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Items: 1 to 20 of 72

1.
Activity of a novel Aurora kinase inhibitor against the T315I mutant form of BCR‐ABL: In vitro and in vivo studies
Daigo Akahane, Tetsuzo Tauchi, Seiichi Okabe, Kousuke Nunoda, Kazuma Ohyashiki
Cancer Sci. 2008 Jun; 99(6): 1251–1257. Published online 2008 Apr 21. doi: 10.1111/j.1349-7006.2008.00810.x
PMCID:
PMC11158598
AbstractArticlePDF–451K
2.
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility
Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao
Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5
PMCID:
PMC10307852
AbstractArticlePDF–8.8M
3.
Mapping Brain Gene Coexpression in Daytime Transcriptomes Unveils Diurnal Molecular Networks and Deciphers Perturbation Gene Signatures
Nan Wang, Peter Langfelder, Matthew Stricos, Lalini Ramanathan, Jeffrey B. Richman, Raymond Vaca, Mary Plascencia, Xiaofeng Gu, Shasha Zhang, T. Katherine Tamai, Liguo Zhang, Fuying Gao, Koliane Ouk, Xiang Lu, Leonya Ivanov, Tom Vogt, Qing Richard Lu, A. Jennifer Morton, Christopher Colwell, Jeffrey S. Aaronson, Jim Rosinski, Steve Horvath, X. William Yang
Neuron. Author manuscript; available in PMC 2023 Oct 19.
Published in final edited form as: Neuron. 2022 Oct 19; 110(20): 3318–3338.e9. doi: 10.1016/j.neuron.2022.09.028
PMCID:
PMC9665885
AbstractArticlePDF–4.5M
4.
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3
Corina M. Borza, Gema Bolas, Fabian Bock, Xiuqi Zhang, Favour C. Akabogu, Ming-Zhi Zhang, Mark de Caestecker, Min Yang, Haichun Yang, Ethan Lee, Leslie Gewin, Agnes B. Fogo, W. Hayes McDonald, Roy Zent, Ambra Pozzi
JCI Insight. 2022 Feb 8; 7(3): e150887. Published online 2022 Feb 8. doi: 10.1172/jci.insight.150887
PMCID:
PMC8855801
AbstractArticlePDF–12M
5.
IFITM3 functions as PIP3-scaffold to amplify PI3K signaling in B-cells
Jaewoong Lee, Mark E. Robinson, Ning Ma, Dewan Artadji, Mohamed A. Ahmed, Gang Xiao, Teresa Sadras, Gauri Deb, Janet Winchester, Kadriye Nehir Cosgun, Huimin Geng, Lai N. Chan, Kohei Kume, Teemu P. Miettinen, Ye Zhang, Matthew A. Nix, Lars Klemm, Chun Wei Chen, Jianjun Chen, Vishal Khairnar, Arun P. Wiita, Andrei Thomas-Tikhonenko, Michael Farzan, Jae U. Jung, David M. Weinstock, Scott R. Manalis, Michael S. Diamond, Nagarajan Vaidehi, Markus Müschen
Nature. Author manuscript; available in PMC 2021 May 4.
Published in final edited form as: Nature. 2020 Dec; 588(7838): 491–497. Published online 2020 Nov 4. doi: 10.1038/s41586-020-2884-6
PMCID:
PMC8087162
AbstractArticlePDF–6.5M
6.
CRISPR/CAS9-mediated knockout of Abi1 inhibits p185Bcr-Abl-induced leukemogenesis and signal transduction to ERK and PI3K/Akt pathways
James Faulkner, Peixin Jiang, Delaney Farris, Ryan Walker, Zonghan Dai
J Hematol Oncol. 2020; 13: 34. Published online 2020 Apr 10. doi: 10.1186/s13045-020-00867-5
PMCID:
PMC7147029
AbstractArticlePDF–2.2M
7.
