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Select item 107161551.

Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa

Miranda L. Scalabrino, Mishek Thapa, Tian Wang, Alapakkam P. Sampath, Jeannie Chen, Greg D. Field

Nat Commun. 2023; 14: 8256. Published online 2023 Dec 12. doi: 10.1038/s41467-023-44063-8

PMCID:: PMC10716155

Abstract Article PDF–3.1M

Select item 95601592.

Robust cone-mediated signaling persists late into rod photoreceptor degeneration

Miranda L Scalabrino, Mishek Thapa, Lindsey A Chew, Esther Zhang, Jason Xu, Alapakkam P Sampath, Jeannie Chen, Greg D Field

eLife. 2022; 11: e80271. Published online 2022 Aug 30. doi: 10.7554/eLife.80271

PMCID:: PMC9560159

Abstract Article PDF–7.8M

Select item 89461863.

Inherited Retinal Degeneration: PARP-Dependent Activation of Calpain Requires CNG Channel Activity

Jie Yan, Alexander Günter, Soumyaparna Das, Regine Mühlfriedel, Stylianos Michalakis, Kangwei Jiao, Mathias W. Seeliger, François Paquet-Durand

Biomolecules. 2022 Mar; 12(3): 455. Published online 2022 Mar 15. doi: 10.3390/biom12030455

PMCID:: PMC8946186

Abstract Article PDF–4.9M

Select item 80263544.

The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim

Jillian N. Pearring, Jorge Martínez-Márquez, Jason R. Willer, Eric C. Lieu, Raquel Y. Salinas, Vadim Y. Arshavsky

J Neurosci. 2021 Apr 7; 41(14): 3094–3104. doi: 10.1523/JNEUROSCI.2609-20.2021

PMCID:: PMC8026354

Abstract Article PDF–3.1M

Select item 72270285.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 67038856.

Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina

Tian Wang, Johan Pahlberg, Jon Cafaro, Rikard Frederiksen, A.J. Cooper, Alapakkam P. Sampath, Greg D. Field, Jeannie Chen

J Neurosci. 2019 Aug 21; 39(34): 6798–6810. doi: 10.1523/JNEUROSCI.2902-18.2019

PMCID:: PMC6703885

Abstract Article PDF–4.5M

Select item 66227677.

The Glutamic Acid-Rich Protein Is a Gating Inhibitor of Cyclic Nucleotide-Gated Channels

Stylianos Michalakis, Xiangang Zong, Elvir Becirovic, Verena Hammelmann, Thomas Wein, Klaus T. Wanner, Martin Biel

J Neurosci. 2011 Jan 5; 31(1): 133–141. doi: 10.1523/JNEUROSCI.4735-10.2011

PMCID:: PMC6622767

Abstract Article PDF–1.9M

Select item 61775828.

The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx

Tian Wang, Jürgen Reingruber, Michael L. Woodruff, Anurima Majumder, Andres Camarena, Nikolai O. Artemyev, Gordon L. Fain, Jeannie Chen

J Biol Chem. 2018 Oct 5; 293(40): 15332–15346. Published online 2018 Aug 20. doi: 10.1074/jbc.RA118.004459

PMCID:: PMC6177582

Abstract Article PDF–3.5M

Select item 60755819.

Two pathways of rod photoreceptor cell death induced by elevated cGMP

Tian Wang, Stephen H. Tsang, Jeannie Chen

Hum Mol Genet. 2017 Jun 15; 26(12): 2299–2306. Published online 2017 Apr 3. doi: 10.1093/hmg/ddx121

PMCID:: PMC6075581

Abstract Article PDF–571K

Select item 574953910.

Patients and animal models of CNGβ1-deficient retinitis pigmentosa support gene augmentation approach

Simon M. Petersen-Jones, Laurence M. Occelli, Paige A. Winkler, Winston Lee, Janet R. Sparrow, Mai Tsukikawa, Sanford L. Boye, Vince Chiodo, Jenina E. Capasso, Elvir Becirovic, Christian Schön, Mathias W. Seeliger, Alex V. Levin, Stylianos Michalakis, William W. Hauswirth, Stephen H. Tsang

J Clin Invest. 2018 Jan 2; 128(1): 190–206. Published online 2017 Nov 20. doi: 10.1172/JCI95161

PMCID:: PMC5749539

Abstract Article PDF–23M

Select item 553205811.

