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Items: 1 to 20 of 75

1.
Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease
Kira Behrens, Maria Kauppi, Elizabeth M. Viney, Andrew J. Kueh, Craig D. Hyland, Tracy A. Willson, Liam Salleh, Carolyn A. de Graaf, Jeffrey J. Babon, Marco J. Herold, Nicos A. Nicola, Warren S. Alexander
Leukemia. 2024; 38(6): 1342–1352. Published online 2024 Mar 15. doi: 10.1038/s41375-024-02219-5
PMCID:
PMC11147766
AbstractArticlePDF–3.7M
2.
Platelets mediate the clearance of senescent red blood cells by forming prophagocytic platelet-cell complexes
Dian C. Ningtyas, Florentina Leitner, Huma Sohail, Yee Lin Thong, Sarah M. Hicks, Sidra Ali, Megan Drew, Kiran Javed, Jiwon Lee, Enny Kenangalem, Jeanne R. Poespoprodjo, Nicholas M. Anstey, Melanie Rug, Philip Y.-I. Choi, Steven Kho, Elizabeth E. Gardiner, Brendan J. McMorran
Blood. 2024 Feb 8; 143(6): 535–547. Published online 2023 Nov 24. doi: 10.1182/blood.2023021611
PMCID:
PMC10934294
AbstractArticle
3.
Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin
Kaiseal T. G. Sarson-Lawrence, Joshua M. Hardy, Josephine Iaria, Dina Stockwell, Kira Behrens, Tamanna Saiyed, Cyrus Tan, Leila Jebeli, Nichollas E. Scott, Toby A. Dite, Nicos A. Nicola, Andrew P. Leis, Jeffrey J. Babon, Nadia J. Kershaw
Nat Commun. 2024; 15: 1135. Published online 2024 Feb 7. doi: 10.1038/s41467-024-45356-2
PMCID:
PMC10850085
AbstractArticlePDF–3.2M
4.
Structure of the thrombopoietin MPL receptor complex is a blueprint for biasing hematopoiesis
Naotaka Tsutsumi, Zahra Masoumi, Sophie C. James, Julie A. Tucker, Hauke Winkelmann, William Grey, Lora K. Picton, Lucie Moss, Steven C. Wilson, Nathanael A. Caveney, Kevin M. Jude, Cornelius Gati, Jacob Piehler, Ian S. Hitchcock, K. Christopher Garcia
Cell. Author manuscript; available in PMC 2024 Sep 14.
Published in final edited form as: Cell. 2023 Sep 14; 186(19): 4189–4203.e22. Published online 2023 Aug 25. doi: 10.1016/j.cell.2023.07.037
PMCID:
PMC10528194
AbstractArticlePDF–3.6M
5.
Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag
Yun-Ruei Kao, Jiahao Chen, Swathi-Rao Narayanagari, Tihomira I. Todorova, Maria M. Aivalioti, Mariana Ferreira, Pedro Ramos-Marques, Celine Pallaud, Ioannis Mantzaris, Aditi Shastri, James B. Bussel, Amit Verma, Ulrich Steidl, Britta Will
Sci Transl Med. Author manuscript; available in PMC 2023 Feb 4.
Published in final edited form as: Sci Transl Med. 2018 Sep 12; 10(458): eaas9563. doi: 10.1126/scitranslmed.aas9563
PMCID:
PMC9899005
AbstractArticlePDF–2.2M
6.
Pro-inflammatory megakaryocyte gene expression in murine models of breast cancer
Harvey G. Roweth, Michael W. Malloy, Gregory J. Goreczny, Isabelle C. Becker, Qiuchen Guo, Elizabeth A. Mittendorf, Joseph E. Italiano, Jr., Sandra S. McAllister, Elisabeth M. Battinelli
Sci Adv. 2022 Oct; 8(41): eabo5224. Published online 2022 Oct 12. doi: 10.1126/sciadv.abo5224
PMCID:
PMC9555784
AbstractArticlePDF–9.1M
7.
Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression
Colin Valet, Mélia Magnen, Longhui Qiu, Simon J. Cleary, Kristin M. Wang, Serena Ranucci, Elodie Grockowiak, Rafik Boudra, Catharina Conrad, Yurim Seo, Daniel R. Calabrese, John R. Greenland, Andrew D. Leavitt, Emmanuelle Passegué, Simón Méndez-Ferrer, Filip K. Swirski, Mark R. Looney
J Clin Invest. 2022 Apr 1; 132(7): e153920. Published online 2022 Apr 1. doi: 10.1172/JCI153920
PMCID:
PMC8970674
AbstractArticlePDF–11M
8.
Protein Quality Control Through Endoplasmic Reticulum-Associated Degradation Maintains Hematopoietic Stem Cell Identity and Niche Interactions
Longyong Xu, Xia Liu, Fanglue Peng, Weijie Zhang, Liting Zheng, Yao Ding, Tianpeng Gu, Kaosheng Lv, Jin Wang, Laura Ortinau, Tianyuan Hu, Xiangguo Shi, Guojun Shi, Ge Shang, Shengyi Sun, Takao Iwawaki, Yewei Ji, Wei Li, Jeffrey M. Rosen, Xiang H.-F. Zhang, Dongsu Park, Stanley Adoro, Andre Catic, Wei Tong, Ling Qi, Daisuke Nakada, Xi Chen
Nat Cell Biol. Author manuscript; available in PMC 2021 Mar 21.
Published in final edited form as: Nat Cell Biol. 2020 Oct; 22(10): 1162–1169. Published online 2020 Sep 21. doi: 10.1038/s41556-020-00581-x
PMCID:
PMC7888538
AbstractArticlePDF–2.7M
9.
C‐Cbl regulates c‐MPL receptor trafficking and its internalization
Melanie Märklin, Claudia Tandler, Hans‐Georg Kopp, Kyle L. Hoehn, Leticia Quintanilla‐Martinez, Oliver Borst, Martin R. Müller, Sebastian J. Saur
J Cell Mol Med. 2020 Nov; 24(21): 12491–12503. Published online 2020 Sep 20. doi: 10.1111/jcmm.15785
PMCID:
PMC7687000
AbstractArticlePDF–1.7M
10.
Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera
Jerry L. Spivak, Akil Merchant, Donna M. Williams, Ophelia Rogers, Wanke Zhao, Amy Duffield, Linda S. Resar, Alison R. Moliterno, Zhizhuang J. Zhao
PLoS One. 2020; 15(6): e0232801. Published online 2020 Jun 1. doi: 10.1371/journal.pone.0232801
PMCID:
PMC7263591
AbstractArticlePDF–3.1M
11.
JAK2V617F Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion in Mice through Thrombopoietin/MPL signaling
Yu Zhang, Chi Hua Sarah Lin, Kenneth Kaushansky, Huichun Zhan
Stem Cells. Author manuscript; available in PMC 2019 Oct 29.
Published in final edited form as: Stem Cells. 2018 Nov; 36(11): 1676–1684. Published online 2018 Jul 29. doi: 10.1002/stem.2888
PMCID:
PMC6819142
AbstractArticlePDF–1.1M
12.
Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia
Taisuke Kanaji, My-Nuong Vo, Sachiko Kanaji, Alessandro Zarpellon, Ryan Shapiro, Yosuke Morodomi, Akinori Yuzuriha, Koji Eto, Rajesh Belani, Minh-Ha Do, Xiang-Lei Yang, Zaverio M. Ruggeri, Paul Schimmel
Proc Natl Acad Sci U S A. 2018 Aug 28; 115(35): E8228–E8235. Published online 2018 Aug 13. doi: 10.1073/pnas.1807000115
PMCID:
PMC6126720
AbstractArticlePDF–1.6M
13.
Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice
Viola Lorenz, Haley Ramsey, Zhi-Jian Liu, Joseph Italiano, Jr., Karin Hoffmeister, Sihem Bihorel, Donald Mager, Zhongbo Hu, William B. Slayton, Benjamin T. Kile, Martha Sola-Visner, Francisca Ferrer-Marin
Thromb Haemost. Author manuscript; available in PMC 2018 Dec 6.
