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Select item 100389921.

Calpain activity is negatively regulated by a KCTD7–Cullin-3 complex via non-degradative ubiquitination

Jaiprakash Sharma, Shalaka Mulherkar, Uan-I Chen, Yan Xiong, Lakshya Bajaj, Byoung-Kyu Cho, Young Ah Goo, Hon-Chiu Eastwood Leung, Kimberley F. Tolias, Marco Sardiello

Cell Discov. 2023; 9: 32. Published online 2023 Mar 24. doi: 10.1038/s41421-023-00533-3

PMCID:: PMC10038992

Abstract Article PDF–15M

Select item 92107122.

Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis

Li Zhang, Dong Zheng, Yuemei Yan, Yong Yu, Ruizhen Chen, Zheng Li, Peter A. Greer, Tianqing Peng, Qiang Wang

Arthritis Res Ther. 2022; 24: 148. Published online 2022 Jun 21. doi: 10.1186/s13075-022-02833-7

PMCID:: PMC9210712

Abstract Article PDF–20M

Select item 91108933.

Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis

Risako Akasu, Takuro Miyazaki, Mohamed Z. Elhussiny, Yuki Sugiura, Yuki Tomitsuka, Shogo Haraguchi, Kinya Otsu, Vishwajit S. Chowdhury, Akira Miyazaki

J Biol Chem. 2022 Jun; 298(6): 101953. Published online 2022 Apr 18. doi: 10.1016/j.jbc.2022.101953

PMCID:: PMC9110893

Abstract Article PDF–3.6M

Select item 88859964.

Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis

Xin Huang, Kai-jie Zhang, Jun-jie Jiang, Shou-yin Jiang, Jia-bin Lin, Yi-jia Lou

Front Endocrinol (Lausanne) 2022; 13: 801260. Published online 2022 Feb 15. doi: 10.3389/fendo.2022.801260

PMCID:: PMC8885996

Abstract Article PDF–15M

Select item 87419875.

Calpain-mediated protein targets in cardiac mitochondria following ischemia–reperfusion

Ling Li, Jeremy Thompson, Ying Hu, Edward J. Lesnefsky, Belinda Willard, Qun Chen

Sci Rep. 2022; 12: 138. Published online 2022 Jan 7. doi: 10.1038/s41598-021-03947-9

PMCID:: PMC8741987

Abstract Article PDF–2.8M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 78640767.

Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways

Liwen Liang, Huili Li, Ting Cao, Lina Qu, Lulu Zhang, Guo-Chang Fan, Peter A. Greer, Jianmin Li, Douglas L. Jones, Tianqing Peng

J Biol Chem. 2020 Dec 4; 295(49): 16840–16851. Published online 2021 Jan 13. doi: 10.1074/jbc.RA119.011890

PMCID:: PMC7864076

Abstract Article PDF–1.9M

Select item 77102778.

Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury

Xuefei Tian, Kazunori Inoue, Yan Zhang, Ying Wang, C. John Sperati, Christopher E. Pedigo, Tingting Zhao, Meihua Yan, Marwin Groener, Dennis G. Moledina, Karen Ebenezer, Wei Li, Zhenhai Zhang, Dan A. Liebermann, Lois Greene, Peter Greer, Chirag R. Parikh, Shuta Ishibe

JCI Insight. 2020 Nov 19; 5(22): e142740. Published online 2020 Nov 19. doi: 10.1172/jci.insight.142740

PMCID:: PMC7710277

Abstract Article PDF–5.2M

Select item 73605479.

Targeted inhibition of endothelial calpain delays wound healing by reducing inflammation and angiogenesis

Chenlong Yi, Weihua Wu, Dong Zheng, Guangying Peng, Haoyue Huang, Zhenya Shen, Xiaomei Teng

Cell Death Dis. 2020 Jul; 11(7): 533. Published online 2020 Jul 14. doi: 10.1038/s41419-020-02737-x

PMCID:: PMC7360547

Abstract Article PDF–4.2M

Select item 709271510.

Endoplasmic Reticulum Stress-induced Complex I Defect: Central Role of Calcium Overload

Ahmed A. Mohsin, Jeremy Thompson, Ying Hu, John Hollander, Edward J. Lesnefsky, Qun Chen

Arch Biochem Biophys. Author manuscript; available in PMC 2021 Apr 15.

Published in final edited form as: Arch Biochem Biophys. 2020 Apr 15; 683: 108299. Published online 2020 Feb 12. doi: 10.1016/j.abb.2020.108299

PMCID:: PMC7092715

Abstract Article PDF–1.7M

Select item 670267211.

Selective deletion of endothelial cell calpain in mice reduces diabetic cardiomyopathy by improving angiogenesis

Xiaomei Teng, Chen Ji, Huiting Zhong, Dong Zheng, Rui Ni, David J. Hill, Sidong Xiong, Guo-Chang Fan, Peter A. Greer, Zhenya Shen, Tianqing Peng

Diabetologia. Author manuscript; available in PMC 2019 Aug 21.

