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Items: 1 to 20 of 29

1.
Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling
Jian Xiao, Le-Wei Dong, Shuai Liu, Fan-Hua Meng, Chang Xie, Xiao-Yi Lu, Weiping J. Zhang, Jie Luo, Bao-Liang Song
Nat Commun. 2023; 14: 6469. Published online 2023 Oct 13. doi: 10.1038/s41467-023-42179-5
PMCID:
PMC10575946
AbstractArticlePDF–7.7M
2.
NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice
Lin Jia, Yinyan Ma, Jamie Haywood, Long Jiang, Bingzhong Xue, Hang Shi, Paul A. Dawson, Liqing Yu
Cells. 2021 Dec; 10(12): 3468. Published online 2021 Dec 9. doi: 10.3390/cells10123468
PMCID:
PMC8700447
AbstractArticlePDF–1.5M
3.
Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice
Hongfei Ge, Gongxin Liu, Tracy M. Yamawaki, Caroline Tao, Shawn T. Alexander, Kimberly Ly, Preston Fordstrom, Artem A. Shkumatov, Chi-Ming Li, Sridharan Rajamani, Mingyue Zhou, Brandon Ason
Sci Rep. 2021; 11: 17449. Published online 2021 Aug 31. doi: 10.1038/s41598-021-96936-x
PMCID:
PMC8408133
AbstractArticlePDF–6.7M
4.
NPC1L1-dependent transport of 27-alkyne cholesterol in intestinal epithelial cells
Alexander L. Ticho, Nathan Calzadilla, Pooja Malhotra, Hyunjin Lee, Arivarasu Natarajan Anbazhagan, Seema Saksena, Pradeep K. Dudeja, Daesung Lee, Ravinder K. Gill, Waddah A. Alrefai
Am J Physiol Cell Physiol. 2021 May 1; 320(5): C916–C925. Published online 2021 Mar 24. doi: 10.1152/ajpcell.00062.2021
PMCID:
PMC8163569
AbstractArticle
5.
NPC1L1 Facilitates Sphingomyelin Absorption and Regulates Diet-Induced Production of VLDL/LDL-associated S1P
Yoshihide Yamanashi, Tappei Takada, Hideaki Yamamoto, Hiroshi Suzuki
Nutrients. 2020 Sep; 12(9): 2641. Published online 2020 Aug 30. doi: 10.3390/nu12092641
PMCID:
PMC7551898
AbstractArticlePDF–1.5M
6.
Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
Piyali Saha, Justin L Shumate, Jenna G Caldwell, Nadia Elghobashi-Meinhardt, Albert Lu, Lichao Zhang, Niclas E Olsson, Joshua E Elias, Suzanne R Pfeffer
eLife. 2020; 9: e57089. Published online 2020 May 15. doi: 10.7554/eLife.57089
PMCID:
PMC7228765
AbstractArticlePDF–6.2M
7.
Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice
Youlin Wang, Pan Yang, Bo Zhang, Yao Ding, Shun Lei, Yuning Hou, Xiaoqing Guan, Qingwang Li
Mol Med Rep. 2019 Oct; 20(4): 3224–3232. Published online 2019 Aug 1. doi: 10.3892/mmr.2019.10549
PMCID:
PMC6755247
AbstractArticlePDF–768K
8.
Osteopontin deficiency protects mice from cholesterol gallstone formation by reducing expression of intestinal NPC1L1
Jing Lin, Wei-Qing Shao, Qing-Zhi Chen, Wen-Wei Zhu, Lu Lu, Hu-Liang Jia, Jin-Hong Chen
Mol Med Rep. 2017 Aug; 16(2): 1785–1792. Published online 2017 Jun 14. doi: 10.3892/mmr.2017.6774
PMCID:
PMC5561929
AbstractArticlePDF–1.5M
9.
NPC1L1 knockout protects against colitis-associated tumorigenesis in mice
Jianming He, Hyunsu Shin, Xing Wei, Anil Kumar G Kadegowda, Rui Chen, Sandy Krystal Xie
BMC Cancer. 2015; 15: 189. Published online 2015 Mar 27. doi: 10.1186/s12885-015-1230-0
PMCID:
PMC4378275
AbstractArticlePDF–1.4M
10.