Youwen Zhang, Glen R. Rubin, Naomi Fineberg, Carrie Huisingh, Gerald McGwin, Steven J. Pittler, Timothy W. Kraft

Doc Ophthalmol. Author manuscript; available in PMC 2017 Jul 27.

Published in final edited form as: Doc Ophthalmol. 2012 Jun; 124(3): 163–175. Published online 2012 Feb 26. doi: 10.1007/s10633-012-9317-2

PMCID:: PMC5532058

Abstract Article PDF–2.2M

Select item 530985112.

GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel β-subunit knockout mice

Marci L. DeRamus, Delores A. Stacks, Youwen Zhang, Carrie E. Huisingh, Gerald McGwin, Steven J. Pittler

Sci Rep. 2017; 7: 42545. Published online 2017 Feb 15. doi: 10.1038/srep42545

PMCID:: PMC5309851

Abstract Article PDF–2.6M

Select item 521462413.

Simultaneous Loss of NCKX4 and CNG Channel Desensitization Impairs Olfactory Sensitivity

Christopher H. Ferguson, Haiqing Zhao

J Neurosci. 2017 Jan 4; 37(1): 110–119. doi: 10.1523/JNEUROSCI.2527-16.2016

PMCID:: PMC5214624

Abstract Article PDF–1.9M

Select item 486144114.

The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility

Xi-Qin Ding, Arjun Thapa, Hongwei Ma, Jianhua Xu, Michael H. Elliott, Karla K. Rodgers, Marci L. Smith, Jin-Shan Wang, Steven J. Pittler, Vladimir J. Kefalov

J Biol Chem. 2016 Apr 15; 291(16): 8721–8734. Published online 2016 Feb 18. doi: 10.1074/jbc.M115.696138

PMCID:: PMC4861441

Abstract Article PDF–3.0M

Select item 477727515.

Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration

Dibyendu Chakraborty, Shannon M. Conley, Steven J. Pittler, Muna I. Naash

Invest Ophthalmol Vis Sci. 2016 Mar; 57(3): 787–797. Published online 2016 Mar 1. doi: 10.1167/iovs.15-18516

PMCID:: PMC4777275

Abstract Article PDF–2.0M

Select item 469941216.

Varying the GARP2-to-RDS Ratio Leads to Defects in Rim Formation and Rod and Cone Function

Dibyendu Chakraborty, Shannon M. Conley, Marci L. DeRamus, Steven J. Pittler, Muna I. Naash

Invest Ophthalmol Vis Sci. 2015 Dec; 56(13): 8187–8198. Published online 2015 Dec 28. doi: 10.1167/iovs.15-17785

PMCID:: PMC4699412

Abstract Article PDF–2.1M

Select item 458161417.

A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease

Frans Vinberg, Tian Wang, Robert S. Molday, Jeannie Chen, Vladimir J. Kefalov

Hum Mol Genet. 2015 Oct 15; 24(20): 5915–5929. Published online 2015 Aug 5. doi: 10.1093/hmg/ddv319

PMCID:: PMC4581614

Abstract Article PDF–1.1M

Select item 423098318.

Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration

Blanca Arango-Gonzalez, Dragana Trifunović, Ayse Sahaboglu, Katharina Kranz, Stylianos Michalakis, Pietro Farinelli, Susanne Koch, Fred Koch, Sandra Cottet, Ulrike Janssen-Bienhold, Karin Dedek, Martin Biel, Eberhart Zrenner, Thomas Euler, Per Ekström, Marius Ueffing, François Paquet-Durand

PLoS One. 2014; 9(11): e112142. Published online 2014 Nov 13. doi: 10.1371/journal.pone.0112142