Published in final edited form as: Diabetologia. 2019 May; 62(5): 860–872. Published online 2019 Feb 18. doi: 10.1007/s00125-019-4828-y

PMCID:: PMC6702672

Abstract Article PDF–1.5M

Select item 535878212.

Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin

Hung Huy Nguyen, Mihaly Varadi, Peter Tompa, Kris Pauwels

PLoS One. 2017; 12(3): e0174125. Published online 2017 Mar 20. doi: 10.1371/journal.pone.0174125

PMCID:: PMC5358782

Abstract Article PDF–1.3M

Select item 506687413.

Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress

Shengcun Li, Lulu Zhang, Rui Ni, Ting Cao, Dong Zheng, Sidong Xiong, Peter A. Greer, Guo-Chang Fan, Tianqing Peng

Biochim Biophys Acta. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: Biochim Biophys Acta. 2016 Nov; 1862(11): 2023–2033. Published online 2016 Aug 12. doi: 10.1016/j.bbadis.2016.08.005

PMCID:: PMC5066874

Abstract Article PDF–1.2M

Select item 496713014.

Calpain-2 activates Akt via TGF-β₁-mTORC2 pathway in pulmonary artery smooth muscle cells

Prasanna Abeyrathna, Laszlo Kovacs, Weihong Han, Yunchao Su

Am J Physiol Cell Physiol. 2016 Jul 1; 311(1): C24–C34. Published online 2016 Apr 20. doi: 10.1152/ajpcell.00295.2015

PMCID:: PMC4967130

Abstract Article

Select item 494643215.

Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis

Stacy Grieve, Yan Gao, Christine Hall, Jing Hu, Peter A. Greer

Mol Cell Biol. 2016 Aug 1; 36(15): 2078–2088. Prepublished online 2016 May 23. Published online 2016 Jul 14. doi: 10.1128/MCB.01062-15

PMCID:: PMC4946432

Abstract Article PDF–2.0M

Select item 482103516.

Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension

Laszlo Kovacs, Weihong Han, Ruslan Rafikov, Zsolt Bagi, Stefan Offermanns, Takaomi C. Saido, Stephen M. Black, Yunchao Su

Am J Respir Cell Mol Biol. 2016 Mar; 54(3): 384–393. doi: 10.1165/rcmb.2015-0151OC

PMCID:: PMC4821035

Abstract Article PDF–1.6M

Select item 468695317.

Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy

Rui Ni, Dong Zheng, Sidong Xiong, David J. Hill, Tao Sun, Richard B. Gardiner, Guo-Chang Fan, Yanrong Lu, E. Dale Abel, Peter A. Greer, Tianqing Peng

Diabetes. 2016 Jan; 65(1): 255–268. Published online 2015 Oct 15. doi: 10.2337/db15-0963

PMCID:: PMC4686953

Abstract Article PDF–1.6M

Select item 457391118.

Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation

Rui Ni, Dong Zheng, Qiang Wang, Yong Yu, Ruizhen Chen, Tao Sun, Wang Wang, Guo-Chang Fan, Peter A. Greer, Richard B. Gardiner, Tianqing Peng

Circ Heart Fail. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Circ Heart Fail. 2015 Sep; 8(5): 988–996. Published online 2015 Aug 5. doi: 10.1161/CIRCHEARTFAILURE.115.002383

PMCID:: PMC4573911

Abstract Article PDF–984K

Select item 441853419.

Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation

Dong Zheng, Grace Wang, Shuai Li, Guo-Chang Fan, Tianqing Peng

Biochim Biophys Acta. Author manuscript; available in PMC 2015 May 4.

Published in final edited form as: Biochim Biophys Acta. 2015 May; 1852(5): 882–892. Published online 2015 Feb 4. doi: 10.1016/j.bbadis.2015.01.019

PMCID:: PMC4418534

Abstract Article PDF–1.5M

Select item 415356020.

Conditional Disruption of Calpain in the CNS Alters Dendrite Morphology, Impairs LTP, and Promotes Neuronal Survival following Injury

Mandana Amini, Chun-lei Ma, Rasoul Farazifard, Guoqi Zhu, Yi Zhang, Jacqueline Vanderluit, Joanna Susie Zoltewicz, Fadi Hage, Joseph M. Savitt, Diane C. Lagace, Ruth S. Slack, Jean-Claude Beique, Michel Baudry, Peter A. Greer, Richard Bergeron, David S. Park

J Neurosci. 2013 Mar 27; 33(13): 5773–5784. doi: 10.1523/JNEUROSCI.4247-12.2013

PMCID:: PMC4153560

Abstract Article PDF–2.3M

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