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Select item 111689071.

SLC34A2 promotes cell proliferation by activating STX17‐mediated autophagy in esophageal squamous cell carcinoma

Yi Xu, Shiyu Duan, Wen Ye, Zhousan Zheng, Jiaxing Zhang, Ying Gao, Sheng Ye

Thorac Cancer. 2024 Jun; 15(17): 1369–1384. Published online 2024 May 8. doi: 10.1111/1759-7714.15314

PMCID:: PMC11168907

Abstract Article PDF–8.9M

Select item 111525712.

Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation

Saori Shinoda, Yuji Sakai, Takahide Matsui, Masaaki Uematsu, Ikuko Koyama-Honda, Jun-ichi Sakamaki, Hayashi Yamamoto, Noboru Mizushima

eLife. 2024; 12: RP92189. Published online 2024 Jun 4. doi: 10.7554/eLife.92189

PMCID:: PMC11152571

Abstract Article PDF–5.5M

Select item 111333893.

Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation

Xinyue Cui, Bo Wang, Dongjian Han, Mengdie Cheng, Peiyu Yuan, Pengchong Du, Yachen Hou, Chang Su, Junnan Tang, Jinying Zhang

J Cell Mol Med. 2024 May; 28(10): e18402. Published online 2024 May 28. doi: 10.1111/jcmm.18402

PMCID:: PMC11133389

Abstract Article PDF–21M

Select item 109902774.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 103927395.

Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury

Yanping Li, Jingyuan Xu, Weiting Chen, Xingxing Wang, Zhibo Zhao, Yuqi Li, Linkun Zhang, Junkui Jiao, Qin Yang, Qiuying Ding, Ping Yang, Li Wei, Yao Chen, Yaxi Chen, Xiong Z. Ruan, Lei Zhao

Autophagy. 2023; 19(9): 2504–2519. Published online 2023 Apr 23. doi: 10.1080/15548627.2023.2196876

PMCID:: PMC10392739

Abstract Article PDF–8.0M

Select item 103167046.

ULK phosphorylation of STX17 controls autophagosome maturation via FLNA

Yufen Wang, Huilin Que, ChuangPeng Li, Zhe Wu, Fenglei Jian, Yuan Zhao, Haohao Tang, Yang Chen, Shuaixin Gao, Catherine C.L. Wong, Ying Li, Chongchong Zhao, Yueguang Rong

J Cell Biol. 2023 Aug 7; 222(8): e202211025. Published online 2023 Jun 30. doi: 10.1083/jcb.202211025

PMCID:: PMC10316704

Abstract Article PDF–13M

Select item 102409987.

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805

Yunpeng Bai, Guimei Yu, Hong-Ming Zhou, Ovini Amarasinghe, Yuan Zhou, Peipei Zhu, Qinglin Li, Lujuan Zhang, Frederick Nguele Meke, Yiming Miao, Eli Chapman, W. Andy Tao, Zhong-Yin Zhang

Autophagy. 2023; 19(5): 1562–1581. Published online 2022 Nov 7. doi: 10.1080/15548627.2022.2140558

PMCID:: PMC10240998

Abstract Article PDF–4.4M

Select item 94819338.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 92792859.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 866666510.

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre

iScience. 2021 Dec 17; 24(12): 103538. Published online 2021 Dec 1. doi: 10.1016/j.isci.2021.103538

PMCID:: PMC8666665

Abstract Article PDF–3.2M

Select item 866412911.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

Marcel Morgenstern, Christian D. Peikert, Philipp Lübbert, Ida Suppanz, Cinzia Klemm, Oliver Alka, Conny Steiert, Nataliia Naumenko, Alexander Schendzielorz, Laura Melchionda, Wignand W.D. Mühlhäuser, Bettina Knapp, Jakob D. Busch, Sebastian B. Stiller, Stefan Dannenmaier, Caroline Lindau, Mariya Licheva, Christopher Eickhorst, Riccardo Galbusera, Ralf M. Zerbes, Michael T. Ryan, Claudine Kraft, Vera Kozjak-Pavlovic, Friedel Drepper, Sven Dennerlein, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann, Bettina Warscheid

Cell Metab. 2021 Dec 7; 33(12): 2464–2483.e18. doi: 10.1016/j.cmet.2021.11.001

PMCID:: PMC8664129

Abstract Article

Select item 859151112.

Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi

Jannis Schoppe, Evelyn Schubert, Amir Apelbaum, Erdal Yavavli, Oliver Birkholz, Heike Stephanowitz, Yaping Han, Angela Perz, Oliver Hofnagel, Fan Liu, Jacob Piehler, Stefan Raunser, Christian Ungermann

J Biol Chem. 2021 Nov; 297(5): 101334. Published online 2021 Oct 22. doi: 10.1016/j.jbc.2021.101334

PMCID:: PMC8591511

Abstract Article PDF–4.7M

Select item 855290713.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 834253114.

BRUCE silencing leads to axonal dystrophy by repressing autophagosome-lysosome fusion in Alzheimer’s disease

Lu Zhang, Yu Fang, Xinyu Zhao, Yake Zheng, Yunqing Ma, Shuang Li, Zhi Huang, Lihao Li

Transl Psychiatry. 2021; 11: 421. Published online 2021 Aug 5. doi: 10.1038/s41398-021-01427-2

PMCID:: PMC8342531

Abstract Article PDF–2.4M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 814322216.

Acetylation of STX17 (syntaxin 17) controls autophagosome maturation

Qiuhong Shen, Yin Shi, Jiaqi Liu, Hua Su, Jingtao Huang, Yi Zhang, Chao Peng, Tianhua Zhou, Qiming Sun, Wei Wan, Wei Liu

Autophagy. 2021; 17(5): 1157–1169. Published online 2020 Apr 15. doi: 10.1080/15548627.2020.1752471

PMCID:: PMC8143222

Abstract Article PDF–4.9M

Select item 785526917.

A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress

Kavisha Arora, Pramodha Liyanage, Qing Zhong, Anjaparavanda P. Naren

FASEB J. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: FASEB J. 2021 Feb; 35(2): e21185. Published online 2020 Nov 15. doi: 10.1096/fj.201903210R

PMCID:: PMC7855269

Abstract Article PDF–1.0M

Select item 783223518.

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

Guangyan Miao, Hongyu Zhao, Yan Li, Mingming Ji, Yong Chen, Yi Shi, Yuhai Bi, Peihui Wang, Hong Zhang

Dev Cell. 2021 Feb 22; 56(4): 427–442.e5. Published online 2020 Dec 16. doi: 10.1016/j.devcel.2020.12.010

PMCID:: PMC7832235

Abstract Article PDF–5.9M

Select item 747469819.

Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome–lysosome fusion

Ying Li, Xiaofang Cheng, Miao Li, Yingli Wang, Tao Fu, Zixuan Zhou, Yaru Wang, Xinyu Gong, Xiaolong Xu, Jianping Liu, Lifeng Pan

Proc Natl Acad Sci U S A. 2020 Sep 1; 117(35): 21391–21402. Published online 2020 Aug 19. doi: 10.1073/pnas.2006997117

PMCID:: PMC7474698

Abstract Article PDF–2.6M

Select item 727904920.

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired

Marioara Chiritoiu, Gabriela N. Chiritoiu, Cristian V. A. Munteanu, Florin Pastrama, N. Erwin Ivessa, Stefana M. Petrescu

Int J Mol Sci. 2020 May; 21(10): 3468. Published online 2020 May 14. doi: 10.3390/ijms21103468

PMCID:: PMC7279049

Abstract Article PDF–12M

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