel E. Riccio, Sarah J. Kopp, Igal Ifergan, Stephen D. Miller, Richard Longnecker

mBio. 2020 May-Jun; 11(3): e00790-20. Published online 2020 May 12. doi: 10.1128/mBio.00790-20

PMCID:: PMC7218284

Abstract Article PDF–1.4M

Select item 66662839.

Developmental Regulation of Sensory Neurite Growth by the Tumor Necrosis Factor Superfamily Member LIGHT

Núria Gavaldà, Humberto Gutierrez, Alun M. Davies

J Neurosci. 2009 Feb 11; 29(6): 1599–1607. doi: 10.1523/JNEUROSCI.3566-08.2009

PMCID:: PMC6666283

Abstract Article PDF–620K

Select item 650491610.

Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection

Raquel Mejías-Luque, Ivonne Lozano-Pope, Andreas Wanisch, Matthias Heikenwälder, Markus Gerhard, Marygorret Obonyo

Sci Rep. 2019; 9: 7030. Published online 2019 May 7. doi: 10.1038/s41598-019-43417-x

PMCID:: PMC6504916

Abstract Article PDF–2.6M

Select item 626240011.

The Tumor Necrosis Factor Superfamily Members TNFSF14 (LIGHT), Lymphotoxin β and Lymphotoxin β Receptor Interact to Regulate Intestinal Inflammation

Daniel A. Giles, Sonja Zahner, Petra Krause, Esmé Van Der Gracht, Thomas Riffelmacher, Venetia Morris, Alexei Tumanov, Mitchell Kronenberg

Front Immunol. 2018; 9: 2585. Published online 2018 Nov 22. doi: 10.3389/fimmu.2018.02585

PMCID:: PMC6262400

Abstract Article PDF–1.7M

Select item 589342612.

The TNF superfamily molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection

Pritesh Desai, Vikas Tahiliani, Tarun E. Hutchinson, Farhad Dastmalchi, Jessica Stanfield, Georges Abboud, Paul G. Thomas, Carl F. Ware, Jianxun Song, Michael Croft, Shahram Salek-Ardakani

J Immunol. Author manuscript; available in PMC 2019 Apr 15.

Published in final edited form as: J Immunol. 2018 Apr 15; 200(8): 2894–2904. Published online 2018 Mar 7. doi: 10.4049/jimmunol.1701499

PMCID:: PMC5893426

Abstract Article PDF–1.0M

Select item 578940713.

LIGHT–HVEM signaling in keratinocytes controls development of dermatitis

Rana Herro, Jr-Wen Shui, Sonja Zahner, Daniel Sidler, Yuko Kawakami, Toshiaki Kawakami, Koji Tamada, Mitchell Kronenberg, Michael Croft

J Exp Med. 2018 Feb 5; 215(2): 415–422. doi: 10.1084/jem.20170536

PMCID:: PMC5789407

Abstract Article PDF–1.4M

Select item 541017414.

LIGHT elevation enhances immune eradication of colon cancer metastases

Guilin Qiao, Jianzhong Qin, Nicholas Kunda, Jed F. Calata, Dolores L. Mahmud, Peter Gann, Yang-Xin Fu, Steven A. Rosenberg, Bellur S. Prabhakar, Ajay V. Maker

Cancer Res. Author manuscript; available in PMC 2018 Apr 15.

Published in final edited form as: Cancer Res. 2017 Apr 15; 77(8): 1880–1891. Published online 2017 Mar 1. doi: 10.1158/0008-5472.CAN-16-1655

PMCID:: PMC5410174

Abstract Article PDF–1.9M

Select item 529307515.

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

Dana M. Hardbower, Mohammad Asim, Paula B. Luis, Kshipra Singh, Daniel P. Barry, Chunying Yang, Meredith A. Steeves, John L. Cleveland, Claus Schneider, M. Blanca Piazuelo, Alain P. Gobert, Keith T. Wilson

Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5): E751–E760. Published online 2017 Jan 17. doi: 10.1073/pnas.1614958114

PMCID:: PMC5293075

Abstract Article PDF–1.9M

Select item 502975516.

Mechanical stretch‐induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection

Li‐Xin Jia, Wen‐Mei Zhang, Hong‐Jia Zhang, Tao‐Tao Li, Yue‐Li Wang, Yan‐Wen Qin, Hong Gu, Jie Du

J Pathol. 2015 Jul; 236(3): 373–383. Published online 2015 Apr 27. doi: 10.1002/path.4534

PMCID:: PMC5029755

Abstract Article PDF–3.5M

Select item 502063617.

LIGHT/IFN‐γ triggers β cells apoptosis via NF‐κB/Bcl2‐dependent mitochondrial pathway

Quan‐You Zheng, Zhao‐Hui Cao, Xiao‐Bo Hu, Gui‐Qing Li, Shi‐Fang Dong, Gui‐Lian Xu, Ke‐Qin Zhang

J Cell Mol Med. 2016 Oct; 20(10): 1861–1871. Published online 2016 May 31. doi: 10.1111/jcmm.12876

PMCID:: PMC5020636

Abstract Article PDF–3.8M

Select item 498045718.

LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration

Yaoyao Shi, Weiwei Wu, Qian Chai, Qingqing Li, Yu Hou, Huan Xia, Boyang Ren, Hairong Xu, Xiaohuan Guo, Caiwei Jin, Mengjie Lv, Zhongnan Wang, Yang-Xin Fu, Mingzhao Zhu

Nat Commun. 2016; 7: 12369. Published online 2016 Aug 5. doi: 10.1038/ncomms12369

PMCID:: PMC4980457

Abstract Article PDF–1.3M

Select item 496684119.

Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells

Maria-Luisa del Rio, Carlos Fernandez-Renedo, Olivier Chaloin, Stefanie Scheu, Klaus Pfeffer, Yasushi Shintani, Jose-Antonio Perez-Simon, Pascal Schneider, Jose-Ignacio Rodriguez-Barbosa

MAbs. 2016 Apr; 8(3): 478–490. Published online 2016 Jan 11. doi: 10.1080/19420862.2015.1132130

Correction in:: MAbs. 2016 Nov-Dec; 8(8): 1620.

PMCID:: PMC4966841

Abstract Article PDF–1.2M

Select item 484642820.

Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM

Yuwen Zhu, Sheng Yao, Mathew M. Augustine, Haiying Xu, Jun Wang, Jingwei Sun, Megan Broadwater, William Ruff, Liqun Luo, Gefeng Zhu, Koji Tamada, Lieping Chen

Sci Adv. 2016 Apr; 2(4): e1500637. Published online 2016 Apr 8. doi: 10.1126/sciadv.1500637