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Select item 106796531.

The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5

Bonnie E.J. Maven, Casey A. Gifford, Melanie Weilert, Barbara Gonzalez-Teran, Ruth Hüttenhain, Angelo Pelonero, Kathryn N. Ivey, Kaitlen Samse-Knapp, Wesley Kwong, David Gordon, Michael McGregor, Tomohiro Nishino, Eyuche Okorie, Sage Rossman, Mauro W. Costa, Nevan J. Krogan, Julia Zeitlinger, Deepak Srivastava

Stem Cell Reports. 2023 Nov 14; 18(11): 2138–2153. Published online 2023 Oct 19. doi: 10.1016/j.stemcr.2023.09.014

PMCID:: PMC10679653

Abstract Article PDF–5.0M

Select item 101894952.

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Yu-Han H. Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu, April Kim, Kalliopi Tsafou, Natalie Petrossian, William Crotty, Jung Min Suh, Jackson Riseman, Jacqueline M. Martin, Julia C. Biagini, Daya Mena, Joshua K.T. Ching, Edyta Malolepsza, Taibo Li, Tarjinder Singh, Tian Ge, Shawn B. Egri, Benjamin Tanenbaum, Caroline R. Stanclift, Annie M. Apffel, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Steven A. Carr, Monica Schenone, Jake Jaffe, Nadine Fornelos, Hailiang Huang, Kevin C. Eggan, Kasper Lage

iScience. 2023 May 19; 26(5): 106701. Published online 2023 Apr 18. doi: 10.1016/j.isci.2023.106701

PMCID:: PMC10189495

Abstract Article PDF–5.3M

Select item 100254253.

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders

Greta Pintacuda, Yu-Han H. Hsu, Kalliopi Tsafou, Ka Wan Li, Jacqueline M. Martín, Jackson Riseman, Julia C. Biagini, Joshua K.T. Ching, Daya Mena, Miguel A. Gonzalez-Lozano, Shawn B. Egri, Jake Jaffe, August B. Smit, Nadine Fornelos, Kevin C. Eggan, Kasper Lage

Cell Genom. 2023 Mar 8; 3(3): 100250. Published online 2023 Jan 24. doi: 10.1016/j.xgen.2022.100250

PMCID:: PMC10025425

Abstract Article PDF–22M

Select item 99536314.

Genetic Variants of ISL1 Gene Promoter Identified from Congenital Tetralogy of Fallot Patients Alter Cellular Function Forming Disease Basis

Xiu-Yun Yin, Huan-Xin Chen, Zhuo Chen, Qin Yang, Jun Han, Guo-Wei He

Biomolecules. 2023 Feb; 13(2): 358. Published online 2023 Feb 13. doi: 10.3390/biom13020358

PMCID:: PMC9953631

Abstract Article PDF–1.9M

Select item 87489585.

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing

Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6

PMCID:: PMC8748958

Abstract Article PDF–3.0M

Select item 85783906.

ISL1 promotes enzalutamide resistance in castration-resistant prostate cancer (CRPC) through epithelial to mesenchymal transition (EMT)

Jae Duck Choi, Tae Jin Kim, Byong Chang Jeong, Hwang Gyun Jeon, Seong Soo Jeon, Min Yong Kang, Seon Yong Yeom, Seong Il Seo

Sci Rep. 2021; 11: 21984. Published online 2021 Nov 9. doi: 10.1038/s41598-021-01003-0

PMCID:: PMC8578390

Abstract Article PDF–1.4M

Select item 82061287.

ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma

Mengzhen Li, Chengtao Sun, Xiaoyun Bu, Yi Que, Lian Zhang, Yu Zhang, Li Zhang, Suying Lu, Junting Huang, Jia Zhu, Juan Wang, Feifei Sun, Yizhuo Zhang

Cell Death Dis. 2021 Jun; 12(6): 620. Published online 2021 Jun 15. doi: 10.1038/s41419-021-03894-3

PMCID:: PMC8206128

Abstract Article PDF–7.0M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81234499.

Overexpression of Isl1 under the Pax2 Promoter, Leads to Impaired Sound Processing and Increased Inhibition in the Inferior Colliculus

Tetyana Chumak, Diana Tothova, Iva Filova, Zbynek Bures, Jiri Popelar, Gabriela Pavlinkova, Josef Syka

Int J Mol Sci. 2021 May; 22(9): 4507. Published online 2021 Apr 26. doi: 10.3390/ijms22094507

PMCID:: PMC8123449

Abstract Article PDF–3.5M

Select item 810619210.

Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer

Qiong Shi, Xiaomei Ni, Ming Lei, Quansong Xia, Yan Dong, Qiao Zhang, Weiping Wang

Mol Med. 2021; 27: 47. Published online 2021 May 7. doi: 10.1186/s10020-021-00302-6

PMCID:: PMC8106192

Abstract Article PDF–3.7M

Select item 800904811.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 796888612.

Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4

Ting Guo, Yan‐Hua Bai, Xiao‐Jing Cheng, Hai‐Bo Han, Hong Du, Ying Hu, Shu‐Qin Jia, Xiao‐Fang Xing, Jia‐Fu Ji

Cancer Commun (Lond) 2021 Mar; 41(3): 258–272. Published online 2021 Feb 11. doi: 10.1002/cac2.12141

PMCID:: PMC7968886

Abstract Article PDF–2.6M

Select item 795799413.

Association of ISL1 polymorphisms and eosinophilic levels among otitis media patients

Abhishek Kondyarpu, Chinmay Sundar Ray, Khirod Chandra Panda, Narayan Chandra Biswal, Puppala Venkat Ramchander

J Clin Lab Anal. 2021 Mar; 35(3): e23702. Published online 2021 Jan 21. doi: 10.1002/jcla.23702

PMCID:: PMC7957994

Abstract Article PDF–535K

Select item 789389114.

Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation

Emilia Solomon, Katie Davis-Anderson, Blake Hovde, Sofiya Micheva-Viteva, Jennifer Foster Harris, Scott Twary, Rashi Iyer

BMC Mol Cell Biol. 2021; 22: 13. Published online 2021 Feb 18. doi: 10.1186/s12860-021-00343-z

PMCID:: PMC7893891

Abstract Article PDF–1.5M

Select item 765465215.

Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors

Masood Sepehrimanesh, Baojin Ding

Am J Physiol Cell Physiol. 2020 Oct 1; 319(4): C771–C780. Published online 2020 Aug 12. doi: 10.1152/ajpcell.00279.2020

PMCID:: PMC7654652

Abstract Article

Select item 734350716.

microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway

Qin Sun, Jun Zeng, Yang Liu, JingYan Chen, Qing-Cui Zeng, Yan-Qiu Chen, Li-Li Tu, Ping Chen, Fan Yang, Min Zhang

Aging (Albany NY) 2020 Jun 30; 12(12): 11446–11465. Published online 2020 Jun 16. doi: 10.18632/aging.103230

PMCID:: PMC7343507

Abstract Article PDF–2.6M

Select item 716998317.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 695988418.

Correlations between ISL1 rs1017 polymorphism and congenital heart disease risk: A PRISMA-compliant meta-analysis

Zhaohong Ding, Wenke Yang, Kang Yi, Yunhan Ding, Dan Zhou, Xiaodong Xie, Tao You

Medicine (Baltimore) 2020 Jan; 99(2): e18715. Published online 2020 Jan 10. doi: 10.1097/MD.0000000000018715

PMCID:: PMC6959884

Abstract Article PDF–493K

Select item 679692619.

Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate

Rui Gao, Xingqun Liang, Sirisha Cheedipudi, Julio Cordero, Xue Jiang, Qingquan Zhang, Luca Caputo, Stefan Günther, Carsten Kuenne, Yonggang Ren, Shoumo Bhattacharya, Xuejun Yuan, Guillermo Barreto, Yihan Chen, Thomas Braun, Sylvia M. Evans, Yunfu Sun, Gergana Dobreva

Cell Res. 2019 Jun; 29(6): 486–501. Published online 2019 Apr 25. doi: 10.1038/s41422-019-0168-1

PMCID:: PMC6796926

Abstract Article PDF–6.5M

Select item 675013020.

Direct Nkx2‐5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity

Tatjana Dorn, Alexander Goedel, Jason T. Lam, Jessica Haas, Qinghai Tian, Franziska Herrmann, Karin Bundschu, Gergana Dobreva, Matthias Schiemann, Ralf Dirschinger, Yanchun Guo, Susanne J. Kühl, Daniel Sinnecker, Peter Lipp, Karl-Ludwig Laugwitz, Michael Kühl, Alessandra Moretti

Stem Cells. 2015 Apr; 33(4): 1113–1129. Published online 2015 Mar 24. doi: 10.1002/stem.1923

PMCID:: PMC6750130

Abstract Article PDF–1.3M

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