Published in final edited form as: Thromb Haemost. 2017 Dec; 117(12): 2322–2333. Published online 2017 Dec 6. doi: 10.1160/TH17-06-0433
PMCID:
PMC5911346
AbstractArticlePDF–1.4M
14.
The JAK2V617F-bearing vascular niche promotes clonal expansion in myeloproliferative neoplasms
H Zhan, C H S Lin, Y Segal, K Kaushansky
Leukemia. 2018 Feb; 32(2): 462–469. Prepublished online 2017 Jul 24. Published online 2017 Aug 11. doi: 10.1038/leu.2017.233
PMCID:
PMC5783797
AbstractArticlePDF–1.7M
15.
Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling
Amanda E. Au, Marion Lebois, Starling A. Sim, Ping Cannon, Jason Corbin, Pradnya Gangatirkar, Craig D. Hyland, Diane Moujalled, Angelika Rutgersson, Fatme Yassinson, Benjamin T. Kile, Kylie D. Mason, Ashley P. Ng, Warren S. Alexander, Emma C. Josefsson
Sci Rep. 2017; 7: 14953. Published online 2017 Nov 2. doi: 10.1038/s41598-017-15023-2
PMCID:
PMC5668349
AbstractArticlePDF–2.5M
16.
The lung is a site of platelet biogenesis and a reservoir for hematopoietic progenitors
Emma Lefrançais, Guadalupe Ortiz-Muñoz, Axelle Caudrillier, Beñat Mallavia, Fengchun Liu, David M. Sayah, Emily E. Thornton, Mark B. Headley, Tovo David, Shaun R. Coughlin, Matthew F. Krummel, Andrew D. Leavitt, Emmanuelle Passegué, Mark R. Looney
Nature. Author manuscript; available in PMC 2017 Oct 31.
Published in final edited form as: Nature. 2017 Apr 6; 544(7648): 105–109. Published online 2017 Mar 22. doi: 10.1038/nature21706
PMCID:
PMC5663284
AbstractArticlePDF–6.7M
17.
Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A
Cora M.L. Beckers, Kingsley R. Simpson, Kathryn J. Griffin, Jane M. Brown, Lih T. Cheah, Kerrie A. Smith, Jean Vacher, Paul A. Cordell, Mark T. Kearney, Peter J. Grant, Richard J. Pease
Arterioscler Thromb Vasc Biol. 2017 Aug; 37(8): 1494–1502. Published online 2017 Jul 26. doi: 10.1161/ATVBAHA.117.309271
PMCID:
PMC5526434
AbstractArticlePDF–754K
18.
The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature
M Zingariello, L Sancillo, F Martelli, F Ciaffoni, M Marra, L Varricchio, R A Rana, C Zhao, J D Crispino, A R Migliaccio
Blood Cancer J. 2017 Jun; 7(6): e572. Published online 2017 Jun 16. doi: 10.1038/bcj.2017.51
PMCID:
PMC5520398
AbstractArticlePDF–3.9M
19.
C-Mpl is expressed on osteoblasts and osteoclasts and is important in regulating skeletal homeostasis
Tomas E. Meijome, Jenna T. Baughman, R. Adam Hooker, Ying-Hua Cheng, Wendy A. Ciovacco, Sanjeev M. Balamohan, Trishya L. Srinivasan, Brahmananda R. Chitteti, Pierre P. Eleniste, Mark C. Horowitz, Edward F. Srour, Angela Bruzzaniti, Robyn K. Fuchs, Melissa A. Kacena
J Cell Biochem. Author manuscript; available in PMC 2017 Apr 1.
Published in final edited form as: J Cell Biochem. 2016 Apr; 117(4): 959–969. Published online 2015 Oct 6. doi: 10.1002/jcb.25380
PMCID:
PMC4883670
AbstractArticlePDF–1.6M
20.
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors
Ying Cheng, Kudakwashe Chikwava, Chao Wu, Haibing Zhang, Anchit Bhagat, Dehua Pei, John K. Choi, Wei Tong
J Clin Invest. 2016 Apr 1; 126(4): 1267–1281. Published online 2016 Mar 14. doi: 10.1172/JCI81468
PMCID:
PMC4811117
AbstractArticlePDF–3.0M

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