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Select item 114470001.

Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability

Timothy A. Fenton, Olivia Y. Haouchine, Elizabeth B. Hallam, Emily M. Smith, Kiya C. Jackson, Darlene Rahbarian, Cesar P. Canales, Anna Adhikari, Alex S. Nord, Roy Ben-Shalom, Jill L. Silverman

Transl Psychiatry. 2024; 14: 405. Published online 2024 Oct 2. doi: 10.1038/s41398-024-03077-6

PMCID:: PMC11447000

Abstract Article PDF–1.6M

Select item 109198772.

FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid–liquid phase separation

Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O. Collins, Seth G. N. Grant, Yasunori Hayashi, Toru Takumi

PLoS Biol. 2024 Mar; 22(3): e3002006. Published online 2024 Mar 7. doi: 10.1371/journal.pbio.3002006

PMCID:: PMC10919877

Abstract Article PDF–5.4M

Select item 109015133.

A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis

Pengfei Guo, Rebecca C Lim, Keshari Rajawasam, Tiffany Trinh, Hong Sun, Hui Zhang

eLife. 2024; 13: e86168. Published online 2024 Feb 12. doi: 10.7554/eLife.86168

PMCID:: PMC10901513

Abstract Article PDF–9.2M

Select item 105001864.

Mouse models of SYNGAP1-related intellectual disability

Yoichi Araki, Elizabeth E. Gerber, Kacey E. Rajkovich, Ingie Hong, Richard C. Johnson, Hey-Kyoung Lee, Alfredo Kirkwood, Richard L. Huganir

Proc Natl Acad Sci U S A. 2023 Sep 12; 120(37): e2308891120. Published online 2023 Sep 5. doi: 10.1073/pnas.2308891120

PMCID:: PMC10500186

Abstract Article PDF–1.6M

Select item 104766405.

Interneuron-Targeted Disruption of SYNGAP1 Alters Sensory Representations in the Neocortex and Impairs Sensory Learning

Meiling Zhao, Sung Eun Kwon

J Neurosci. 2023 Aug 30; 43(35): 6212–6226. doi: 10.1523/JNEUROSCI.1997-22.2023

PMCID:: PMC10476640

Abstract Article PDF–4.6M

Select item 103078526.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 102459517.

Mouse models of SYNGAP1-related intellectual disability

Yoichi Araki, Elizabeth E. Gerber, Kacey E. Rajkovich, Ingie Hong, Richard C. Johnson, Hey-Kyoung Lee, Alfredo Kirkwood, Richard L. Huganir

Version 2. bioRxiv. Preprint. 2023 May 26. doi: 10.1101/2023.05.25.542312

Published in:: Proc Natl Acad Sci U S A. 2023 Sep 12; 120(37): e2308891120.

PMCID:: PMC10245951

Abstract Article PDF–3.1M

Select item 102089588.

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome

Brianna K. Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M. Ronen, Jennifer Howe, Aurélie Caye-Eude, Alain Verloes, Brad W. Doble, Laurence Faivre, Antonio Vitobello, Stephen W. Scherer, Yu Lu, Peter Penzes, Karun K. Singh

Mol Psychiatry. 2023; 28(4): 1747–1769. Published online 2023 Jan 6. doi: 10.1038/s41380-022-01937-5

PMCID:: PMC10208958

Abstract Article PDF–7.0M

Select item 101988179.

Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing

Runwei Yang, Xinran Feng, Alejandra Arias-Cavieres, Robin M. Mitchell, Ashleigh Polo, Kaining Hu, Rong Zhong, Cai Qi, Rachel S. Zhang, Nathaniel Westneat, Cristabel A. Portillo, Marcelo A. Nobrega, Christian Hansel, Alfredo J. Garcia, III, Xiaochang Zhang

Neuron. Author manuscript; available in PMC 2024 May 17.

Published in final edited form as: Neuron. 2023 May 17; 111(10): 1637–1650.e5. Published online 2023 Mar 13. doi: 10.1016/j.neuron.2023.02.021

PMCID:: PMC10198817

Abstract Article PDF–1.3M

Select item 1016612810.

