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Items: 1 to 20 of 72

1.
Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency
Sarah Aminov, Orsi Giricz, David T. Melnekoff, R. Alejandro Sica, Veronika Polishchuk, Cristian Papazoglu, Bonnie Yates, Hao-Wei Wang, Srabani Sahu, Yanhua Wang, Shanisha Gordon-Mitchell, Violetta V. Leshchenko, Carolina Schinke, Kith Pradhan, Srinivas Aluri, Moah Sohn, Stefan K. Barta, Beamon Agarwal, Mendel Goldfinger, Ioannis Mantzaris, Aditi Shastri, William Matsui, Ulrich Steidl, Joshua D. Brody, Nirali N. Shah, Samir Parekh, Amit Verma
J Clin Invest. 2024 Apr 15; 134(8): e175199. Published online 2024 Feb 20. doi: 10.1172/JCI175199
PMCID:
PMC11014656
AbstractArticlePDF–1.5M
2.
Host B cells escape CAR-T immunotherapy by reversible downregulation of CD19
Sara Fioretti, Courtney A. Matson, Kenneth M. Rosenberg, Nevil J. Singh
Cancer Immunol Immunother. 2023 Jan; 72(1): 257–264. Published online 2022 Jun 26. doi: 10.1007/s00262-022-03231-3
PMCID:
PMC10608797
AbstractArticlePDF–3.0M
3.
Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia
Nathaniel D. Anderson, Jack Birch, Theo Accogli, Ignacio Criado, Eleonora Khabirova, Conor Parks, Yvette Wood, Matthew D. Young, Tarryn Porter, Rachel Richardson, Sarah J. Albon, Bilyana Popova, Andre Lopes, Robert Wynn, Rachael Hough, Satyen H. Gohil, Martin Pule, Persis J. Amrolia, Sam Behjati, Sara Ghorashian
Nat Med. 2023; 29(7): 1700–1709. Published online 2023 Jul 6. doi: 10.1038/s41591-023-02415-3
PMCID:
PMC10353931
AbstractArticlePDF–7.3M
4.
Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function
Isabel Leung, Megan L. Templeton, Yun Lo, Anusha Rajan, Sylvia M. Stull, Sarah M. Garrison, Alexander I. Salter, Kimberly S. Smythe, Colin E. Correnti, Shivani Srivastava, Cecilia C. S. Yeung, Stanley R. Riddell
Blood Adv. 2023 Jun 27; 7(12): 2718–2730. Published online 2022 Dec 7. doi: 10.1182/bloodadvances.2022008559
PMCID:
PMC10275707
AbstractArticlePDF–1.6M
5.
ROR1/CD19 receptor complex promotes growth of mantle cell lymphoma cells independently of the B Cell Receptor-BTK signaling pathway
Qian Zhang, Hong Y Wang, Xiaobin Liu, Selene Nunez-Cruz, Mowafaq Jillab, Olga Melnikov, Kavindra Nath, Jerry Glickson, Mariusz A Wasik
J Immunol. Author manuscript; available in PMC 2023 Mar 14.
Published in final edited form as: J Immunol. 2019 Oct 15; 203(8): 2043–2048. Published online 2019 Sep 18. doi: 10.4049/jimmunol.1801327
PMCID:
PMC10013414
AbstractArticlePDF–808K
6.
CD19+ B cell values predict the increase of anti-SARS CoV2 antibodies in fingolimod-treated and COVID-19-vaccinated patients with multiple sclerosis
Irene Schiavetti, Lucrezia Barcellini, Caterina Lapucci, Francesco Tazza, Maria Cellerino, Elisabetta Capello, Diego Franciotta, Matilde Inglese, Maria Pia Sormani, Antonio Uccelli, Alice Laroni
Mult Scler Relat Disord. 2023 Feb; 70: 104494. Published online 2022 Dec 30. doi: 10.1016/j.msard.2022.104494
PMCID:
PMC9800324
AbstractArticlePDF–958K
7.