The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest
Joseph G Duman, Shalaka Mulherkar, Yen-Kuei Tu, Kelly C Erikson, Christopher P Tzeng, Vasilis C Mavratsas, Tammy Szu-Yu Ho, Kimberley F Tolias
eLife. 2019; 8: e47566. Published online 2019 Aug 28. doi: 10.7554/eLife.47566
PMCID:
PMC6713510
AbstractArticlePDF–3.4M
8.
TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections
Hannah P Savage, Kathrin Kläsener, Fauna L Smith, Zheng Luo, Michael Reth, Nicole Baumgarth
eLife. 2019; 8: e46997. Published online 2019 Aug 21. doi: 10.7554/eLife.46997
PMCID:
PMC6703853
AbstractArticlePDF–4.5M
9.
Loss of the BCR-FGFR1 GEF domain suppresses RHOA activation and enhances B-lymphomagenesis in mice.
Tianxiang Hu, Yating Chong, Sumin Lu, Haiyan Qin, Mingqiang Ren, Natasha M Savage, Chang-Sheng Chang, John K Cowell
Cancer Res. Author manuscript; available in PMC 2020 Jan 1.
Published in final edited form as: Cancer Res. 2019 Jan 1; 79(1): 114–124. Published online 2018 Nov 9. doi: 10.1158/0008-5472.CAN-18-1889
PMCID:
PMC6484845
AbstractArticlePDF–1.8M
10.
Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation
Xiao Yong Yang, Robert E Stanley, Adam P Ross, Aaron M Robitaille, John A Gray, Benjamin N R Cheyette
Cereb Cortex. 2019 Feb; 29(2): 505–516. Published online 2017 Dec 26. doi: 10.1093/cercor/bhx333
Correction in:
Cereb Cortex. 2019 Mar; 29(3): 1217.
PMCID:
PMC6319175
AbstractArticlePDF–1.0M
11.
Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders
Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba
Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.
Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594
PMCID:
PMC5645082
AbstractArticlePDF–2.3M
12.
Metabolic gatekeeper function of B-lymphoid transcription factors
Lai N. Chan, Zhengshan Chen, Daniel Braas, Jae-Woong Lee, Gang Xiao, Huimin Geng, Kadriye Nehir Cosgun, Christian Hurtz, Seyedmehdi Shojaee, Valeria Cazzaniga, Hilde Schjerven, Thomas Ernst, Andreas Hochhaus, Steven M. Kornblau, Marina Konopleva, Miles A. Pufall, Giovanni Cazzaniga, Grace J. Liu, Thomas A. Milne, H. Philip Koeffler, Theodora S. Ross, Isidro Sanchez-Garcia, Arndt Borkhardt, Keith R. Yamamoto, Ross A. Dickins, Thomas G. Graeber, Markus Müschen
Nature. Author manuscript; available in PMC 2017 Sep 29.
Published in final edited form as: Nature. 2017 Feb 23; 542(7642): 479–483. Published online 2017 Feb 13. doi: 10.1038/nature21076
PMCID:
PMC5621518
AbstractArticlePDF–5.0M
13.
Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction
Andrew C. Hiday, Michael C. Edler, Asma B. Salek, Cameron W. Morris, Morrent Thang, Tyler J. Rentz, Kristie L. Rose, Lisa M. Jones, Anthony J. Baucum, II
Neural Plast. 2017; 2017: 4153076. Published online 2017 May 28. doi: 10.1155/2017/4153076
PMCID:
PMC5467389
AbstractArticlePDF–3.2M
14.
The Proximal Signaling Network of the BCR-ABL1 Oncogene Shows a Modular Organization
Björn Titz, Tracey Low, Evangelia Komisopoulou, Sharon S Chen, Liudmilla Rubbi, Thomas G Graeber
Oncogene. Author manuscript; available in PMC 2017 Feb 14.