Syngap1 Disruption Induced by Recombination between Inverted loxP Sites Is Associated with Hippocampal Interneuron Dysfunction

Abdessattar Khlaifia, Vidya Jadhav, Marc Danik, Théo Badra, Martin H. Berryer, Alexandre Dionne-Laporte, Bidisha Chattopadhyaya, Graziella Di Cristo, Jean-Claude Lacaille, Jacques L. Michaud

eNeuro. 2023 May; 10(5): ENEURO.0475-22.2023. Prepublished online 2023 Apr 18. Published online 2023 May 4. doi: 10.1523/ENEURO.0475-22.2023

PMCID:: PMC10166128

Abstract Article PDF–5.0M

Select item 906429011.

Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection

Murat Kilinc, Vineet Arora, Thomas K Creson, Camilo Rojas, Aliza A Le, Julie Lauterborn, Brent Wilkinson, Nicolas Hartel, Nicholas Graham, Adrian Reich, Gemma Gou, Yoichi Araki, Àlex Bayés, Marcelo Coba, Gary Lynch, Courtney A Miller, Gavin Rumbaugh

eLife. 2022; 11: e75707. Published online 2022 Apr 8. doi: 10.7554/eLife.75707

PMCID:: PMC9064290

Abstract Article PDF–3.4M

Select item 840396812.

Syngap1 regulates experience-dependent cortical ensemble plasticity by promoting in vivo excitatory synapse strengthening

Nerea Llamosas, Sheldon D. Michaelson, Thomas Vaissiere, Camilo Rojas, Courtney A. Miller, Gavin Rumbaugh

Proc Natl Acad Sci U S A. 2021 Aug 24; 118(34): e2100579118. Published online 2021 Aug 17. doi: 10.1073/pnas.2100579118

PMCID:: PMC8403968

Abstract Article PDF–3.8M

Select item 837873913.

SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian-gated locomotor activity and light-entrainment capacity

Sydney Aten, Anisha Kalidindi, Hyojung Yoon, Gavin Rumbaugh, Kari R. Hoyt, Karl Obrietan

Eur J Neurosci. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Eur J Neurosci. 2021 Feb; 53(3): 732–749. Published online 2020 Nov 30. doi: 10.1111/ejn.15043

PMCID:: PMC8378739

Abstract Article PDF–2.3M

Select item 831323914.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 809881415.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Shalini Menon, Dennis Goldfarb, Chris T. Ho, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, M. Ben Major, Stephanie L. Gupton

Mol Biol Cell. 2021 Feb 15; 32(4): 314–330. doi: 10.1091/mbc.E20-10-0622

PMCID:: PMC8098814

Abstract Article PDF–7.7M

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 775431817.

SynGAP splice variants display heterogeneous spatio‐temporal expression and subcellular distribution in the developing mammalian brain

Gemma Gou, Adriana Roca‐Fernandez, Murat Kilinc, Elena Serrano, Rita Reig‐Viader, Yoichi Araki, Richard L. Huganir, Cristian de Quintana‐Schmidt, Gavin Rumbaugh, Àlex Bayés

J Neurochem. 2020 Sep; 154(6): 618–634. Published online 2020 Mar 10. doi: 10.1111/jnc.14988

PMCID:: PMC7754318

Abstract Article PDF–2.0M

Select item 774639118.

pSynGAP1 disturbance-mediated hippocampal oscillation network impairment might contribute to long-term neurobehavioral abnormities in sepsis survivors

Yong Wang, Hua Wei, Jianhua Tong, Muhuo Ji, Jianjun Yang

Aging (Albany NY) 2020 Nov 30; 12(22): 23146–23164. Published online 2020 Nov 16. doi: 10.18632/aging.104080

PMCID:: PMC7746391

Abstract Article PDF–2.6M

Select item 761567019.

Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2

Alexa E. Horner, Rebecca H. Norris, Robbie McLaren-Jones, Liam Alexander, Noboru H. Komiyama, Seth G. N. Grant, Jess Nithianantharajah, Maksym V. Kopanitsa

Genes Brain Behav. Author manuscript; available in PMC 2024 Feb 26.

Published in final edited form as: Genes Brain Behav. 2021 Jan 1; 20(1): e12723. Published online 2020 Dec 29. doi: 10.1111/gbb.12723

PMCID:: PMC7615670

Abstract Article PDF–2.3M

Select item 729232220.

Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice

Ryuichi Nakajima, Keizo Takao, Satoko Hattori, Hirotaka Shoji, Noboru H. Komiyama, Seth G. N. Grant, Tsuyoshi Miyakawa

Neuropsychopharmacol Rep. 2019 Sep; 39(3): 223–237. Published online 2019 Jul 19. doi: 10.1002/npr2.12073

PMCID:: PMC7292322

Abstract Article PDF–1000K

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