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Select item 114057551.

Contribution of A1 to macrophage survival in cooperation with MCL-1 and BCL-X_L in a murine cell model of myeloid differentiation

Juliane Vier, Georg Häcker, Susanne Kirschnek

Cell Death Dis. 2024 Sep; 15(9): 677. Published online 2024 Sep 16. doi: 10.1038/s41419-024-07064-z

PMCID:: PMC11405755

Abstract Article PDF–904K

Select item 103078522.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 73031763.

The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils

Robyn L. Schenk, Lahiru Gangoda, Kate E. Lawlor, Lorraine A. O’Reilly, Andreas Strasser, Marco J. Herold

Cell Death Dis. 2020 Jun; 11(6): 474. Published online 2020 Jun 18. doi: 10.1038/s41419-020-2676-9

PMCID:: PMC7303176

Article PDF–571K

Select item 58642404.

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells

Mark Mensink, Natasha S. Anstee, Mikara Robati, Robyn L. Schenk, Marco J. Herold, Suzanne Cory, Cassandra J. Vandenberg

Cell Death Differ. 2018 Apr; 25(4): 795–806. Published online 2018 Jan 16. doi: 10.1038/s41418-017-0045-8

PMCID:: PMC5864240

Abstract Article PDF–982K

Select item 54252545.

Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection

Alexander M Price, Joanne Dai, Quentin Bazot, Luv Patel, Pavel A Nikitin, Reza Djavadian, Peter S Winter, Cristina A Salinas, Ashley Perkins Barry, Kris C Wood, Eric C Johannsen, Anthony Letai, Martin J Allday, Micah A Luftig

eLife. 2017; 6: e22509. Published online 2017 Apr 20. doi: 10.7554/eLife.22509

PMCID:: PMC5425254

Abstract Article PDF–3.0M

Select item 54231126.

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David CS Huang, Andreas Strasser, Suzanne Cory, Marco J Herold, Andrew M Lew

Cell Death Differ. 2017 May; 24(5): 878–888. Published online 2017 Mar 31. doi: 10.1038/cdd.2017.30

PMCID:: PMC5423112

Abstract Article PDF–862K

Select item 53957007.

MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis

M Sochalska, F Schuler, J G Weiss, M Prchal-Murphy, V Sexl, A Villunger

Oncogene. 2017 Apr; 36(15): 2066–2073. Published online 2016 Oct 3. doi: 10.1038/onc.2016.362

PMCID:: PMC5395700

Abstract Article PDF–2.1M

Select item 53834478.

Constitutive expression of the anti‐apoptotic Bcl‐2 family member A1 in murine endothelial cells leads to transplant tolerance

L. A. Smyth, L. Meader, F. Xiao, M. Woodward, H. J. M. Brady, R. Lechler, G. Lombardi

Clin Exp Immunol. 2017 May; 188(2): 219–225. Published online 2017 Mar 2. doi: 10.1111/cei.12931

PMCID:: PMC5383447

Abstract Article PDF–302K

Select item 53442139.

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment

Robyn L Schenk, Selma Tuzlak, Emma M Carrington, Yifan Zhan, Susanne Heinzel, Charis E Teh, Daniel H Gray, Lin Tai, Andrew M Lew, Andreas Villunger, Andreas Strasser, Marco J Herold

Cell Death Differ. 2017 Mar; 24(3): 534–545. Published online 2017 Jan 13. doi: 10.1038/cdd.2016.156

PMCID:: PMC5344213

Abstract Article PDF–3.8M

Select item 534421210.

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection

Selma Tuzlak, Robyn L Schenk, Ajithkumar Vasanthakumar, Simon P Preston, Manuel D Haschka, Dimitra Zotos, Axel Kallies, Andreas Strasser, Andreas Villunger, Marco J Herold

Cell Death Differ. 2017 Mar; 24(3): 523–533. Published online 2017 Jan 13. doi: 10.1038/cdd.2016.155

PMCID:: PMC5344212

Abstract Article PDF–1.7M

Select item 498663511.

