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Items: 1 to 20 of 44

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
FHL1 promotes chikungunya and o’nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design
Wern Hann Ng, Xiang Liu, Zheng L. Ling, Camilla N. O. Santos, Lucas S. Magalhães, Andrew J. Kueh, Marco J. Herold, Adam Taylor, Joseph R. Freitas, Sandra Koit, Sainan Wang, Andrew R. Lloyd, Mauro M. Teixeira, Andres Merits, Roque P. Almeida, Nicholas J. C. King, Suresh Mahalingam
Nat Commun. 2023; 14: 6605. Published online 2023 Oct 26. doi: 10.1038/s41467-023-42330-2
PMCID:
PMC10603155
AbstractArticlePDF–1.8M
3.
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility
Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao
Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5
PMCID:
PMC10307852
AbstractArticlePDF–8.8M
4.
Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2
Sophie Broadway-Stringer, He Jiang, Kirsty Wadmore, Charlotte Hooper, Gillian Douglas, Violetta Steeples, Amar J. Azad, Evie Singer, Jasmeet S. Reyat, Frantisek Galatik, Elisabeth Ehler, Pauline Bennett, Jacinta I. Kalisch-Smith, Duncan B. Sparrow, Benjamin Davies, Kristina Djinovic-Carugo, Mathias Gautel, Hugh Watkins, Katja Gehmlich
Cells. 2023 Mar; 12(5): 721. Published online 2023 Feb 24. doi: 10.3390/cells12050721
PMCID:
PMC10001372
AbstractArticlePDF–2.7M
5.
Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler
Florian Noack, Silvia Vangelisti, Gerald Raffl, Madalena Carido, Jeisimhan Diwakar, Faye Chong, Boyan Bonev
Nat Neurosci. 2022; 25(2): 154–167. Published online 2022 Feb 7. doi: 10.1038/s41593-021-01002-4
PMCID:
PMC8825286
AbstractArticlePDF–24M
6.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
MiR-183-5p induced by saturated fatty acids regulates the myogenic differentiation by directly targeting FHL1 in C2C12 myoblasts
Mai Thi Nguyen, Kyung-Ho Min, Wan Lee
BMB Rep. 2020 Nov 30; 53(11): 605–610. Published online 2020 Nov 30. doi: 10.5483/BMBRep.2020.53.11.175
PMCID:
PMC7704217
AbstractArticlePDF–4.7M
9.
Cardiomyopathy and altered integrin-actin signaling in Fhl1 mutant female mice
Akatsuki Kubota, Martí Juanola-Falgarona, Valentina Emmanuele, Maria Jose Sanchez-Quintero, Shingo Kariya, Fusako Sera, Shunichi Homma, Kurenai Tanji, Catarina M Quinzii, Michio Hirano
Hum Mol Genet. 2019 Jan 15; 28(2): 209–219. Published online 2018 Sep 26. doi: 10.1093/hmg/ddy299
PMCID:
PMC7594173
AbstractArticlePDF–32M
10.
FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction
Christine Veith, Dariusch Neghabian, Himal Luitel, Jochen Wilhelm, Bakytbek Egemnazarov, Caja Muntanjohl, Jan-Hendrik Fischer, Bhola Kumar Dahal, Ralph Theo Schermuly, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Ludger Fink, Grazyna Kwapiszewska, Norbert Weissmann, Akylbek Sydykov
Basic Res Cardiol. 2020; 115(2): 17. Published online 2020 Jan 24. doi: 10.1007/s00395-019-0767-5
PMCID:
PMC6981327
AbstractArticlePDF–1.9M
11.
Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina
Joel B. Miesfeld, Myung-soon Moon, Amy N. Riesenberg, Ashley N. Contreras, Rhett A. Kovall, Nadean L. Brown
Sci Rep. 2018; 8: 10195. Published online 2018 Jul 5. doi: 10.1038/s41598-018-28420-y
PMCID:
PMC6033939
AbstractArticlePDF–3.4M
12.
Src-mediated phosphorylation converts FHL1 from tumor suppressor to tumor promoter
Xiang Wang, Xiaofan Wei, Yang Yuan, Qingrui Sun, Jun Zhan, Jing Zhang, Yan Tang, Feng Li, Lihua Ding, Qinong Ye, Hongquan Zhang
J Cell Biol. 2018 Apr 2; 217(4): 1335–1351. doi: 10.1083/jcb.201708064
PMCID:
PMC5881501
AbstractArticlePDF–3.2M
13.
Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes
Judith Krysiak, Andreas Unger, Lisa Beckendorf, Nazha Hamdani, Marion von Frieling-Salewsky, Margaret M. Redfield, Cris G. dos Remedios, Farah Sheikh, Ulrich Gergs, Peter Boknik, Wolfgang A. Linke
Nat Commun. 2018; 9: 262. Published online 2018 Jan 17. doi: 10.1038/s41467-017-02483-3
PMCID:
PMC5772059
AbstractArticlePDF–5.9M
14.
A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity
Xiaojie Xu, Zhongyi Fan, Chaoyang Liang, Ling Li, Lili Wang, Yingchun Liang, Jun Wu, Shaohong Chang, Zhifeng Yan, Zhaohui Lv, Jing Fu, Yang Liu, Shuai Jin, Tao Wang, Tian Hong, Yishan Dong, Lihua Ding, Long Cheng, Rui Liu, Shenbo Fu, Shunchang Jiao, Qinong Ye
Nat Commun. 2017; 8: 14059. Published online 2017 Jan 17. doi: 10.1038/ncomms14059
PMCID:
PMC5247581
AbstractArticlePDF–4.9M
15.
KyoT2 downregulates airway remodeling in asthma
Mei Hu, Hai-Feng Ou-Yang, Xing-Peng Han, Xin-Yu Ti, Chang-Gui Wu
Int J Clin Exp Pathol. 2015; 8(11): 14171–14179. Published online 2015 Nov 1.
PMCID:
PMC4713516
AbstractArticlePDF–1.0M
16.
Fhl1 W122S causes loss of protein function and late-onset mild myopathy
Valentina Emmanuele, Akatsuki Kubota, Beatriz Garcia-Diaz, Caterina Garone, Hasan O. Akman, Daniel Sánchez-Gutiérrez, Luis M. Escudero, Shingo Kariya, Shunichi Homma, Kurenai Tanji, Catarina M. Quinzii, Michio Hirano
Hum Mol Genet. 2015 Feb 1; 24(3): 714–726. Published online 2014 Sep 30. doi: 10.1093/hmg/ddu490
PMCID:
PMC4342698
AbstractArticlePDF–1007K
17.
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress
Liyong Zhang, Xin Chen, Parveen Sharma, Mark Moon, Alex D. Sheftel, Fayez Dawood, Mai P. Nghiem, Jun Wu, Ren-Ke Li, Anthony O. Gramolini, Poul H. Sorensen, Josef M. Penninger, John H. Brumell, Peter P. Liu
Nat Commun. 2014 Mar 11; 5: 3430. Published online 2014 Mar 11. doi: 10.1038/ncomms4430
PMCID:
PMC3959209
AbstractArticlePDF–3.6M
18.
Structure and Function of the CSL-KyoT2 Corepressor Complex – a Negative Regulator of Notch Signaling
Kelly J. Collins, Zhenyu Yuan, Rhett A. Kovall
Structure. Author manuscript; available in PMC 2015 Jan 7.
Published in final edited form as: Structure. 2014 Jan 7; 22(1): 70–81. Published online 2013 Nov 27. doi: 10.1016/j.str.2013.10.010
PMCID:
PMC3947186
AbstractArticlePDF–4.5M
19.
5′RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy
Danos C. Christodoulou, Hiroko Wakimoto, Kenji Onoue, Seda Eminaga, Joshua M. Gorham, Steve R. DePalma, Daniel S. Herman, Polakit Teekakirikul, David A. Conner, David M. McKean, Andrea A. Domenighetti, Anton Aboukhalil, Stephen Chang, Gyan Srivastava, Barbara McDonough, Philip L. De Jager, Ju Chen, Martha L. Bulyk, Jochen D. Muehlschlegel, Christine E. Seidman, J.G. Seidman
J Clin Invest. 2014 Mar 3; 124(3): 1364–1370. Published online 2014 Feb 10. doi: 10.1172/JCI70108
PMCID:
PMC3934171
AbstractArticlePDF–943K
20.
Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes
Konstantina Stathopoulou, Friederike Cuello, Alexandra J. Candasamy, Elizabeth M. Kemp, Elisabeth Ehler, Robert S. Haworth, Metin Avkiran
Biochem J. 2014 Feb 1; 457(Pt 3): 451–461. Prepublished online 2013 Nov 13. Published online 2014 Jan 10. doi: 10.1042/BJ20131026
PMCID:
PMC3927927
AbstractArticlePDF–1.3M

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