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Select item 115259201.

N-acetyltransferase 10 is implicated in the pathogenesis of cycling T cell-mediated autoimmune and inflammatory disorders in mice

Wen-ping Li, Xin-tao Mao, Jia-huan Xie, Jie-yu Li, Bao-qin Liu, Le-xi Wu, Bing Yang, Yi-yuan Li, Jin Jin

Nat Commun. 2024; 15: 9388. Published online 2024 Oct 30. doi: 10.1038/s41467-024-53350-x

PMCID:: PMC11525920

Abstract Article PDF–4.6M

Select item 110026682.

The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury

Zhezhe Qu, Xiaochen Pang, Zhongting Mei, Ying Li, Yaozhi Zhang, Chuanhao Huang, Kuiwu Liu, Shuting Yu, Changhao Wang, Zhiyong Sun, Yingqi Liu, Xin Li, Yingqiong Jia, Yuechao Dong, Meixi Lu, Tiantian Ju, Fan Wu, Min Huang, Na Li, Shunkang Dou, Jianhao Jiang, Xianhui Dong, Yi Zhang, Wanhong Li, Baofeng Yang, Weijie Du

Redox Biol. 2024 Jun; 72: 103145. Published online 2024 Apr 2. doi: 10.1016/j.redox.2024.103145

PMCID:: PMC11002668

Abstract Article PDF–11M

Select item 109626793.

NAT10‐mediated ac⁴C‐modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear‐cell renal cell carcinoma by attenuating YWHAE‐driven cytoplasmic retention of YAP1

Daojia Miao, Jian Shi, Qingyang Lv, Diaoyi Tan, Chuanyi Zhao, Zhiyong Xiong, Xiaoping Zhang

Cancer Commun (Lond) 2024 Mar; 44(3): 361–383. Published online 2024 Feb 26. doi: 10.1002/cac2.12523

PMCID:: PMC10962679

Abstract Article PDF–21M

Select item 109239144.

N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration

Wenya Ma, Yanan Tian, Leping Shi, Jing Liang, Qimeng Ouyang, Jianglong Li, Hongyang Chen, Hongyue Sun, Haoyu Ji, Xu Liu, Wei Huang, Xinlu Gao, Xiaoyan Jin, Xiuxiu Wang, Yining Liu, Yang Yu, Xiaofei Guo, Ye Tian, Fan Yang, Faqian Li, Ning Wang, Benzhi Cai

Nat Commun. 2024; 15: 2137. Published online 2024 Mar 8. doi: 10.1038/s41467-024-46458-7

PMCID:: PMC10923914

Abstract Article PDF–20M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105917156.

NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity

Zizhao Yang, Emma Wilkinson, Yan-Hong Cui, Haixia Li, Yu-Ying He

Toxicol Appl Pharmacol. Author manuscript; available in PMC 2024 Oct 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2023 Oct 15; 477: 116688. Published online 2023 Sep 14. doi: 10.1016/j.taap.2023.116688

PMCID:: PMC10591715

Abstract Article PDF–1.1M

Select item 102877007.

Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice

Xue Jiang, Yu Cheng, Yuzhang Zhu, Caoling Xu, Qiaodan Li, Xuemei Xing, Wenqing Li, Jiaqi Zou, Lan Meng, Muhammad Azhar, Yuzhu Cao, Xianhong Tong, Weibing Qin, Xiaoli Zhu, Jianqiang Bao

Nat Commun. 2023; 14: 3729. Published online 2023 Jun 22. doi: 10.1038/s41467-023-39256-0

PMCID:: PMC10287700

Abstract Article PDF–13M

Select item 101464898.

The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons

Ming Zhang, Kehui Yang, Qi-Hui Wang, Ling Xie, Qiaoqiao Liu, Runa Wei, Yang Tao, Hong-Li Zheng, Ninghua Lin, Hengjun Xu, Li Yang, Hongjun Wang, Tingruo Zhang, Zhouya Xue, Jun-Li Cao, Zhiqiang Pan

J Neurosci. 2023 Apr 26; 43(17): 3009–3027. doi: 10.1523/JNEUROSCI.2321-22.2023

PMCID:: PMC10146489

Abstract Article PDF–6.0M

Select item 96389099.