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival

M Sochalska, E Ottina, S Tuzlak, S Herzog, M Herold, A Villunger

Cell Death Differ. 2016 Apr; 23(4): 628–639. Published online 2015 Oct 9. doi: 10.1038/cdd.2015.130

PMCID:: PMC4986635

Abstract Article PDF–4.1M

Select item 497021312.

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA

Xiaoyun Liu, Yan Jiao, Yanhong Cao, Nan Deng, Yonghui Ma, Karen A. Hasty, Andrew Kang, Hong Chen, John M. Stuart, Weikuan Gu

BMC Immunol. 2016; 17: 25. Published online 2016 Aug 2. doi: 10.1186/s12865-016-0163-y

PMCID:: PMC4970213

Abstract Article PDF–2.5M

Select item 495111113.

Selective Impairment of T_H17-Differentiation and Protection against Autoimmune Arthritis after Overexpression of BCL2A1 in T Lymphocytes

Marcos Iglesias, Juan Jesús Augustin, Pilar Alvarez, Inés Santiuste, Jorge Postigo, Jesús Merino, Ramón Merino

PLoS One. 2016; 11(7): e0159714. Published online 2016 Jul 19. doi: 10.1371/journal.pone.0159714

PMCID:: PMC4951111

Abstract Article PDF–2.7M

Select item 456236514.

Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy

Maja Sochalska, Selma Tuzlak, Alexander Egle, Andreas Villunger

FEBS J. Author manuscript; available in PMC 2015 Sep 8.

Published in final edited form as: FEBS J. 2015 Mar; 282(5): 834–849. Published online 2015 Jan 23. doi: 10.1111/febs.13188

PMCID:: PMC4562365

Abstract Article PDF–899K

Select item 446788615.

5,10-Methenyltetrahydrofolate Synthetase Activity is Increased in Tumors and Modifies the Efficacy of Antipurine LY309887

Martha S. Field, Montserrat C. Anguera, Rodney Page, Patrick J. Stover

Arch Biochem Biophys. Author manuscript; available in PMC 2015 Jun 15.

Published in final edited form as: Arch Biochem Biophys. 2009 Jan 15; 481(2): 145–150. Published online 2008 Nov 8. doi: 10.1016/j.abb.2008.11.001

PMCID:: PMC4467886

Abstract Article PDF–275K

Select item 429812616.

Knockdown of the Antiapoptotic Bcl-2 Family Member A1/Bfl-1 Protects Mice from Anaphylaxis

Eleonora Ottina, Katarina Lyberg, Maja Sochalska, Andreas Villunger, Gunnar P. Nilsson

J Immunol. 2015 Feb 1; 194(3): 1316–1322. Published online 2014 Dec 29. doi: 10.4049/jimmunol.1400637

PMCID:: PMC4298126

Abstract Article PDF–972K

Select item 357241017.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 356837218.

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration

Stephen Lumayag, Caroline E. Haldin, Nicola J. Corbett, Karl J. Wahlin, Colleen Cowan, Sanja Turturro, Peter E. Larsen, Beatrix Kovacs, P. Dane Witmer, David Valle, Donald J. Zack, Daniel A. Nicholson, Shunbin Xu

Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6): E507–E516. Published online 2013 Jan 22. doi: 10.1073/pnas.1212655110

PMCID:: PMC3568372

Abstract Article PDF–2.1M

Select item 348407219.

BCL2A1a Over-Expression in Murine Hematopoietic Stem and Progenitor Cells Decreases Apoptosis and Results in Hematopoietic Transformation

Jean-Yves Métais, Thomas Winkler, Julia T. Geyer, Rodrigo T. Calado, Peter D. Aplan, Michael A. Eckhaus, Cynthia E. Dunbar

PLoS One. 2012; 7(10): e48267. Published online 2012 Oct 30. doi: 10.1371/journal.pone.0048267

PMCID:: PMC3484072

Abstract Article PDF–894K

Select item 341876920.

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

Eleonora Ottina, Francesca Grespi, Denise Tischner, Claudia Soratroi, Stephan Geley, Andreas Ploner, Holger M. Reichardt, Andreas Villunger, Marco J. Herold

Blood. 2012 Jun 21; 119(25): 6032–6042. Prepublished online 2012 May 11. doi: 10.1182/blood-2011-12-399089