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia
Matthew T. Witkowski, Soobeom Lee, Eric Wang, Anna K. Lee, Alexis Talbot, Chao Ma, Nikolaos Tsopoulidis, Justin Brumbaugh, Yaqi Zhao, Kathryn G. Roberts, Simon J. Hogg, Sofia Nomikou, Yohana Ghebrechristos, Palaniraja Thandapani, Charles G. Mullighan, Konrad Hochedlinger, Weiqiang Chen, Omar Abdel-Wahab, Justin Eyquem, Iannis Aifantis
Nat Immunol. Author manuscript; available in PMC 2023 Apr 1.
Published in final edited form as: Nat Immunol. 2022 Oct; 23(10): 1424–1432. Published online 2022 Sep 22. doi: 10.1038/s41590-022-01314-y
PMCID:
PMC9611506
AbstractArticlePDF–5.2M
8.
Identification of genomic signatures in bone marrow associated with clinical response of CD19 CAR T-cell therapy
Lipei Shao, Avinash Iyer, Yingdong Zhao, Rob Somerville, Sandhya Panch, Alejandra Pelayo, David F. Stroncek, Ping Jin
Sci Rep. 2022; 12: 2830. Published online 2022 Feb 18. doi: 10.1038/s41598-022-06830-3
PMCID:
PMC8857276
AbstractArticlePDF–3.4M
9.
CD19 CAR-T cell treatment conferred sustained remission in B-ALL patients with minimal residual disease
Wenyi Lu, Yunxiong Wei, Yaqing Cao, Xia Xiao, Qing Li, Hairong Lyu, Yili Jiang, Huan Zhang, Xin Li, Yanyu Jiang, Juanxia Meng, Ting Yuan, Haibo Zhu, Xiaoyuan He, Xin Jin, Rui Sun, Tao Sui, Kaiqi Liu, Mingfeng Zhao
Cancer Immunol Immunother. 2021 Dec; 70(12): 3501–3511. Published online 2021 Apr 25. doi: 10.1007/s00262-021-02941-4
PMCID:
PMC8571234
AbstractArticlePDF–1.2M
10.
CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial
Shaun Cordoba, Shimobi Onuoha, Simon Thomas, Daniela Soriano Pignataro, Rachael Hough, Sara Ghorashian, Ajay Vora, Denise Bonney, Paul Veys, Kanchan Rao, Giovanna Lucchini, Robert Chiesa, Jan Chu, Liz Clark, Mei Mei Fung, Koval Smith, Carlotta Peticone, Muhammad Al-Hajj, Vania Baldan, Mathieu Ferrari, Saket Srivastava, Ram Jha, Frederick Arce Vargas, Kevin Duffy, William Day, Paul Virgo, Lucy Wheeler, Jeremy Hancock, Farzin Farzaneh, Sabine Domning, Yiyun Zhang, Nushmia Z. Khokhar, Vijay G. R. Peddareddigari, Robert Wynn, Martin Pule, Persis J. Amrolia
Nat Med. 2021; 27(10): 1797–1805. Published online 2021 Oct 12. doi: 10.1038/s41591-021-01497-1
PMCID:
PMC8516648
AbstractArticlePDF–7.9M
11.
CD19 target evasion as a mechanism of relapse in large B-cell lymphoma treated with axicabtagene ciloleucel
Vicki Plaks, John M. Rossi, Justin Chou, Linghua Wang, Soumya Poddar, Guangchun Han, Zixing Wang, Shao-Qing Kuang, Fuliang Chu, Richard E. Davis, Francisco Vega, Zahid Bashir, Caron A. Jacobson, Frederick L. Locke, Patrick M. Reagan, Scott J. Rodig, Lazaros J. Lekakis, Ian W. Flinn, David B. Miklos, Adrian Bot, Sattva S. Neelapu
Blood. 2021 Sep 23; 138(12): 1081–1085. Prepublished online 2021 May 27. doi: 10.1182/blood.2021010930
PMCID:
PMC8462361
Article
12.
SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
Yukai Jing, Li Luo, Ying Chen, Lisa S. Westerberg, Peng Zhou, Zhiping Xu, Andrés A. Herrada, Chan-Sik Park, Masato Kubo, Heng Mei, Yu Hu, Pamela Pui-Wah Lee, Bing Zheng, Zhiwei Sui, Wei Xiao, Quan Gong, Zhongxin Lu, Chaohong Liu
Signal Transduct Target Ther. 2021; 6: 345. Published online 2021 Sep 22. doi: 10.1038/s41392-021-00749-3
PMCID:
PMC8456405
AbstractArticlePDF–6.1M
13.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
14.
Cryo-EM Structure of the B Cell Co-receptor CD19 Bound to the Tetraspanin CD81
Katherine J. Susa, Shaun Rawson, Andrew C. Kruse, Stephen C. Blacklow
Science. Author manuscript; available in PMC 2021 May 15.
Published in final edited form as: Science. 2021 Jan 15; 371(6526): 300–305. doi: 10.1126/science.abd9836
PMCID:
PMC8111558
AbstractArticlePDF–946K
15.
Early Recovery of Circulating Immature B Cells in B-Lymphoblastic Leukemia Patients after CD19 Targeted CAR T Cell Therapy: A Pitfall for Minimal Residual Disease Detection
Wenbin Xiao, Dalia Salem, Catharine S. McCoy, Daniel Lee, Nirali N. Shah, Maryalice Stetler-Stevenson, Constance M. Yuan
Cytometry B Clin Cytom. Author manuscript; available in PMC 2021 Apr 23.
Published in final edited form as: Cytometry B Clin Cytom. 2018 May; 94(3): 434–443. Published online 2017 Oct 31. doi: 10.1002/cyto.b.21591
PMCID:
PMC8064034
AbstractArticlePDF–1.2M
16.
Frequency of IL-10+CD19+ B cells in patients with prostate cancer compared to patients with benign prostatic hyperplasia
Nazmabadi Roya, Taheri Fatemeh, Mohammad-Alibeigi Faramarz, Sabzevary-Ghahfarokhi Milad, Sanaei Mohammad-Javad, Salehi-Vanani Najmeh, Mirzaei Yousef, Bagheri Nader
Afr Health Sci. 2020 Sep; 20(3): 1264–1272. doi: 10.4314/ahs.v20i3.31
PMCID:
PMC7751534
AbstractArticlePDF–448K
17.
CD9 Is a Very Helpful Marker for Discriminating AML-M3 from HLA-DR-Negative Non-M3 AML
Esmaeil Shahabi Satlsar, Mohammad Mosleh, Mahdieh Mehrpouri
Turk J Haematol. 2020 Dec; 37(4): 287–289. Published online 2020 Nov 19. doi: 10.4274/tjh.galenos.2020.2020.0110
PMCID:
PMC7702646
ArticlePDF–377K
18.
TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy
Nuoyan Zheng, Kaifeng Xie, Hongjian Ye, Yu Dong, Bing Wang, Ning Luo, Jinjin Fan, Jiaqing Tan, Wei Chen, Xueqing Yu
JCI Insight. 2020 Jul 23; 5(14): e136965. Published online 2020 Jul 23. doi: 10.1172/jci.insight.136965
PMCID:
PMC7453916
AbstractArticlePDF–9.8M
19.
A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking
Katherine J Susa, Tom CM Seegar, Stephen C Blacklow, Andrew C Kruse
eLife. 2020; 9: e52337. Published online 2020 Apr 27. doi: 10.7554/eLife.52337
PMCID:
PMC7228769
AbstractArticlePDF–3.4M
20.
Mismatched related vs matched unrelated donors in TCRαβ/CD19-depleted HSCT for primary immunodeficiencies
Alexandra Laberko, Elvira Sultanova, Elena Gutovskaya, Irina Shipitsina, Larisa Shelikhova, Elena Kurnikova, Yakov Muzalevskii, Alexei Kazachenok, Dmitriy Pershin, Kirill Voronin, Anna Shcherbina, Michael Maschan, Alexey Maschan, Dmitry Balashov
Blood. 2019 Nov 14; 134(20): 1755–1763. Prepublished online 2019 Sep 26. doi: 10.1182/blood.2019001757
PMCID:
PMC6856988
AbstractArticle

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