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Select item 102286421.

Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice

Rachel H. McMahan, Holly J. Hulsebus, Kevin M. Najarro, Lauren E. Giesy, Daniel N. Frank, Elizabeth J. Kovacs

Alcohol. Author manuscript; available in PMC 2023 May 30.

Published in final edited form as: Alcohol. 2023 Mar; 107: 136–143. Published online 2022 Sep 21. doi: 10.1016/j.alcohol.2022.08.011

PMCID:: PMC10228642

Abstract Article PDF–1.0M

Select item 90325222.

Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in the ApoE^−/− Mouse Model

Natalie Längst, Julia Adler, Anna Kuret, Andreas Peter, Peter Ruth, Karsten Boldt, Robert Lukowski

Cells. 2022 Apr; 11(8): 1364. Published online 2022 Apr 17. doi: 10.3390/cells11081364

PMCID:: PMC9032522

Abstract Article PDF–5.4M

Select item 88944893.

Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8^+/− mouse model of ASD-like behavior

You Yu, Bing Zhang, Peifeng Ji, Zhenqiang Zuo, Yongxi Huang, Ning Wang, Chang Liu, Shuang-Jiang Liu, Fangqing Zhao

Nat Commun. 2022; 13: 1151. Published online 2022 Mar 3. doi: 10.1038/s41467-022-28746-2

PMCID:: PMC8894489

Abstract Article PDF–3.1M

Select item 85706914.

IFN-γ mediates Paneth cell death via suppression of mTOR

Alessandra Araujo, Alexandra Safronova, Elise Burger, Américo López-Yglesias, Shilpi Giri, Ellie T Camanzo, Andrew T Martin, Sergei Grivennikov, Felix Yarovinsky

eLife. 2021; 10: e60478. Published online 2021 Oct 11. doi: 10.7554/eLife.60478

PMCID:: PMC8570691

Abstract Article PDF–14M

Select item 81924975.

Western Diet Induces Paneth Cell Defects through Microbiome Alterations and Farnesoid X Receptor and Type I Interferon Activation

Ta-Chiang Liu, Justin T. Kern, Umang Jain, Naomi M. Sonnek, Shanshan Xiong, Katherine F. Simpson, Kelli L. VanDussen, Emma S. Winkler, Talin Haritunians, Atika Malique, Qiuhe Lu, Yo Sasaki, Chad Storer, Michael S. Diamond, Richard D. Head, Dermot P.B. McGovern, Thaddeus S. Stappenbeck

Cell Host Microbe. Author manuscript; available in PMC 2022 Jun 9.

Published in final edited form as: Cell Host Microbe. 2021 Jun 9; 29(6): 988–1001.e6. Published online 2021 May 18. doi: 10.1016/j.chom.2021.04.004

PMCID:: PMC8192497

Abstract Article PDF–1.9M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 78485447.

The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells

Yalong Wang, Kaixin He, Baifa Sheng, Xuqiu Lei, Wanyin Tao, Xiaoliang Zhu, Zheng Wei, Rongjie Fu, Anlei Wang, Shengdan Bai, Zhao Zhang, Na Hong, Chao Ye, Ye Tian, Jun Wang, Mingsong Li, Kaiguang Zhang, Lin Li, Hua Yang, Hua-Bing Li, Richard A. Flavell, Shu Zhu

Proc Natl Acad Sci U S A. 2021 Jan 26; 118(4): e2017432118. Published online 2021 Jan 22. doi: 10.1073/pnas.2017432118

Correction in:: Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2111936118.

PMCID:: PMC7848544

Abstract Article PDF–1.6M

Select item 77727748.

Paneth cell–derived growth factors support tumorigenesis in the small intestine

Qing Chen, Kohei Suzuki, Luis Sifuentes-Dominguez, Naoteru Miyata, Jie Song, Adam Lopez, Petro Starokadomskyy, Purva Gopal, Igor Dozmorov, Shuai Tan, Bujun Ge, Ezra Burstein

Life Sci Alliance. 2021 Mar; 4(3): e202000934. Published online 2020 Dec 28. doi: 10.26508/lsa.202000934

PMCID:: PMC7772774

Abstract Article PDF–3.1M

Select item 73329819.

LGR5 controls extracellular matrix production by stem cells in the developing intestine

Valeria Fernandez Vallone, Morgane Leprovots, Didac Ribatallada‐Soriano, Romain Gerbier, Anne Lefort, Frédérick Libert, Gilbert Vassart, Marie‐Isabelle Garcia

EMBO Rep. 2020 Jul 3; 21(7): e49224. Published online 2020 May 28. doi: 10.15252/embr.201949224

PMCID:: PMC7332981

Abstract Article PDF–7.1M

Select item 638670410.

Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis

QiXing Chen, Yang Yang, JinChao Hou, Qiang Shu, YiXuan Yin, WeiTao Fu, Feng Han, TingJun Hou, CongLi Zeng, Elizabeta Nemeth, Rose Linzmeier, Tomas Ganz, XiangMing Fang

Proc Natl Acad Sci U S A. 2019 Feb 19; 116(8): 3161–3170. Published online 2019 Feb 4. doi: 10.1073/pnas.1812947116

Correction in:: Proc Natl Acad Sci U S A. 2022 Jan 25; 119(4): e2121889119.

PMCID:: PMC6386704

Abstract Article PDF–1.7M

Select item 617944511.

Loss of Paneth cell autophagy causes acute susceptibility to Toxoplasma gondii-mediated inflammation

Elise Burger, Alessandra Araujo, Américo López-Yglesias, Michael W. Rajala, Linda Geng, Beth Levine, Lora V. Hooper, Ezra Burstein, Felix Yarovinsky

Cell Host Microbe. Author manuscript; available in PMC 2019 Feb 14.

Published in final edited form as: Cell Host Microbe. 2018 Feb 14; 23(2): 177–190.e4. Published online 2018 Jan 18. doi: 10.1016/j.chom.2018.01.001

PMCID:: PMC6179445

Abstract Article PDF–1.1M

Select item 574632112.

Cryptdin-2 predicts intestinal injury during heatstroke in mice

Jingjing Ji, Zhengtao Gu, Hui Li, Lei Su, Zhifeng Liu

Int J Mol Med. 2018 Jan; 41(1): 137–146. Published online 2017 Nov 1. doi: 10.3892/ijmm.2017.3229

PMCID:: PMC5746321

Abstract Article PDF–1.0M

Select item 357241013.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 323681614.

Biosynthesis and antimicrobial evaluation of backbone-cyclized alpha-defensins^#

Angie E. Garcia, Kenneth P. Tai, Shadakshara S. Puttamadappa, Alexander Shekhtman, Andre J. Ouellette, Julio A. Camarero

Biochemistry. Author manuscript; available in PMC 2012 Dec 6.

Published in final edited form as: Biochemistry. 2011 Dec 6; 50(48): 10508–10519. Published online 2011 Nov 9. doi: 10.1021/bi201430f

PMCID:: PMC3236816

Abstract Article PDF–1.9M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 312827316.

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

Roxana C Mustata, Tom Van Loy, Anne Lefort, Frédérick Libert, Sandra Strollo, Gilbert Vassart, Marie-Isabelle Garcia

EMBO Rep. 2011 Jun; 12(6): 558–564. Published online 2011 Apr 21. doi: 10.1038/embor.2011.52

PMCID:: PMC3128273

Abstract Article PDF–1.5M

Select item 301990617.

Strain-Specific Polymorphisms in Paneth Cell α-Defensins of C57BL/6 Mice and Evidence of Vestigial Myeloid α-Defensin Pseudogenes

Michael T. Shanahan, Hiroki Tanabe, André J. Ouellette

Infect Immun. 2011 Jan; 79(1): 459–473. Published online 2010 Nov 1. doi: 10.1128/IAI.00996-10

PMCID:: PMC3019906

Abstract Article PDF–4.3M

Select item 284419718.

Elevated Expression of Paneth Cell CRS4C in Ileitis-prone SAMP1/YitFc Mice: REGIONAL DISTRIBUTION, SUBCELLULAR LOCALIZATION, AND MECHANISM OF ACTION

Michael T. Shanahan, Alda Vidrich, Yoshinori Shirafuji, Claire L. Dubois, Agnes Henschen-Edman, Susan J. Hagen, Steven M. Cohn, André J. Ouellette

J Biol Chem. 2010 Mar 5; 285(10): 7493–7504. Published online 2010 Jan 7. doi: 10.1074/jbc.M109.083220

PMCID:: PMC2844197

Abstract Article PDF–1.9M

Select item 280744119.

Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome

Clara Amid, Linda M Rehaume, Kelly L Brown, James GR Gilbert, Gordon Dougan, Robert EW Hancock, Jennifer L Harrow

BMC Genomics. 2009; 10: 606. Published online 2009 Dec 15. doi: 10.1186/1471-2164-10-606

PMCID:: PMC2807441

Abstract Article PDF–477K

Select item 277254620.

Electropositive Charge in α-Defensin Bactericidal Activity: Functional Effects of Lys-for-Arg Substitutions Vary with the Peptide Primary Structure

R. Alan Llenado, Colby S. Weeks, Melanie J. Cocco, André J. Ouellette

Infect Immun. 2009 Nov; 77(11): 5035–5043. Published online 2009 Sep 8. doi: 10.1128/IAI.00695-09

PMCID:: PMC2772546

Abstract Article PDF–1.7M

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