Published in final edited form as: Oncogene. 2010 Nov 4; 29(44): 5895–5910. Published online 2010 Aug 9. doi: 10.1038/onc.2010.331
PMCID:
PMC5308218
AbstractArticlePDF–3.8M
15.
Regulation of Synaptic Rac1 Activity, Long-Term Potentiation Maintenance, and Learning and Memory by BCR and ABR Rac GTPase-Activating Proteins
Daeyoung Oh, Seungnam Han, Jinsoo Seo, Jae-Ran Lee, Jeonghoon Choi, John Groffen, Karam Kim, Yi Sul Cho, Han-Saem Choi, Hyewon Shin, Jooyeon Woo, Hyejung Won, Soon Kwon Park, Soo-Young Kim, Jihoon Jo, Daniel J. Whitcomb, Kwangwook Cho, Hyun Kim, Yong Chul Bae, Nora Heisterkamp, Se-Young Choi, Eunjoon Kim
J Neurosci. 2010 Oct 20; 30(42): 14134–14144. doi: 10.1523/JNEUROSCI.1711-10.2010
PMCID:
PMC5076888
AbstractArticlePDF–3.3M
16.
BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma
M J Carter, K L Cox, S J Blakemore, Y D Bogdanov, L Happo, C L Scott, A Strasser, G K Packham, M S Cragg
Cell Death Differ. 2016 Feb; 23(2): 303–312. Published online 2015 Jul 17. doi: 10.1038/cdd.2015.97
PMCID:
PMC4716310
AbstractArticlePDF–2.2M
17.
UV Differentially Induces Oxidative Stress, DNA Damage and Apoptosis in BCR-ABL1-Positive Cells Sensitive and Resistant to Imatinib
Ewelina Synowiec, Grazyna Hoser, Katarzyna Wojcik, Elzbieta Pawlowska, Tomasz Skorski, Janusz Błasiak
Int J Mol Sci. 2015 Aug; 16(8): 18111–18128. Published online 2015 Aug 5. doi: 10.3390/ijms160818111
PMCID:
PMC4581238
AbstractArticlePDF–1.6M
18.
In Vivo Imaging of Bcr-Abl Overexpressing Tumors with a Radiolabeled Imatinib Analog as an Imaging Surrogate for Imatinib
Athanasios P. Glekas, Nagavara Kishore Pillarsetty, Blesida Punzalan, Nahida Khan, Peter Smith-Jones, Steven M. Larson
J Nucl Med. Author manuscript; available in PMC 2015 May 13.
Published in final edited form as: J Nucl Med. 2011 Aug; 52(8): 1301–1307. Published online 2011 Jul 15. doi: 10.2967/jnumed.110.085050
PMCID:
PMC4429778
AbstractArticlePDF–582K
19.
PDZK1 Prevents Neointima Formation via Suppression of Breakpoint Cluster Region Kinase in Vascular Smooth Muscle
Wan Ru Lee, Anastasia Sacharidou, Erica Behling-Kelly, Sarah C. Oltmann, Weifei Zhu, Mohamed Ahmed, Robert D. Gerard, David Y. Hui, Jun-ichi Abe, Philip W. Shaul, Chieko Mineo
PLoS One. 2015; 10(4): e0124494. Published online 2015 Apr 17. doi: 10.1371/journal.pone.0124494
PMCID:
PMC4401672
AbstractArticlePDF–5.8M
20.
Huntingtin-Associated Protein 1 Interacts with Breakpoint Cluster Region Protein to Regulate Neuronal Differentiation
Pai-Tsang Huang, Chien-Ho Chen, I-Uen Hsu, Shaima’a Ahmad Salim, Shu-Huei Kao, Chao-Wen Cheng, Chang-Hao Lai, Cheng-Fan Lee, Yung-Feng Lin
PLoS One. 2015; 10(2): e0116372. Published online 2015 Feb 11. doi: 10.1371/journal.pone.0116372
PMCID:
PMC4324908
AbstractArticlePDF–1.8M

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