Epigenetic Modulation of Intestinal Cholesterol Transporter Niemann-Pick C1-like 1 (NPC1L1) Gene Expression by DNA Methylation
Pooja Malhotra, Vinay Soni, Anoop Kumar, Arivarasu N. Anbazhagan, Amish Dudeja, Seema Saksena, Ravinder K. Gill, Pradeep K. Dudeja, Waddah A. Alrefai
J Biol Chem. 2014 Aug 15; 289(33): 23132–23140. Published online 2014 Jun 5. doi: 10.1074/jbc.M113.546283
PMCID:
PMC4132811
AbstractArticlePDF–1.3M
11.
d-Glucose modulates intestinal Niemann-Pick C1-like 1 (NPC1L1) gene expression via transcriptional regulation
Pooja Malhotra, Craig S. Boddy, Vinay Soni, Seema Saksena, Pradeep K. Dudeja, Ravinder K. Gill, Waddah A. Alrefai
Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2): G203–G210. Published online 2012 Nov 8. doi: 10.1152/ajpgi.00288.2012
PMCID:
PMC3543648
AbstractArticle
12.
Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor
Bruno Sainz, Naina Barretto, Danyelle N. Martin, Nobuhiko Hiraga, Michio Imamura, Snawar Hussain, Katherine A. Marsh, Xuemei Yu, Kazuaki Chayama, Waddah A. Alrefai, Susan L. Uprichard
Nat Med. Author manuscript; available in PMC 2012 Dec 27.
Published in final edited form as: Nat Med. 2012 Feb; 18(2): 281–285. Published online 2012 Jan 8. doi: 10.1038/nm.2581
PMCID:
PMC3530957
AbstractArticlePDF–1.6M
13.
The Small GTPase Cdc42 Interacts with Niemann-Pick C1-like 1 (NPC1L1) and Controls Its Movement from Endocytic Recycling Compartment to Plasma Membrane in a Cholesterol-dependent Manner
Chang Xie, Na Li, Zheng-Jun Chen, Bo-Liang Li, Bao-Liang Song
J Biol Chem. 2011 Oct 14; 286(41): 35933–35942. Published online 2011 Aug 15. doi: 10.1074/jbc.M111.270199
PMCID:
PMC3195612
AbstractArticlePDF–5.4M
14.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
15.
Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver
Weiqing Tang, Lin Jia, Yinyan Ma, Ping Xie, Jamie Haywood, Paul A. Dawson, Jian Li, Liqing Yu
Biochim Biophys Acta. Author manuscript; available in PMC 2012 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Sep; 1811(9): 549–555. Published online 2011 Jun 12. doi: 10.1016/j.bbalip.2011.05.013
PMCID:
PMC3140631
AbstractArticlePDF–504K
16.
The N-terminal Domain of NPC1L1 Protein Binds Cholesterol and Plays Essential Roles in Cholesterol Uptake
Jin-Hui Zhang, Liang Ge, Wei Qi, Liqing Zhang, Hong-Hua Miao, Bo-Liang Li, Maojun Yang, Bao-Liang Song
J Biol Chem. 2011 Jul 15; 286(28): 25088–25097. Published online 2011 May 20. doi: 10.1074/jbc.M111.244475
PMCID:
PMC3137082
AbstractArticlePDF–3.1M
17.
Use of NBD-cholesterol to identify a minor but NPC1L1-independent cholesterol absorption pathway in mouse intestine
Michelle R. Adams, Eddy Konaniah, James G. Cash, David Y. Hui
Am J Physiol Gastrointest Liver Physiol. 2011 Jan; 300(1): G164–G169. Published online 2010 Nov 11. doi: 10.1152/ajpgi.00392.2010
PMCID:
PMC3025510
AbstractArticle
18.
Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake
Liang Ge, Wei Qi, Li-Juan Wang, Hong-Hua Miao, Yu-Xiu Qu, Bo-Liang Li, Bao-Liang Song
Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2): 551–556. Published online 2010 Dec 27. doi: 10.1073/pnas.1014434108
PMCID:
PMC3021008
AbstractArticlePDF–2.3M
19.
Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis
Lin Jia, Yinyan Ma, Shunxing Rong, Jenna L. Betters, Ping Xie, Soonkyu Chung, Nanping Wang, Weiqing Tang, Liqing Yu
J Lipid Res. 2010 Nov; 51(11): 3135–3144. doi: 10.1194/jlr.M006353
PMCID:
PMC2952554
AbstractArticlePDF–760K
20.
Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1
Lin Jia, Yinyan Ma, George Liu, Liqing Yu
J Lipid Res. 2010 Oct; 51(10): 3024–3033. doi: 10.1194/jlr.M008599
PMCID:
PMC2936752
AbstractArticlePDF–744K

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