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Select item 112379301.

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 109902772.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 107563453.

Metastatic Lymph Node 64 (MLN64) Expression in Gastric Cancer: The Clinical and Molecular Implications in Drug Resistance

AMBER XINYU LI, JIMMY JIANYUAN ZENG, ELYAS KHAN, Q. PING DOU, XINGUO ZHUANG, EDISON KE JI, FIONA RUGE, TRACEY A. MARTIN, SHUQIN JIA, WEN G. JIANG

Cancer Genomics Proteomics. 2024 Jan-Feb; 21(1): 30–40. Published online 2024 Jan 3. doi: 10.21873/cgp.20427

PMCID:: PMC10756345

Abstract Article PDF–3.9M

Select item 104699914.

Methionine sulfoxide reductases and cholesterol transporter STARD3 constitute an efficient system for detoxification of cholesterol hydroperoxides

Jung Mi Lim, Venkata R. Sabbasani, Rolf E. Swenson, Rodney L. Levine

J Biol Chem. 2023 Sep; 299(9): 105099. Published online 2023 Jul 26. doi: 10.1016/j.jbc.2023.105099

PMCID:: PMC10469991

Abstract Article PDF–1.5M

Select item 91197365.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 90375546.

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy

Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell

Autophagy. 2022; 18(4): 829–840. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1960116

PMCID:: PMC9037554

Abstract Article PDF–4.1M

Select item 89515567.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 87558318.

Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions

Jaimy Jose, Monira Hoque, Johanna Engel, Syed S. Beevi, Mohamed Wahba, Mariya Ilieva Georgieva, Kendelle J. Murphy, William E. Hughes, Blake J. Cochran, Albert Lu, Francesc Tebar, Andrew J. Hoy, Paul Timpson, Kerry-Anne Rye, Carlos Enrich, Carles Rentero, Thomas Grewal

Sci Rep. 2022; 12: 596. Published online 2022 Jan 12. doi: 10.1038/s41598-021-04584-y

PMCID:: PMC8755831

Abstract Article PDF–3.6M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 770545010.

FFAT motif phosphorylation controls formation and lipid transfer function of inter‐organelle contacts

Thomas Di Mattia, Arthur Martinet, Souade Ikhlef, Alastair G McEwen, Yves Nominé, Corinne Wendling, Pierre Poussin‐Courmontagne, Laetitia Voilquin, Pascal Eberling, Frank Ruffenach, Jean Cavarelli, John Slee, Timothy P Levine, Guillaume Drin, Catherine Tomasetto, Fabien Alpy

EMBO J. 2020 Dec 1; 39(23): e104369. Published online 2020 Oct 30. doi: 10.15252/embj.2019104369

PMCID:: PMC7705450

Abstract Article PDF–4.4M

Select item 764232711.

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner

Nat Commun. 2020; 11: 5559. Published online 2020 Nov 3. doi: 10.1038/s41467-020-19032-0

PMCID:: PMC7642327

Abstract Article PDF–12M

Select item 716998312.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 692775413.

Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong

eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223

PMCID:: PMC6927754

Abstract Article PDF–5.1M

Select item 603070114.

Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites

Thomas Di Mattia, Léa P Wilhelm, Souade Ikhlef, Corinne Wendling, Danièle Spehner, Yves Nominé, Francesca Giordano, Carole Mathelin, Guillaume Drin, Catherine Tomasetto, Fabien Alpy

EMBO Rep. 2018 Jul; 19(7): e45453. Published online 2018 Jun 1. doi: 10.15252/embr.201745453

PMCID:: PMC6030701

Abstract Article PDF–4.6M

Select item 599210415.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni

Proteomics. 2018 May; 18(10): 1700444. Published online 2018 Apr 17. doi: 10.1002/pmic.201700444

PMCID:: PMC5992104

Abstract Article PDF–1.2M

Select item 567858116.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 543022818.

STARD3 mediates endoplasmic reticulum‐to‐endosome cholesterol transport at membrane contact sites

Léa P Wilhelm, Corinne Wendling, Benoît Védie, Toshihide Kobayashi, Marie‐Pierre Chenard, Catherine Tomasetto, Guillaume Drin, Fabien Alpy

EMBO J. 2017 May 15; 36(10): 1412–1433. Published online 2017 Apr 4. doi: 10.15252/embj.201695917

PMCID:: PMC5430228

Abstract Article PDF–3.5M

Select item 534432519.

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content

Elisa Balboa, Juan Castro, María-José Pinochet, Gonzalo I. Cancino, Nuria Matías, Pablo José Sáez, Alexis Martínez, Alejandra R. Álvarez, Carmen Garcia-Ruiz, José C. Fernandez-Checa, Silvana Zanlungo

Redox Biol. 2017 Aug; 12: 274–284. Published online 2017 Mar 2. doi: 10.1016/j.redox.2017.02.024

PMCID:: PMC5344325

Abstract Article PDF–1.3M

Select item 497330220.

Structure of the lutein-binding domain of human StARD3 at 1.74 Å resolution and model of a complex with lutein

Martin P. Horvath, Evan W. George, Quang T. Tran, Kody Baumgardner, Gabe Zharov, Sarah Lee, Hassan Sharifzadeh, Saeed Shihab, Ty Mattinson, Binxing Li, Paul S. Bernstein

Acta Crystallogr F Struct Biol Commun. 2016 Aug 1; 72(Pt 8): 609–618. Published online 2016 Jul 27. doi: 10.1107/S2053230X16010694

PMCID:: PMC4973302

Abstract Article PDF–1.6M

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