NAT10-mediated N⁴-acetylcytidine modification is required for meiosis entry and progression in male germ cells

Lu Chen, Wen-Jing Wang, Qiang Liu, Yu-Ke Wu, Yun-Wen Wu, Yu Jiang, Xiu-Quan Liao, Fei Huang, Yang Li, Li Shen, Chao Yu, Song-Ying Zhang, Li-Ying Yan, Jie Qiao, Qian-Qian Sha, Heng-Yu Fan

Nucleic Acids Res. 2022 Oct 28; 50(19): 10896–10913. Published online 2022 Jul 8. doi: 10.1093/nar/gkac594

PMCID:: PMC9638909

Abstract Article PDF–15M

Select item 944877110.

NAT10 regulates neutrophil pyroptosis in sepsis via acetylating ULK1 RNA and activating STING pathway

Hao Zhang, Zhaoyuan Chen, Ji’an Zhou, Jiahui Gu, Han Wu, Yi Jiang, Shenjia Gao, Yun Liao, Ruling Shen, Changhong Miao, Wankun Chen

Commun Biol. 2022; 5: 916. Published online 2022 Sep 6. doi: 10.1038/s42003-022-03868-x

Correction in:: Commun Biol. 2022; 5: 1091.

PMCID:: PMC9448771

Abstract Article PDF–3.8M

Select item 907601311.

NAT10‐mediated mRNA N4‐acetylcytidine modification promotes bladder cancer progression

Ganping Wang, Ming Zhang, Yiming Zhang, Yanqi Xie, Jiepeng Zou, Jianye Zhong, Zhijia Zheng, Xianghui Zhou, Yuhang Zheng, Binshen Chen, Chunxiao Liu

Clin Transl Med. 2022 May; 12(5): e738. Published online 2022 May 6. doi: 10.1002/ctm2.738

PMCID:: PMC9076013

Abstract Article PDF–11M

Select item 901455912.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 668547813.

RNA‐Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation

Hong‐Bin Liu, Tahir Muhammad, Yueshuai Guo, Meng‐Jing Li, Qian‐Qian Sha, Chuan‐Xin Zhang, Hui Liu, Shi‐Gang Zhao, Han Zhao, Hao Zhang, Yan‐Zhi Du, Kang Sun, Kui Liu, Gang Lu, Xue‐Jiang Guo, Jiahao Sha, Heng‐Yu Fan, Fei Gao, Zi‐Jiang Chen

Adv Sci (Weinh) 2019 Aug 7; 6(15): 1900295. Published online 2019 May 24. doi: 10.1002/advs.201900295

PMCID:: PMC6685478

Abstract Article PDF–3.0M

Select item 645951014.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 624418315.

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch

Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262

PMCID:: PMC6244183

Abstract Article PDF–753K

Select item 592338316.

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson

Nat Commun. 2018; 9: 1700. Published online 2018 Apr 27. doi: 10.1038/s41467-018-03770-3

PMCID:: PMC5923383

Abstract Article PDF–2.1M

Select item 564508217.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 538122618.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 459183819.

The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid Transporters

Shereen M. Aleidi, Vicky Howe, Laura J. Sharpe, Alryel Yang, Geetha Rao, Andrew J. Brown, Ingrid C. Gelissen

J Biol Chem. 2015 Oct 2; 290(40): 24604–24613. Published online 2015 Aug 20. doi: 10.1074/jbc.M115.675579

PMCID:: PMC4591838

Abstract Article PDF–1.2M

Select item 451183320.

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPa N-terminal leukemia

Florian Grebien, Masoud Vedadi, Matthäus Getlik, Roberto Giambruno, Amit Grover, Roberto Avellino, Anna Skucha, Sarah Vittori, Ekaterina Kuznetsova, David Smil, Dalia Barsyte-Lovejoy, Fengling Li, Gennadiy Poda, Matthieu Schapira, Hong Wu, Aiping Dong, Guillermo Senisterra, Alexey Stukalov, Kilian V. M. Huber, Andreas Schönegger, Richard Marcellus, Martin Bilban, Christoph Bock, Peter J. Brown, Johannes Zuber, Keiryn L. Bennett, Rima Al-awar, Ruud Delwel, Claus Nerlov, Cheryl H. Arrowsmith, Giulio Superti-Furga

Nat Chem Biol. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Nat Chem Biol. 2015 Aug; 11(8): 571–578. Published online 2015 Jul 13. doi: 10.1038/nchembio.1859

PMCID:: PMC4511833

Abstract Article PDF–2.2M

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