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Select item 112138821.

Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer’s disease

Sergio Branciamore, Grigoriy Gogoshin, Andrei S. Rodin, Amanda J. Myers

Sci Rep. 2024; 14: 14954. Published online 2024 Jun 28. doi: 10.1038/s41598-024-65010-7

PMCID:: PMC11213882

Abstract Article PDF–2.0M

Select item 93485762.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92929973.

A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

Brooke D Huisman, Zheng Dai, David K Gifford, Michael E Birnbaum

eLife. 2022; 11: e78589. Published online 2022 Jul 4. doi: 10.7554/eLife.78589

PMCID:: PMC9292997

Abstract Article PDF–2.7M

Select item 92581744.

HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC

Jie Mei, Guanyu Jiang, Yundi Chen, Yongrui Xu, Yuan Wan, Ruo Chen, Feng Liu, Wenjun Mao, Mingfeng Zheng, Junying Xu

BMC Cancer. 2022; 22: 738. Published online 2022 Jul 6. doi: 10.1186/s12885-022-09840-6

PMCID:: PMC9258174

Abstract Article PDF–9.1M

Select item 86322295.

Combination of HLA-DR on Mycobacterium tuberculosis-Specific Cells and Tuberculosis Antigen/Phytohemagglutinin Ratio for Discriminating Active Tuberculosis From Latent Tuberculosis Infection

Ying Luo, Ying Xue, Guoxing Tang, Qun Lin, Huijuan Song, Wei Liu, Botao Yin, Jin Huang, Wei Wei, Liyan Mao, Feng Wang, Ziyong Sun

Front Immunol. 2021; 12: 761209. Published online 2021 Nov 11. doi: 10.3389/fimmu.2021.761209

PMCID:: PMC8632229

Abstract Article PDF–3.2M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 77387477.

Shared Signature of Recent Positive Selection on the TSBP1–BTNL2–HLA-DRA Genes in Five Native Populations from North Borneo

Boon-Peng Hoh, Xiaoxi Zhang, Lian Deng, Kai Yuan, Chee-Wei Yew, Woei-Yuh Saw, Mohammad Zahirul Hoque, Farhang Aghakhanian, Maude E Phipps, Yik-Ying Teo, Vijay Kumar Subbiah, Shuhua Xu

Genome Biol Evol. 2020 Dec; 12(12): 2245–2257. Published online 2020 Oct 6. doi: 10.1093/gbe/evaa207

PMCID:: PMC7738747

Abstract Article PDF–694K

Select item 76423278.

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner

Nat Commun. 2020; 11: 5559. Published online 2020 Nov 3. doi: 10.1038/s41467-020-19032-0

PMCID:: PMC7642327

Abstract Article PDF–12M

Select item 73475159.

Characterising the prognostic potential of HLA-DR during colorectal cancer development

Margaret R. Dunne, James J. Phelan, Adriana J. Michielsen, Aoife A. Maguire, Cara Dunne, Petra Martin, Sinead Noonan, Miriam Tosetto, Robert Geraghty, David Fennelly, Kieran Sheahan, Elizabeth J. Ryan, Jacintha O’Sullivan

Cancer Immunol Immunother. 2020 Aug; 69(8): 1577–1588. Published online 2020 Apr 18. doi: 10.1007/s00262-020-02571-2

PMCID:: PMC7347515

Abstract Article PDF–2.7M

Select item 734201910.

The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

Eric Alix, Camilla Godlee, Ondrej Cerny, Samkeliso Blundell, Romina Tocci, Sophie Matthews, Mei Liu, Jonathan N. Pruneda, Kirby N. Swatek, David Komander, Tabitha Sleap, David W. Holden

Cell Host Microbe. 2020 Jul 8; 28(1): 54–68.e7. doi: 10.1016/j.chom.2020.04.024

PMCID:: PMC7342019

Abstract Article

Select item 717688011.

Coronary artery bypass grafting is associated with immunoparalysis of monocytes and dendritic cells

Alexis J. Perros, Arlanna Esguerra‐Lallen, Kelly Rooks, Fenny Chong, Sanne Engkilde‐Pedersen, Helen M. Faddy, Elise Hewlett, Rishendran Naidoo, John‐Paul Tung, John F. Fraser, Peter Tesar, Marc Ziegenfuss, Susan Smith, Donalee O’Brien, Robert L. Flower, Melinda M. Dean

J Cell Mol Med. 2020 Apr; 24(8): 4791–4803. Published online 2020 Mar 17. doi: 10.1111/jcmm.15154

PMCID:: PMC7176880

Abstract Article PDF–1.3M

Select item 694204412.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 674146913.

HIV-1 Gag-Virus-Like Particles Induce Natural Killer Cell Immune Responses via Activation and Maturation of Dendritic Cells

Myint Oo Chang, Tomoyuki Suzuki, Hitoshi Suzuki, Hiroshi Takaku

J Innate Immun. 2012 Feb; 4(2): 187–200. Published online 2011 Jul 22. doi: 10.1159/000329226

PMCID:: PMC6741469

Abstract Article PDF–990K

Select item 660998914.

Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes

Özkan Aydemir, Janelle A. Noble, Jeffrey A. Bailey, Åke Lernmark, Patrick Marsh, Agnes Andersson Svärd, Frank Bearoff, Elizabeth P. Blankenhorn, John P. Mordes, the Better Diabetes Diagnosis (BDD) Study Group

Diabetes. 2019 Jul; 68(7): 1523–1527. Published online 2019 Apr 8. doi: 10.2337/db18-1128

PMCID:: PMC6609989

Abstract Article PDF–535K

Select item 590385015.

Dominant protection from HLA-linked autoimmunity by antigen specific regulatory T cells

Joshua D. Ooi, Jan Petersen, Yu H. Tan, Megan Huynh, Zoe J. Willett, Sri H. Ramarathinam, Peter J. Eggenhuizen, Khai L. Loh, Katherine A. Watson, Poh-Y. Gan, Maliha A. Alikhan, Nadine L. Dudek, Andreas Handel, Billy G. Hudson, Lars Fugger, David A. Power, Stephen G. Holt, P. Toby Coates, Jon W. Gregersen, Anthony W. Purcell, Stephen R. Holdsworth, Nicole L. La Gruta, Hugh H. Reid, Jamie Rossjohn, A. Richard Kitching

Nature. Author manuscript; available in PMC 2018 May 11.

Published in final edited form as: Nature. 2017 May 11; 545(7653): 243–247. Published online 2017 May 3. doi: 10.1038/nature22329

PMCID:: PMC5903850

Abstract Article PDF–3.9M

Select item 554266016.

Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?

Martin Sebastian Winkler, Anne Rissiek, Marion Priefler, Edzard Schwedhelm, Linda Robbe, Antonia Bauer, Corinne Zahrte, Christian Zoellner, Stefan Kluge, Axel Nierhaus

PLoS One. 2017; 12(8): e0182427. Published online 2017 Aug 3. doi: 10.1371/journal.pone.0182427

PMCID:: PMC5542660

Abstract Article PDF–3.8M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 550977318.

Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders

Ralf Brisch, Johann Steiner, Christian Mawrin, Marta Krzyżanowska, Zbigniew Jankowski, Tomasz Gos

Eur Arch Psychiatry Clin Neurosci. 2017; 267(5): 403–415. Published online 2017 Feb 22. doi: 10.1007/s00406-017-0774-1

PMCID:: PMC5509773

Abstract Article PDF–873K

Select item 510112819.

Circulating Memory CD4⁺ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans

Lyndsey M. Muehling, Duy T. Mai, William W. Kwok, Peter W. Heymann, Anna Pomés, Judith A. Woodfolk

J Immunol. Author manuscript; available in PMC 2017 Oct 15.

Published in final edited form as: J Immunol. 2016 Oct 15; 197(8): 3214–3224. Published online 2016 Sep 2. doi: 10.4049/jimmunol.1600663

PMCID:: PMC5101128

Abstract Article PDF–2.4M

Select item 500810020.

Major Histocompatibility Complex Class II HLA-DRα Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8

Zhiguo Sun, Hem Chandra Jha, Yong-gang Pei, Erle S. Robertson

J Virol. 2016 Sep 15; 90(18): 8047–8058. Prepublished online 2016 Jun 29. Published online 2016 Aug 26. doi: 10.1128/JVI.01079-16

PMCID:: PMC5008100

Abstract Article PDF–1.6M

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